Page last updated: 2024-11-06

reserpine and Depression

reserpine has been researched along with Depression in 240 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence."9.41The effects of reserpine on depression: A systematic review. ( Cave, J; Jauhar, S; Javed, RR; Strawbridge, R; Young, AH, 2023)
"The aim of this study was to construct an animal model of depression that reproduces the human clinical manifestation, to evaluate the possible benefits of curcumin (CUR) in the treatment of depression and to compare its effect with the effect of a classic antidepressant, escitalopram (ESC)."8.31The effect of curcumin on reserpine-induced depression-like behaviour in rats. ( Decea, R; Donosa, M; Dudau, LE; Filip, GA; Moisa, E; Moldovan, R; Sevastre-Berghian, A; Stancu, B, 2023)
"Proteomic analysis of reserpine-induced depression and the effects of berberine on this were investigated to delineate the possible underlying mechanism."8.12Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine. ( Wang, Y; Yang, N; Zou, L, 2022)
"The current study evaluates the free gallic acid (GA) and GA-loaded mesoporous silica nanoparticles (MSNs) antidepressant efficacy in a rat model of depression caused by reserpine."8.12Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats. ( Ahmed, NA; Fahmy, HM; Hussein, AA; Khadrawy, YA; Mohamed, ER, 2022)
" This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed."8.02Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021)
"The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model."7.96Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020)
"Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression."7.91BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. ( Chen, Z; Lv, D; Shen, M; Wang, C; Yu, H; Zhang, Y; Zhou, D, 2019)
"Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine."7.88Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018)
"A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)."7.83Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."7.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats."7.77Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011)
"p injection of reserpine for 15 days to establish the animal model of depression."7.77Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. ( El-Shamy, KA; Khadrawy, YA; Mohamed, SI, 2011)
"Experimental depression was induced by subcutaneous injection of reserpine in mice."7.73[Experimental study of the total flavonoid in Hypericum perforatum on depression]. ( Liu, JX; Tu, PF; Wang, JN; Wei, CE; Xu, L; Zhao, MB, 2005)
"To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions."7.72[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats]. ( Chen, Y; Han, T; Liu, MR; Qin, LP; Rui, YC; Zheng, HC, 2004)
"Reserpine induced behavioral depression partially via brain interleukin-1 beta generation."7.72Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats. ( Hao, XL; Huang, QJ; Jiang, H; Minor, TR, 2004)
"For five decades it has been generally accepted that reserpine, an antihypertensive and antipsychotic drug, causes depression."7.72The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis. ( Baumeister, AA; Hawkins, MF; Uzelac, SM, 2003)
"The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution."7.66Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression. ( Bein, HJ, 1978)
"Long-term administration of lithium hydroxybutyrate (10 mg/kg, for 7 days) prevents the depression of avoidance behavior in rats and EEG alterations in the cortex and subcortical structures of rabbit brain induced by a single injection of 0."7.66[Efficacy of lithium hydroxybutyrate in reserpine depression]. ( Saratikov, AS; Zamoshchina, TA, 1983)
"Experiments on male-rats with a chronic administration of lithium show that it exerts a dose-dependence ambivalent action on the biochemical and behavioural characterisics of "reseprine depressions"."7.65[Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect]. ( Baru, AM; Kholodyĭ, IuG; Sedykh, LI, 1977)
"This article reviews the chemistry, pharmacology, pharmacokinetics, therapeutic use, tolerability, drug-interaction potential, and dosing and administration of TBZ."6.46Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010)
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test."5.72Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022)
"Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies."5.62Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021)
"Depression is one of the most common mental health disorders and it is generally characterized by negative mood."5.62Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. ( Alizadeh Makvandi, A; Amiri Moghaddam, S; Khalili, M; Roghani, M, 2021)
"Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice."5.56Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020)
"The present study aims to evaluate the antidepressant effect of different formulations of Thymoquinone; free Thymoquinone (TQ), Thymoquinone-loaded Chitosan nanoparticles (TQ-TPP-Cs NPs) and Thymoquinone-loaded Chitosan nanoparticles coated with polysorbate 80 (TQ-TPP-Cs NPs-PSb80) that have been prepared to avoid the low bioavailability of TQ."5.56Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. ( Abd Rabo, AA; Abd-El Daim, TM; Elfeky, AS; Fahmy, HM; Khadrawy, YA; Mostafa, IT; Mustafa, AB, 2020)
"Treatment-resistant depression is a major health problem worldwide."5.46Repeated treatment with reserpine as a progressive animal model of depression. ( Haleem, DJ; Ikram, H, 2017)
"Chronic pain has consistently been correlated with depression."5.43Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016)
"Associations between reserpine and depression are inconsistent and limited by a lack of high-quality evidence."5.41The effects of reserpine on depression: A systematic review. ( Cave, J; Jauhar, S; Javed, RR; Strawbridge, R; Young, AH, 2023)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."5.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
"Depression and pain are often diagnosed in the same patients."5.37Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011)
"Reserpine was added for both antipsychotic coverage and reported beneficial effects in the treatment of TD."5.27Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia. ( Holt, RJ, 1984)
"This paper reviews recent research on the contribution of the proinflammatory cytokine interleukin-1 (IL- 1) and the purine nucleoside adenosine in mediating behavioral depression and related symptoms of conservation-withdrawal in animal models of both major depression and illness."4.86Biochemical and anatomical substrates of depression and sickness behavior. ( Furst, SJ; Hanff, TC; Minor, TR, 2010)
"By a combination of biochemical and pharmacodynamical analyses the author conducted a differentiated study of the role of separate neurohormones (adrenalin, noradrenalin, dopamine, serotonine) and their interconnection with other regulating systems (corticosteroids, nucleic acids) in the neurochemical structure of experimental models in depressive behaviour (reserpine depressions, depressions due to inhibitors of dopamine-beta-oxydase)."4.75[Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)]. ( Baru, AM, 1975)
" monnieri improves depression comparable to citalopram in reserpine-induced depression."4.12Neuroprotective role of Bacopa monnieri extract in modulating depression in an experimental rat model. ( Al-Shafei, AI; Daoud, NN; El-Gendy, OA; Zaazaa, AM, 2022)
" This study aimed to evaluate the anti-depressant effect of Cerebrolysin (CBL) in Reserpine-induced depressed rats, its effect on oxidative stress, inflammation, regulatory cyclic AMP-dependent response element binding protein (CREB)/brain derived neurotropic factor (BDNF) signaling pathways, brain monoamines and histopathological changes was assessed."4.02Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence. ( Ahmed-Farid, OA; El Awdan, SA; El-Marasy, SA; Hassan, A; Ogaly, HA, 2021)
"The main study objective was to examine the role of pregabalin in depressive symptomatology comorbid to chronic widespread pain using a reserpine-induced myalgia model."3.96Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats. ( Alfosea-Cuadrado, GM; Blasco-Serra, A; Gonzalez-Soler, EM; Igual-Lopez, M; Orduna-Valls, J; Tornero-Tornero, C; Valverde-Navarro, AA, 2020)
"Reserpine treatment in rodents has been shown to induce depression-like behaviors that mimic monoamine dysfunction implicated in the development of depression."3.91BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. ( Chen, Z; Lv, D; Shen, M; Wang, C; Yu, H; Zhang, Y; Zhou, D, 2019)
"Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine."3.88Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018)
" Twenty four rats were divided into: control, rat model of depression induced by reserpine and depressive-like rats treated with Cannabis sativa extract (10mg/kg expressed as Δ9-tetrahydrocannabinol)."3.85Cannabis exacerbates depressive symptoms in rat model induced by reserpine. ( Abdel-Salam, OME; Hosny, EN; Khadrawy, YA; Sawie, HG, 2017)
" Animals were induced to a reserpine-induced depression model and were then chronically treated with duloxetine, desvenlafaxine or vehicle."3.85A standardization of the Novelty-Suppressed Feeding Test protocol in rats. ( Blasco-Serra, A; Cervera-Ferri, A; González-Soler, EM; Teruel-Martí, V; Valverde-Navarro, AA, 2017)
"A new (aryloxyalkyl)adenine derivative Adeprophen (9-[2-(4-isopropylphenoxy)ethyl]adenine, VMA-99-82) has a strong antidepressant effect on the model of reserpine-induced depression in rats (single dose 4 mg/kg, intraperitoneally)."3.83Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats. ( Bagmetova, VV; Chernysheva, YV; Ozerov, AA; Tyurenkov, IN, 2016)
"This study is to offer a clinical pain-depression dyad therapy of ferulic acid, the pain-depression dyad induced by reserpine was established and the dose-effect relationship of ferulic acid on ameliorating pain-depression dyad was explored."3.79[Influence of ferulic acid on the pain-depression dyad induced by reserpine]. ( Pan, JC; Shi, HM; Wang, QD; Zhang, L, 2013)
"5mg/kg), which could antagonize reserpine-induced ptosis and hypothermia, moreover, both of them could elevate the contents of NE, 5-HT in hippocampus as well as NE, 5-HT, DA in striatum significantly."3.79Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. ( Cui, YL; Ding, SL; Mao, HP; Qi, XJ; Wang, QS, 2013)
"The findings from the current study suggested that reserpine-induced neurochemical alterations and dysregulation of oxidative-nitrosative stress induced inflammatory cascade underlies the co-morbidity of nociceptive behaviour and associated depression in rats."3.79Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model. ( Arora, V; Chopra, K, 2013)
"p injection of reserpine for 15 days to establish the animal model of depression."3.77Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression. ( El-Shamy, KA; Khadrawy, YA; Mohamed, SI, 2011)
"), potentiated the 5-hydroxytryptophan (5-HTP)-induced head twitch responses in mice and antagonized the reserpine-induced hypothermia in rats."3.77Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression. ( Bhatt, S; Gautam, B; Jindal, A; Mahesh, R; Pandey, D, 2011)
" A possible mechanism was explored in the test of antagonism of reserpine-induced ptosis and hypothermia in mice."3.76Antidepressant-like effect of genipin in mice. ( Chi, W; Cui, YL; Dong, TJ; Gao, S; Hu, LM; Liu, LP; Tian, JS, 2010)
"This study investigates the effect of the petroleum ether, chloroform, and ethyl acetate fractions of the total ethanolic extract of Convolvulus pluricaulis Choisy (Family: Convolvulaceae) on depression in mice."3.74Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests. ( Dhingra, D; Valecha, R, 2007)
"Experimental depression was induced by subcutaneous injection of reserpine in mice."3.73[Experimental study of the total flavonoid in Hypericum perforatum on depression]. ( Liu, JX; Tu, PF; Wang, JN; Wei, CE; Xu, L; Zhao, MB, 2005)
"To evaluate the effects of madecassoside (MC) on the depression behavior of mice and the activities of monoamine oxidase (MAO) in different rat brain regions."3.72[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats]. ( Chen, Y; Han, T; Liu, MR; Qin, LP; Rui, YC; Zheng, HC, 2004)
"After chronic administration of propranolol (1 and 5 mg/kg, 14 days) to rats time-course of forced swimming changed with the decrease of rhythmical index of depression."3.68[The antidepressive properties of anaprilin]. ( Arushanian, EB; Beĭer, EV, 1992)
"Reserpine or beta-blocker therapy did not cause any more depression than any other antihypertensive treatment."3.68Depression associated with antihypertensive drugs. ( Adams, MA; Carr, AA; Fincham, JE; Prisant, LM; Spruill, WJ; Wade, WE, 1991)
"The study was made on the reserpine model of behavioural depression in cats."3.68[Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats]. ( Khaĭsman, EB; Kushnarev, VV, 1990)
"Since reserpine precipitates depression in some hypertensive patients, we tested this drug on our animal model of depression."3.67Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine. ( Aprison, MH; Brugge, KL; Hingtgen, JN, 1987)
" The drug does not possess an antidepressant action proper but activates the aggressive-defensive behaviour in experimental reserpine depression and reduces the provocation-induced aggressive behaviour in experimental haloperidol depression."3.66[Psychopharmacologic spectrum of melanostatin]. ( Klusha, VE; Kozlovskaia, MM; Svirskis, ShV; Val'dman, AV, 1980)
"The choice of reserpine as practically the sole model substance used in research in depression over two decades was not dictated by rational considerations alone: hypothetical notions, prospects of the rapid realization of experimental research aims and the fascination of the exotic origin of this "natural" drug made a significant contribution."3.66Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression. ( Bein, HJ, 1978)
"Depression was assessed using the CES-D scale (Center for Epidemiological Studies--Depressed Mood), administered at baseline and again approximately 1 year after randomization."2.67Effect of withdrawal of antihypertensive drug on depressive mood. ( Blaufox, MD; Langford, HG; Oberman, A; Thaler, L; Wassertheil-Smoller, S, 1993)
"This article reviews the chemistry, pharmacology, pharmacokinetics, therapeutic use, tolerability, drug-interaction potential, and dosing and administration of TBZ."2.46Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders. ( Guay, DR, 2010)
"Depression is a leading cause of disability worldwide and the psychiatric diagnosis most commonly associated with suicide."1.91Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system. ( Chen, Q; Hu, J; Lan, J; Li, X; Liu, M; Peng, Y; Shang, N; Wang, H; Xiang, L; Xiao, Q; Yin, D, 2023)
"Depression has become an important disease threatening human health."1.72Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis. ( Chen, N; Chu, S; He, F; He, J; Lai, K; Li, D; Li, Y; Wang, S; Wei, D; Wei, G; Wei, J; Xie, J; Zhang, Z, 2022)
"Repeated reserpine injection induced hyperalgesia and depressive behaviors with decreased sucrose preference and horizontal movement distance, and increased immobility time in forced swimming test."1.72Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model. ( Du, Y; Gao, X; Li, L; Lu, Y; Shi, W; Wang, A; Wang, Y; Zhang, S; Zhao, J, 2022)
"Depression is one of the most common mental health disorders and it is generally characterized by negative mood."1.62Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression. ( Alizadeh Makvandi, A; Amiri Moghaddam, S; Khalili, M; Roghani, M, 2021)
"Depression is the most frequent affective disorder and is the leading cause of disability worldwide."1.62A Reliable High-Throughput Screening Model for Antidepressant. ( He, J; Lai, Y; Liu, Q; Qiao, C; Shang, J; Zhang, R; Zhong, H, 2021)
"Pain and depression are often co-existing pathological states that promote mutual severity resulting in limited efficacy of current treatment strategies."1.62Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation. ( Bhatti, R; Garg, S; Kaur, A; Singh, L, 2021)
"Reserpine (1 mg/kg) was subcutaneously injected once daily for three consecutive days in male Swiss mice."1.56Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model. ( Brum, EDS; Dalla Corte, CL; Fialho, MFP; Fischer, SPM; Gonçalves, DF; Hartmann, DD; Machado-de-Ávila, RA; Oliveira, SM; Scussel, R; Soares, FAA, 2020)
"The present study aims to evaluate the antidepressant effect of different formulations of Thymoquinone; free Thymoquinone (TQ), Thymoquinone-loaded Chitosan nanoparticles (TQ-TPP-Cs NPs) and Thymoquinone-loaded Chitosan nanoparticles coated with polysorbate 80 (TQ-TPP-Cs NPs-PSb80) that have been prepared to avoid the low bioavailability of TQ."1.56Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model. ( Abd Rabo, AA; Abd-El Daim, TM; Elfeky, AS; Fahmy, HM; Khadrawy, YA; Mostafa, IT; Mustafa, AB, 2020)
"Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal."1.51Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019)
"Chronic pain has consistently been correlated with depression."1.43Echinocystic acid reduces reserpine-induced pain/depression dyad in mice. ( Deng, YT; Feng, B; Han, J; Li, S; Wang, DS; Wang, XS; Yang, Q; Zhao, MG, 2016)
"Gentiopicroside (Gent) is a secoiridoid compound isolated from Gentiana lutea that exhibits analgesic properties and inhibits the expression of GluN2B-containing N-methyl-D-aspartate (NMDA) receptors in the anterior cingulate cortex of mice."1.40Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice. ( Gao, GD; Guo, HJ; Li, XS; Liu, SB; Tian, Z; Zhang, N; Zhao, MG; Zhao, R, 2014)
"Depression and pain are often diagnosed in the same patients."1.37Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences. ( Arora, V; Chopra, K; Kuhad, A; Tiwari, V, 2011)
" Chronic administration of berberine (5 mg/kg, i."1.35On the mechanism of antidepressant-like action of berberine chloride. ( Dhir, A; Kulkarni, SK, 2008)
" The dose-response relationship shifted to the left following REMs deprivation (ED50 values in the group-housed, isolated, and REMs-deprived mice were 250, 200, and 27 micrograms/kg, respectively)."1.29Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. ( Asakura, W; Matsumoto, K; Ohta, H; Watanabe, H, 1994)
"Bupropion is a novel antidepressant, distinct from tricyclic antidepressants both neurochemically and behaviorally."1.28Antidepressant profile of bupropion and three metabolites in mice. ( Colin, JN; Lacomblez, L; Martin, P; Massol, J; Puech, AJ, 1990)
"Reserpine was added for both antipsychotic coverage and reported beneficial effects in the treatment of TD."1.27Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia. ( Holt, RJ, 1984)
"2."1.27Activation of brain function by S-135, a benzodiazepine receptor inverse agonist. ( Eigyo, M; Kawasaki, K; Matsubara, K; Matsushita, A; Shindo, H; Takada, S, 1988)

