reserpine has been researched along with Cystic Fibrosis in 35 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 7.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 7.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "The present investigation was undertaken to determine whether or not there are histochemical and morphological changes in the intestine of the chronically reserpine-treated rat, an animal model of cystic fibrosis." | 7.67 | Morphological and histochemical changes in intestinal mucosa in the reserpine-treated rat model of cystic fibrosis. ( Applegarth, DA; Owen, DA; Park, CM; Reid, PE; Sanker, JM, 1987) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 7.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "Chronic reserpine treatment of animals, an experimental model for cystic fibrosis (CF), results in generalized exocrinopathy, impaired secretion, and decreased pancreatic content of amylase." | 3.68 | Alterations of amylase secretion in the chronically reserpinized rat: an acetylcholine-mediated phenomenon. ( Benrezzak, O; Bérubé, FL; Morisset, J, 1991) |
| "Two experimental animal models exhibiting functional and morphologic changes of exocrine glands similar to those seen in patients with cystic fibrosis (CF) have been reported in the rat: chronic stimulation with reserpine (Martinez et al." | 3.67 | Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis. ( Boyd, RL; Fletcher, MT; Francis, EM; Mangos, JA, 1984) |
| "The chronically isoproterenol-treated rat has been proposed as an animal model for cystic fibrosis." | 3.67 | The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland. ( Müller, RM; Roomans, GM, 1984) |
| "The chronically reserpine-treated rat, an experimental model for cystic fibrosis, exhibits generalized exocrinopathy, impaired pancreatic secretion, and decreased pancreatic amylase." | 3.67 | Effects of malnutrition and chronic reserpine treatment on pancreatic exocrine function. ( Brannon, PM; Hazlett, D; Korc, M, 1986) |
| "Chronic reserpine treatment of animals, an experimental model for cystic fibrosis (CF), results in generalized exocrinopathy, impaired pancreatic secretion, and decreased pancreatic content of amylase." | 3.67 | Impairment of pancreatic acinar function by reserpine in vivo and in vitro. ( Brannon, PM; Scott, D, 1987) |
| "The effects of reserpine injections were studied on the morphology of the pancreas in an experimental model for cystic fibrosis, the chronically reserpinized rat." | 3.67 | Light and electron microscopy of the exocrine pancreas in the chronically reserpinized rat. ( Grondin, G; LeBel, D; Leblond, FA; Morisset, J, 1989) |
| "Elemental distribution and ultrastructure of the submandibular gland, the parotid gland and the pancreas were investigated in three suggested animal models of the disease cystic fibrosis: the chronically reserpinized rat, the chronically isoproterenol-treated rat, and the chronically pilocarpine-treated rat." | 3.67 | X-ray microanalysis of exocrine glands in animal models for cystic fibrosis. ( Müller, RM; Roomans, GM, 1985) |
| "Reserpine treatment in rats induces morphological and functional disturbances in exocrine glands which resemble those produced by cystic fibrosis." | 3.67 | Reserpine treatment increases viscosity of fluid in the epididymis of rats. ( Wen, RQ; Wong, PY, 1988) |
| "Chronic treatment of rats with reserpine, isoproterenol, or a combination of these two agents has been suggested as a means to produce an experimental animal model for the chronic exocrinopathy cystic fibrosis." | 3.67 | Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol. ( Maltarello, MC; Müller, RM; Roomans, GM; Versura, P, 1988) |
