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reserpine and Chronic Disease

reserpine has been researched along with Chronic Disease in 45 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
" Intraperitoneal reserpine (5 mg/kg every day for 5 days) produced chronic gastric ulceration in all rats after 4 weeks."3.67Role of oxygen-derived free radicals in the mechanism of chronic gastric ulceration in the rat: implications for cytoprotection. ( Salim, AS, 1989)
"Reserpine treatment, shown previously to increase levels of TH, was found to increase both LC firing rate and levels of soluble cAMP-dependent protein kinase activity in the LC."1.28Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments. ( Duman, RS; Haycock, JW; Melia, KR; Nestler, EJ; Rasmussen, K; Terwilliger, RZ, 1992)
"The reserpine-treated rats also exhibited stereotypy in response to acute injection of the D1-selective agonist SKF-38393 (10 mg/kg), which was not observed in control rats."1.28Neurochemical changes associated with the persistence of spontaneous oral dyskinesia in rats following chronic reserpine treatment. ( Lucki, I; McGonigle, P; Neisewander, JL, 1991)
"Reserpine-treated rats also showed a significant increase in the total protein recovered in the lung lavage fluid with a 233% increase in the absolute and relative amounts of a low molecular weight glycoprotein (15,000 mol wt)."1.26The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid. ( Martinez, JR; Quissell, DO; Thompson, FE; Williams, CH, 1976)

Research

Studies (45)

TimeframeStudies, this research(%)All Research%
pre-199041 (91.11)18.7374
1990's2 (4.44)18.2507
2000's1 (2.22)29.6817
2010's1 (2.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Demitsu, T1
Yoneda, K1
Kakurai, M1
Sasaki, K1
Hiratsuka, Y1
Azuma, R1
Yamada, T1
Umemoto, N1
MORGAN, DR1
BELISLE, JA1
JENKINS, SB1
CARSON, JE1
JONES, C1
LUSTIG, B1
MATHELIE-GUINLET, G1
MISSERE, G1
BABBINI, M1
TONINI, G1
Jain, S1
Sharma, R1
WIDIMSKY, J1
KASALICKY, J1
DEJDAR, R1
VYSLOUZIL, Z1
LUKES, M1
MATVEEV, VF1
Popa, M1
Pappo, A1
Stan, M1
Runcan, V1
Takata, C1
Noseworthy, TW1
Weir, B1
Boisvert, D1
Espinosa, F1
Overton, T1
Marshal, ML1
Eninia, GI1
Smeltere, ES1
Godlevska, MA1
Uzulinia, IP1
Shvedenko, LA1
Parashchak, AP1
Iurkevich, ST1
Neporadnyĭ, MD1
Bigar', PV1
Kewitz, H1
Jesdinsky, HJ1
Kreutz, G1
Schulz, R1
Jus, A1
Jus, K1
Villeneuve, A1
Gautier, J1
Pires, P1
Lachance, R1
Itil, TM1
Wadud, A1
Foidart, JM1
Rorive, G1
Pekarskaia, IM1
Brushkovskaia, LL1
Thompson, FE1
Quissell, DO1
Williams, CH1
Martinez, JR1
Freis, ED1
Melia, KR1
Rasmussen, K1
Terwilliger, RZ1
Haycock, JW1
Nestler, EJ1
Duman, RS1
Neisewander, JL1
Lucki, I1
McGonigle, P1
Leviashvili, BI1
Salim, AS1
Bacher, NM1
Field, PB1
Elkashef, A1
Whittier, JR1
Korenyi, C1
Bollinger, A1
Gilmore, HR1
Bant, W2
Mise, J1
Spach, MO1
Bloch, R1
Velly, J1
Imbs, JL1
Bousquet, P1
Schwartz, J1
Loggie, JM1
Kline, NS1
Blair, J1
Cooper, TB1
Esser, AH1
Hackett, E1
Vestergaard, P1
McFarland, J1
Willerson, JT1
Dinsmore, RE1
Austen, WG1
Buckley, MJ1
Sanders, CA1
DeSanctis, RW1
Brest, AN1
Ar'eva, EM1
Iaroshevskiĭ, AIa1
Häfner, H2
Schliack, E2
Zenz, H2
Corsi, G1
Saia, B1
Gekle, D1
Kawabata, S1
Ayers, CR1
Harris, RH1
Lefer, LG1