Research

Studies (240)

TimeframeStudies, this research(%)All Research%
pre-1990158 (65.83)18.7374
1990's12 (5.00)18.2507
2000's14 (5.83)29.6817
2010's33 (13.75)24.3611
2020's23 (9.58)2.80

Authors

AuthorsStudies
Zhang, R1
Qiao, C1
Liu, Q1
He, J2
Lai, Y1
Shang, J1
Zhong, H1
Samad, N1
Khaliq, S1
Alam, M1
Yasmin, F1
Ahmad, S1
Mustafa, S1
Azizuddin, -1
Raza, U1
Bhatt, S3
Behl, T1
Sehgal, A1
Singh, S1
Sharma, N1
Chigurupati, S1
Ahmed, AS1
Gari, SBV1
Yang, N1
Zou, L1
Wang, Y3
Zaazaa, AM1
Daoud, NN1
El-Gendy, OA1
Al-Shafei, AI1
Fahmy, HM2
Mohamed, ER1
Hussein, AA1
Khadrawy, YA4
Ahmed, NA1
Zhao, J1
Shi, W1
Lu, Y1
Gao, X1
Wang, A1
Zhang, S2
Du, Y1
Li, L1
Strawbridge, R1
Javed, RR1
Cave, J1
Jauhar, S1
Young, AH1
de Melo Martins, GM1
Petersen, BD1
Rübensam, G1
da Silva, JMK1
Gaspary, KV1
Wiprich, MT1
Altenhofen, S1
Bonan, CD1
Li, D1
Wei, J1
Wang, S1
Chu, S1
Zhang, Z1
He, F1
Wei, D1
Li, Y1
Xie, J1
Lai, K1
Chen, N1
Wei, G1
Foudah, AI1
Alqarni, MH1
Alam, A1
Devi, S1
Salkini, MA1
Alam, P1
Wang, H2
Hu, J2
Chen, Q1
Shang, N1
Liu, M1
Li, X2
Xiang, L1
Yin, D1
Lan, J1
Xiao, Q1
Peng, Y1
Dudau, LE1
Moisa, E1
Sevastre-Berghian, A1
Moldovan, R1
Decea, R1
Donosa, M1
Filip, GA1
Stancu, B1
Qian, X1
Zhong, Z1
Lu, S1
Zhang, Y3
Yang, K1
Yu, J1
Nong, K1
Niu, A1
Chen, W1
Dong, J1
Wang, J1
Soliman, E1
Essmat, N1
Mahmoud, MF1
Mahmoud, AAA1
Bakre, AG1
Olayemi, JO1
Ojo, OR1
Odusanya, ST1
Agu, GA1
Aderibigbe, AO1
Abd-El Daim, TM1
Elfeky, AS1
Abd Rabo, AA1
Mustafa, AB1
Mostafa, IT1
Brum, EDS1
Fialho, MFP1
Fischer, SPM1
Hartmann, DD1
Gonçalves, DF1
Scussel, R1
Machado-de-Ávila, RA1
Dalla Corte, CL1
Soares, FAA1
Oliveira, SM1
Singh, L1
Kaur, A1
Garg, S1
Bhatti, R1
Tian, DD1
Wang, M1
Liu, A1
Gao, MR1
Qiu, C1
Yu, W1
Wang, WJ1
Zhang, K1
Yang, L1
Jia, YY1
Yang, CB1
Wu, YM1
Gonzalez-Soler, EM3
Blasco-Serra, A3
Alfosea-Cuadrado, GM1
Igual-Lopez, M1
Orduna-Valls, J1
Tornero-Tornero, C1
Valverde-Navarro, AA3
El-Marasy, SA1
El Awdan, SA1
Hassan, A1
Ahmed-Farid, OA1
Ogaly, HA1
Alizadeh Makvandi, A1
Khalili, M1
Roghani, M1
Amiri Moghaddam, S1
Ikram, H1
Haleem, DJ1
Cervera-Ferri, A2
Teruel-Martí, V2
Ruiz, P1
Calliari, A1
Pautassi, RM1
Amoateng, P1
Kukuia, KKE1
Mensah, JA1
Osei-Safo, D1
Adjei, S1
Eklemet, AA1
Vinyo, EA1
Karikari, TK1
Liu, X1
Sun, M1
Zhang, Q1
Li, T1
Xu, J1
Zhao, X1
Chen, D1
Feng, X1
Park, BK1
Kim, YR1
Kim, YH1
Yang, C1
Seo, CS1
Jung, IC1
Jang, IS1
Kim, SH1
Lee, MY1
Siemian, JN1
Shang, L1
Seaman, RW1
Zhu, Q1
Li, JX1
Yu, H1
Lv, D1
Shen, M1
Zhou, D1
Chen, Z1
Wang, C1
Roversi, K1
de David Antoniazzi, CT1
Milanesi, LH1
Rosa, HZ1
Kronbauer, M1
Rossato, DR1
Duarte, T1
Duarte, MM1
Burger, ME1
Xu, Y1
Zhang, L2
Shao, T1
Ruan, L1
Wang, L1
Sun, J1
Li, J1
Zhu, X1
O'Donnell, JM1
Pan, J1
Wang, QD1
Shi, HM1
Pan, JC1
Wang, QS1
Ding, SL1
Mao, HP1
Cui, YL2
Qi, XJ1
Arora, V2
Chopra, K2
Liu, SB1
Zhao, R1
Li, XS1
Guo, HJ1
Tian, Z1
Zhang, N1
Gao, GD1
Zhao, MG2
Tian, J1
Zhang, F1
Cheng, J1
Guo, S1
Liu, P1
Minaiyan, M1
Hajhashemi, V1
Rabbani, M1
Fattahian, E1
Mahzouni, P1
Ishimoto, T1
Mano, H1
Mori, H1
Escrihuela-Vidal, F1
Martínez-Expósito, F1
Blasco-Ausina, MC1
Martínez-Bellver, S1
Li, S1
Han, J1
Wang, DS1
Feng, B1
Deng, YT1
Wang, XS1
Yang, Q1
Gao, ZY1
Yang, P1
Huang, QJ2
Xu, HY1
Ozerov, AA1
Bagmetova, VV1
Chernysheva, YV1
Tyurenkov, IN1
Mohammed, HS1
Sawie, HG1
Abdel-Salam, OME1
Hosny, EN1
Mao, Q1
Huang, Z1
Ip, S1
Che, C1
Kulkarni, SK3
Dhir, A3
Mao, QQ1
Ip, SP1
Tsai, SH1
Che, CT1
Tian, JS1
Hu, LM1
Gao, S1
Chi, W1
Dong, TJ1
Liu, LP1
Hanff, TC1
Furst, SJ1
Minor, TR2
Guay, DR1
Malik, S1
Kessar, SV1
Singh, KN1
Kuhad, A1
Tiwari, V1
Mahesh, R2
Jindal, A2
Gautam, B1
Pandey, D1
El-Shamy, KA1
Mohamed, SI1
Cui, J1
Jiang, L1
Xiang, H1
Kumar, B1
Pandey, DK1
Devadoss, T1
Skalisz, LL1
Beijamini, V1
Joca, SL1
Vital, MA1
Da Cunha, C1
Andreatini, R1
Baumeister, AA1
Hawkins, MF1
Uzelac, SM1
FREIS, ED2
HIOB, J1
HIPPIUS, H2
KASS, I1
BROWN, EC1
LEREBOULLET, J1
VIDART, L1
AMSTUTZ, C1
BURRELL, RH1
MACKENZIE-VAN DER NOORDAA, MC1
DUBOUCHER, G1
LJUNGBERG, E2
REISNER, H2
FAUCETT, RL1
LITIN, EM1
ACHOR, RW1
GAHAGAN, LH1
BARISON, F1
MASSIGNAN, L1
LANDGREBE, B1
BUSSOW, H1
LINDNER, W1
WALTER, B1
HOLZINGER, HH1
SAUNDERS, JC1
RADINGER, N1
ROCHLIN, D1
KLINE, NS2
SIMKO, A1
KROGSGAARD, AR1
BARTLET, JE1
JENSEN, K1
ASSAEL, M1
GABAY, F1
KHAZAN, N1
SULMAN, FG1
WINNIK, HZ1
FOUKS, L1
MYSCHETZKY, A1
RASMUSSEN, EB2
HASLUND, J1
STEIN, L1
THOMAS, K1
COULLAUT MENDIGUTIA, R1
POELDINGER, W1
POLLITT, J1
INGROVA, L1
BOJANOVSKY, J1
CHLOUPKOVA, K1
RIPKA, O1
TRIPI, E1
DERZSI, S1
FENYVESI, T1
PRANGE, AJ1
STROEMGREN, E1
KLEIN, JJ1
SEGAL, RL1
WARNER, RR1
MAGUS, RD1
KRAUSE, FW1
RIEDEL, BE1
GERMANO, G1
ROSENBERG, FJ1
SAVARIE, PJ1
WEIDTMANN, W1
RECH, RH1
MEIRING, PD1
PEARCE, A1
CAZZULLO, CL1
BERLIN, R1
FERGUSON, JT1
DRAKE, FR1
EBAUGH, FG1
DAVIES, DL1
SHEPHERD, M1
KRISTJANSEN, P1
RISER, M1
GAYRAL, L1
STERN, H2
TURNIN, J1
CARRIE, J1
BACCHIOCHI, M1
NAHUNEK, K2
RODOVA, A1
HOSAK, L1
JAROS, M1
HADLIK, J1
Jiang, H1
Hao, XL1
Liu, MR1
Han, T1
Chen, Y1
Qin, LP1
Zheng, HC1
Rui, YC1
Leung, JS1
Xu, L1
Wei, CE1
Zhao, MB1
Wang, JN1
Tu, PF1
Liu, JX1
Stone, EA1
Lehmann, ML1
Lin, Y1
Quartermain, D1
Dhingra, D2
Valecha, R2
Matsuzaki, M1
Bovi, A1
Frisone, L1
Hsu, JJ1
Yap, AT1
Eriksson, E1
Modigh, K2
Weber, E1
Val'dman, AV1
Kozlovskaia, MM1
Klusha, VE1
Svirskis, ShV1
Casacchia, M1
Ianiri, G1
Sethy, VH1
Hodges, DH1
Holt, RJ1
Anokhina, IP1
Gamaleia, NB1
Vardi, Y1
Regev, I1
Rosenbaum, M1
Flechter, S1
Mailman, RB1
Frye, GD1
Mueller, RA1
Breese, GR2
Saratikov, AS1
Zamoshchina, TA1
Leith, NJ1
Barrett, RJ1
Lewis, H1
Bacher, N1
Blumenthal, MD1
Asakura, W1
Matsumoto, K1
Ohta, H1
Watanabe, H1
Thaler, L1
Wassertheil-Smoller, S1
Blaufox, MD1
Oberman, A1
Langford, HG1
Arushanian, EB3
El'bekian, KS1
Kato, M1
Iwata, H1
Katayama, T1
Asai, H1
Narita, H1
Endo, T1
Decollogne, S1
Tomas, A1
Lecerf, C1
Adamowicz, E1
Seman, M1
Yamashita, K1
Kitayama, I1
Hamanaka, K1
Nomura, J1
El'bek'ian, KS1
Beĭer, EV2
Leonard, BE1
Carlsson, A1
Bant, WP1
Moussaoui, D1
Henning, M1
Lingjaerde, O2
Luchins, D1
Nies, AS1
Bein, HJ1
Baru, AM2
Sedykh, LI1
Kholodyĭ, IuG1
Sandifer, MG1
Hopkinson, G1
Kenny, F1
Simon, KH1
Lion, JR1
Millan, C1
Raylor, RJ1
Fleishman, M1
Singh, V1
Khanna, R1
Srivastava, VK1
Palit, G1
Shanker, K1
Prisant, LM1
Spruill, WJ1
Fincham, JE1
Wade, WE1
Carr, AA1
Adams, MA1
Khaĭsman, EB1
Kushnarev, VV1
Martin, P1
Massol, J1
Colin, JN1
Lacomblez, L1
Puech, AJ1
Matsushita, A1
Kawasaki, K1
Matsubara, K1
Eigyo, M1
Shindo, H1
Takada, S1
Vetulani, J1
Antkiewicz-Michaluk, L1
Rokosz-Pelc, A1
Michaluk, J1
Brugge, KL1
Hingtgen, JN1
Aprison, MH1
Baizman, ER1
Ezrin, AM1
Ferrari, RA1
Luttinger, D1
Rosen, RC1
Kostis, JB1
Widmer, RB1
McCarthy, JR1
Wright, DL1
Schuster, AJ1
Abdallah, AH1
Shea, PJ1
Eyster, R1
Golochevskaia, VS1
Segal, DS1
Kuczenski, R1
Mandell, AJ1
Goodwin, FK2
Bunney, WE2
Akiskal, HS1
McKinney, WT1
Elhardt, S1
Mendels, J1
Frazer, A1
Weil-Malherbe, H1
Bucci, L1
Aillon, GA1
Schildkraut, JJ2
Schanberg, SM2
Kopin, IJ2
Aceto, MD1
Harris, LS1
Lesher, GY1
Pearl, J1
Brown, TG1
Bilikiewicz, A1
Góra, S1
von Zerssen, D1
Strian, F2
Schwarz, D2
Shader, RI1
Bant, W2
Snaith, RP1
McCoubrie, M1
Ananth, J1
Ruskin, R1
Tedeschi, DH1
Boshek, RL1
Boston, JE1
Simpson, FO2
Lapin, IP1
Raisfeld, IH1
Michel, D1
Cheah, JS1
Ambrosino, SV1
Abrams, R2
Plotnikoff, NP1
Kastin, AJ1
Anderson, MS1
Schally, AV1
Benesová, O3
Benes, V1
Fink, M1
King, DJ1
Jain, ML1
Curtis, B1
Forbes, J1
Krantz, J1
Bickel, MH1
Lehmann, HE1
Haskovec, L2
Rysánek, K3
Durell, J1
Mashkovskiĭ, MD2
Davis, JM1
Murphy, DL1
Brodie, HK1
Matussek, N3
Fischer, E1
Spatz, H1
Heller, B1
Reggiani, H1
Ziance, RJ1
Sipes, IG1
Kinnard, WJ1
Buckley, JP1
Hollister, LE1
Waal-Manning, HJ1
König, J1
Iriye, TT1
Simmonds, FA1
Jensen, L1
Meyer, JS1
Eadie, GA1
Ericsson, AD1
Hoobler, SW1
MacMahon, HR1
Carney, MW1
Thakurdas, H1
Sebastian, J1
Dewhurst, WG1
Polezhaeva, AI1
Avrutskii, GIa1
Vertozgadova, OP1
Smulevich, AB1
Wålinder, J1
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Pohlmeier, H1
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Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum Disorders[NCT02983188]Phase 2/Phase 3113 participants (Actual)Interventional2018-04-25Completed
[NCT00005464]0 participants Observational1991-02-28Completed
Cerebral Neuroinflammation During Major Depressive Episode: Multicentric Comparative Study.[NCT03314155]60 participants (Anticipated)Interventional2018-12-07Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

26 reviews available for reserpine and Depression

ArticleYear
The effects of reserpine on depression: A systematic review.
    Journal of psychopharmacology (Oxford, England), 2023, Volume: 37, Issue:3

    Topics: Adult; Antidepressive Agents; Anxiety; Anxiety Disorders; Depression; Humans; Reserpine

2023
Biochemical and anatomical substrates of depression and sickness behavior.
    The Israel journal of psychiatry and related sciences, 2010, Volume: 47, Issue:1

    Topics: Adenosine; Adrenergic Uptake Inhibitors; Animals; Basal Ganglia; Brain; Depression; Disease Models,

2010
Tetrabenazine, a monoamine-depleting drug used in the treatment of hyperkinetic movement disorders.
    The American journal of geriatric pharmacotherapy, 2010, Volume: 8, Issue:4

    Topics: Adrenergic Uptake Inhibitors; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Cytochrome P

2010
[Drug-induced depression].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antineoplastic Agents; Aspirin; Ca

2007
Depression, alpha 2-receptors and sex hormones: neuroendocrine studies in rat.
    Advances in biochemical psychopharmacology, 1984, Volume: 39

    Topics: Animals; Antidepressive Agents; Apomorphine; Carbidopa; Castration; Clonidine; Depression; Dihydrote

1984
Neurochemical and neuropharmacological aspects of depression.
    International review of neurobiology, 1975, Volume: 18

    Topics: Addison Disease; Adrenal Cortex Hormones; Amphetamines; Animals; Antidepressive Agents, Tricyclic; B

1975
The contribution of drug research to investigating the nature of endogenous depression.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1976, Volume: 9, Issue:1

    Topics: Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Female; Fenclonine; Histamine H1 Antag

1976
[Biochemistry of depression. Literature analysis].
    L'Encephale, 1978, Volume: 4, Issue:3

    Topics: Adrenal Cortex Hormones; Animals; Antidepressive Agents, Tricyclic; Brain; Depression; Dopamine; Hum

1978
Biogenic amines and affective disorders. A critical analysis.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:3

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar

1976
[Catecholamines in the pathochemical structure of depressive conditions (according to material from a biological study)].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1975, Volume: 75, Issue:8

    Topics: Adrenal Cortex Hormones; Adrenal Medulla; Animals; Brain; Catecholamines; Cell Nucleus; Depression;

1975
Biobehavioral sequellae associated with adrenergic-inhibiting antihypertensive agents: a critical review.
    Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 1985, Volume: 4, Issue:6

    Topics: Animals; Antihypertensive Agents; Cats; Cognition; Depression; Electroencephalography; Fatigue; Feed

1985
[Side effects of anti-arrhythmic agents].
    Klinicheskaia meditsina, 1971, Volume: 49, Issue:10

    Topics: 1-Propanol; Adrenal Cortex Hormones; Agranulocytosis; Anorexia Nervosa; Anti-Arrhythmia Agents; Anti

1971
Depressions following reserpine: a reevaluation.
    Seminars in psychiatry, 1971, Volume: 3, Issue:4

    Topics: Administration, Oral; Depression; Dreams; Drug Therapy, Combination; Electroconvulsive Therapy; Huma

1971
Depressive disorders: toward a unified hypothesis.
    Science (New York, N.Y.), 1973, Oct-05, Volume: 182, Issue:4107

    Topics: Age Factors; Animals; Anxiety, Separation; Behavior, Animal; Biogenic Amines; Conditioning, Operant;

1973
The biochemistry of the functional psychoses.
    Advances in enzymology and related areas of molecular biology, 1967, Volume: 29

    Topics: Acetylcholinesterase; Adenosine Triphosphatases; Animals; Behavior, Animal; Blood Proteins; Catatoni

1967
Drug-induced depression and tryptophan metabolism.
    Diseases of the nervous system, 1972, Volume: 33, Issue:2

    Topics: Adrenocorticotropic Hormone; Contraceptives, Oral; Cortisone; Depression; Estrogens; Female; Humans;

1972
Biochemistry of depression (a review of the literature).
    Behavioral neuropsychiatry, 1971, Volume: 3, Issue:9

    Topics: Adrenal Glands; Amines; Biogenic Amines; Brain Chemistry; Carbohydrate Metabolism; Catecholamines; C

1971
Cardiovascular complications of antidepressant therapy. Interactions at the adrenergic neuron.
    American heart journal, 1972, Volume: 83, Issue:1

    Topics: Antidepressive Agents; Cardiovascular Diseases; Depression; Drug Interactions; Electrocardiography;

1972
Depressive reactions associated with reserpine.
    New York state journal of medicine, 1974, Volume: 74, Issue:5

    Topics: Administration, Oral; Affective Symptoms; Anxiety; Compulsive Behavior; Depression; Female; Humans;

1974
Recent clinical studies of ECT.
    Seminars in psychiatry, 1972, Volume: 4, Issue:1

    Topics: Adjustment Disorders; Aged; Anesthesia, Intravenous; Animals; Antidepressive Agents; Anxiety; Atropi

1972
[Studies on the biochemistry and pharmacology of thymoleptics].
    Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques, 1968, Volume: 11

    Topics: Amines; Animals; Antidepressive Agents; Behavior, Animal; Brain Chemistry; Catecholamines; Cats; Dep

1968
Serotonin, and its effects on the pituitary-adrenal axis in depression.
    The Chicago Medical School quarterly, 1970, Volume: 29, Issue:1

    Topics: Amphetamine; Animals; Behavior, Animal; Brain Chemistry; Depression; Humans; Hypothalamus; Mental Di

1970
[Relation of monoamines to mental disorders].
    Activitas nervosa superior, 1970, Volume: 12, Issue:2

    Topics: Amines; Animals; Bipolar Disorder; Catecholamines; Central Nervous System; Depression; Dihydroxyphen

1970
[Adrenergic mechanisms of antidepressant action].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1970, Volume: 70, Issue:5

    Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Brain Chemistry; Cats; Depression; Dogs; Humans;

1970
Theories of biological etiology of affective disorders.
    International review of neurobiology, 1970, Volume: 12

    Topics: Adrenal Cortex Hormones; Affective Symptoms; Amines; Amphetamine; Antidepressive Agents; Bipolar Dis

1970
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
    Biological psychiatry, 1970, Volume: 2, Issue:4

    Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho

1970

Trials

13 trials available for reserpine and Depression

ArticleYear
Effect of withdrawal of antihypertensive drug on depressive mood.
    American journal of hypertension, 1993, Volume: 6, Issue:12

    Topics: Affect; Antihypertensive Agents; Depression; Female; Humans; Hypertension; Male; Middle Aged; Psychi

1993
Biogenic amines and affective disorders. A critical analysis.
    International pharmacopsychiatry, 1976, Volume: 11, Issue:3

    Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar

1976
Treatment with reserpine of patients resistant to tricyclic antidepressants. A double-blind trial.
    Psychiatria clinica, 1975, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; Depression; Drug Eval

1975
[Depressive effects during treatment with antihypertensive drugs (author's transl)].
    Archiv fur Psychiatrie und Nervenkrankheiten, 1973, Nov-27, Volume: 218, Issue:1

    Topics: Age Factors; Clinical Trials as Topic; Clonidine; Depression; Dose-Response Relationship, Drug; Drug

1973
Comparison between reserpine and propranolol as adjuncts in the treatment of hyperthyroidism.
    Current medical research and opinion, 1973, Volume: 1, Issue:7

    Topics: Administration, Oral; Adult; Asthma; Basal Metabolism; Blood Pressure; Body Weight; Clinical Trials

1973
The action of reserpine in imipramine-resistant depressive patients. Clinical and biochemical study.
    Psychopharmacologia, 1967, Volume: 11, Issue:1

    Topics: Adult; Bipolar Disorder; Blood Pressure; Body Temperature; Clinical Trials as Topic; Depression; Dru

1967
Affective disorders and norepinephrine pharmacology.
    International psychiatry clinics, 1969, Volume: 6, Issue:2

    Topics: Animals; Behavior; Behavior, Animal; Body Temperature; Brain; Brain Chemistry; Chlorpromazine; Clini

1969
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
    Biological psychiatry, 1970, Volume: 2, Issue:4

    Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho

1970
Psychopharmacology.
    Acta psychiatrica Scandinavica. Supplementum, 1970, Volume: 217

    Topics: Alcoholism; Anxiety; Brain Damage, Chronic; Chronic Disease; Clinical Trials as Topic; Depression; E

1970
Clinical and animal experiments concerning the function of brain catecholamines.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:3

    Topics: Animals; Antidepressive Agents; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Brain; Ca

1971
A pilot study of antihypertensive therapy in cerebrovascular disease.
    Journal of the American Geriatrics Society, 1967, Volume: 15, Issue:4

    Topics: Adult; Cerebrovascular Disorders; Clinical Trials as Topic; Depression; Female; Humans; Hypertension

1967
Correlation between the experimental data from animal studies and therapetical effects of antidepressant drugs.
    Psychopharmacologia, 1971, Volume: 20, Issue:4

    Topics: Animals; Antidepressive Agents; Depression; Electroencephalography; Female; Humans; Male; Nicotine;

1971
[The effects of dopa on inhibited depressions].
    Klinische Wochenschrift, 1966, Jun-15, Volume: 44, Issue:12

    Topics: Blood Pressure Determination; Depression; Dihydroxyphenylalanine; Drug Synergism; Humans; Placebos;

1966

Other Studies

203 other studies available for reserpine and Depression

ArticleYear
A Reliable High-Throughput Screening Model for Antidepressant.
    International journal of molecular sciences, 2021, Sep-01, Volume: 22, Issue:17

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Drug Evaluatio

2021
Tryptophan lessens reserpine induced anxiety, depression and memory impairment by modulating oxidative stress and serotonergic activity.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:4(Suppleme

    Topics: Acetylcholinesterase; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antidepressive Agents, Se

2021
Investigation of Cochlospermum religiosum leaves for antidepressant and anxiolytic activities and its synergistic effect with imipramine and fluoxetine.
    Environmental science and pollution research international, 2022, Volume: 29, Issue:18

    Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bixaceae; Depression; Fluoxet

2022
Label-free quantitative proteomic analysis of reserpine-induced depression in mice intervened by berberine.
    Pakistan journal of pharmaceutical sciences, 2022, Volume: 35, Issue:1

    Topics: Animals; Antipsychotic Agents; Berberine; Depression; Male; Mice; Mice, Inbred ICR; Proteomics; Rese

2022
Neuroprotective role of Bacopa monnieri extract in modulating depression in an experimental rat model.
    Journal of affective disorders, 2022, 07-01, Volume: 308

    Topics: Animals; Bacopa; Brain-Derived Neurotrophic Factor; Citalopram; Depression; Dopamine; Humans; Male;

2022
Evaluation of the therapeutic effect of mesoporous silica nanoparticles loaded with Gallic acid on reserpine-induced depression in Wistar rats.
    BMC pharmacology & toxicology, 2022, 06-15, Volume: 23, Issue:1

    Topics: Animals; Depression; Dopamine; Gallic Acid; Nanoparticles; Norepinephrine; Rats; Rats, Wistar; Reser

2022
Alterations of monoamine neurotransmitters, HPA-axis hormones, and inflammation cytokines in reserpine-induced hyperalgesia and depression comorbidity rat model.
    BMC psychiatry, 2022, 06-22, Volume: 22, Issue:1

    Topics: Adrenocorticotropic Hormone; Animals; Comorbidity; Cytokines; Depression; Hydrocortisone; Hyperalges

2022
Physical exercise prevents behavioral alterations in a reserpine-treated zebrafish: A putative depression model.
    Pharmacology, biochemistry, and behavior, 2022, Volume: 220

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Behavior, Animal; COVID-19; Depressi

2022
Mahonia Alkaloids (MA) Ameliorate Depression Induced Gap Junction Dysfunction by miR-205/Cx43 Axis.
    Neurochemical research, 2022, Volume: 47, Issue:12

    Topics: Alkaloids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Connexin 43; Corticost

2022
Rutin Improves Anxiety and Reserpine-Induced Depression in Rats.
    Molecules (Basel, Switzerland), 2022, Oct-27, Volume: 27, Issue:21

    Topics: Acetylcholinesterase; Animals; Antidepressive Agents; Antioxidants; Anxiety; Depression; Rats; Reser

2022
Antidepressant effect of 4-Butyl-alpha-agarofuran via HPA axis and serotonin system.
    Brain research bulletin, 2023, 06-15, Volume: 198

    Topics: Animals; Antidepressive Agents; Depression; Disease Models, Animal; Hippocampus; Hypothalamo-Hypophy

2023
The effect of curcumin on reserpine-induced depression-like behaviour in rats.
    Psychiatry research. Neuroimaging, 2023, Volume: 334

    Topics: Animals; Antidepressive Agents; Brain; Curcumin; Depression; Humans; Rats; Reserpine

2023
Repeated reserpine treatment induces depressive-like behaviors accompanied with hippocampal impairment and synapse deficit in mice.
    Brain research, 2023, 11-15, Volume: 1819

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models, Animal; Hippocampus; H

2023
Discovery of Potent, Selective, and Direct Acid Sphingomyelinase Inhibitors with Antidepressant Activity.
    Journal of medicinal chemistry, 2020, 02-13, Volume: 63, Issue:3

    Topics: Animals; Antidepressive Agents; Cell Line, Tumor; Cerebral Cortex; Depression; Drug Design; Enzyme I

2020
Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation.
    Naunyn-Schmiedeberg's archives of pharmacology, 2020, Volume: 393, Issue:8

    Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antidepressive Agent

2020
Antidepressant-like effect of ethanol extract of Blighia unijugata Bak. (Sapindaceae) leaves in acute and chronic models of depression in mice.
    Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2019, Dec-31, Volume: 34, Issue:2

    Topics: Animals; Blighia; Brain; Depression; Disease Models, Animal; Drug Evaluation, Preclinical; Locomotio

2019
Thymoquinone-encapsulated chitosan nanoparticles coated with polysorbate 80 as a novel treatment agent in a reserpine-induced depression animal model.
    Physiology & behavior, 2020, 08-01, Volume: 222

    Topics: Animals; Benzoquinones; Chitosan; Depression; Disease Models, Animal; Nanoparticles; Polysorbates; R

2020
Relevance of Mitochondrial Dysfunction in the Reserpine-Induced Experimental Fibromyalgia Model.
    Molecular neurobiology, 2020, Volume: 57, Issue:10

    Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Fatigue; Fibromyalgia; Male; Mice; Mi

2020
Skimmetin/osthole mitigates pain-depression dyad via inhibiting inflammatory and oxidative stress-mediated neurotransmitter dysregulation.
    Metabolic brain disease, 2021, Volume: 36, Issue:1

    Topics: Animals; Behavior, Animal; Brain; Coumarins; Cytokines; Depression; Drug Therapy, Combination; Femal

2021
Antidepressant Effect of Paeoniflorin Is Through Inhibiting Pyroptosis CASP-11/GSDMD Pathway.
    Molecular neurobiology, 2021, Volume: 58, Issue:2

    Topics: Adenosine Triphosphate; Animals; Antidepressive Agents; Behavior, Animal; CA1 Region, Hippocampal; C

2021
Chronic Pregabalin Treatment Ameliorates Pain, but not Depressive-Like Behaviors, in a Reserpine-Induced Myalgia Model in Rats.
    Pain physician, 2020, Volume: 23, Issue:6

    Topics: Animals; Anticonvulsants; Antihypertensive Agents; Chronic Pain; Depression; Disease Models, Animal;

2020
Anti-depressant effect of cerebrolysin in reserpine-induced depression in rats: Behavioral, biochemical, molecular and immunohistochemical evidence.
    Chemico-biological interactions, 2021, Jan-25, Volume: 334

    Topics: Amino Acids; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Cyc

2021
Hesperetin ameliorates electroconvulsive therapy-induced memory impairment through regulation of hippocampal BDNF and oxidative stress in a rat model of depression.
    Journal of chemical neuroanatomy, 2021, Volume: 117

    Topics: Adrenergic Uptake Inhibitors; Animals; Brain-Derived Neurotrophic Factor; Depression; Disease Models

2021
Repeated treatment with reserpine as a progressive animal model of depression.
    Pakistan journal of pharmaceutical sciences, 2017, Volume: 30, Issue:3

