reserpine has been researched along with Cognition Disorders in 8 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine." | 7.88 | Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018) |
| "Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine." | 3.88 | Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM). ( Chen, D; Feng, X; Li, T; Li, X; Liu, X; Sun, M; Xu, J; Zhang, Q; Zhang, S; Zhao, X, 2018) |
| "If atenolol was contraindicated, 0." | 2.67 | Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program. ( Applegate, WB; Camel, GH; Greenlick, MR; Hadley, E; Luhr, J; Moye, L; Perry, HM; Pressel, S; Shekelle, RB; Wittes, J, 1994) |
| "Musculoskeletal pain is a widespread complex regional pain syndrome associated with altered emotional and cognitive functioning along with heightened physical disability that has become a global health concern." | 1.62 | Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin. ( Bhatti, R; Garg, S; Kaur, A; Kaur, H; Singh, L; Singh, N, 2021) |
| "Reserpine (RES) is an irreversible inhibitor of VMAT2 used to study Parkinson's disease (PD) and screening for antiparkinsonian treatments in rodents." | 1.62 | Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and Spontaneously Hypertensive Rats (SHR): Implications for cognitive deficits in a progressive animal model for Parkinson's disease. ( Abílio, VC; Conceição, IM; Freitas, TA; Izídio, GS; Leão, AHFF; Medeiros, AM; Meurer, YSR; Ribeiro, AM; Silva, RH, 2021) |
| "Reserpine-treated animals also showed poor retention of memory in the elevated plus maze paradigm." | 1.37 | Korean ginseng extract attenuates reserpine-induced orofacial dyskinesia and improves cognitive dysfunction in rats. ( Barhate, SA; Kasture, SB; Mahajan, MS; Mohan, M; Sanghavi, CR, 2011) |
| "Reserpine treated animals also showed poor retention of memory in the elevated plus maze task paradigm." | 1.33 | Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction. ( Kulkarni, SK; Naidu, PS; Singh, A, 2006) |
| "Reserpine-treated animals also showed poor retention of memory in elevated plus-maze task paradigm." | 1.32 | Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin. ( Kulkarni, SK; Naidu, PS; Singh, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaur, A | 1 |
| Singh, L | 1 |
| Garg, S | 1 |
| Kaur, H | 1 |
| Singh, N | 1 |
| Bhatti, R | 1 |
| Leão, AHFF | 1 |
| Meurer, YSR | 1 |
| Freitas, TA | 1 |
| Medeiros, AM | 1 |
| Abílio, VC | 1 |
| Izídio, GS | 1 |
| Conceição, IM | 1 |
| Ribeiro, AM | 1 |
| Silva, RH | 1 |
| Zhang, S | 1 |
| Liu, X | 1 |
| Sun, M | 1 |
| Zhang, Q | 1 |
| Li, T | 1 |
| Li, X | 1 |
| Xu, J | 1 |
| Zhao, X | 1 |
| Chen, D | 1 |
| Feng, X | 1 |
| Sanghavi, CR | 1 |
| Barhate, SA | 1 |
| Mahajan, MS | 1 |
| Mohan, M | 1 |
| Kasture, SB | 1 |
| Veselinovic, T | 1 |
| Schorn, H | 1 |
| Vernaleken, IB | 1 |
| Hiemke, C | 1 |
| Zernig, G | 1 |
| Gur, R | 1 |
| Gründer, G | 1 |
| Naidu, PS | 2 |
| Singh, A | 2 |
| Kulkarni, SK | 2 |
| Applegate, WB | 1 |
| Pressel, S | 1 |
| Wittes, J | 1 |
| Luhr, J | 1 |
| Shekelle, RB | 1 |
| Camel, GH | 1 |
| Greenlick, MR | 1 |
| Hadley, E | 1 |
| Moye, L | 1 |
| Perry, HM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00000514] | Phase 3 | 0 participants | Interventional | 1984-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for reserpine and Cognition Disorders
| Article | Year |
|---|---|
Effects of antipsychotic treatment on cognition in healthy subjects.
Topics: Adrenergic Uptake Inhibitors; Adult; Antipsychotic Agents; Aripiprazole; Attention; Brain; Cognition | 2013 |
Impact of the treatment of isolated systolic hypertension on behavioral variables. Results from the systolic hypertension in the elderly program.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Atenolol; Cerebrovascular Disorders; Chlorthali | 1994 |
6 other studies available for reserpine and Cognition Disorders
| Article | Year |
|---|---|
Involvement of Oxidative Stress and Nerve Growth Factor in Behavioral and Biochemical Deficits of Experimentally Induced Musculoskeletal Pain in Mice: Ameliorative Effects of Heraclin.
Topics: Analgesics; Animals; Anxiety; Brain Chemistry; Cognition Disorders; Cytokines; Drug Evaluation, Prec | 2021 |
Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and Spontaneously Hypertensive Rats (SHR): Implications for cognitive deficits in a progressive animal model for Parkinson's disease.
Topics: Animals; Cognition Disorders; Disease Models, Animal; Dopamine; Hippocampus; Male; Parkinson Disease | 2021 |
Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM).
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Cognition Disorders; Depression; Drugs | 2018 |
Korean ginseng extract attenuates reserpine-induced orofacial dyskinesia and improves cognitive dysfunction in rats.
Topics: Animals; Antioxidants; Behavior, Animal; Brain; Catalase; Cognition Disorders; Dose-Response Relatio | 2011 |
Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Blood Proteins; Catalase; Cognition Disorders; Dysk | 2004 |
Effect of Withania somnifera root extract on reserpine-induced orofacial dyskinesia and cognitive dysfunction.
Topics: Animals; Antioxidants; Brain; Cognition Disorders; Dyskinesia, Drug-Induced; Glutathione; Male; Malo | 2006 |