Reviews

4 reviews available for reserpine and Chronic Disease

ArticleYear
Treatment of human aggression with major tranquilizers, antidepressants, and newer psychotropic drugs.
    The Journal of nervous and mental disease, 1975, Volume: 160, Issue:2-1

    Topics: Adolescent; Affective Symptoms; Aggression; Alcoholism; Antidepressive Agents; Antipsychotic Agents;

1975
The treatment of chronic hypertension.
    The Medical clinics of North America, 1971, Volume: 55, Issue:2

    Topics: Adult; Blood Pressure Determination; Chronic Disease; Diuretics; Female; Ganglionic Blockers; Guanet

1971
Pulmonary hypertension.
    Japanese circulation journal, 1974, Volume: 38, Issue:12

    Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary;

1974
Hypertension in children and adolescents. II. Drug therapy.
    The Journal of pediatrics, 1969, Volume: 74, Issue:4

    Topics: Age Factors; Antihypertensive Agents; Blood Pressure Determination; Child; Chlorothiazide; Chronic D

1969

Trials

3 trials available for reserpine and Chronic Disease

ArticleYear
[Effect of dibazol and reserpine on the contractile capacity of the myocardium].
    Vrachebnoe delo, 1979, Issue:2

    Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Benzimidazoles; Chronic Disease; Clinical Trials a

1979
A controlled sevn year study of endocrine and other indices in drug treated chronic schizophrenics.
    Acta psychiatrica Scandinavica. Supplementum, 1968, Volume: 206

    Topics: 17-Ketosteroids; Androsterone; Cholesterol; Chronic Disease; Clinical Trials as Topic; Computers; Cr

1968
Psychopharmacology.
    Acta psychiatrica Scandinavica. Supplementum, 1970, Volume: 217

    Topics: Alcoholism; Anxiety; Brain Damage, Chronic; Chronic Disease; Clinical Trials as Topic; Depression; E

1970

Other Studies

38 other studies available for reserpine and Chronic Disease

ArticleYear
Clinical efficacy of reserpine as "add-on therapy" to antihistamines in patients with recalcitrant chronic idiopathic urticaria and urticarial vasculitis.
    The Journal of dermatology, 2010, Volume: 37, Issue:9

    Topics: Anti-Allergic Agents; Chronic Disease; Drug Therapy, Combination; Female; Histamine Antagonists; Hum

2010
The combined use of chlorpromazine and reserpine in the treatment of chronic mental illness: a preliminary report.
    The Medical journal of Australia, 1955, Jul-16, Volume: 42, Issue:2 3

    Topics: Antihypertensive Agents; Chlorpromazine; Chronic Disease; Mental Disorders; Psychotherapy; Reserpine

1955
Evaluation of chlorpromazine and reserpine in intensive treatment of chronic psychotic patients.
    Journal - Michigan State Medical Society, 1957, Volume: 56, Issue:7

    Topics: Chlorpromazine; Chronic Disease; Mental Disorders; Reserpine

1957
[Experiences with sedaraupin in chronic mental disorders].
    Medizinische Klinik, 1957, Dec-13, Volume: 52, Issue:50

    Topics: Chronic Disease; Humans; Mental Disorders; Psychotherapy; Reserpine

1957
The place of reserpine in the treatment of mitral heart disease.
    Semaine medicale professionelle et medico-sociale, 1957, Dec-30, Volume: 33, Issue:46

    Topics: Chronic Disease; Disease; Heart Diseases; Heart Valve Diseases; Humans; Mitral Valve; Reserpine; Rhe

1957
[Research on chronic morphine poisoning. II. Effects of reserpine, chlorpromazine & N-allylnormorphine on activity manifestations induced by morphine].
    Bollettino della Societa italiana di biologia sperimentale, 1959, Jun-30, Volume: 35, Issue:12

    Topics: Chlorpromazine; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Morphine; Nalorphi

