Page last updated: 2024-11-06

reserpine and Dementia

reserpine has been researched along with Dementia in 19 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.

Research Excerpts

ExcerptRelevanceReference
"Present study was designed to monitor the cognitive profile of the animals upon repeated administration of reserpine, so as to determine that whether these animals should be used as animal models of Parkinson's dementia."7.91Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's dementia. ( Haleem, DJ; Ikram, H, 2019)
"Present study was designed to monitor the cognitive profile of the animals upon repeated administration of reserpine, so as to determine that whether these animals should be used as animal models of Parkinson's dementia."3.91Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's dementia. ( Haleem, DJ; Ikram, H, 2019)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199016 (84.21)18.7374
1990's0 (0.00)18.2507
2000's2 (10.53)29.6817
2010's1 (5.26)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ikram, H1
Haleem, DJ1
BLACKMAN, LH2
GLENN, A2
OLINGER, L2
PROCTOR, RC1
BAILEY, WH1
MOREHOUSE, WG1
ABD-EL-NABY, S1
BARUCCI, M1
MORI, F1
BECKENSTEIN, N1
PALMER, LS1
ABSE, DW1
DAHLSTROM, WG1
KRONBERGEROVA, J1
DERZSI, S1
FENYVESI, T1
THUILLIER, H1
NAKAJIMA, H1
GRANDJEAN, JL1
LHULLIER, J1
ROBINSON, DB1
Hirai, S1
Bovi, A1
Frisone, L1
Di Bari, M1
Pahor, M1
Franse, LV1
Shorr, RI1
Wan, JY1
Ferrucci, L1
Somes, GW1
Applegate, WB1
Snyder, BD1
Harris, S1
Wettstein, A1
Bertolotti, P1
Spaggiari, G1
Fischer, E1
Spatz, H1
Heller, B1
Reggiani, H1

Reviews

1 review available for reserpine and Dementia

ArticleYear
[Dementia induced by cardiokinetic and anti-hypertensive drugs].
    Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl

    Topics: Antihypertensive Agents; Cardiotonic Agents; Clonidine; Dementia; Digitoxin; Digoxin; Half-Life; Hum

2004

Trials

1 trial available for reserpine and Dementia

ArticleYear
Dementia and disability outcomes in large hypertension trials: lessons learned from the systolic hypertension in the elderly program (SHEP) trial.
    American journal of epidemiology, 2001, Jan-01, Volume: 153, Issue:1

    Topics: Aged; Antihypertensive Agents; Atenolol; Bias; Chlorthalidone; Dementia; Disabled Persons; Double-Bl

2001

Other Studies

17 other studies available for reserpine and Dementia

ArticleYear
Repeated treatment with a low dose of reserpine as a progressive model of Parkinson's dementia.
    Pakistan journal of pharmaceutical sciences, 2019, Volume: 32, Issue:2

    Topics: Animals; Brain; Dementia; Disease Models, Animal; Dopamine; Hydroxyindoleacetic Acid; Male; Memory;

2019
The use of vitarespital in the treatment of elderly psychotic patients.
    International record of medicine and general practice clinics, 1958, Volume: 171, Issue:1

    Topics: Amphetamine; Amphetamines; Dementia; Humans; Mental Disorders; Psychotic Disorders; Reserpine; Vitam

1958
An analeptic tranquilizer for senile psychoses; report of clinical and pharmacological studies of nicozol with reserpine.
    Journal of the American Geriatrics Society, 1958, Volume: 6, Issue:4

    Topics: Central Nervous System Stimulants; Dementia; Mental Disorders; Niacin; Pentylenetetrazole; Psychotic

1958
Reserpine in the treatment of organic and senile psychosis.
    The Journal of the Egyptian Medical Association, 1957, Volume: 40, Issue:9

    Topics: Dementia; Mental Disorders; Psychosurgery; Psychotic Disorders; Reserpine

1957
[Effects of reserpine combined with a psycho-analeptic drug on mental efficiency of the aged].
    Rivista di patologia nervosa e mentale, 1957, Volume: 78, Issue:3

