reserpine has been researched along with Diabetes Mellitus, Adult-Onset in 7 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Studies were performed to determine if early treatment with an angiotensin II (Ang II) receptor blocker (ARB), olmesartan, prevents the onset of microalbuminuria by attenuating glomerular podocyte injury in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with type 2 diabetes mellitus." | 7.78 | Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. ( Hara, T; Hayden, MR; Hitomi, H; Ichimura, A; Ito, S; Kaifu, K; Kawachi, H; Kiyomoto, H; Kobori, H; Kohno, M; Matsumoto, S; Nishijima, Y; Nishiyama, A; Ohsaki, H; Sofue, T; Sowers, JR; Urushihara, M; Whaley-Connell, A, 2012) |
| " To determine whether thiazide-induced diabetes is mediated by changes in potassium, we analyzed data from 3790 nondiabetic participants in the Systolic Hypertension in Elderly Program, a randomized clinical trial of isolated systolic hypertension in individuals aged >or=60 years treated with chlorthalidone or placebo." | 5.13 | Changes in serum potassium mediate thiazide-induced diabetes. ( Appel, LJ; Klag, MJ; Miller, ER; Parekh, RS; Shafi, T, 2008) |
| "Studies were performed to determine if early treatment with an angiotensin II (Ang II) receptor blocker (ARB), olmesartan, prevents the onset of microalbuminuria by attenuating glomerular podocyte injury in Otsuka Long-Evans Tokushima Fatty (OLETF) rats with type 2 diabetes mellitus." | 3.78 | Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. ( Hara, T; Hayden, MR; Hitomi, H; Ichimura, A; Ito, S; Kaifu, K; Kawachi, H; Kiyomoto, H; Kobori, H; Kohno, M; Matsumoto, S; Nishijima, Y; Nishiyama, A; Ohsaki, H; Sofue, T; Sowers, JR; Urushihara, M; Whaley-Connell, A, 2012) |
| "We compared the effects of long-term treatment with the angiotensin-converting enzyme inhibitor perindopril and triple therapy (hydrochlorothiazide, reserpine, and hydralazine) on the metabolic and renal features in the SHR/N-corpulent (cp) rat, a genetic model of non-insulin-dependent diabetes mellitus and hypertension." | 3.69 | Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat. ( Abraham, AA; Michaelis, OE; Scalbert, E; Striffler, JS; Thibault, N; Velasquez, MT, 1997) |
| "Also in a rat model of NIDDM, neonatally streptozotocin diabetic rats (STZ), the insulin response to glucose is profoundly suppressed when studied in vivo or in the perfused pancreas." | 1.29 | Release of catecholamines is increased but does not contribute to the impaired insulin secretion in the perfused pancreata of diabetic rats. ( Efendic, S; Hjemdahl, P; Ostenson, CG, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Soliman, E | 1 |
| Essmat, N | 1 |
| Mahmoud, MF | 1 |
| Mahmoud, AAA | 1 |
| Shafi, T | 1 |
| Appel, LJ | 1 |
| Miller, ER | 1 |
| Klag, MJ | 1 |
| Parekh, RS | 1 |
| Zhang, MZ | 1 |
| Wang, S | 1 |
| Yang, S | 1 |
| Yang, H | 1 |
| Fan, X | 1 |
| Takahashi, T | 1 |
| Harris, RC | 1 |
| Sofue, T | 1 |
| Kiyomoto, H | 1 |
| Kobori, H | 1 |
| Urushihara, M | 1 |
| Nishijima, Y | 1 |
| Kaifu, K | 1 |
| Hara, T | 1 |
| Matsumoto, S | 1 |
| Ichimura, A | 1 |
| Ohsaki, H | 1 |
| Hitomi, H | 1 |
| Kawachi, H | 1 |
| Hayden, MR | 1 |
| Whaley-Connell, A | 1 |
| Sowers, JR | 1 |
| Ito, S | 1 |
| Kohno, M | 1 |
| Nishiyama, A | 1 |
| Ostenson, CG | 1 |
| Hjemdahl, P | 1 |
| Efendic, S | 1 |
| Velasquez, MT | 1 |
| Striffler, JS | 1 |
| Abraham, AA | 1 |
| Michaelis, OE | 1 |
| Scalbert, E | 1 |
| Thibault, N | 1 |
| Maison, P | 1 |
| Planchat-Fely, P | 1 |
| Vauzelle-Kervroëdan, F | 1 |
| Sermet, C | 1 |
| Eschwège, E | 1 |
1 trial available for reserpine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Changes in serum potassium mediate thiazide-induced diabetes.
Topics: Aged; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Diabetes Mellitus, Type 2; | 2008 |
6 other studies available for reserpine and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation.
Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antidepressive Agent | 2020 |
Role of blood pressure and the renin-angiotensin system in development of diabetic nephropathy (DN) in eNOS-/- db/db mice.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopri | 2012 |
Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats.
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Glucos | 2012 |
Release of catecholamines is increased but does not contribute to the impaired insulin secretion in the perfused pancreata of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Epinephrine; Female; Glucose; I | 1993 |
Perindopril ameliorates glomerular and renal tubulointerstitial injury in the SHR/N-corpulent rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Diabetes Mellitus, Type | 1997 |
Trends in antihypertensive drug use among orally treated diabetic patients, in France between 1981 and 1992. Impact of guidelines and new drugs.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive | 2001 |