reserpine has been researched along with Epilepsy in 29 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Reserpine pretreatment could also diminish CL seizure-induced accumulation of cAMP." | 1.28 | [Effect of reserpine on both CL seizures and cAMP levels in seizure mice brain]. ( Chen, Q; Huang, M; Xie, Y, 1990) |
| "Pretreatment with reserpine had no effect on either the time to onset or duration of maximal dentate activation." | 1.28 | Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus. ( Lothman, EW; Stringer, JL, 1991) |
| "Correlation between the kindled seizure susceptibility and brain monoamine levels was investigated in the hippocampal and amygdaloid kindled cats." | 1.26 | [Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation]. ( Mitsunobu, K; Nakashima, T; Otsuki, S; Sato, M, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (89.66) | 18.7374 |
| 1990's | 3 (10.34) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| CARTER, CH | 1 |
| HOLT, EK | 3 |
| NISWANDER, GD | 3 |
| ROSENBERG, CM | 1 |
| BROOKS, C | 1 |
| FONTANARI, D | 1 |
| CURRO DOSSI, U | 1 |
| PALLISTER, PD | 1 |
| TRIPI, E | 1 |
| HAEFNER, H | 1 |
| KUTSCHER, I | 1 |
| LEONBERG, SC | 1 |
| GREEN, JB | 1 |
| ELLIOTT, FA | 1 |
| SAMSON, M | 1 |
| CHUSID, JG | 1 |
| KOPELOFF, LM | 1 |
| KOPELOFF, N | 1 |
| ZIMMERMAN, FT | 1 |
| BURGEMEISTER, BB | 1 |
| COLOMBATI, S | 1 |
| BENASSI, P | 1 |
| Neduva, SSh | 1 |
| Sato, M | 1 |
| Nakashima, T | 1 |
| Mitsunobu, K | 1 |
| Otsuki, S | 1 |
| Itil, TM | 2 |
| Wadud, A | 1 |
| Kobayashi, K | 2 |
| Mori, A | 2 |
| Wada, JA | 1 |
| Kariya, T | 1 |
| Huang, M | 1 |
| Xie, Y | 1 |
| Chen, Q | 1 |
| al-Tajir, G | 1 |
| Chandler, CJ | 1 |
| Starr, BS | 1 |
| Starr, MS | 1 |
| Stringer, JL | 1 |
| Lothman, EW | 1 |
| Neuman, RS | 1 |
| Van Gelder, NM | 1 |
| Sherwin, AL | 1 |
| Rasmussen, T | 1 |
| Blazsó, S | 1 |
| Borenstein, P | 1 |
| Dongier, M | 1 |
| Fink, M | 1 |
| Florio, V | 2 |
| Longo, VG | 1 |
| Mellerio, F | 1 |
| Naquet, R | 1 |
| Pampiglione, G | 1 |
| Titeca, J | 1 |
| Verdeaux, G | 1 |
5 reviews available for reserpine and Epilepsy
| Article | Year |
|---|---|
[COMPLICATIONS DURING CLINICAL THERAPY WITH PSYCHOPHARMACA].
Topics: Agranulocytosis; Autonomic Nervous System Diseases; Chemical and Drug Induced Liver Injury; Chlorpro | 1964 |
Treatment of human aggression with major tranquilizers, antidepressants, and newer psychotropic drugs.
Topics: Adolescent; Affective Symptoms; Aggression; Alcoholism; Antidepressive Agents; Antipsychotic Agents; | 1975 |
Brain monoamines in seizure mechanism (review).
Topics: Animals; Brain; Carbonic Anhydrase Inhibitors; Catecholamines; Child; Dextroamphetamine; Dopamine; E | 1977 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
[Epilepsy and monoamines in the brain].
Topics: Animals; Biogenic Amines; Brain; Catecholamines; Cats; Dihydroxyphenylalanine; Dopamine; Drug Antago | 1975 |
24 other studies available for reserpine and Epilepsy
| Article | Year |
|---|---|
The effects of reserpine and methylphenidylacetate (ritalin) in mental defectives, spastics, and epileptics.
Topics: Antihypertensive Agents; Diet, Reducing; Epilepsy; Intellectual Disability; Methylphenidate; Muscle | 1956 |
Combination reserpine-methylphenidylacetate in epileptics with psychosis.
Topics: Epilepsy; Methylphenidate; Psychotic Disorders; Reserpine | 1957 |
Combination reserpine-methylphenidylacetate in epileptics with psychosis.
Topics: Epilepsy; Methylphenidate; Psychotic Disorders; Reserpine | 1957 |
Combination reserpine-methylphenidylacetate in epileptics with psychosis.
Topics: Epilepsy; Methylphenidate; Psychotic Disorders; Reserpine | 1957 |
Combination reserpine-methylphenidylacetate in epileptics with psychosis.
Topics: Epilepsy; Methylphenidate; Psychotic Disorders; Reserpine | 1957 |
Treatment of psychomotor epileptics with reserpine.
Topics: Epilepsy; Epilepsy, Complex Partial; Reserpine | 1957 |
The use of reserpine (serpasil) in mentally ill epileptics.
Topics: Epilepsy; Mentally Ill Persons; Reserpine | 1957 |
Combination reserpine-methylphenidate in epileptics with psychosis; final report.
Topics: Epilepsy; Mental Disorders; Methylphenidate; Psychotic Disorders; Reserpine | 1958 |
[Effects of medical therapy on character disorders in epileptics].
Topics: Behavior; Chlorpromazine; Epilepsy; Mental Disorders; Personality Disorders; Reserpine | 1958 |
Aggravation of epilepsy by reserpine.
Topics: Epilepsy; Humans; Reserpine | 1959 |
[CRITICAL NOTE ON THE USEFULNESS OF A NEW DRUG, THE METHYL ETHER OF METHYL 18-EPIRESERPATE, IN PSYCHIATRY].
Topics: Biomedical Research; Depression; Epilepsy; Humans; Intellectual Disability; Mental Disorders; Methyl | 1963 |
THE RESPONSE OF STROKE PATIENTS TO VERY SMALL DOSES OF PARENTERAL RESERPINE.
Topics: Aged; Blood Pressure Determination; Cerebrovascular Disorders; Drug Therapy; Epilepsy; Geriatrics; H | 1964 |
[SEROTONIN AND THE CENTRAL NERVOUS SYSTEM].
Topics: Brain Chemistry; Central Nervous System; Epilepsy; Humans; Infant, Newborn; Metabolism; Migraine Dis | 1964 |
Reserpine (serpasil) effects on epileptic monkeys.
Topics: Animals; Antihypertensive Agents; Electroencephalography; Epilepsy; Haplorhini; Humans; Reserpine; S | 1955 |
Preliminary report upon the effect of reserpine on epilepsy and behavior problems in children.
Topics: Antihypertensive Agents; Behavior; Epilepsy; Intellectual Disability; Mental Disorders; Reserpine; S | 1955 |
[Electroencephalographic observations on a Rauwolfia alkaloid (Serpasil)].
Topics: Antihypertensive Agents; Electroencephalography; Epilepsy; Rauwolfia; Reserpine; Secologanin Tryptam | 1955 |
[On the topography and dynamics of skin potentials under normal conditions and in some diseases of the central nervous system (schizophrenia and epilepsy)].
Topics: Chlorpromazine; Depressive Disorder, Major; Electroencephalography; Electrophysiology; Epilepsy; Hum | 1966 |
[Correlation between seizure susceptibility and brain catecholamine levels. An experimental study using a kindling preparation].
Topics: 5-Hydroxytryptophan; Amygdala; Animals; Brain Chemistry; Catecholamines; Cats; Dopamine; Electric St | 1976 |
[Convulsions and monoamines].
Topics: Animals; Biogenic Amines; Brain Chemistry; Dopamine; Epilepsy; Homovanillic Acid; Mice; Rats; Reserp | 1978 |
[Effect of reserpine on both CL seizures and cAMP levels in seizure mice brain].
Topics: Animals; Brain; Cyclic AMP; Epilepsy; Female; Lactones; Male; Mice; Mice, Inbred Strains; Reserpine | 1990 |
Opposite effects of stimulation of D1 and D2 dopamine receptors on the expression of motor seizures in mouse and rat.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Benzazepines; Dopamine Agents; | 1990 |
Cholinergic and adrenergic agents modify the initiation and termination of epileptic discharges in the dentate gyrus.
Topics: Animals; Atropine; Clonidine; Electric Stimulation; Epilepsy; Hippocampus; Male; Parasympathomimetic | 1991 |
Suppression of penicillin-induced epileptiform activity by noxious stimulation: mediation by 5-hydroxytryptamine.
Topics: 5-Hydroxytryptophan; Animals; Cerebral Cortex; Epilepsy; Fenclonine; Locus Coeruleus; Male; Membrane | 1986 |
Amino acid content of epileptogenic human brain: focal versus surrounding regions.
Topics: Adolescent; Adult; Alanine; Amino Acids; Aminobutyrates; Aspartic Acid; Brain; Cerebral Cortex; Chil | 1972 |
[On the pharmacotherapeutic treatment of cerebral palsy. II. Treatment of oligophrenia and epilepsy].
Topics: Cerebral Palsy; Child; Child, Preschool; Chlorpromazine; Epilepsy; Epilepsy, Absence; Glutamates; Hu | 1965 |
The neuroleptics. 6. Clinical and experimental electroencephalography.
Topics: Animals; Brain; Butyrophenones; Cats; Chlorpromazine; Dopamine; Electroencephalography; Epilepsy; Ha | 1970 |
[Study of the central action of amantadine].
Topics: Amantadine; Animals; Butyrophenones; Central Nervous System; Chlorpromazine; Dihydroxyphenylalanine; | 1971 |