| "The present investigation was undertaken to determine whether or not there are histochemical and morphological changes in the intestine of the chronically reserpine-treated rat, an animal model of cystic fibrosis." | 3.67 | Morphological and histochemical changes in intestinal mucosa in the reserpine-treated rat model of cystic fibrosis. ( Applegarth, DA; Owen, DA; Park, CM; Reid, PE; Sanker, JM, 1987) |
| "Rats treated for 7 days with reserpine develop structural changes in the submaxillary gland that resemble those that have been reported in cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure. ( Adelstein, E; Barbero, GJ; Martinez, JR; Quissel, D, 1975) |
| "Elevated calcium and protein concentration are a consistent abnormality in submaxillary saliva from patients with cystic fibrosis (CF) and from experimental animal models developed by the chronic administration of either isoproterenol (IPR) or reserpine." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland. ( Martinez, R; Wood, DL, 1977) |
| "Submaxillary saliva from reserpine-treated rats was found to have alterations in composition similar to those reported in the same secretion from patients with cystic fibrosis." | 3.65 | The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva. ( Adshead, PC; Barbero, GJ; Martinez, JR; Quissell, DO, 1975) |
| "Reserpine treatment resulted in altered enzyme secretion from rat pancreatic acini in response to carbamylcholine and secretin (1,2)." | 1.29 | Alterations of pancreatic amylase secretion in the reserpinized rat model of cystic fibrosis. Effects of cerulein and EGF. ( Benrezzak, O; Bérubé, FL; Morisset, J; Vanier, M, 1994) |
| "Rats treated with reserpine for seven days revealed significantly lower values of plasma immunoreactive cationic trypsin (ogen) (39." | 1.29 | Plasma immunoreactive cationic trypsin(ogen) pattern in reserpinized rat model of cystic fibrosis. Resemblance to humans. ( Weizman, Z, 1996) |
| "Reserpine-treated rats also showed a significant increase in the total protein recovered in the lung lavage fluid with a 233% increase in the absolute and relative amounts of a low molecular weight glycoprotein (15,000 mol wt)." | 1.26 | The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid. ( Martinez, JR; Quissell, DO; Thompson, FE; Williams, CH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 31 (88.57) | 18.7374 |
| 1990's | 4 (11.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chernick, WS | 1 |
| Barbero, GJ | 5 |
| Morton, D | 1 |
| Parker, A | 1 |
| Estrada, P | 1 |
| Martinez, JR | 12 |
| McCurdy, RE | 1 |
| Martinez, R | 2 |
| Shiffman, ML | 2 |
| Gillon, MJ | 1 |
| Galey, WR | 2 |
| Roscher, AA | 1 |
| Wiesmann, UN | 1 |
| Honegger, UE | 1 |
| Boyd, RL | 1 |
| Francis, EM | 1 |
| Fletcher, MT | 1 |
| Mangos, JA | 1 |
| Forstner, J | 1 |
| Roomi, N | 1 |
| Fahim, R | 1 |
| Gall, G | 1 |
| Perdue, M | 1 |
| Forstner, G | 1 |
| Bylund, DB | 1 |
| Mawhinney, T | 1 |
| Camden, J | 1 |
| Ray, G | 1 |
| Müller, RM | 4 |
| Roomans, GM | 5 |
| Spitzer, RE | 1 |
| Swender, PT | 1 |
| Mawhinney, TP | 2 |
| Feather, MS | 2 |
| Morisset, J | 4 |
| Bérubé, FL | 2 |
| Vanier, M | 1 |
| Benrezzak, O | 2 |
| Weizman, Z | 1 |
| Adelstein, E | 1 |
| Quissel, D | 1 |
| Sordelli, DO | 1 |
| Cassino, RJ | 1 |
| Pivetta, OH | 1 |
| Martinez, AM | 2 |
| Garrett, L | 1 |
| Korman, P | 1 |
| Perlmutter, J | 1 |
| Wood, DL | 1 |
| Thompson, FE | 1 |
| Quissell, DO | 2 |
| Williams, CH | 1 |
| Adshead, PC | 2 |
| Kilburn, KH | 1 |
| Hess, RA | 1 |
| Hjelte, L | 1 |
| Strandvik, B | 1 |
| Sagström, S | 1 |
| Hazlett, D | 1 |
| Korc, M | 1 |
| Brannon, PM | 2 |
| Scott, D | 1 |
| Leblond, FA | 2 |
| LeBel, D | 2 |
| Grondin, G | 1 |
| Wen, RQ | 1 |
| Wong, PY | 1 |
| Versura, P | 1 |
| Maltarello, MC | 1 |
| Park, CM | 1 |
| Reid, PE | 1 |
| Owen, DA | 1 |
| Sanker, JM | 1 |
| Applegarth, DA | 1 |
| Cassity, N | 1 |
35 other studies available for reserpine and Cystic Fibrosis
| Article | Year |
|---|---|
Reversal of submaxillary salivary alterations in cystic fibrosis by guanethidine.
Topics: Amylases; Bretylium Compounds; Calcium; Cystic Fibrosis; Guanethidine; Humans; Neuraminic Acids; Nit | 1967 |
Exocrine pancreatic secretion in rats treated with reserpine after stimulation with pilocarpine, dopamine, and caerulein.
Topics: Amylases; Animals; Bicarbonates; Ceruletide; Chlorides; Cystic Fibrosis; Disease Models, Animal; Dop | 1980 |
The chronically reserpinized rat as a model for cystic fibrosis: alterations in pancreatic enzyme secretion and storage.
Topics: Amylases; Animals; Cholecystokinin; Chymotrypsin; Cystic Fibrosis; Disease Models, Animal; Male; Pan | 1981 |
Pancreatic function in the reserpinized rabbit--a model for cystic fibrosis. I. Effect of secretin.
Topics: Amylases; Animals; Bicarbonates; Calcium; Cystic Fibrosis; Male; Pancreatic Juice; Proteins; Rabbits | 1982 |
Changes in beta adrenergic receptors in submaxillary glands of chronically reserpine- or isoproterenol-treated rats.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Feedback; Isoproterenol; Kinetics; Nucleotidases; | 1981 |
Pulmonary function of the reserpine and isoproterenol models of cystic fibrosis.
Topics: Airway Resistance; Animals; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lung Volume Meas | 1984 |
Acute and chronic models for hypersecretion of intestinal mucin.
Topics: Anaphylaxis; Animals; Cholera Toxin; Cystic Fibrosis; Diarrhea; Disease Models, Animal; Glycoprotein | 1984 |
The chronically reserpinized rat as a model for cystic fibrosis: alterations in the mucus-secreting sublingual gland.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Potassium; Rats; Rats, Inbred Strains; Receptors, | 1983 |
The chronically isoproterenol-treated rat in the study of cystic fibrosis: X-ray microanalysis of the submandibular gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Interactions; Electron Probe Microan | 1984 |
Altered bicarbonate reabsorption in the pancreas of reserpine-treated rabbits--a model for cystic fibrosis.
Topics: Animals; Bicarbonates; Cystic Fibrosis; Disease Models, Animal; Male; Pancreatic Juice; Rabbits; Res | 1983 |
Composition of pulmonary lavage fluid in control and reserpine-treated rats following chronic isoproterenol and pilocarpine administration.
Topics: Animals; Body Fluids; Carbohydrates; Cystic Fibrosis; Disease Models, Animal; Isoproterenol; Lipids; | 1980 |
Alterations of pancreatic amylase secretion in the reserpinized rat model of cystic fibrosis. Effects of cerulein and EGF.
Topics: Amylases; Animals; Carbachol; Ceruletide; Cystic Fibrosis; Disease Models, Animal; Epidermal Growth | 1994 |
Plasma immunoreactive cationic trypsin(ogen) pattern in reserpinized rat model of cystic fibrosis. Resemblance to humans.
Topics: Analysis of Variance; Animals; Cystic Fibrosis; Disease Models, Animal; Humans; Male; Mice; Pancreat | 1996 |
The chronically reserpinized rat as a possible model for cystic fibrosis. I. Submaxillary gland morphology and ultrastructure.
Topics: Animals; Body Weight; Cell Nucleus; Cystic Fibrosis; Cytoplasm; Disease Models, Animal; Endoplasmic | 1975 |
Animal model for cystic fibrosis: pulmonary clearance of Staphylococcus aureus in mice treated with reserpine.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Female; Lung; Male; Mice; Mice, Inbred BALB C; Res | 1979 |
The chronically reserpinized rat as an animal model for cystic fibrosis: I. Acute effect of isoproterenol and pilocarpine upon pulmonary lavage fluid.
Topics: Animals; Carbohydrate Metabolism; Cholesterol; Cystic Fibrosis; Isoproterenol; Lipid Metabolism; Lun | 1979 |
Chronically reserpinized rat as a model for cystic fibrosis: Na+ transport inhibitory effect in submaxillary saliva.
Topics: Animals; Cystic Fibrosis; Freezing; Hot Temperature; Parotid Gland; Rats; Reserpine; Saliva; Secreto | 1979 |
The chronically reserpinized rat as a possible model for cystic fibrosis. VII. Alterations in the secretory response to cholecystokinin and to secretin from the pancreas in vivo.
Topics: Amylases; Animals; Cholecystokinin; Cystic Fibrosis; Disease Models, Animal; Electrolytes; Male; Org | 1978 |
The chronically reserpinized rat as a possible model for cystic fibrosis. VI. Synergistic effects of isoproterenol on Ca++ and protein in the submaxillary gland.
Topics: Animals; Calcium; Cystic Fibrosis; Disease Models, Animal; Drug Synergism; Isoproterenol; Male; Prot | 1977 |
The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid.
Topics: Adult; Animals; Child; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Glycoproteins; Huma | 1976 |
Ciliary inhibition and axonemal microtubule alterations in freshwater mussels.
Topics: Animals; Bivalvia; Blood; Cilia; Cystic Fibrosis; Heterozygote; Homozygote; Humans; Male; Microscopy | 1975 |
The chronically reserpinized rat as a possible model for cystic fibrosis. II. Comparison and cilioinhibitory effects of submaxillary saliva.
Topics: Animals; Biological Assay; Bivalvia; Calcium; Carbohydrates; Cilia; Cystic Fibrosis; Disease Models, | 1975 |
Alterations of amylase secretion in the chronically reserpinized rat: an acetylcholine-mediated phenomenon.
Topics: Acetylcholine; Amylases; Animals; Body Weight; Carbachol; Ceruletide; Cystic Fibrosis; Disease Model | 1991 |
Essential fatty acid deficient rats in the study of cystic fibrosis: an X-ray microanalytical and ultrastructural study in chronically reserpinized rats.
Topics: Animals; Cystic Fibrosis; Electron Probe Microanalysis; Fatty Acids, Essential; Female; Microscopy, | 1990 |
Effects of malnutrition and chronic reserpine treatment on pancreatic exocrine function.
Topics: Amylases; Animals; Body Weight; Cystic Fibrosis; Disease Models, Animal; Eating; Lipase; Male; Nutri | 1986 |
Impairment of pancreatic acinar function by reserpine in vivo and in vitro.
Topics: Amylases; Animals; Cells, Cultured; Cystic Fibrosis; Male; Pancreas; Phenylalanine; Rats; Rats, Inbr | 1987 |
Alterations of pancreatic growth and of GP-2 content in the reserpinized rat model of cystic fibrosis.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Enzyme P | 1989 |
Light and electron microscopy of the exocrine pancreas in the chronically reserpinized rat.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Dose-Response Relationship, Drug; Endoplasmic Reti | 1989 |
X-ray microanalysis of exocrine glands in animal models for cystic fibrosis.
Topics: Adrenergic beta-Agonists; Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; El | 1985 |
Reserpine treatment increases viscosity of fluid in the epididymis of rats.
Topics: Animals; Body Weight; Cystic Fibrosis; Disease Models, Animal; Epididymis; Male; Organ Size; Protein | 1988 |
The reserpine-treated rat as an experimental animal model for cystic fibrosis: abnormal Cl transport in pancreatic acinar cells.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfo | 1988 |
Changes in glycoconjugates in rat submandibular gland after chronic treatment with reserpine and isoproterenol.
Topics: Animals; Cystic Fibrosis; Cytoplasmic Granules; Disease Models, Animal; Glycoconjugates; Isoproteren | 1988 |
Morphological and histochemical changes in intestinal mucosa in the reserpine-treated rat model of cystic fibrosis.
Topics: Animals; Cystic Fibrosis; Disease Models, Animal; Intestinal Mucosa; Intestine, Large; Intestine, Sm | 1987 |
Calcium and cystic fibrosis.
Topics: Animals; Calcium; Cells, Cultured; Cystic Fibrosis; Disease Models, Animal; Electron Probe Microanal | 1986 |
The chronically reserpinized rat as a model for cystic fibrosis: abnormal Cl- transport as the basis for reduced salivary fluid secretion.
Topics: Acetylcholine; Animals; Biological Transport; Chlorides; Cystic Fibrosis; Electrolytes; Furosemide; | 1985 |