reserpine has been researched along with Chronic Disease in 45 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Intraperitoneal reserpine (5 mg/kg every day for 5 days) produced chronic gastric ulceration in all rats after 4 weeks." | 3.67 | Role of oxygen-derived free radicals in the mechanism of chronic gastric ulceration in the rat: implications for cytoprotection. ( Salim, AS, 1989) |
| "Reserpine treatment, shown previously to increase levels of TH, was found to increase both LC firing rate and levels of soluble cAMP-dependent protein kinase activity in the LC." | 1.28 | Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments. ( Duman, RS; Haycock, JW; Melia, KR; Nestler, EJ; Rasmussen, K; Terwilliger, RZ, 1992) |
| "The reserpine-treated rats also exhibited stereotypy in response to acute injection of the D1-selective agonist SKF-38393 (10 mg/kg), which was not observed in control rats." | 1.28 | Neurochemical changes associated with the persistence of spontaneous oral dyskinesia in rats following chronic reserpine treatment. ( Lucki, I; McGonigle, P; Neisewander, JL, 1991) |
| "Reserpine-treated rats also showed a significant increase in the total protein recovered in the lung lavage fluid with a 233% increase in the absolute and relative amounts of a low molecular weight glycoprotein (15,000 mol wt)." | 1.26 | The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid. ( Martinez, JR; Quissell, DO; Thompson, FE; Williams, CH, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 41 (91.11) | 18.7374 |
| 1990's | 2 (4.44) | 18.2507 |
| 2000's | 1 (2.22) | 29.6817 |
| 2010's | 1 (2.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Demitsu, T | 1 |
| Yoneda, K | 1 |
| Kakurai, M | 1 |
| Sasaki, K | 1 |
| Hiratsuka, Y | 1 |
| Azuma, R | 1 |
| Yamada, T | 1 |
| Umemoto, N | 1 |
| MORGAN, DR | 1 |
| BELISLE, JA | 1 |
| JENKINS, SB | 1 |
| CARSON, JE | 1 |
| JONES, C | 1 |
| LUSTIG, B | 1 |
| MATHELIE-GUINLET, G | 1 |
| MISSERE, G | 1 |
| BABBINI, M | 1 |
| TONINI, G | 1 |
| Jain, S | 1 |
| Sharma, R | 1 |
| WIDIMSKY, J | 1 |
| KASALICKY, J | 1 |
| DEJDAR, R | 1 |
| VYSLOUZIL, Z | 1 |
| LUKES, M | 1 |
| MATVEEV, VF | 1 |
| Popa, M | 1 |
| Pappo, A | 1 |
| Stan, M | 1 |
| Runcan, V | 1 |
| Takata, C | 1 |
| Noseworthy, TW | 1 |
| Weir, B | 1 |
| Boisvert, D | 1 |
| Espinosa, F | 1 |
| Overton, T | 1 |
| Marshal, ML | 1 |
| Eninia, GI | 1 |
| Smeltere, ES | 1 |
| Godlevska, MA | 1 |
| Uzulinia, IP | 1 |
| Shvedenko, LA | 1 |
| Parashchak, AP | 1 |
| Iurkevich, ST | 1 |
| Neporadnyĭ, MD | 1 |
| Bigar', PV | 1 |
| Kewitz, H | 1 |
| Jesdinsky, HJ | 1 |
| Kreutz, G | 1 |
| Schulz, R | 1 |
| Jus, A | 1 |
| Jus, K | 1 |
| Villeneuve, A | 1 |
| Gautier, J | 1 |
| Pires, P | 1 |
| Lachance, R | 1 |
| Itil, TM | 1 |
| Wadud, A | 1 |
| Foidart, JM | 1 |
| Rorive, G | 1 |
| Pekarskaia, IM | 1 |
| Brushkovskaia, LL | 1 |
| Thompson, FE | 1 |
| Quissell, DO | 1 |
| Williams, CH | 1 |
| Martinez, JR | 1 |
| Freis, ED | 1 |
| Melia, KR | 1 |
| Rasmussen, K | 1 |
| Terwilliger, RZ | 1 |
| Haycock, JW | 1 |
| Nestler, EJ | 1 |
| Duman, RS | 1 |
| Neisewander, JL | 1 |
| Lucki, I | 1 |
| McGonigle, P | 1 |
| Leviashvili, BI | 1 |
| Salim, AS | 1 |
| Bacher, NM | 1 |
| Field, PB | 1 |
| Elkashef, A | 1 |
| Whittier, JR | 1 |
| Korenyi, C | 1 |
| Bollinger, A | 1 |
| Gilmore, HR | 1 |
| Bant, W | 2 |
| Mise, J | 1 |
| Spach, MO | 1 |
| Bloch, R | 1 |
| Velly, J | 1 |
| Imbs, JL | 1 |
| Bousquet, P | 1 |
| Schwartz, J | 1 |
| Loggie, JM | 1 |
| Kline, NS | 1 |
| Blair, J | 1 |
| Cooper, TB | 1 |
| Esser, AH | 1 |
| Hackett, E | 1 |
| Vestergaard, P | 1 |
| McFarland, J | 1 |
| Willerson, JT | 1 |
| Dinsmore, RE | 1 |
| Austen, WG | 1 |
| Buckley, MJ | 1 |
| Sanders, CA | 1 |
| DeSanctis, RW | 1 |
| Brest, AN | 1 |
| Ar'eva, EM | 1 |
| Iaroshevskiĭ, AIa | 1 |
| Häfner, H | 2 |
| Schliack, E | 2 |
| Zenz, H | 2 |
| Corsi, G | 1 |
| Saia, B | 1 |
| Gekle, D | 1 |
| Kawabata, S | 1 |
| Ayers, CR | 1 |
| Harris, RH | 1 |
| Lefer, LG | 1 |
4 reviews available for reserpine and Chronic Disease
| Article | Year |
|---|---|
Treatment of human aggression with major tranquilizers, antidepressants, and newer psychotropic drugs.
Topics: Adolescent; Affective Symptoms; Aggression; Alcoholism; Antidepressive Agents; Antipsychotic Agents; | 1975 |
The treatment of chronic hypertension.
Topics: Adult; Blood Pressure Determination; Chronic Disease; Diuretics; Female; Ganglionic Blockers; Guanet | 1971 |
Pulmonary hypertension.
Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary; | 1974 |
Hypertension in children and adolescents. II. Drug therapy.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure Determination; Child; Chlorothiazide; Chronic D | 1969 |
3 trials available for reserpine and Chronic Disease
| Article | Year |
|---|---|
[Effect of dibazol and reserpine on the contractile capacity of the myocardium].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Benzimidazoles; Chronic Disease; Clinical Trials a | 1979 |
A controlled sevn year study of endocrine and other indices in drug treated chronic schizophrenics.
Topics: 17-Ketosteroids; Androsterone; Cholesterol; Chronic Disease; Clinical Trials as Topic; Computers; Cr | 1968 |
Psychopharmacology.
Topics: Alcoholism; Anxiety; Brain Damage, Chronic; Chronic Disease; Clinical Trials as Topic; Depression; E | 1970 |
38 other studies available for reserpine and Chronic Disease
| Article | Year |
|---|---|
Clinical efficacy of reserpine as "add-on therapy" to antihistamines in patients with recalcitrant chronic idiopathic urticaria and urticarial vasculitis.
Topics: Anti-Allergic Agents; Chronic Disease; Drug Therapy, Combination; Female; Histamine Antagonists; Hum | 2010 |
The combined use of chlorpromazine and reserpine in the treatment of chronic mental illness: a preliminary report.
Topics: Antihypertensive Agents; Chlorpromazine; Chronic Disease; Mental Disorders; Psychotherapy; Reserpine | 1955 |
Evaluation of chlorpromazine and reserpine in intensive treatment of chronic psychotic patients.
Topics: Chlorpromazine; Chronic Disease; Mental Disorders; Reserpine | 1957 |
[Experiences with sedaraupin in chronic mental disorders].
Topics: Chronic Disease; Humans; Mental Disorders; Psychotherapy; Reserpine | 1957 |
The place of reserpine in the treatment of mitral heart disease.
Topics: Chronic Disease; Disease; Heart Diseases; