reserpine has been researched along with Depression in 240 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence." | 9.41 | The effects of reserpine on depression: A systematic review. ( Cave, J; Jauhar, S; Javed, RR; Strawbridge, R; Young, AH, 2023) |
| "The aim of this study was to construct an animal model of depression that reproduces the human clinical manifestation, to evaluate the possible benefits of curcumin (CUR) in the treatment of depression and to compare its effect with the effect of a classic antidepressant, escitalopram (ESC)." | 8.31 | The effect of curcumin on reserpine-induced depression-like behaviour in rats. ( Decea, R; Donosa, M; Dudau, LE; Filip, GA; Moisa, E; Moldovan, R; Sevastre-Berghian, A; Stancu, B, 2023) |
| "Proteomic analysis of reserpine-induced depression and the effects of berberine on this were investigated to delineate the possible underlying mechanism." | 8.12 | Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine. ( Wang, Y; Yang, N; Zou, L, 2022) |
| "The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine." | 8.12 | Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats. ( Ahmed, NA; Fahmy, HM; Hussein, AA; Khadrawy, YA; Mohamed, ER, 2022) |
| " This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed." | 8.02 | Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021) |
| "The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model." | 7.96 | Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020) |
| "Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression." | 7.91 | BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. ( Chen, Z; Lv, D; Shen, M; Wang, C; Yu, H; Zhang, Y; Zhou, D, 2019) |
| "Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine." | 7.88 | Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 7.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 7.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
| "), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats." | 7.77 | Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011) |
| "p injection of reserpine for 15 days to establish the animal model of depression." | 7.77 | Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. ( El-Shamy, KA; Khadrawy, YA; Mohamed, SI, 2011) |
| "Experimental depression was induced by subcutaneous injection of reserpine in mice." | 7.73 | [Experimental study of the total flavonoid in Hypericum perforatum on depression]. ( Liu, JX; Tu, PF; Wang, JN; Wei, CE; Xu, L; Zhao, MB, 2005) |
| "To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions." | 7.72 | [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats]. ( Chen, Y; Han, T; Liu, MR; Qin, LP; Rui, YC; Zheng, HC, 2004) |
| "Reserpine induced behavioral depression partially via brain interleukin-1 beta generation." | 7.72 | Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats. ( Hao, XL; Huang, QJ; Jiang, H; Minor, TR, 2004) |
| "For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression." | 7.72 | The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis. ( Baumeister, AA; Hawkins, MF; Uzelac, SM, 2003) |
| "The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution." | 7.66 | Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression. ( Bein, HJ, 1978) |
| "Long-term administration of lithium hydroxybutyrate (10 mg/kg, for 7 days) prevents the depression of avoidance behavior in rats and EEG alterations in the cortex and subcortical structures of rabbit brain induced by a single injection of 0." | 7.66 | [Efficacy of lithium hydroxybutyrate in reserpine depression]. ( Saratikov, AS; Zamoshchina, TA, 1983) |
| "Experiments on male-rats with a chronic administration of lithium show that it exerts a dose-dependence ambivalent action on the biochemical and behavioural characterisics of "reseprine depressions"." | 7.65 | [Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect]. ( Baru, AM; Kholodyĭ, IuG; Sedykh, LI, 1977) |
| "This article reviews the chemistry, pharmacology, pharmacokinetics, therapeutic use, tolerability, drug-interaction potential, and dosing and administration of TBZ." | 6.46 | Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010) |
| "Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test." | 5.72 | Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022) |
| "Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies." | 5.62 | Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021) |
| "Depression is one of the most common mental health disorders and it is generally characterized by negative mood." | 5.62 | Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. ( Alizadeh Makvandi, A; Amiri Moghaddam, S; Khalili, M; Roghani, M, 2021) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 5.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| "The present study aims to evaluate the antidepressant effect of different formulations of Thymoquinone; free Thymoquinone (TQ), Thymoquinone-loaded Chitosan nanoparticles (TQ-TPP-Cs NPs) and Thymoquinone-loaded Chitosan nanoparticles coated with polysorbate 80 (TQ-TPP-Cs NPs-PSb80) that have been prepared to avoid the low bioavailability of TQ." | 5.56 | Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. ( Abd Rabo, AA; Abd-El Daim, TM; Elfeky, AS; Fahmy, HM; Khadrawy, YA; Mostafa, IT; Mustafa, AB, 2020) |
| "Treatment-resistant depression is a major health problem worldwide." | 5.46 | Repeated treatment with reserpine as a progressive animal model of depression. ( Haleem, DJ; Ikram, H, 2017) |
| "Chronic pain has consistently been correlated with depression." | 5.43 | Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016) |
| "Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence." | 5.41 | The effects of reserpine on depression: A systematic review. ( Cave, J; Jauhar, S; Javed, RR; Strawbridge, R; Young, AH, 2023) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 5.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| "Depression and pain are often diagnosed in the same patients." | 5.37 | Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| "Reserpine was added for both antipsychotic coverage and reported beneficial effects in the treatment of TD." | 5.27 | Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia. ( Holt, RJ, 1984) |
| "This paper reviews recent research on the contribution of the proinflammatory cytokine interleukin-1 (IL- 1) and the purine nucleoside adenosine in mediating behavioral depression and related symptoms of conservation-withdrawal in animal models of both major depression and illness." | 4.86 | Biochemical and anatomical substrates of depression and sickness behavior. ( Furst, SJ; Hanff, TC; Minor, TR, 2010) |
| "By a combination of biochemical and pharmacodynamical analyses the author conducted a differentiated study of the role of separate neurohormones (adrenalin, noradrenalin, dopamine, serotonine) and their interconnection with other regulating systems (corticosteroids, nucleic acids) in the neurochemical structure of experimental models in depressive behaviour (reserpine depressions, depressions due to inhibitors of dopamine-beta-oxydase)." | 4.75 | [Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)]. ( Baru, AM, 1975) |
| " monnieri improves depression comparable to citalopram in reserpine-induced depression." | 4.12 | Neuroprotective role of Bacopa monnieri extract in modulating depression in an experimental rat model. ( Al-Shafei, AI; Daoud, NN; El-Gendy, OA; Zaazaa, AM, 2022) |
| " This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed." | 4.02 | Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021) |
| "The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model." | 3.96 | Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020) |
| "Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression." | 3.91 | BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. ( Chen, Z; Lv, D; Shen, M; Wang, C; Yu, H; Zhang, Y; Zhou, D, 2019) |
| "Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine." | 3.88 | Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018) |
| " Twenty four rats were divided into: control, rat model of depression induced by reserpine and depressive-like rats treated with Cannabis sativa extract (10mg/kg expressed as Δ9-tetrahydrocannabinol)." | 3.85 | Cannabis exacerbates depressive symptoms in rat model induced by reserpine. ( Abdel-Salam, OME; Hosny, EN; Khadrawy, YA; Sawie, HG, 2017) |
| " Animals were induced to a reserpine-induced depression model and were then chronically treated with duloxetine, desvenlafaxine or vehicle." | 3.85 | A standardization of the Novelty-Suppressed Feeding Test protocol in rats. ( Blasco-Serra, A; Cervera-Ferri, A; González-Soler, EM; Teruel-Martí, V; Valverde-Navarro, AA, 2017) |
| "A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)." | 3.83 | Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016) |
| "This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored." | 3.79 | [Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013) |
| "5mg/kg), which could antagonize reserpine-induced ptosis and hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE, 5-HT, DA in striatum significantly." | 3.79 | Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013) |
| "The findings from the current study suggested that reserpine-induced neurochemical alterations and dysregulation of oxidative-nitrosative stress induced inflammatory cascade underlies the co-morbidity of nociceptive behaviour and associated depression in rats." | 3.79 | Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013) |
| "p injection of reserpine for 15 days to establish the animal model of depression." | 3.77 | Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. ( El-Shamy, KA; Khadrawy, YA; Mohamed, SI, 2011) |
| "), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats." | 3.77 | Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011) |
| " A possible mechanism was explored in the test of antagonism of reserpine-induced ptosis and hypothermia in mice." | 3.76 | Antidepressant-like effect of genipin in mice. ( Chi, W; Cui, YL; Dong, TJ; Gao, S; Hu, LM; Liu, LP; Tian, JS, 2010) |
| "This study investigates the effect of the petroleum ether, chloroform, and ethyl acetate fractions of the total ethanolic extract of Convolvulus pluricaulis Choisy (Family: Convolvulaceae) on depression in mice." | 3.74 | Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests. ( Dhingra, D; Valecha, R, 2007) |
| "Experimental depression was induced by subcutaneous injection of reserpine in mice." | 3.73 | [Experimental study of the total flavonoid in Hypericum perforatum on depression]. ( Liu, JX; Tu, PF; Wang, JN; Wei, CE; Xu, L; Zhao, MB, 2005) |
| "To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions." | 3.72 | [Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats]. ( Chen, Y; Han, T; Liu, MR; Qin, LP; Rui, YC; Zheng, HC, 2004) |
| "After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression." | 3.68 | [The antidepressive properties of anaprilin]. ( Arushanian, EB; Beĭer, EV, 1992) |
| "Reserpine or beta-blocker therapy did not cause any more depression than any other antihypertensive treatment." | 3.68 | Depression associated with antihypertensive drugs. ( Adams, MA; Carr, AA; Fincham, JE; Prisant, LM; Spruill, WJ; Wade, WE, 1991) |
| "The study was made on the reserpine model of behavioural depression in cats." | 3.68 | [Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats]. ( Khaĭsman, EB; Kushnarev, VV, 1990) |
| "Since reserpine precipitates depression in some hypertensive patients, we tested this drug on our animal model of depression." | 3.67 | Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. ( Aprison, MH; Brugge, KL; Hingtgen, JN, 1987) |
| " The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression." | 3.66 | [Psychopharmacologic spectrum of melanostatin]. ( Klusha, VE; Kozlovskaia, MM; Svirskis, ShV; Val'dman, AV, 1980) |
| "The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution." | 3.66 | Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression. ( Bein, HJ, 1978) |
| "Depression was assessed using the CES-D scale (Center for Epidemiological Studies--Depressed Mood), administered at baseline and again approximately 1 year after randomization." | 2.67 | Effect of withdrawal of antihypertensive drug on depressive mood. ( Blaufox, MD; Langford, HG; Oberman, A; Thaler, L; Wassertheil-Smoller, S, 1993) |
| "This article reviews the chemistry, pharmacology, pharmacokinetics, therapeutic use, tolerability, drug-interaction potential, and dosing and administration of TBZ." | 2.46 | Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010) |
| "Depression is a leading cause of disability worldwide and the psychiatric diagnosis most commonly associated with suicide." | 1.91 | Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system. ( Chen, Q; Hu, J; Lan, J; Li, X; Liu, M; Peng, Y; Shang, N; Wang, H; Xiang, L; Xiao, Q; Yin, D, 2023) |
| "Depression has become an important disease threatening human health." | 1.72 | Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. ( Chen, N; Chu, S; He, F; He, J; Lai, K; Li, D; Li, Y; Wang, S; Wei, D; Wei, G; Wei, J; Xie, J; Zhang, Z, 2022) |
| "Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test." | 1.72 | Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022) |
| "Depression is one of the most common mental health disorders and it is generally characterized by negative mood." | 1.62 | Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. ( Alizadeh Makvandi, A; Amiri Moghaddam, S; Khalili, M; Roghani, M, 2021) |
| "Depression is the most frequent affective disorder and is the leading cause of disability worldwide." | 1.62 | A Reliable High-Throughput Screening Model for Antidepressant. ( He, J; Lai, Y; Liu, Q; Qiao, C; Shang, J; Zhang, R; Zhong, H, 2021) |
| "Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies." | 1.62 | Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021) |
| "Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice." | 1.56 | Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020) |
| "The present study aims to evaluate the antidepressant effect of different formulations of Thymoquinone; free Thymoquinone (TQ), Thymoquinone-loaded Chitosan nanoparticles (TQ-TPP-Cs NPs) and Thymoquinone-loaded Chitosan nanoparticles coated with polysorbate 80 (TQ-TPP-Cs NPs-PSb80) that have been prepared to avoid the low bioavailability of TQ." | 1.56 | Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. ( Abd Rabo, AA; Abd-El Daim, TM; Elfeky, AS; Fahmy, HM; Khadrawy, YA; Mostafa, IT; Mustafa, AB, 2020) |
| "Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal." | 1.51 | Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019) |
| "Chronic pain has consistently been correlated with depression." | 1.43 | Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016) |
| "Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice." | 1.40 | Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014) |
| "Depression and pain are often diagnosed in the same patients." | 1.37 | Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011) |
| " Chronic administration of berberine (5 mg/kg, i." | 1.35 | On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008) |
| " The dose-response relationship shifted to the left following REMs deprivation (ED50 values in the group-housed, isolated, and REMs-deprived mice were 250, 200, and 27 micrograms/kg, respectively)." | 1.29 | Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. ( Asakura, W; Matsumoto, K; Ohta, H; Watanabe, H, 1994) |
| "Bupropion is a novel antidepressant, distinct from tricyclic antidepressants both neurochemically and behaviorally." | 1.28 | Antidepressant profile of bupropion and three metabolites in mice. ( Colin, JN; Lacomblez, L; Martin, P; Massol, J; Puech, AJ, 1990) |
| "Reserpine was added for both antipsychotic coverage and reported beneficial effects in the treatment of TD." | 1.27 | Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia. ( Holt, RJ, 1984) |
| "2." | 1.27 | Activation of brain function by S-135, a benzodiazepine receptor inverse agonist. ( Eigyo, M; Kawasaki, K; Matsubara, K; Matsushita, A; Shindo, H; Takada, S, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 158 (65.83) | 18.7374 |
| 1990's | 12 (5.00) | 18.2507 |
| 2000's | 14 (5.83) | 29.6817 |
| 2010's | 33 (13.75) | 24.3611 |
| 2020's | 23 (9.58) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, R | 1 |
| Qiao, C | 1 |
| Liu, Q | 1 |
| He, J | 2 |
| Lai, Y | 1 |
| Shang, J | 1 |
| Zhong, H | 1 |
| Samad, N | 1 |
| Khaliq, S | 1 |
| Alam, M | 1 |
| Yasmin, F | 1 |
| Ahmad, S | 1 |
| Mustafa, S | 1 |
| Azizuddin, - | 1 |
| Raza, U | 1 |
| Bhatt, S | 3 |
| Behl, T | 1 |
| Sehgal, A | 1 |
| Singh, S | 1 |
| Sharma, N | 1 |
| Chigurupati, S | 1 |
| Ahmed, AS | 1 |
| Gari, SBV | 1 |
| Yang, N | 1 |
| Zou, L | 1 |
| Wang, Y | 3 |
| Zaazaa, AM | 1 |
| Daoud, NN | 1 |
| El-Gendy, OA | 1 |
| Al-Shafei, AI | 1 |
| Fahmy, HM | 2 |
| Mohamed, ER | 1 |
| Hussein, AA | 1 |
| Khadrawy, YA | 4 |
| Ahmed, NA | 1 |
| Zhao, J | 1 |
| Shi, W | 1 |
| Lu, Y | 1 |
| Gao, X | 1 |
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| Zhao, MG | 2 |
| Tian, J | 1 |
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| Han, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188] | Phase 2/Phase 3 | 113 participants (Actual) | Interventional | 2018-04-25 | Completed | ||
| [NCT00005464] | 0 participants | Observational | 1991-02-28 | Completed | |||
| Cerebral Neuroinflammation During Major Depressive Episode: Multicentric Comparative Study.[NCT03314155] | 60 participants (Anticipated) | Interventional | 2018-12-07 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
26 reviews available for reserpine and Depression
| Article | Year |
|---|---|
The effects of reserpine on depression: A systematic review.
Topics: Adult; Antidepressive Agents; Anxiety; Anxiety Disorders; Depression; Humans; Reserpine | 2023 |
Biochemical and anatomical substrates of depression and sickness behavior.
Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Basal Ganglia; Brain; Depression; Disease Models, | 2010 |
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders.
Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Cytochrome P | 2010 |
[Drug-induced depression].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antineoplastic Agents; Aspirin; Ca | 2007 |
Depression, alpha 2-receptors and sex hormones: neuroendocrine studies in rat.
Topics: Animals; Antidepressive Agents; Apomorphine; Carbidopa; Castration; Clonidine; Depression; Dihydrote | 1984 |
Neurochemical and neuropharmacological aspects of depression.
Topics: Addison Disease; Adrenal Cortex Hormones; Amphetamines; Animals; Antidepressive Agents, Tricyclic; B | 1975 |
The contribution of drug research to investigating the nature of endogenous depression.
Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Female; Fenclonine; Histamine H1 Antag | 1976 |
[Biochemistry of depression. Literature analysis].
Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Hum | 1978 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
[Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)].
Topics: Adrenal Cortex Hormones; Adrenal Medulla; Animals; Brain; Catecholamines; Cell Nucleus; Depression; | 1975 |
Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: a critical review.
Topics: Animals; Antihypertensive Agents; Cats; Cognition; Depression; Electroencephalography; Fatigue; Feed | 1985 |
[Side effects of anti-arrhythmic agents].
Topics: 1-Propanol; Adrenal Cortex Hormones; Agranulocytosis; Anorexia Nervosa; Anti-Arrhythmia Agents; Anti | 1971 |
Depressions following reserpine: a reevaluation.
Topics: Administration, Oral; Depression; Dreams; Drug Therapy, Combination; Electroconvulsive Therapy; Huma | 1971 |
Depressive disorders: toward a unified hypothesis.
Topics: Age Factors; Animals; Anxiety, Separation; Behavior, Animal; Biogenic Amines; Conditioning, Operant; | 1973 |
The biochemistry of the functional psychoses.
Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Behavior, Animal; Blood Proteins; Catatoni | 1967 |
Drug-induced depression and tryptophan metabolism.
Topics: Adrenocorticotropic Hormone; Contraceptives, Oral; Cortisone; Depression; Estrogens; Female; Humans; | 1972 |
Biochemistry of depression (a review of the literature).
Topics: Adrenal Glands; Amines; Biogenic Amines; Brain Chemistry; Carbohydrate Metabolism; Catecholamines; C | 1971 |
Cardiovascular complications of antidepressant therapy. Interactions at the adrenergic neuron.
Topics: Antidepressive Agents; Cardiovascular Diseases; Depression; Drug Interactions; Electrocardiography; | 1972 |
Depressive reactions associated with reserpine.
Topics: Administration, Oral; Affective Symptoms; Anxiety; Compulsive Behavior; Depression; Female; Humans; | 1974 |
Recent clinical studies of ECT.
Topics: Adjustment Disorders; Aged; Anesthesia, Intravenous; Animals; Antidepressive Agents; Anxiety; Atropi | 1972 |
[Studies on the biochemistry and pharmacology of thymoleptics].
Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Catecholamines; Cats; Dep | 1968 |
Serotonin, and its effects on the pituitary-adrenal axis in depression.
Topics: Amphetamine; Animals; Behavior, Animal; Brain Chemistry; Depression; Humans; Hypothalamus; Mental Di | 1970 |
[Relation of monoamines to mental disorders].
Topics: Amines; Animals; Bipolar Disorder; Catecholamines; Central Nervous System; Depression; Dihydroxyphen | 1970 |
[Adrenergic mechanisms of antidepressant action].
Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cats; Depression; Dogs; Humans; | 1970 |
Theories of biological etiology of affective disorders.
Topics: Adrenal Cortex Hormones; Affective Symptoms; Amines; Amphetamine; Antidepressive Agents; Bipolar Dis | 1970 |
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho | 1970 |
13 trials available for reserpine and Depression
| Article | Year |
|---|---|
Effect of withdrawal of antihypertensive drug on depressive mood.
Topics: Affect; Antihypertensive Agents; Depression; Female; Humans; Hypertension; Male; Middle Aged; Psychi | 1993 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
Treatment with reserpine of patients resistant to tricyclic antidepressants. A double-blind trial.
Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Drug Eval | 1975 |
[Depressive effects during treatment with antihypertensive drugs (author's transl)].
Topics: Age Factors; Clinical Trials as Topic; Clonidine; Depression; Dose-Response Relationship, Drug; Drug | 1973 |
Comparison between reserpine and propranolol as adjuncts in the treatment of hyperthyroidism.
Topics: Administration, Oral; Adult; Asthma; Basal Metabolism; Blood Pressure; Body Weight; Clinical Trials | 1973 |
The action of reserpine in imipramine-resistant depressive patients. Clinical and biochemical study.
Topics: Adult; Bipolar Disorder; Blood Pressure; Body Temperature; Clinical Trials as Topic; Depression; Dru | 1967 |
Affective disorders and norepinephrine pharmacology.
Topics: Animals; Behavior; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Chlorpromazine; Clini | 1969 |
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho | 1970 |
Psychopharmacology.
Topics: Alcoholism; Anxiety; Brain Damage, Chronic; Chronic Disease; Clinical Trials as Topic; Depression; E | 1970 |
Clinical and animal experiments concerning the function of brain catecholamines.
Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca | 1971 |
A pilot study of antihypertensive therapy in cerebrovascular disease.
Topics: Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Depression; Female; Humans; Hypertension | 1967 |
Correlation between the experimental data from animal studies and therapetical effects of antidepressant drugs.
Topics: Animals; Antidepressive Agents; Depression; Electroencephalography; Female; Humans; Male; Nicotine; | 1971 |
[The effects of dopa on inhibited depressions].
Topics: Blood Pressure Determination; Depression; Dihydroxyphenylalanine; Drug Synergism; Humans; Placebos; | 1966 |
203 other studies available for reserpine and Depression
| Article | Year |
|---|---|
A Reliable High-Throughput Screening Model for Antidepressant.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Evaluatio | 2021 |
Tryptophan lessens reserpine induced anxiety, depression and memory impairment by modulating oxidative stress and serotonergic activity.
Topics: Acetylcholinesterase; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Se | 2021 |
Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bixaceae; Depression; Fluoxet | 2022 |
Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine.
Topics: Animals; Antipsychotic Agents; Berberine; Depression; Male; Mice; Mice, Inbred ICR; Proteomics; Rese | 2022 |
Neuroprotective role of Bacopa monnieri extract in modulating depression in an experimental rat model.
Topics: Animals; Bacopa; Brain-Derived Neurotrophic Factor; Citalopram; Depression; Dopamine; Humans; Male; | 2022 |
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats.
Topics: Animals; Depression; Dopamine; Gallic Acid; Nanoparticles; Norepinephrine; Rats; Rats, Wistar; Reser | 2022 |
Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.
Topics: Adrenocorticotropic Hormone; Animals; Comorbidity; Cytokines; Depression; Hydrocortisone; Hyperalges | 2022 |
Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Behavior, Animal; COVID-19; Depressi | 2022 |
Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis.
Topics: Alkaloids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Connexin 43; Corticost | 2022 |
Rutin Improves Anxiety and Reserpine-Induced Depression in Rats.
Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Antioxidants; Anxiety; Depression; Rats; Reser | 2022 |
Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system.
Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hippocampus; Hypothalamo-Hypophy | 2023 |
The effect of curcumin on reserpine-induced depression-like behaviour in rats.
Topics: Animals; Antidepressive Agents; Brain; Curcumin; Depression; Humans; Rats; Reserpine | 2023 |
Repeated reserpine treatment induces depressive-like behaviors accompanied with hippocampal impairment and synapse deficit in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; H | 2023 |
Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.
Topics: Animals; Antidepressive Agents; Cell Line, Tumor; Cerebral Cortex; Depression; Drug Design; Enzyme I | 2020 |
Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation.
Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antidepressive Agent | 2020 |
Antidepressant-like effect of ethanol extract of Blighia unijugata Bak. (Sapindaceae) leaves in acute and chronic models of depression in mice.
Topics: Animals; Blighia; Brain; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Locomotio | 2019 |
Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model.
Topics: Animals; Benzoquinones; Chitosan; Depression; Disease Models, Animal; Nanoparticles; Polysorbates; R | 2020 |
Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Fatigue; Fibromyalgia; Male; Mice; Mi | 2020 |
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.
Topics: Animals; Behavior, Animal; Brain; Coumarins; Cytokines; Depression; Drug Therapy, Combination; Femal | 2021 |
Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway.
Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; C | 2021 |
Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats.
Topics: Animals; Anticonvulsants; Antihypertensive Agents; Chronic Pain; Depression; Disease Models, Animal; | 2020 |
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence.
Topics: Amino Acids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyc | 2021 |
Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression.
Topics: Adrenergic Uptake Inhibitors; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models | 2021 |
Repeated treatment with reserpine as a progressive animal model of depression.
Topics: Animals; Antidepressive Agents; Chromatography, High Pressure Liquid; Depression; Male; Models, Anim | 2017 |
A standardization of the Novelty-Suppressed Feeding Test protocol in rats.
Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Duloxetine | 2017 |
Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption.
Topics: Alcohol Drinking; Animals; Depression; Dopamine; Ethanol; Female; Fluoxetine; Male; Rats; Rats, Wist | 2018 |
An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms.
Topics: Animals; Antidepressive Agents; Asteraceae; Behavior, Animal; Depression; Disease Models, Animal; Fe | 2018 |
Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Cognition Disorders; Depression; Drugs | 2018 |
Antidepressant-Like Effects of
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder; | 2018 |
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id | 2019 |
BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hi | 2019 |
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi | 2019 |
Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses.
Topics: Animals; Behavior, Animal; Brain; Coumaric Acids; Depression; Disease Models, Animal; Dopamine; Mice | 2013 |
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr | 2013 |
Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Coptis; Corpus Striatum; Depr | 2013 |
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc | 2013 |
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression | 2014 |
Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Dopamine; Hindlimb Suspension; Hyperic | 2014 |
Evaluation of anti-colitic effect of fluvoxamine against acetic acid-induced colitis in normal and reserpinized depressed rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-Generation; Antipsyc | 2015 |
In vivo imaging of CREB phosphorylation in awake-mouse brain.
Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Depr | 2015 |
Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Depression; Disease Models, Animal; Exploratory Behavior; Fee | 2015 |
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice.
Topics: Analgesics; Animals; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Anima | 2016 |
The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats.
Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Depression; Dizoci | 2016 |
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models | 2016 |
Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine in rats.
Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Electroencephalography; Infrar | 2016 |
Cannabis exacerbates depressive symptoms in rat model induced by reserpine.
Topics: Acetylcholinesterase; Animals; Cannabis; Cerebral Cortex; Depression; Disease Models, Animal; Dopami | 2017 |
Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Blepharoptosis; Clomipramine; Depression; Dise | 2008 |
On the mechanism of antidepressant-like action of berberine chloride.
Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De | 2008 |
Antidepressant-like effect of peony glycosides in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Blepharoptosis; Cerebrum; Depression; Disease Mode | 2008 |
Antidepressant-like effect of genipin in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Blepharoptosis; Depression; D | 2010 |
Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Beha | 2011 |
Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Curcumin | 2011 |
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
Topics: 5-Hydroxytryptophan; Acetamides; Animals; Antidepressive Agents; Behavior; Depression; Disease Model | 2011 |
Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression.
Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippo | 2011 |
Ginsenoside Rb3 exerts antidepressant-like effects in several animal models.
Topics: Action Potentials; Animals; Antidepressive Agents; Atrophy; Behavior, Animal; Brain-Derived Neurotro | 2012 |
Antidepressant and anxiolytic-like effects of 4n, a novel 5-HT3 receptor antagonist using behaviour based rodent models.
Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Emotions; Mice; Olfactory Bul | 2012 |
Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association.
Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Food Preferences; Injections, Intrape | 2002 |
The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis.
Topics: Biogenic Monoamines; Depression; History, 20th Century; Humans; Reserpine | 2003 |
Mental depression in hypertensive patients treated for long periods with large doses of reserpine.
Topics: Depression; Depressive Disorder; Humans; Hypertension; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1954 |
[Clinical trials of Rauwolfia alkaloid, reserpine, in psychiatry].
Topics: Depression; Depressive Disorder, Major; Mental Disorders; Psychiatry; Psychotherapy; Psychotic Disor | 1955 |
Treatment of hypertensive patients with Rauwolfia compounds and reserpine; depressive and psychotic changes.
Topics: Antihypertensive Agents; Depression; Depressive Disorder; Humans; Hypertension; Psychoses, Substance | 1955 |
[Painful phantom limb with a depressive syndrome; spectacular cure with reserpine].
Topics: Antihypertensive Agents; Depression; Depressive Disorder; Phantom Limb; Reserpine; Secologanin Trypt | 1955 |
Reserpine depression treated with sodium succinate; a preliminary report.
Topics: Antihypertensive Agents; Central Nervous System Stimulants; Depression; Depressive Disorder; Humans; | 1955 |
[Depression after reserpine therapy of essential hypertension].
Topics: Antihypertensive Agents; Depression; Depressive Disorder; Essential Hypertension; Hypertension; Rese | 1956 |
[Depressive states with melancholia behavior during treatment of arterial hypertension with reserpine or Rauwolfia serpentina alkaloids].
Topics: Antihypertensive Agents; Depression; Depressive Disorder; Hypertension; Rauwolfia; Reserpine; Secolo | 1956 |
[Risks of depression with Rauwolfia management].
Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk | 1956 |
[Risks of depression with Rauwolfia management].
Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk | 1956 |
[Risks of depression with Rauwolfia management].
Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk | 1956 |
[Risks of depression with Rauwolfia management].
Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk | 1956 |
[Rauwolfia and depressive states].
Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1956 |
[Rauwolfia and depressive states].
Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1956 |
[Rauwolfia and depressive states].
Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1956 |
[Rauwolfia and depressive states].
Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1956 |
[Cases of administration of massive doses of reserpine].
Topics: Depression; Depressive Disorder; Reserpine | 1956 |
[Cases of administration of massive doses of reserpine].
Topics: Depression; Depressive Disorder; Reserpine | 1956 |
[Cases of administration of massive doses of reserpine].
Topics: Depression; Depressive Disorder; Reserpine | 1956 |
[Cases of administration of massive doses of reserpine].
Topics: Depression; Depressive Disorder; Reserpine | 1956 |
Neuropharmacologic action of Rauwolfia compounds and its psychodynamic implications.
Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine | 1957 |
Ineffectiveness of chlorpromazine and Rauwolfia serpentina preparations in the treatment of depression.
Topics: Chlorpromazine; Depression; Depressive Disorder; Rauwolfia; Reserpine | 1957 |
[Observations on neurotic depressions with reference to a combined serpasil-ritalin treatment].
Topics: Combined Modality Therapy; Depression; Depressive Disorder; Manipulation, Osteopathic; Methylphenida | 1956 |
[Results of treatment with a new combination preparation in autonomic function disorders and depressive states].
Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Depression; Depressive Disorder; Ergot | 1957 |
[Inverse doriden effect in the course of a reserpine treatment of depressions].
Topics: Depression; Depressive Disorder; Glutethimide; Humans; Hypnotics and Sedatives; Reserpine | 1958 |
[Influencing of depressive states in geriatrics].
Topics: Aged; Depression; Depressive Disorder; Geriatrics; Methylphenidate; Reserpine | 1958 |
Treatment of depressed and regressed patients with iproniazid and reserpine.
Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids; Reserpine | 1959 |
[Evaluation and management of depressive states appearing during reserpine therapy].
Topics: Depression; Depressive Disorder; Diphenhydramine; Disease Management; Humans; Reserpine | 1958 |
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression.
Topics: Depression; Depressive Disorder; Essential Hypertension; Humans; Hypertension; Obesity; Reserpine; W | 1958 |
Place of methyl phenidate hydrochloride in psychiatric practice.
Topics: Depression; Depressive Disorder; Methylphenidate; Reserpine; Salts | 1959 |
Depressions in patients treated with reserpine for arterial hypertension.
Topics: Depression; Depressive Disorder; Humans; Hypertension; Reserpine | 1959 |
The mechanism of the combined treatment of depression with iproniazid and reserpine.
Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R | 1960 |
[The psychoanaleptic action of Disipal in the neuroleptic syndrome and in senile depression].
Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Anxiety; Depression; Depressive Disorder; Huma | 1961 |
[Combined iproniazid-reserpine treatment-a placebo experiment].
Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R | 1960 |
Effects and interactions of imipramine, chlorpromazine, reserpine and amphetamine on self-stimulation: possible neurophysiological basis of depression.
Topics: Amphetamine; Amphetamines; Chlorpromazine; Depression; Depressive Disorder; Imipramine; Reserpine; S | 1961 |
[Suicide prevention with special reference to the pharmacopsychiatric treatment of depression].
Topics: Anti-Allergic Agents; Depression; Depressive Disorder; Histamine H1 Antagonists; Parasympatholytics; | 1962 |
[Endogenous depression and its treatment].
Topics: Antidepressive Agents; Depression; Depressive Disorder; Electroconvulsive Therapy; Humans; Imipramin | 1963 |
COMBINED ADMINISTRATION OF DESIPRAMINE AND RESERPINE OR TETRABENAZINE IN DEPRESSIVE PATIENTS.
Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Reserpine; | 1963 |
CURRENT THERAPEUTICS. CXC. THE CURRENT STATUS OF THE TRANQUILLIZERS.
Topics: Anxiety; Chlorpromazine; Depression; Female; Humans; Phenothiazines; Premenstrual Syndrome; Rauwolfi | 1963 |
[TREATMENT OF ENDOGENOUS DEPRESSIONS WITH INTERMITTENT DOSES OF RESERPINE].
Topics: Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Paranoid Disorders; Reserpine | 1963 |
[HYPOTENSIVE AND SIDE-EFFECTS OF METHOXYPHENOSERPINE, A NEW RESERPINE DERIVATIVE].
Topics: Antihypertensive Agents; Anxiety; Depression; Depressive Disorder; Nasal Mucosa; Rauwolfia; Reserpin | 1963 |
[CRITICAL NOTE ON THE USEFULNESS OF A NEW DRUG, THE METHYL ETHER OF METHYL 18-EPIRESERPATE, IN PSYCHIATRY].
Topics: Biomedical Research; Depression; Epilepsy; Humans; Intellectual Disability; Mental Disorders; Methyl | 1963 |
HIREPINE IN PSYCHIATRY.
Topics: Catatonia; Chlorpromazine; Convulsive Therapy; Dementia; Depression; Electroconvulsive Therapy; Huma | 1964 |
THE PHARMACOLOGY AND BIOCHEMISTRY OF DEPRESSION.
Topics: Amitriptyline; Antidepressive Agents; Biochemical Phenomena; Biochemistry; Brain; Depression; Depres | 1964 |
PSYCHOSES CAUSED BY NEUROLEPTICS.
Topics: Antipsychotic Agents; Chlorpromazine; Delirium; Depression; Geriatrics; Humans; Mental Disorders; Ps | 1964 |
GALACTORRHEA DUE TO IMIPRAMINE. REPORT OF A CASE.
Topics: Amenorrhea; Chlorpromazine; Depression; Depressive Disorder; Female; Galactorrhea; Humans; Hypothyro | 1964 |
DISSOCIATION OF RESERPINE-INDUCED DEPRESSION OF SPONTANEOUS MOTOR ACTIVITY AND RELEASE OF BRAIN SEROTONIN IN RATS.
Topics: Brain; Brain Chemistry; Depression; Fluorometry; Motor Activity; Movement; Pharmacology; Rats; Resea | 1964 |
THE PRACTICAL MANAGEMENT OF DEPRESSION.
Topics: Amitriptyline; Antidepressive Agents; Benzoates; Classification; Depression; Depressive Disorder; Dr | 1964 |
[PROTRACTED RESERPINE TREATMENT AND ELECTROSHOCK: CONSIDERATIONS ON THE OPPORTUNITIES AND POSSIBILITIES OF ASSOCIATION].
Topics: Adolescent; Apnea; Biomedical Research; Catatonia; Convulsive Therapy; Depression; Drug Therapy; Ele | 1964 |
HISTAMINE AND THE REVERSAL OF CHLORPROMAZINE-INDUCED DEPRESSION.
Topics: Anti-Allergic Agents; Behavior, Animal; Chlorpromazine; Depression; Depressive Disorder; Histamine; | 1964 |
[SOMATOTHERAPY OF ENDOGENOUS PSYCHOSES AT MARBURG UNIVERSITY NEUROLOGIC CLINIC].
Topics: Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Convulsive Therapy; Depression; | 1964 |
ANTAGONISM OF RESERPINE BEHAVIORAL DEPRESSION BY D-AMPHETAMINE.
Topics: Amphetamine; Amphetamines; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Depressio | 1964 |
EXPERIENCES WITH THE LONG-TERM USE OF METHYLDOPA ("ALDOMET") IN HYPERTENSION.
Topics: Benzothiadiazines; Blood Pressure Determination; Depression; Drug Therapy; Drug Tolerance; Glomerulo | 1965 |
PITFALLS IN THE DIAGNOSIS OF PSYCHIATRIC DISEASE.
Topics: Anxiety; Anxiety Disorders; Brain Neoplasms; Carcinoid Tumor; Depression; Diagnosis; Drug Therapy; G | 1965 |
[THE CHEMOTHERAPY OF ANXIETY].
Topics: Anxiety; Chlorprothixene; Depression; Drug Therapy; Humans; Nervous System Diseases; Reserpine; Schi | 1965 |
DEPRESSION AFTER METHOSERPIDINE.
Topics: Depression; Drug Therapy; Hypertension; Psychopharmacology; Rauwolfia; Reserpine; Toxicology | 1965 |
Treatment of reserpine-induced depression with a new analeptic: phenidylate.
Topics: Central Nervous System Stimulants; Depression; Depressive Disorder; Mental Disorders; Methylphenidat | 1955 |
The use of reserpine in office psychiatry: preliminary report.
Topics: Depression; Depressive Disorder; Mental Disorders; Psychiatry; Psychotherapy; Reserpine; Secologanin | 1955 |
Reserpine in the treatment of anxious and depressed patients.
Topics: Antihypertensive Agents; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Reserpine; Sec | 1955 |
Iproniazid and combined iproniazid-reserpine treatment of depressive and inactive patients.
Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R | 1959 |
[Treatment of melancholic states with new chemotherapy agents: levomepromazine, imipramine, iproniazid, reserpine, deprol].
Topics: Antineoplastic Agents; Depression; Depressive Disorder; Imipramine; Iproniazid; Methotrimeprazine; P | 1959 |
[Nialamid and its combinations with reserpine-like substances (fenoharman, reserpine) in the therapy of endogenous depressions].
Topics: Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Reserpine | 1962 |
Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats.
Topics: Animals; Brain; Cerebral Cortex; Depression; Hippocampus; Hypothalamus; Injections, Intraventricular | 2004 |
[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].
Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Brain; Depression; Imipramine; Male | 2004 |
Suicides in general hospitals.
Topics: Adrenergic beta-Antagonists; Analgesics; Anti-Infective Agents, Urinary; Antipsychotic Agents; Cloni | 2004 |
[Experimental study of the total flavonoid in Hypericum perforatum on depression].
Topics: Animals; Antidepressive Agents; Brain; Depression; Female; Flavonoids; Hypericum; Male; Mice; Mice, | 2005 |
Depressive behavior in mice due to immune stimulation is accompanied by reduced neural activity in brain regions involved in positively motivated behavior.
Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Brain; Cerebral Cor | 2006 |
Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor.
Topics: Animals; Antidepressive Agents, Second-Generation; Arginine; Behavior, Animal; Body Temperature; Bra | 2007 |
Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.
Topics: Acetates; Alkanes; Animals; Antidepressive Agents; Chloroform; Convolvulus; Depression; Fenclonine; | 2007 |
Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Chemistry, Pharmaceutical; Depression; Drug Evalua | 2007 |
[The use of a reserpine derivative in the neuroses of the aged].
Topics: Aged; Anxiety Disorders; Dementia; Depression; Female; Humans; Hypochondriasis; Male; Middle Aged; R | 1967 |
Autonomic reactions in relation to psychotropic drugs.
Topics: Adolescent; Adult; Autonomic Nervous System; Blood Pressure; Chlorpromazine; Darkness; Depression; F | 1967 |
[Drugs in medical practice. Prescription and control].
Topics: Adrenergic beta-Antagonists; Analgesics; Antineoplastic Agents; Depression; Digitalis Glycosides; Di | 1980 |
[Psychopharmacologic spectrum of melanostatin].
Topics: Aggression; Amantadine; Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catalepsy; Cats | 1980 |
[Drug-induced depression].
Topics: Adrenal Cortex Hormones; Antipsychotic Agents; Contraceptives, Oral; Depression; Dihydroxyphenylalan | 1980 |
Alprazolam in a biochemical model of depression.
Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Depression; Diazepam; Disease Models, Ani | 1982 |
Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia.
Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Depression; Dyskinesia, Drug-Induced; Human | 1984 |
[Current biochemical conceptions of mental diseases. II. Role of changes in the biogenic amine system in the pathogenesis of affective disorders].
Topics: 3-Methoxy-4-hydroxyphenylethanol; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; | 1980 |
The behavioral effect of salbutamol (a beta-adrenergic receptor stimulant) on reserpine- and propranolol-treated rats.
Topics: Albuterol; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Propranolol; | 1983 |
The effects of thyrotropin-releasing hormone (TRH) and other drugs on the actions of alcohol.
Topics: Animals; Brain; Cerebellum; Chlorpromazine; Cyclic GMP; Depression; Diazepam; Dose-Response Relation | 1980 |
[Efficacy of lithium hydroxybutyrate in reserpine depression].
Topics: Animals; Avoidance Learning; Conditioning, Classical; Depression; Drug Antagonism; Electroencephalog | 1983 |
Effects of chronic amphetamine or reserpine on self-stimulation responding: animal model of depression?
Topics: Animals; Depression; Dextroamphetamine; Humans; Male; Rats; Reserpine; Self Stimulation; Sodium Chlo | 1980 |
Early reserpine sensitivity and depression in schizophrenia.
Topics: Depression; Humans; Reserpine; Schizophrenia | 1981 |
Depressive illness in old age: getting behind the mask.
Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Diagnosis, Differential; Drug Interactions; Elec | 1980 |
Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test.
Topics: Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain C | 1994 |
[The role of relationship between the epiphysis and the sympathetico-adrenal system in the depressogenic effect of reserpine].
Topics: Adrenal Medulla; Animals; Depression; Dopamine; Hypothalamus; Male; Norepinephrine; Pineal Gland; Ra | 1996 |
Possible therapeutic effect of T-794, a novel reversible inhibitor of monoamine oxidase-A, on post-stroke emotional disturbances, assessed in animal models of depression.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Depression; Disease Models, Anim | 1997 |
NMDA receptor complex blockade by oral administration of magnesium: comparison with MK-801.
Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Depression; Dizocilpine Maleate; Drug Synergis | 1997 |
Effect of reserpine on 3-methoxy-4-hydroxyphenylethyleneglycol and 3,4-dihydroxyphenylacetic acid in the hippocampus of depression-model rats: an in vivo microdialysis study.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Depression; Female; Hippocampus; Kinetics; Methoxyhydroxyph | 1998 |
[Putative contribution of the epiphyseal-adrenocortical system in the antidepressive effect of imipramine].
Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Drug Interact | 1998 |
Antihypertensive drugs and depression: a reappraisal.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Dep | 1978 |
Adverse reactions to antihypertensive drug therapy: central nervous system.
Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Brain; Clonidine; Depression; Humans; Hypnotic | 1979 |
[The role of serotonin in affective disorders (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depression; Humans; Hydroxyindoleacetic A | 1979 |
Electroconvulsive shock and postsynaptic catecholamine effects: increased psychomotor stimulant action of apomorphine and clonidine in reserpine pretreated mice by repeated ECS.
Topics: Animals; Apomorphine; Brain; Catecholamines; Clonidine; Depression; Electroshock; Humans; Male; Mice | 1975 |
Adverse reactions and interactions limiting the use of antihypertensive drugs.
Topics: Antihypertensive Agents; Blood Pressure; Depression; Dose-Response Relationship, Drug; Drug Interact | 1975 |
Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression.
Topics: Catecholamines; Depression; Disease Models, Animal; History, 20th Century; Humans; Psychopharmacolog | 1978 |
[Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect].
Topics: Adrenal Glands; Animals; Depression; Epinephrine; Humans; Hypothalamus; Lithium; Norepinephrine; Rat | 1977 |
The hypertensive psychiatric patient: pharmacologic problems.
Topics: Antihypertensive Agents; Clonidine; Depression; Diuretics; Drug Interactions; Guanethidine; Humans; | 1978 |
Drugs for hypertension.
Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Depression; Diuretics; Drug Combinations; Dru | 1977 |
[News from the control of thoughts].
Topics: Central Nervous System; Cognition; Depression; Humans; Hypothyroidism; Lithium; Reserpine; Tryptopha | 1975 |
Reserpine in hypertension: present status.
Topics: Animals; Benzothiadiazines; Breast Neoplasms; Chronic Disease; Depression; Diuretics; Drug Therapy, | 1975 |
Reserpine and the induction of depression: a case report.
Topics: Adult; Antisocial Personality Disorder; Depression; Humans; Male; Psychotherapy; Reserpine | 1975 |
Letter: Reserpine, ECT, and depression.
Topics: Depression; Electroconvulsive Therapy; Humans; Male; Reserpine | 1975 |
Severe depression caused by reserpine.
Topics: Depression; Humans; Hypertension; Reserpine | 1976 |
[The antidepressive properties of anaprilin].
Topics: Animals; Antidepressive Agents; Clonidine; Depression; Disease Models, Animal; Dose-Response Relatio | 1992 |
Synthesis and pharmacological evaluation of some phenothiazines as antidepressants.
Topics: Amphetamine; Animals; Antidepressive Agents; Depression; Drug Synergism; Female; Male; Mice; Nervous | 1992 |
Depression associated with antihypertensive drugs.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl | 1991 |
[Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats].
Topics: Adrenergic Fibers; Animals; Antidepressive Agents; Benzamides; Cats; Depression; Injections, Subcuta | 1990 |
Antidepressant profile of bupropion and three metabolites in mice.
Topics: Animals; Antidepressive Agents; Apomorphine; Body Temperature; Bupropion; Depression; Male; Mice; Mo | 1990 |
[Depression in patients with somatic illnesses].
Topics: Depression; Humans; Patient Care Team; Physicians, Family; Reserpine | 1989 |
Activation of brain function by S-135, a benzodiazepine receptor inverse agonist.
Topics: Animals; Antidepressive Agents; Avoidance Learning; Brain; Cerebral Cortex; Deoxyglucose; Depression | 1988 |
Effects of chronically administered antidepressants and electroconvulsive treatment on cerebral neurotransmitter receptors in rodents with 'model depression'.
Topics: Animals; Antidepressive Agents; Brain; Cyclic AMP; Depression; Disease Models, Animal; Electroconvul | 1986 |
Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine.
Topics: 5-Hydroxytryptophan; Animals; Depression; Disease Models, Animal; Drug Synergism; Male; Rats; Rats, | 1987 |
Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models.
Topics: Animals; Antidepressive Agents; Biological Transport; Blepharoptosis; Brain; Depression; Disease Mod | 1987 |
Reserpine: the maligned antihypertensive drug.
Topics: Antihypertensive Agents; Breast Neoplasms; Depression; Depressive Disorder; Humans; Hypertension; Re | 1985 |
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.