    Topics: Aged; Arteriosclerosis; Central Nervous System Stimulants; Dementia; Mental Disorders; Methylphenida

1957
The combination of tranquilizer, sympathomimetic drug and vitamins in the treatment of elderly psychotic patients.
    Journal of the American Geriatrics Society, 1958, Volume: 6, Issue:7

    Topics: Amphetamine; Amphetamines; Dementia; Humans; Hypnotics and Sedatives; Mental Disorders; Psychotic Di

1958
Use of reserpine (rau-sed) in the treatment of the senile and cerebral arteriosclerotic psychotic.
    The Psychiatric quarterly, 1958, Volume: 32, Issue:2

    Topics: Brain; Dementia; Humans; Mental Disorders; Psychotic Disorders; Reserpine

1958
The value of chemotherapy in senile mental distrubances. Controlled comparison of chlorpromazine, reserpine-pipradrol, and opium.
    JAMA, 1960, Dec-17, Volume: 174

    Topics: Chlorpromazine; Dementia; Humans; Mental Disorders; Opium; Piperidines; Psychopharmacology; Psychoti

1960
[CHANGES IN THE CLINICAL PICTURE OF ARTERIOSCLEROTIC AND SENILE DISEASES].
    Ceskoslovenska psychiatrie, 1963, Volume: 59

    Topics: Antihypertensive Agents; Chlorpromazine; Dementia; Electroconvulsive Therapy; Geriatrics; Intracrani

1963
HIREPINE IN PSYCHIATRY.
    Therapia Hungarica (English edition), 1964, Volume: 12

    Topics: Catatonia; Chlorpromazine; Convulsive Therapy; Dementia; Depression; Electroconvulsive Therapy; Huma

1964
[EXPERIMENTAL NEUROPHARMACOLOGY OF FACILITATION OF ELECTRICAL CONVULSIONS AS A BASIS FOR RESEARCH IN GERONTOLOGICAL PSYCHIATRY].
    Revue francaise de gerontologie, 1964, Volume: 10

    Topics: Central Nervous System Stimulants; Convulsive Therapy; Dementia; Electroconvulsive Therapy; Neuropha

1964
Evaluation of certain drugs in geriatric patients: effects of chlorpromazine, reserpine, pentylenetetrazol U. S. P., and placebo on eighty-four female geriatric patients in a state hospital.
    A.M.A. archives of general psychiatry, 1959, Volume: 1

    Topics: Chlorpromazine; Dementia; Female; Hospitals, State; Mental Disorders; Pentylenetetrazole; Psychotic

1959
[The use of a reserpine derivative in the neuroses of the aged].
    Minerva medica, 1967, Feb-14, Volume: 58, Issue:13

    Topics: Aged; Anxiety Disorders; Dementia; Depression; Female; Humans; Hypochondriasis; Male; Middle Aged; R

1967
Treatable aspects of the dementia syndrome.
    Journal of the American Geriatrics Society, 1976, Volume: 24, Issue:4

    Topics: Adjustment Disorders; Aged; Dementia; Diagnosis, Differential; Drug Interactions; Drug Therapy, Comb

1976
[Remarks on the drug treatment of demented patients].
    Schweizer Archiv fur Neurologie und Psychiatrie (Zurich, Switzerland : 1985), 1985, Volume: 136, Issue:4

    Topics: Aged; Alzheimer Disease; Antidepressive Agents; Antipsychotic Agents; Blood Glucose; Cerebrovascular

1985
[Note on the use of dihydrogenated derivatives of ergotoxin (Hydergine) and their association with psychopharmacology in the treatment of aged neuropsychiatric patients].
    Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1966, Oct-31, Volume: 90, Issue:5

    Topics: Aged; Barbiturates; Butyrophenones; Dementia; Ergoloid Mesylates; Female; Humans; Imipramine; Male;

1966
Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration.
    Experientia, 1972, Mar-15, Volume: 28, Issue:3

    Topics: Adjustment Disorders; Animals; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Dementia; D

1972