1959
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
    Indian journal of experimental biology, 2002, Volume: 40, Issue:11

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio

2002
Effect of reserpine on the lesser circulation in chronic pulmonary diseases.
    British heart journal, 1962, Volume: 24

    Topics: Chronic Disease; Humans; Hypertension; Hypertension, Pulmonary; Lung Abscess; Lung Diseases; Reserpi

1962
[The effect of therapeutic and subtoxic doses of serpasil on the brain and internal organs of animals in chronic experimental conditions].
    Arkhiv patologii, 1961, Volume: 23(12)

    Topics: Brain; Central Nervous System; Chronic Disease; Intestines; Kidney; Liver; Reserpine

1961
[Research on catecholamines in chronic hepatitis following epidemic hepatitis].
    Studii si cercetari de medicina interna, 1967, Volume: 8, Issue:5

    Topics: Adolescent; Adult; Catecholamines; Chronic Disease; Female; Hepatitis; Hepatitis A; Humans; Male; Mi

1967
[Effects of reserpine on pulmonary circulation and respiratory function, especially on pulmonary hypertension].
    Japanese circulation journal, 1967, Volume: 31, Issue:4

    Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Blood Pressure; Bronchial Diseases; Chronic Disease; Fe

1967
Effect of reserpine-kanamycin treatment on chronic vasospasm after platelet-enriched subarachnoid hemorrhage in primates.
    Neurosurgery, 1984, Volume: 14, Issue:2

    Topics: Animals; Blood Platelets; Chronic Disease; Drug Therapy, Combination; Female; Ischemic Attack, Trans

1984
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension].
    Klinicheskaia meditsina, 1984, Volume: 62, Issue:3

    Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea

1984
[Changes in the hemodynamic indices of hypertension patients].
    Vrachebnoe delo, 1983, Issue:4

    Topics: Adult; Aged; Antihypertensive Agents; Chronic Disease; Drug Combinations; Drug Evaluation; Female; H

1983
Reserpine and breast cancer.
    Archives internationales de pharmacodynamie et de therapie, 1980, Volume: Suppl

    Topics: Breast Neoplasms; Chronic Disease; Female; Humans; Hypertension; Reserpine

1980
Influence of reserpine on all-night sleep pattern in nonlobotomized and lobotomized chronic schizophrenic patients.
    Biological psychiatry, 1975, Volume: 10, Issue:1

    Topics: Chronic Disease; Dreams; Electrocardiography; Electroencephalography; Electromyography; Female; Huma

1975
[Hypertension and pregnancy].
    Acta cardiologica, 1977, Volume: 32, Issue:3

    Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Chronic Disease; Diuretics; Female; Humans; Hyper

1977
The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid.
    Pediatric research, 1976, Volume: 10, Issue:6

    Topics: Adult; Animals; Child; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Glycoproteins; Huma

1976
Reserpine in hypertension: present status.
    American family physician, 1975, Volume: 11, Issue:6

    Topics: Animals; Benzothiadiazines; Breast Neoplasms; Chronic Disease; Depression; Diuretics; Drug Therapy,

1975
Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments.
    Journal of neurochemistry, 1992, Volume: 58, Issue:2

    Topics: Adrenalectomy; Animals; Antidepressive Agents; Chronic Disease; Cyclic AMP; Electrophysiology; Locus

1992
Neurochemical changes associated with the persistence of spontaneous oral dyskinesia in rats following chronic reserpine treatment.
    Brain research, 1991, Aug-30, Volume: 558, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain; Caudat

1991
[The Kristepin and obzidan treatment of patients with hypertension].
    Vrachebnoe delo, 1989, Issue:6

    Topics: Adult; Antihypertensive Agents; Chronic Disease; Clopamide; Dihydroergotoxine; Drug Combinations; Dr

1989
Role of oxygen-derived free radicals in the mechanism of chronic gastric ulceration in the rat: implications for cytoprotection.
    Digestion, 1989, Volume: 43, Issue:1-2

    Topics: Allopurinol; Animals; Chronic Disease; Dimethyl Sulfoxide; Female; Free Radicals; Gastric Acid; Hydr

1989
Possible enhancing effects of diazepam with reserpine in a chronic schizophrenic patient with tardive dyskinesia.
    Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:4

    Topics: Adult; Antipsychotic Agents; Chronic Disease; Diazepam; Drug Therapy, Combination; Dyskinesia, Drug-

1989
Effect of oral fluphenazine on Huntington's chorea.
    International journal of neuropsychiatry, 1968, Volume: 4, Issue:1

    Topics: Age Factors; Aged; Chronic Disease; Female; Fluphenazine; Humans; Huntington Disease; Male; Mental P

1968
[Internal therapy of peripheral arterial blood circulation disorders].
    Schweizerische medizinische Wochenschrift, 1970, May-02, Volume: 100, Issue:18

    Topics: Adenosine Triphosphate; Aged; Angiotensin II; Anti-Bacterial Agents; Blood Pressure; Chlorpromazine;

1970
Do antihypertensive drugs really cause depression?
    Proceedings of the Royal Society of Medicine, 1974, Volume: 67, Issue:9

    Topics: Acute Disease; Antihypertensive Agents; Chronic Disease; Depression; Guanethidine; Humans; Hypertens

1974
Letter: Methyldopa and depression.
    British medical journal, 1973, Dec-01, Volume: 4, Issue:5891

    Topics: Chronic Disease; Depression; Humans; Methyldopa; Reserpine; Time Factors

1973
[Apparent cure of arterial hypertension].
    La Nouvelle presse medicale, 1974, Feb-02, Volume: 3, Issue:5

    Topics: Adult; Chronic Disease; Drug Therapy, Combination; Female; Guanethidine; Humans; Hydrochlorothiazide

1974
The medical treatment of dissecting aortic aneurysms.
    The New England journal of medicine, 1972, Jan-20, Volume: 286, Issue:3

    Topics: Acute Disease; Adult; Aged; Aortic Aneurysm; Aortic Rupture; Aortography; Chronic Disease; Female; F

1972
Dissecting aortic aneurysm.
    Cardiovascular clinics, 1971, Volume: 3, Issue:1

    Topics: Acute Disease; Administration, Oral; Aortic Aneurysm; Chronic Disease; Guanethidine; Humans; Injecti

1971
[Treatment of chronic glomerulonephritis and pyelonephritis].
    Voenno-meditsinskii zhurnal, 1971, Volume: 3

    Topics: Anti-Bacterial Agents; Benzimidazoles; Chloroquine; Chronic Disease; Diet Therapy; Glomerulonephriti

1971
[The high dosage reserpine cure in the treatment of chronic schizophrenics. A clinical and statistical analysis].
    Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete, 1968, Volume: 36, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Autonomic Nervous System; Chronic Disease; Female; Humans; Mal

1968
[Behavior of urinary 5-hydroxyindolacetic acid before and after administration of a serotonin depleting agent in chronic bronchitis patients].
    La Medicina del lavoro, 1969, Volume: 60, Issue:2

    Topics: Adult; Aged; Bronchitis; Chronic Disease; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Reser

1969
[Therapy of chronic glomerulonephritis].
    Monatsschrift fur Kinderheilkunde, 1970, Volume: 118, Issue:2

    Topics: Acidosis; Blood Pressure; Child; Chronic Disease; Cyclophosphamide; Diet, Sodium-Restricted; Dietary

1970
[Very high reserpine dosage in the treatment of chronic schizophrenia].
    German medical monthly, 1967, Volume: 12, Issue:12

    Topics: Chronic Disease; Female; Humans; Male; Orphenadrine; Reserpine; Schizophrenia

1967
[Effects of reserpine on respiratory functions, with special reference to the increase of anoxemia in cardiac and pulmonary diseases].
    Japanese circulation journal, 1968, Volume: 32, Issue:2

    Topics: Aortic Valve Stenosis; Asthma; Blood Gas Analysis; Bronchiectasis; Bronchitis; Carbon Dioxide; Cardi

1968
Control of renin release in experimental hypertension.
    Circulation research, 1969, Volume: 24, Issue:5 Suppl

    Topics: Acetylcholine; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Catheterization; Chronic Dise

1969