Topics: Aggression; Amidines; Animals; Blepharoptosis; Cerebral Cortex; Chemical Phenomena; Chemistry; Depre | 1985 |
Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.
Topics: Animals; Biogenic Amines; Brain Chemistry; Catecholamines; Caudate Nucleus; Cerebral Cortex; Depress | 1974 |
When a drug is the culprit.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clofibrate; Depression; Drug-Related Side Effect | 1973 |
[Psychosomatic and psychiatric aspects of hypertension (author's transl)].
Topics: Adult; Blood Pressure; Depression; Headache; Humans; Hypertension; Psychophysiologic Disorders; Psyc | 1974 |
Brain biogenic amine depletion and mood.
Topics: Affective Symptoms; Amines; Behavior; Brain; Catecholamines; Depression; Epinephrine; Fenclonine; Hu | 1974 |
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; Chlorpro | 1967 |
Pharmacologic studies with 7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid.
Topics: Amphetamine; Animals; Catecholamines; Chlorine; Depression; Drug Antagonism; Drug Synergism; Humans; | 1967 |
Clinical and pharmacological investigation of a new psychotropic drug sulpiride (Dogmatil).
Topics: Adult; Amides; Amphetamine; Animals; Body Temperature; Central Nervous System Stimulants; Chlorproma | 1971 |
Evaluation of depressive states, especially in longitudinal studies.
Topics: Affect; Antidepressive Agents; Circadian Rhythm; Depression; Diagnosis, Differential; Drug Evaluatio | 1974 |
The concept and phenomenology of depression, with special reference to the aged. Discussion.
Topics: Adult; Aged; Animals; Behavior, Animal; Biogenic Amines; Bipolar Disorder; Brain Chemistry; Depressi | 1974 |
Editorial: Rauwolfia and breast cancer.
Topics: Breast Neoplasms; Depression; Female; Humans; Hypertension; Menopause; Methyldopa; Middle Aged; Phyt | 1974 |
Do antihypertensive drugs really cause depression?
Topics: Acute Disease; Antihypertensive Agents; Chronic Disease; Depression; Guanethidine; Humans; Hypertens | 1974 |
Antihypertensive drugs and depression.
Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Thera | 1974 |
Treatment of intractable depression.
Topics: Amantadine; Antidepressive Agents; Depression; Dextroamphetamine; Drug Therapy, Combination; Hormone | 1974 |
Proceedings: Ptosis as a model of depression.
Topics: Animals; Antidepressive Agents; Blepharoptosis; Depression; Disease Models, Animal; Humans; Imiprami | 1974 |
Editorial: Hypertension and depression and their treatment.
Topics: Animals; Antidepressive Agents; Antihypertensive Agents; Clonidine; Depression; Humans; Hypertension | 1973 |
Proceedings: Antagonism of nicotinic acid and other kynurenines to antidepressants: one of the probable reasons of the therapy-resistance in depression?
Topics: Allopurinol; Amitriptyline; Animals; Depression; Drug Interactions; Humans; Hypnotics and Sedatives; | 1974 |
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Dru | 1973 |
Experimental study on the mechanism of depressogenic action of apomorphine and reserpine.
Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Depression; Diencephalon; Do | 1972 |
Answers to questions frequently asked about ECT.
Topics: Age Factors; Anesthesia, Intravenous; Brain Damage, Chronic; Brain Neoplasms; Depression; Electrocon | 1972 |
Plasma cortisol-binding capacity in mental illness.
Topics: Adult; Anxiety; Binding Sites; Bipolar Disorder; Chlorpromazine; Chromatography, Gel; Depression; Di | 1973 |
Letter: Methyldopa and depression.
Topics: Chronic Disease; Depression; Humans; Methyldopa; Reserpine; Time Factors | 1973 |
The effect of fat diet on reserpine-induced depression in mice.
Topics: Animals; Brain Chemistry; Brain Stem; Depression; Dietary Fats; Fasting; Humans; Hydroxyindoleacetic | 1973 |
Clinical perspectives on antidepressant therapy.
Topics: Adult; Amphetamine; Antidepressive Agents; Depression; Diagnosis, Differential; Electroconvulsive Th | 1968 |
Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration.
Topics: Adjustment Disorders; Animals; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Dementia; D | 1972 |
Central nervous system effects of fenfluramine hydrochloride.
Topics: Animals; Brain; Brain Chemistry; Central Nervous System; Depression; Dextroamphetamine; Dopamine; Dr | 1972 |
Anxiety, depression and psychotropic drugs.
Topics: Antidepressive Agents; Anxiety; Depression; Dibenzoxepins; Humans; Norepinephrine; Reserpine; Tranqu | 1971 |
Hypertension and depression: interrelated problems in therapy.
Topics: Antidepressive Agents; Antihypertensive Agents; Depression; Humans; Hypertension; Methyldopa; Physic | 1971 |
The effect of reserpine and nortriptyline on the excretion of 17-hydroxysteroids.
Topics: Animals; Apomorphine; Behavior, Animal; Depression; Drug Synergism; Grooming; Humans; Imipramine; Li | 1971 |
Possible involvement of glycogen phosphorylase of brain in the affective states.
Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorpromazine; Depression; Desipramine; Drug In | 1971 |
Nosocomial suicides and suicides among discharged patients.
Topics: Adult; Denmark; Depression; Female; Hospitals, Psychiatric; Humans; Interpersonal Relations; Male; M | 1966 |
Effects of imipramine and reserpine in depression.
Topics: Depression; Female; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales; Reserpi | 1969 |
Amines and abnormal mood.
Topics: Affective Symptoms; Blood-Brain Barrier; Catecholamines; Depression; Dihydroxyphenylalanine; Epineph | 1969 |
[The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen].
Topics: Adult; Aged; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Cats; Depression; Depres | 1969 |
[Molecular-biologic causes in psychiatry].
Topics: Antidepressive Agents; Brain; Deficiency Diseases; Depression; Humans; Methylation; Molecular Biolog | 1969 |
[Depressive reactions in treatment with neuroleptics].
Topics: Antidepressive Agents; Depression; Humans; Reserpine; Suicide; Tranquilizing Agents | 1970 |
Is it possible to predict the clinical effect of antidepressants from experimental data in animals?
Topics: Antidepressive Agents; Depression; Humans; Nerve Endings; Norepinephrine; Physostigmine; Psychomotor | 1970 |
[Depression in patients treated with reserpine, still a reality].
Topics: Aged; Depression; Female; Humans; Hypertension; Middle Aged; Plants, Medicinal; Rauwolfia; Reserpine | 1971 |
Psychopharmacological approach to psychosomatic medicine. Experimental and clinical research.
Topics: Amitriptyline; Amphetamine; Animals; Anxiety Disorders; Benactyzine; Depression; Guinea Pigs; Hostil | 1967 |
Biochemical aspects of depression.
Topics: Adrenal Glands; Brain Chemistry; Depression; Dopamine; Electrolytes; Epinephrine; Extracellular Spac | 1969 |