    Topics: Animals; Antidepressive Agents; Chromatography, High Pressure Liquid; Depression; Male; Models, Anim

2017
A standardization of the Novelty-Suppressed Feeding Test protocol in rats.
    Neuroscience letters, 2017, Sep-29, Volume: 658

    Topics: Animals; Antidepressive Agents; Depression; Depressive Disorder; Disease Models, Animal; Duloxetine

2017
Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption.
    Behavioural brain research, 2018, 08-01, Volume: 348

    Topics: Alcohol Drinking; Animals; Depression; Dopamine; Ethanol; Female; Fluoxetine; Male; Rats; Rats, Wist

2018
An extract of Synedrella nodiflora (L) Gaertn exhibits antidepressant properties through monoaminergic mechanisms.
    Metabolic brain disease, 2018, Volume: 33, Issue:4

    Topics: Animals; Antidepressive Agents; Asteraceae; Behavior, Animal; Depression; Disease Models, Animal; Fe

2018
Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).
    Behavioral and brain functions : BBF, 2018, Jun-14, Volume: 14, Issue:1

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Cognition Disorders; Depression; Drugs

2018
Antidepressant-Like Effects of
    BioMed research international, 2018, Volume: 2018

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Depression; Depressive Disorder;

2018
Effects of imidazoline I2 receptor agonists on reserpine-induced hyperalgesia and depressive-like behavior in rats.
    Behavioural pharmacology, 2019, Volume: 30, Issue:5

    Topics: Analgesics; Animals; Benzofurans; Depression; Disease Models, Animal; Fibromyalgia; Hyperalgesia; Id

2019
BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1.
    Psychiatry research, 2019, Volume: 271

    Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Hi

2019
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:9

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi

2019
Ferulic acid increases pain threshold and ameliorates depression-like behaviors in reserpine-treated mice: behavioral and neurobiological analyses.
    Metabolic brain disease, 2013, Volume: 28, Issue:4

    Topics: Animals; Behavior, Animal; Brain; Coumaric Acids; Depression; Disease Models, Animal; Dopamine; Mice

2013
[Influence of ferulic acid on the pain-depression dyad induced by reserpine].
    Yao xue xue bao = Acta pharmaceutica Sinica, 2013, Volume: 48, Issue:1

    Topics: Animals; Antidepressive Agents; Coumaric Acids; Depression; Dopamine; Dose-Response Relationship, Dr

2013
Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice.
    Journal of ethnopharmacology, 2013, Jul-09, Volume: 148, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Behavior, Animal; Coptis; Corpus Striatum; Depr

2013
Possible involvement of oxido-nitrosative stress induced neuro-inflammatory cascade and monoaminergic pathway: underpinning the correlation between nociceptive and depressive behaviour in a rodent model.
    Journal of affective disorders, 2013, Volume: 151, Issue:3

    Topics: Animals; Berberine; Caspase 3; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippoc

2013
Attenuation of reserpine-induced pain/depression dyad by gentiopicroside through downregulation of GluN2B receptors in the amygdala of mice.
    Neuromolecular medicine, 2014, Volume: 16, Issue:2

    Topics: Amygdala; Analgesics; Animals; Biogenic Amines; Brain Chemistry; Caspase 3; Chronic Pain; Depression

2014
Antidepressant-like activity of adhyperforin, a novel constituent of Hypericum perforatum L.
    Scientific reports, 2014, Jul-09, Volume: 4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Depression; Dopamine; Hindlimb Suspension; Hyperic

2014
Evaluation of anti-colitic effect of fluvoxamine against acetic acid-induced colitis in normal and reserpinized depressed rats.
    European journal of pharmacology, 2015, Jan-05, Volume: 746

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Second-Generation; Antipsyc

2015
In vivo imaging of CREB phosphorylation in awake-mouse brain.
    Scientific reports, 2015, Jun-05, Volume: 5

    Topics: Animals; Behavior, Animal; Brain; Cerebral Cortex; Cyclic AMP Response Element-Binding Protein; Depr

2015
Depressive-like symptoms in a reserpine-induced model of fibromyalgia in rats.
    Physiology & behavior, 2015, Nov-01, Volume: 151

    Topics: Adrenergic Uptake Inhibitors; Animals; Depression; Disease Models, Animal; Exploratory Behavior; Fee

2015
Echinocystic acid reduces reserpine-induced pain/depression dyad in mice.
    Metabolic brain disease, 2016, Volume: 31, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Brain; Depression; Depressive Disorder; Disease Models, Anima

2016
The influence of dizocilpine on the reserpine-induced behavioral and neurobiological changes in rats.
    Neuroscience letters, 2016, Feb-12, Volume: 614

    Topics: Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Dentate Gyrus; Depression; Dizoci

2016
Comparison of the Efficiency of Adeprophen and Antidepressants of Various Groups on the Model of Reserpine-Induced Depression in Rats.
    Bulletin of experimental biology and medicine, 2016, Volume: 160, Issue:5

    Topics: Adenine; Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Depression; Disease Models

2016
Transcranial low-level infrared laser irradiation ameliorates depression induced by reserpine in rats.
    Lasers in medical science, 2016, Volume: 31, Issue:8

    Topics: Animals; Behavior, Animal; Brain; Depression; Disease Models, Animal; Electroencephalography; Infrar

2016
Cannabis exacerbates depressive symptoms in rat model induced by reserpine.
    Behavioural brain research, 2017, 05-01, Volume: 324

    Topics: Acetylcholinesterase; Animals; Cannabis; Cerebral Cortex; Depression; Disease Models, Animal; Dopami

2017
Antidepressant-like effect of ethanol extract from Paeonia lactiflora in mice.
    Phytotherapy research : PTR, 2008, Volume: 22, Issue:11

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Blepharoptosis; Clomipramine; Depression; Dise

2008
On the mechanism of antidepressant-like action of berberine chloride.
    European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3

    Topics: Analgesics; Animals; Antidepressive Agents; Behavior, Animal; Berberine; Body Temperature; Brain; De

2008
Antidepressant-like effect of peony glycosides in mice.
    Journal of ethnopharmacology, 2008, Sep-26, Volume: 119, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Blepharoptosis; Cerebrum; Depression; Disease Mode

2008
Antidepressant-like effect of genipin in mice.
    Neuroscience letters, 2010, Aug-02, Volume: 479, Issue:3

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Biogenic Monoamines; Blepharoptosis; Depression; D

2010
Evaluation of antidepressant activity of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a β-substituted phenylethylamine in mice.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2011, Volume: 21, Issue:9

    Topics: Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Beha

2011
Curcumin ameliorates reserpine-induced pain-depression dyad: behavioural, biochemical, neurochemical and molecular evidences.
    Psychoneuroendocrinology, 2011, Volume: 36, Issue:10

    Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biomarkers; Curcumin

2011
Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - an investigation using behavioral tests battery of depression.
    Biochemical and biophysical research communications, 2011, Jun-17, Volume: 409, Issue:4

    Topics: 5-Hydroxytryptophan; Acetamides; Animals; Antidepressive Agents; Behavior; Depression; Disease Model

2011
Nicotine restores monoamine neurotransmitter changes in the cortex and hippocampus of reserpinized rats as a model of depression.
    European review for medical and pharmacological sciences, 2011, Volume: 15, Issue:8

    Topics: Animals; Antidepressive Agents; Cerebral Cortex; Depression; Disease Models, Animal; Dopamine; Hippo

2011
Ginsenoside Rb3 exerts antidepressant-like effects in several animal models.
    Journal of psychopharmacology (Oxford, England), 2012, Volume: 26, Issue:5

    Topics: Action Potentials; Animals; Antidepressive Agents; Atrophy; Behavior, Animal; Brain-Derived Neurotro

2012
Antidepressant and anxiolytic-like effects of 4n, a novel 5-HT3 receptor antagonist using behaviour based rodent models.
    Indian journal of experimental biology, 2012, Volume: 50, Issue:9

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Depression; Emotions; Mice; Olfactory Bul

2012
Evaluation of the face validity of reserpine administration as an animal model of depression--Parkinson's disease association.
    Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:5

    Topics: Animals; Behavior, Animal; Depression; Disease Models, Animal; Food Preferences; Injections, Intrape

2002
The myth of reserpine-induced depression: role in the historical development of the monoamine hypothesis.
    Journal of the history of the neurosciences, 2003, Volume: 12, Issue:2

    Topics: Biogenic Monoamines; Depression; History, 20th Century; Humans; Reserpine

2003
Mental depression in hypertensive patients treated for long periods with large doses of reserpine.
    The New England journal of medicine, 1954, Dec-16, Volume: 251, Issue:25

    Topics: Depression; Depressive Disorder; Humans; Hypertension; Hypnotics and Sedatives; Rauwolfia; Reserpine

1954
[Clinical trials of Rauwolfia alkaloid, reserpine, in psychiatry].
    Deutsche medizinische Wochenschrift (1946), 1955, Oct-14, Volume: 80, Issue:41

    Topics: Depression; Depressive Disorder, Major; Mental Disorders; Psychiatry; Psychotherapy; Psychotic Disor

1955
Treatment of hypertensive patients with Rauwolfia compounds and reserpine; depressive and psychotic changes.
    Journal of the American Medical Association, 1955, Dec-17, Volume: 159, Issue:16

    Topics: Antihypertensive Agents; Depression; Depressive Disorder; Humans; Hypertension; Psychoses, Substance

1955
[Painful phantom limb with a depressive syndrome; spectacular cure with reserpine].
    Revue neurologique, 1955, Volume: 92, Issue:5

    Topics: Antihypertensive Agents; Depression; Depressive Disorder; Phantom Limb; Reserpine; Secologanin Trypt

1955
Reserpine depression treated with sodium succinate; a preliminary report.
    The New Zealand medical journal, 1955, Volume: 54, Issue:303

    Topics: Antihypertensive Agents; Central Nervous System Stimulants; Depression; Depressive Disorder; Humans;

1955
[Depression after reserpine therapy of essential hypertension].
    Nederlands tijdschrift voor geneeskunde, 1956, Apr-07, Volume: 100, Issue:14

    Topics: Antihypertensive Agents; Depression; Depressive Disorder; Essential Hypertension; Hypertension; Rese

1956
[Depressive states with melancholia behavior during treatment of arterial hypertension with reserpine or Rauwolfia serpentina alkaloids].
    Algerie medicale, 1956, Volume: 60, Issue:5

    Topics: Antihypertensive Agents; Depression; Depressive Disorder; Hypertension; Rauwolfia; Reserpine; Secolo

1956
[Risks of depression with Rauwolfia management].
    Svenska lakartidningen, 1956, Nov-02, Volume: 53, Issue:44

    Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk

1956
[Risks of depression with Rauwolfia management].
    Svenska lakartidningen, 1956, Nov-02, Volume: 53, Issue:44

    Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk

1956
[Risks of depression with Rauwolfia management].
    Svenska lakartidningen, 1956, Nov-02, Volume: 53, Issue:44

    Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk

1956
[Risks of depression with Rauwolfia management].
    Svenska lakartidningen, 1956, Nov-02, Volume: 53, Issue:44

    Topics: Alkaloids; Depression; Depressive Disorder; Disease Management; Humans; Rauwolfia; Reserpine; Risk

1956
[Rauwolfia and depressive states].
    La Revue du praticien, 1956, Nov-21, Volume: 6, Issue:30

    Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine

1956
[Rauwolfia and depressive states].
    La Revue du praticien, 1956, Nov-21, Volume: 6, Issue:30

    Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine

1956
[Rauwolfia and depressive states].
    La Revue du praticien, 1956, Nov-21, Volume: 6, Issue:30

    Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine

1956
[Rauwolfia and depressive states].
    La Revue du praticien, 1956, Nov-21, Volume: 6, Issue:30

    Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine

1956
[Cases of administration of massive doses of reserpine].
    Wiener klinische Wochenschrift, 1956, Nov-02, Volume: 68, Issue:44

    Topics: Depression; Depressive Disorder; Reserpine

1956
[Cases of administration of massive doses of reserpine].
    Wiener klinische Wochenschrift, 1956, Nov-02, Volume: 68, Issue:44

    Topics: Depression; Depressive Disorder; Reserpine

1956
[Cases of administration of massive doses of reserpine].
    Wiener klinische Wochenschrift, 1956, Nov-02, Volume: 68, Issue:44

    Topics: Depression; Depressive Disorder; Reserpine

1956
[Cases of administration of massive doses of reserpine].
    Wiener klinische Wochenschrift, 1956, Nov-02, Volume: 68, Issue:44

    Topics: Depression; Depressive Disorder; Reserpine

1956
Neuropharmacologic action of Rauwolfia compounds and its psychodynamic implications.
    A.M.A. archives of neurology and psychiatry, 1957, Volume: 77, Issue:5

    Topics: Alkaloids; Depression; Depressive Disorder; Humans; Hypnotics and Sedatives; Rauwolfia; Reserpine

1957
Ineffectiveness of chlorpromazine and Rauwolfia serpentina preparations in the treatment of depression.
    Diseases of the nervous system, 1957, Volume: 18, Issue:10

    Topics: Chlorpromazine; Depression; Depressive Disorder; Rauwolfia; Reserpine

1957
[Observations on neurotic depressions with reference to a combined serpasil-ritalin treatment].
    Rassegna di neuropsichiatria e scienze affini, 1956, Volume: 10, Issue:5-6

    Topics: Combined Modality Therapy; Depression; Depressive Disorder; Manipulation, Osteopathic; Methylphenida

1956
[Results of treatment with a new combination preparation in autonomic function disorders and depressive states].
    Medizinische Klinik, 1957, Dec-20, Volume: 52, Issue:51

    Topics: Autonomic Nervous System; Autonomic Nervous System Diseases; Depression; Depressive Disorder; Ergot

1957
[Inverse doriden effect in the course of a reserpine treatment of depressions].
    Deutsche medizinische Wochenschrift (1946), 1958, Mar-28, Volume: 83, Issue:13

    Topics: Depression; Depressive Disorder; Glutethimide; Humans; Hypnotics and Sedatives; Reserpine

1958
[Influencing of depressive states in geriatrics].
    Therapie der Gegenwart, 1958, Volume: 97, Issue:2

    Topics: Aged; Depression; Depressive Disorder; Geriatrics; Methylphenidate; Reserpine

1958
Treatment of depressed and regressed patients with iproniazid and reserpine.
    Diseases of the nervous system, 1959, Volume: 20, Issue:1

    Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids; Reserpine

1959
[Evaluation and management of depressive states appearing during reserpine therapy].
    Die Medizinische, 1958, Nov-22, Volume: 32, Issue:47

    Topics: Depression; Depressive Disorder; Diphenhydramine; Disease Management; Humans; Reserpine

1958
Side-effects of reserpine in the treatment of essential hypertension: with special reference to weight gain and mental depression.
    Acta medica Scandinavica, 1958, Dec-20, Volume: 162, Issue:6

    Topics: Depression; Depressive Disorder; Essential Hypertension; Humans; Hypertension; Obesity; Reserpine; W

1958
Place of methyl phenidate hydrochloride in psychiatric practice.
    British medical journal, 1959, Feb-21, Volume: 1, Issue:5120

    Topics: Depression; Depressive Disorder; Methylphenidate; Reserpine; Salts

1959
Depressions in patients treated with reserpine for arterial hypertension.
    Acta psychiatrica et neurologica Scandinavica, 1959, Volume: 34, Issue:2

    Topics: Depression; Depressive Disorder; Humans; Hypertension; Reserpine

1959
The mechanism of the combined treatment of depression with iproniazid and reserpine.
    The Journal of mental science, 1960, Volume: 106

    Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R

1960
[The psychoanaleptic action of Disipal in the neuroleptic syndrome and in senile depression].
    Acta neurologica et psychiatrica Belgica, 1961, Volume: 61

    Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Anxiety; Depression; Depressive Disorder; Huma

1961
[Combined iproniazid-reserpine treatment-a placebo experiment].
    Psychiatria et neurologia, 1960, Volume: 140

    Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R

1960
Effects and interactions of imipramine, chlorpromazine, reserpine and amphetamine on self-stimulation: possible neurophysiological basis of depression.
    Recent advances in biological psychiatry, 1961, Volume: 4

    Topics: Amphetamine; Amphetamines; Chlorpromazine; Depression; Depressive Disorder; Imipramine; Reserpine; S

1961
[Suicide prevention with special reference to the pharmacopsychiatric treatment of depression].
    Therapie der Gegenwart, 1962, Volume: 101

    Topics: Anti-Allergic Agents; Depression; Depressive Disorder; Histamine H1 Antagonists; Parasympatholytics;

1962
[Endogenous depression and its treatment].
    Anales de la Real Academia Nacional de Medicina, 1963, Volume: 80

    Topics: Antidepressive Agents; Depression; Depressive Disorder; Electroconvulsive Therapy; Humans; Imipramin

1963
COMBINED ADMINISTRATION OF DESIPRAMINE AND RESERPINE OR TETRABENAZINE IN DEPRESSIVE PATIENTS.
    Psychopharmacologia, 1963, May-21, Volume: 4

    Topics: Antidepressive Agents; Depression; Depressive Disorder; Desipramine; Humans; Imipramine; Reserpine;

1963
CURRENT THERAPEUTICS. CXC. THE CURRENT STATUS OF THE TRANQUILLIZERS.
    The Practitioner, 1963, Volume: 191

    Topics: Anxiety; Chlorpromazine; Depression; Female; Humans; Phenothiazines; Premenstrual Syndrome; Rauwolfi

1963
[TREATMENT OF ENDOGENOUS DEPRESSIONS WITH INTERMITTENT DOSES OF RESERPINE].
    Activitas nervosa superior, 1963, Volume: 5

    Topics: Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Paranoid Disorders; Reserpine

1963
[HYPOTENSIVE AND SIDE-EFFECTS OF METHOXYPHENOSERPINE, A NEW RESERPINE DERIVATIVE].
    Casopis lekaru ceskych, 1963, Nov-15, Volume: 102

    Topics: Antihypertensive Agents; Anxiety; Depression; Depressive Disorder; Nasal Mucosa; Rauwolfia; Reserpin

1963
[CRITICAL NOTE ON THE USEFULNESS OF A NEW DRUG, THE METHYL ETHER OF METHYL 18-EPIRESERPATE, IN PSYCHIATRY].
    Rassegna di studi psichiatrici, 1963, Volume: 52

    Topics: Biomedical Research; Depression; Epilepsy; Humans; Intellectual Disability; Mental Disorders; Methyl

1963
HIREPINE IN PSYCHIATRY.
    Therapia Hungarica (English edition), 1964, Volume: 12

    Topics: Catatonia; Chlorpromazine; Convulsive Therapy; Dementia; Depression; Electroconvulsive Therapy; Huma

1964
THE PHARMACOLOGY AND BIOCHEMISTRY OF DEPRESSION.
    Diseases of the nervous system, 1964, Volume: 25

    Topics: Amitriptyline; Antidepressive Agents; Biochemical Phenomena; Biochemistry; Brain; Depression; Depres

1964
PSYCHOSES CAUSED BY NEUROLEPTICS.
    L'Encephale, 1964, Volume: 53

    Topics: Antipsychotic Agents; Chlorpromazine; Delirium; Depression; Geriatrics; Humans; Mental Disorders; Ps

1964
GALACTORRHEA DUE TO IMIPRAMINE. REPORT OF A CASE.
    The New England journal of medicine, 1964, Sep-03, Volume: 271

    Topics: Amenorrhea; Chlorpromazine; Depression; Depressive Disorder; Female; Galactorrhea; Humans; Hypothyro

1964
DISSOCIATION OF RESERPINE-INDUCED DEPRESSION OF SPONTANEOUS MOTOR ACTIVITY AND RELEASE OF BRAIN SEROTONIN IN RATS.
    Biochemical pharmacology, 1964, Volume: 13

    Topics: Brain; Brain Chemistry; Depression; Fluorometry; Motor Activity; Movement; Pharmacology; Rats; Resea

1964
THE PRACTICAL MANAGEMENT OF DEPRESSION.
    JAMA, 1964, Nov-23, Volume: 190

    Topics: Amitriptyline; Antidepressive Agents; Benzoates; Classification; Depression; Depressive Disorder; Dr

1964
[PROTRACTED RESERPINE TREATMENT AND ELECTROSHOCK: CONSIDERATIONS ON THE OPPORTUNITIES AND POSSIBILITIES OF ASSOCIATION].
    Rassegna di studi psichiatrici, 1964, Volume: 53

    Topics: Adolescent; Apnea; Biomedical Research; Catatonia; Convulsive Therapy; Depression; Drug Therapy; Ele

1964
HISTAMINE AND THE REVERSAL OF CHLORPROMAZINE-INDUCED DEPRESSION.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Anti-Allergic Agents; Behavior, Animal; Chlorpromazine; Depression; Depressive Disorder; Histamine;

1964
[SOMATOTHERAPY OF ENDOGENOUS PSYCHOSES AT MARBURG UNIVERSITY NEUROLOGIC CLINIC].
    Psychiatria et neurologia, 1964, Volume: 148

    Topics: Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Convulsive Therapy; Depression;

1964
ANTAGONISM OF RESERPINE BEHAVIORAL DEPRESSION BY D-AMPHETAMINE.
    The Journal of pharmacology and experimental therapeutics, 1964, Volume: 146

    Topics: Amphetamine; Amphetamines; Animals; Avoidance Learning; Behavior, Animal; Brain Chemistry; Depressio

1964
EXPERIENCES WITH THE LONG-TERM USE OF METHYLDOPA ("ALDOMET") IN HYPERTENSION.
    The Medical journal of Australia, 1965, Mar-20, Volume: 1, Issue:12

    Topics: Benzothiadiazines; Blood Pressure Determination; Depression; Drug Therapy; Drug Tolerance; Glomerulo

1965
PITFALLS IN THE DIAGNOSIS OF PSYCHIATRIC DISEASE.
    The Practitioner, 1965, Volume: 194

    Topics: Anxiety; Anxiety Disorders; Brain Neoplasms; Carcinoid Tumor; Depression; Diagnosis; Drug Therapy; G

1965
[THE CHEMOTHERAPY OF ANXIETY].
    Minerva medica, 1965, May-26, Volume: 56

    Topics: Anxiety; Chlorprothixene; Depression; Drug Therapy; Humans; Nervous System Diseases; Reserpine; Schi

1965
DEPRESSION AFTER METHOSERPIDINE.
    Lancet (London, England), 1965, Sep-04, Volume: 2, Issue:7410

    Topics: Depression; Drug Therapy; Hypertension; Psychopharmacology; Rauwolfia; Reserpine; Toxicology

1965
Treatment of reserpine-induced depression with a new analeptic: phenidylate.
    Annals of the New York Academy of Sciences, 1955, Apr-15, Volume: 61, Issue:1

    Topics: Central Nervous System Stimulants; Depression; Depressive Disorder; Mental Disorders; Methylphenidat

1955
The use of reserpine in office psychiatry: preliminary report.
    Annals of the New York Academy of Sciences, 1955, Apr-15, Volume: 61, Issue:1

    Topics: Depression; Depressive Disorder; Mental Disorders; Psychiatry; Psychotherapy; Reserpine; Secologanin

1955
Reserpine in the treatment of anxious and depressed patients.
    Lancet (London, England), 1955, Jul-16, Volume: 269, Issue:6881

    Topics: Antihypertensive Agents; Anxiety; Anxiety Disorders; Depression; Depressive Disorder; Reserpine; Sec

1955
Iproniazid and combined iproniazid-reserpine treatment of depressive and inactive patients.
    Acta psychiatrica Scandinavica. Supplementum, 1959, Volume: 34, Issue:136

    Topics: Combined Modality Therapy; Depression; Depressive Disorder; Iproniazid; Manipulation, Osteopathic; R

1959
[Treatment of melancholic states with new chemotherapy agents: levomepromazine, imipramine, iproniazid, reserpine, deprol].
    Toulouse medical, 1959, Volume: 60

    Topics: Antineoplastic Agents; Depression; Depressive Disorder; Imipramine; Iproniazid; Methotrimeprazine; P

1959
[Nialamid and its combinations with reserpine-like substances (fenoharman, reserpine) in the therapy of endogenous depressions].
    Deutsches medizinisches Journal, 1962, Jul-05, Volume: 13

    Topics: Depression; Depressive Disorder; Humans; Monoamine Oxidase Inhibitors; Reserpine

1962
Brain IL-1 beta was involved in reserpine-induced behavioral depression in rats.
    Acta pharmacologica Sinica, 2004, Volume: 25, Issue:3

    Topics: Animals; Brain; Cerebral Cortex; Depression; Hippocampus; Hypothalamus; Injections, Intraventricular

2004
[Effect of madecassoside on depression behavior of mice and activities of MAO in different brain regions of rats].
    Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine, 2004, Volume: 2, Issue:6

    Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Brain; Depression; Imipramine; Male

2004
Suicides in general hospitals.
    Hong Kong medical journal = Xianggang yi xue za zhi, 2004, Volume: 10, Issue:6

    Topics: Adrenergic beta-Antagonists; Analgesics; Anti-Infective Agents, Urinary; Antipsychotic Agents; Cloni

2004
[Experimental study of the total flavonoid in Hypericum perforatum on depression].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2005, Volume: 30, Issue:15

    Topics: Animals; Antidepressive Agents; Brain; Depression; Female; Flavonoids; Hypericum; Male; Mice; Mice,

2005
Depressive behavior in mice due to immune stimulation is accompanied by reduced neural activity in brain regions involved in positively motivated behavior.
    Biological psychiatry, 2006, Oct-15, Volume: 60, Issue:8

    Topics: Adjuvants, Immunologic; Adrenergic Uptake Inhibitors; Animals; Behavior, Animal; Brain; Cerebral Cor

2006
Involvement of nitric oxide (NO) signaling pathway in the antidepressant action of bupropion, a dopamine reuptake inhibitor.
    European journal of pharmacology, 2007, Jul-30, Volume: 568, Issue:1-3

    Topics: Animals; Antidepressive Agents, Second-Generation; Arginine; Behavior, Animal; Body Temperature; Bra

2007
Evaluation of the antidepressant-like activity of Convolvulus pluricaulis choisy in the mouse forced swim and tail suspension tests.
    Medical science monitor : international medical journal of experimental and clinical research, 2007, Volume: 13, Issue:7

    Topics: Acetates; Alkanes; Animals; Antidepressive Agents; Chloroform; Convolvulus; Depression; Fenclonine;

2007
Evaluation of antidepressant-like activity of aqueous and ethanolic extracts of Terminalia bellirica Roxb. fruits in mice.
    Indian journal of experimental biology, 2007, Volume: 45, Issue:7

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Chemistry, Pharmaceutical; Depression; Drug Evalua

2007
[The use of a reserpine derivative in the neuroses of the aged].
    Minerva medica, 1967, Feb-14, Volume: 58, Issue:13

    Topics: Aged; Anxiety Disorders; Dementia; Depression; Female; Humans; Hypochondriasis; Male; Middle Aged; R

1967
Autonomic reactions in relation to psychotropic drugs.
    Diseases of the nervous system, 1967, Volume: 28, Issue:5

    Topics: Adolescent; Adult; Autonomic Nervous System; Blood Pressure; Chlorpromazine; Darkness; Depression; F

1967
[Drugs in medical practice. Prescription and control].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1980, Jan-20, Volume: 56, Issue:2

    Topics: Adrenergic beta-Antagonists; Analgesics; Antineoplastic Agents; Depression; Digitalis Glycosides; Di

1980
[Psychopharmacologic spectrum of melanostatin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1980, Volume: 89, Issue:6

    Topics: Aggression; Amantadine; Animals; Behavior, Animal; Biogenic Amines; Brain Chemistry; Catalepsy; Cats

1980
[Drug-induced depression].
    La Clinica terapeutica, 1980, May-15, Volume: 93, Issue:3

    Topics: Adrenal Cortex Hormones; Antipsychotic Agents; Contraceptives, Oral; Depression; Dihydroxyphenylalan

1980
Alprazolam in a biochemical model of depression.
    Biochemical pharmacology, 1982, Oct-01, Volume: 31, Issue:19

    Topics: Alprazolam; Animals; Anti-Anxiety Agents; Benzodiazepines; Depression; Diazepam; Disease Models, Ani

1982
Alprazolam reversal of reserpine-induced depression in patients with compensated tardive dyskinesia.
    Drug intelligence & clinical pharmacy, 1984, Volume: 18, Issue:4

    Topics: Adult; Alprazolam; Anti-Anxiety Agents; Benzodiazepines; Depression; Dyskinesia, Drug-Induced; Human

1984
[Current biochemical conceptions of mental diseases. II. Role of changes in the biogenic amine system in the pathogenesis of affective disorders].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1980, Volume: 80, Issue:6

    Topics: 3-Methoxy-4-hydroxyphenylethanol; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic;

1980
The behavioral effect of salbutamol (a beta-adrenergic receptor stimulant) on reserpine- and propranolol-treated rats.
    Journal of neurology, 1983, Volume: 230, Issue:1

    Topics: Albuterol; Animals; Antidepressive Agents; Depression; Disease Models, Animal; Humans; Propranolol;

1983
The effects of thyrotropin-releasing hormone (TRH) and other drugs on the actions of alcohol.
    Advances in experimental medicine and biology, 1980, Volume: 126

    Topics: Animals; Brain; Cerebellum; Chlorpromazine; Cyclic GMP; Depression; Diazepam; Dose-Response Relation

1980
[Efficacy of lithium hydroxybutyrate in reserpine depression].
    Biulleten' eksperimental'noi biologii i meditsiny, 1983, Volume: 96, Issue:11

    Topics: Animals; Avoidance Learning; Conditioning, Classical; Depression; Drug Antagonism; Electroencephalog

1983
Effects of chronic amphetamine or reserpine on self-stimulation responding: animal model of depression?
    Psychopharmacology, 1980, Volume: 72, Issue:1

    Topics: Animals; Depression; Dextroamphetamine; Humans; Male; Rats; Reserpine; Self Stimulation; Sodium Chlo

1980
Early reserpine sensitivity and depression in schizophrenia.
    Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:6

    Topics: Depression; Humans; Reserpine; Schizophrenia

1981
Depressive illness in old age: getting behind the mask.
    Geriatrics, 1980, Volume: 35, Issue:4

    Topics: Aged; Antidepressive Agents, Tricyclic; Depression; Diagnosis, Differential; Drug Interactions; Elec

1980
Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:1

    Topics: Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain C

1994
[The role of relationship between the epiphysis and the sympathetico-adrenal system in the depressogenic effect of reserpine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1996, Volume: 121, Issue:6

    Topics: Adrenal Medulla; Animals; Depression; Dopamine; Hypothalamus; Male; Norepinephrine; Pineal Gland; Ra

1996
Possible therapeutic effect of T-794, a novel reversible inhibitor of monoamine oxidase-A, on post-stroke emotional disturbances, assessed in animal models of depression.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:4

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Body Temperature; Depression; Disease Models, Anim

1997
NMDA receptor complex blockade by oral administration of magnesium: comparison with MK-801.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 58, Issue:1

    Topics: Adrenergic alpha-Agonists; Animals; Body Temperature; Depression; Dizocilpine Maleate; Drug Synergis

1997
Effect of reserpine on 3-methoxy-4-hydroxyphenylethyleneglycol and 3,4-dihydroxyphenylacetic acid in the hippocampus of depression-model rats: an in vivo microdialysis study.
    Brain research, 1998, Feb-23, Volume: 785, Issue:1

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Depression; Female; Hippocampus; Kinetics; Methoxyhydroxyph

1998
[Putative contribution of the epiphyseal-adrenocortical system in the antidepressive effect of imipramine].
    Biulleten' eksperimental'noi biologii i meditsiny, 1998, Volume: 125, Issue:6

    Topics: Adrenal Cortex; Animals; Antidepressive Agents, Tricyclic; Corticosterone; Depression; Drug Interact

1998
Antihypertensive drugs and depression: a reappraisal.
    Psychological medicine, 1978, Volume: 8, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Dep

1978
Adverse reactions to antihypertensive drug therapy: central nervous system.
    Acta medica Scandinavica. Supplementum, 1979, Volume: 628

    Topics: Adrenergic beta-Antagonists; Antihypertensive Agents; Brain; Clonidine; Depression; Humans; Hypnotic

1979
[The role of serotonin in affective disorders (author's transl)].
    L'Encephale, 1979, Volume: 5, Issue:5 Suppl

    Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depression; Humans; Hydroxyindoleacetic A

1979
Electroconvulsive shock and postsynaptic catecholamine effects: increased psychomotor stimulant action of apomorphine and clonidine in reserpine pretreated mice by repeated ECS.
    Journal of neural transmission, 1975, Volume: 36, Issue:1

    Topics: Animals; Apomorphine; Brain; Catecholamines; Clonidine; Depression; Electroshock; Humans; Male; Mice

1975
Adverse reactions and interactions limiting the use of antihypertensive drugs.
    The American journal of medicine, 1975, Volume: 58, Issue:4

    Topics: Antihypertensive Agents; Blood Pressure; Depression; Dose-Response Relationship, Drug; Drug Interact

1975
Prejudices in pharmacology and pharmacotherapy: reserpine as a model for experimental research in depression.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1978, Volume: 11, Issue:6

    Topics: Catecholamines; Depression; Disease Models, Animal; History, 20th Century; Humans; Psychopharmacolog

1978
[Experimental study of the emotiontropic effect of lithium: ambivalent dose-dependent effect in "reserpine depression" and preventive anti-stress effect].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1977, Volume: 77, Issue:8

    Topics: Adrenal Glands; Animals; Depression; Epinephrine; Humans; Hypothalamus; Lithium; Norepinephrine; Rat

1977
The hypertensive psychiatric patient: pharmacologic problems.
    The Journal of clinical psychiatry, 1978, Volume: 39, Issue:9

    Topics: Antihypertensive Agents; Clonidine; Depression; Diuretics; Drug Interactions; Guanethidine; Humans;

1978
Drugs for hypertension.
    The Medical letter on drugs and therapeutics, 1977, Mar-11, Volume: 19, Issue:5

    Topics: Antihypertensive Agents; Benzothiadiazines; Clonidine; Depression; Diuretics; Drug Combinations; Dru

1977
[News from the control of thoughts].
    Medizinische Monatsschrift, 1975, Volume: 29, Issue:2

    Topics: Central Nervous System; Cognition; Depression; Humans; Hypothyroidism; Lithium; Reserpine; Tryptopha

1975
Reserpine in hypertension: present status.
    American family physician, 1975, Volume: 11, Issue:6

    Topics: Animals; Benzothiadiazines; Breast Neoplasms; Chronic Disease; Depression; Diuretics; Drug Therapy,

1975
Reserpine and the induction of depression: a case report.
    Diseases of the nervous system, 1975, Volume: 36, Issue:6

    Topics: Adult; Antisocial Personality Disorder; Depression; Humans; Male; Psychotherapy; Reserpine

1975
Letter: Reserpine, ECT, and depression.
    The American journal of psychiatry, 1975, Volume: 132, Issue:10

    Topics: Depression; Electroconvulsive Therapy; Humans; Male; Reserpine

1975
Severe depression caused by reserpine.
    The Medical letter on drugs and therapeutics, 1976, Feb-13, Volume: 18, Issue:4

    Topics: Depression; Humans; Hypertension; Reserpine

1976
[The antidepressive properties of anaprilin].
    Biulleten' eksperimental'noi biologii i meditsiny, 1992, Volume: 114, Issue:10

    Topics: Animals; Antidepressive Agents; Clonidine; Depression; Disease Models, Animal; Dose-Response Relatio

1992
Synthesis and pharmacological evaluation of some phenothiazines as antidepressants.
    Arzneimittel-Forschung, 1992, Volume: 42, Issue:3

    Topics: Amphetamine; Animals; Antidepressive Agents; Depression; Drug Synergism; Female; Male; Mice; Nervous

1992
Depression associated with antihypertensive drugs.
    The Journal of family practice, 1991, Volume: 33, Issue:5

    Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Bl

1991
[Role of peripheral adrenergic links in the development of antidepressive effect in an experimental model of behavioral depression in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1990, Volume: 110, Issue:12

    Topics: Adrenergic Fibers; Animals; Antidepressive Agents; Benzamides; Cats; Depression; Injections, Subcuta

1990
Antidepressant profile of bupropion and three metabolites in mice.
    Pharmacopsychiatry, 1990, Volume: 23, Issue:4

    Topics: Animals; Antidepressive Agents; Apomorphine; Body Temperature; Bupropion; Depression; Male; Mice; Mo

1990
[Depression in patients with somatic illnesses].
    Nederlands tijdschrift voor geneeskunde, 1989, Jul-01, Volume: 133, Issue:26

    Topics: Depression; Humans; Patient Care Team; Physicians, Family; Reserpine

1989
Activation of brain function by S-135, a benzodiazepine receptor inverse agonist.
    Progress in neuro-psychopharmacology & biological psychiatry, 1988, Volume: 12, Issue:6

    Topics: Animals; Antidepressive Agents; Avoidance Learning; Brain; Cerebral Cortex; Deoxyglucose; Depression

1988
Effects of chronically administered antidepressants and electroconvulsive treatment on cerebral neurotransmitter receptors in rodents with 'model depression'.
    Ciba Foundation symposium, 1986, Volume: 123

    Topics: Animals; Antidepressive Agents; Brain; Cyclic AMP; Depression; Disease Models, Animal; Electroconvul

1986
Potentiated 5-hydroxytryptophan induced response suppression in rats following chronic reserpine.
    Pharmacology, biochemistry, and behavior, 1987, Volume: 26, Issue:2

    Topics: 5-Hydroxytryptophan; Animals; Depression; Disease Models, Animal; Drug Synergism; Male; Rats; Rats,

1987
Pharmacologic profile of fezolamine fumarate: a nontricyclic antidepressant in animal models.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Animals; Antidepressive Agents; Biological Transport; Blepharoptosis; Brain; Depression; Disease Mod

1987
Reserpine: the maligned antihypertensive drug.
    The Journal of family practice, 1985, Volume: 20, Issue:1

    Topics: Antihypertensive Agents; Breast Neoplasms; Depression; Depressive Disorder; Humans; Hypertension; Re

1985
New bicyclic antidepressant agent. Synthesis and activity of napactadine and related compounds.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:11

    Topics: Aggression; Amidines; Animals; Blepharoptosis; Cerebral Cortex; Chemical Phenomena; Chemistry; Depre

1985
Theoretical implications of drug-induced adaptive regulation for a biogenic amine hypothesis of affective disorder.
    Biological psychiatry, 1974, Volume: 9, Issue:2

    Topics: Animals; Biogenic Amines; Brain Chemistry; Catecholamines; Caudate Nucleus; Cerebral Cortex; Depress

1974
When a drug is the culprit.
    Geriatrics, 1973, Volume: 28, Issue:9

    Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clofibrate; Depression; Drug-Related Side Effect

1973
[Psychosomatic and psychiatric aspects of hypertension (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Mar-22, Volume: 116, Issue:12

    Topics: Adult; Blood Pressure; Depression; Headache; Humans; Hypertension; Psychophysiologic Disorders; Psyc

1974
Brain biogenic amine depletion and mood.
    Archives of general psychiatry, 1974, Volume: 30, Issue:4

    Topics: Affective Symptoms; Amines; Behavior; Brain; Catecholamines; Depression; Epinephrine; Fenclonine; Hu

1974
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action.
    The American journal of psychiatry, 1967, Volume: 124, Issue:5

    Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; Chlorpro

1967
Pharmacologic studies with 7-benzyl-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid.
    The Journal of pharmacology and experimental therapeutics, 1967, Volume: 158, Issue:2

    Topics: Amphetamine; Animals; Catecholamines; Chlorine; Depression; Drug Antagonism; Drug Synergism; Humans;

1967
Clinical and pharmacological investigation of a new psychotropic drug sulpiride (Dogmatil).
    Activitas nervosa superior, 1971, Volume: 13, Issue:3

    Topics: Adult; Amides; Amphetamine; Animals; Body Temperature; Central Nervous System Stimulants; Chlorproma

1971
Evaluation of depressive states, especially in longitudinal studies.
    Modern problems of pharmacopsychiatry, 1974, Volume: 7, Issue:0

    Topics: Affect; Antidepressive Agents; Circadian Rhythm; Depression; Diagnosis, Differential; Drug Evaluatio

1974
The concept and phenomenology of depression, with special reference to the aged. Discussion.
    Journal of geriatric psychiatry, 1974, Volume: 7, Issue:1

    Topics: Adult; Aged; Animals; Behavior, Animal; Biogenic Amines; Bipolar Disorder; Brain Chemistry; Depressi

1974
Editorial: Rauwolfia and breast cancer.
    British medical journal, 1974, Oct-19, Volume: 4, Issue:5937

    Topics: Breast Neoplasms; Depression; Female; Humans; Hypertension; Menopause; Methyldopa; Middle Aged; Phyt

1974
Do antihypertensive drugs really cause depression?
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:9

    Topics: Acute Disease; Antihypertensive Agents; Chronic Disease; Depression; Guanethidine; Humans; Hypertens

1974
Antihypertensive drugs and depression.
    Psychological medicine, 1974, Volume: 4, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Bethanidine; Chlorthalidone; Depression; Diuretics; Drug Thera

1974
Treatment of intractable depression.
    International pharmacopsychiatry, 1974, Volume: 9, Issue:4

    Topics: Amantadine; Antidepressive Agents; Depression; Dextroamphetamine; Drug Therapy, Combination; Hormone

1974
Proceedings: Ptosis as a model of depression.
    Psychopharmacology bulletin, 1974, Volume: 10, Issue:4

    Topics: Animals; Antidepressive Agents; Blepharoptosis; Depression; Disease Models, Animal; Humans; Imiprami

1974
Editorial: Hypertension and depression and their treatment.
    The Australian and New Zealand journal of psychiatry, 1973, Volume: 7, Issue:3

    Topics: Animals; Antidepressive Agents; Antihypertensive Agents; Clonidine; Depression; Humans; Hypertension

1973
Proceedings: Antagonism of nicotinic acid and other kynurenines to antidepressants: one of the probable reasons of the therapy-resistance in depression?
    Activitas nervosa superior, 1974, Volume: 16, Issue:4

    Topics: Allopurinol; Amitriptyline; Animals; Depression; Drug Interactions; Humans; Hypnotics and Sedatives;

1974
Deserpidine antagonism by a tripeptide, L-prolyl-L-leucyglycinamide.
    Neuroendocrinology, 1973, Volume: 11, Issue:1

    Topics: Animals; Depression; Dihydroxyphenylalanine; Disease Models, Animal; Dose-Response Relationship, Dru

1973
Experimental study on the mechanism of depressogenic action of apomorphine and reserpine.
    Activitas nervosa superior, 1972, Volume: 14, Issue:4

    Topics: Acetylcholine; Animals; Apomorphine; Behavior, Animal; Brain Chemistry; Depression; Diencephalon; Do

1972
Answers to questions frequently asked about ECT.
    Seminars in psychiatry, 1972, Volume: 4, Issue:1

    Topics: Age Factors; Anesthesia, Intravenous; Brain Damage, Chronic; Brain Neoplasms; Depression; Electrocon

1972
Plasma cortisol-binding capacity in mental illness.
    Psychological medicine, 1973, Volume: 3, Issue:1

    Topics: Adult; Anxiety; Binding Sites; Bipolar Disorder; Chlorpromazine; Chromatography, Gel; Depression; Di

1973
Letter: Methyldopa and depression.
    British medical journal, 1973, Dec-01, Volume: 4, Issue:5891

    Topics: Chronic Disease; Depression; Humans; Methyldopa; Reserpine; Time Factors

1973
The effect of fat diet on reserpine-induced depression in mice.
    Research communications in chemical pathology and pharmacology, 1973, Volume: 6, Issue:3

    Topics: Animals; Brain Chemistry; Brain Stem; Depression; Dietary Fats; Fasting; Humans; Hydroxyindoleacetic

1973
Clinical perspectives on antidepressant therapy.
    The American journal of psychiatry, 1968, Volume: 124, Issue:11

    Topics: Adult; Amphetamine; Antidepressive Agents; Depression; Diagnosis, Differential; Electroconvulsive Th

1968
Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration.
    Experientia, 1972, Mar-15, Volume: 28, Issue:3

    Topics: Adjustment Disorders; Animals; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Dementia; D

1972
Central nervous system effects of fenfluramine hydrochloride.
    The Journal of pharmacology and experimental therapeutics, 1972, Volume: 180, Issue:1

    Topics: Animals; Brain; Brain Chemistry; Central Nervous System; Depression; Dextroamphetamine; Dopamine; Dr

1972
Anxiety, depression and psychotropic drugs.
    Drugs, 1971, Volume: 1, Issue:3

    Topics: Antidepressive Agents; Anxiety; Depression; Dibenzoxepins; Humans; Norepinephrine; Reserpine; Tranqu

1971
Hypertension and depression: interrelated problems in therapy.
    Journal of the Royal College of Physicians of London, 1971, Volume: 6, Issue:1

    Topics: Antidepressive Agents; Antihypertensive Agents; Depression; Humans; Hypertension; Methyldopa; Physic

1971
The effect of reserpine and nortriptyline on the excretion of 17-hydroxysteroids.
    Activitas nervosa superior, 1971, Volume: 13, Issue:3

    Topics: Animals; Apomorphine; Behavior, Animal; Depression; Drug Synergism; Grooming; Humans; Imipramine; Li

1971
Possible involvement of glycogen phosphorylase of brain in the affective states.
    International pharmacopsychiatry, 1971, Volume: 6, Issue:2

    Topics: Amphetamine; Animals; Antidepressive Agents; Brain; Chlorpromazine; Depression; Desipramine; Drug In

1971
Nosocomial suicides and suicides among discharged patients.
    Acta psychiatrica Scandinavica. Supplementum, 1966, Volume: 191

    Topics: Adult; Denmark; Depression; Female; Hospitals, Psychiatric; Humans; Interpersonal Relations; Male; M

1966
Effects of imipramine and reserpine in depression.
    Psychopharmacologia, 1969, Volume: 14, Issue:4

    Topics: Depression; Female; Humans; Imipramine; Male; Middle Aged; Psychiatric Status Rating Scales; Reserpi

1969
Amines and abnormal mood.
    Proceedings of the Royal Society of Medicine, 1969, Volume: 62, Issue:11 Part 1

    Topics: Affective Symptoms; Blood-Brain Barrier; Catecholamines; Depression; Dihydroxyphenylalanine; Epineph

1969
[The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1969, Volume: 69, Issue:8

    Topics: Adult; Aged; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Cats; Depression; Depres

1969
[Molecular-biologic causes in psychiatry].
    Munchener medizinische Wochenschrift (1950), 1969, Dec-12, Volume: 111, Issue:50

    Topics: Antidepressive Agents; Brain; Deficiency Diseases; Depression; Humans; Methylation; Molecular Biolog

1969
[Depressive reactions in treatment with neuroleptics].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1970, Mar-01, Volume: 90, Issue:5

    Topics: Antidepressive Agents; Depression; Humans; Reserpine; Suicide; Tranquilizing Agents

1970
Is it possible to predict the clinical effect of antidepressants from experimental data in animals?
    Activitas nervosa superior, 1970, Volume: 12, Issue:2

    Topics: Antidepressive Agents; Depression; Humans; Nerve Endings; Norepinephrine; Physostigmine; Psychomotor

1970
[Depression in patients treated with reserpine, still a reality].
    Lakartidningen, 1971, Mar-31, Volume: 68, Issue:14

    Topics: Aged; Depression; Female; Humans; Hypertension; Middle Aged; Plants, Medicinal; Rauwolfia; Reserpine

1971
Psychopharmacological approach to psychosomatic medicine. Experimental and clinical research.
    Acta neurologica latinoamericana, 1967, Volume: 13, Issue:1

    Topics: Amitriptyline; Amphetamine; Animals; Anxiety Disorders; Benactyzine; Depression; Guinea Pigs; Hostil

1967
Biochemical aspects of depression.
    International psychiatry clinics, 1969, Volume: 6, Issue:2

    Topics: Adrenal Glands; Brain Chemistry; Depression; Dopamine; Electrolytes; Epinephrine; Extracellular Spac

1969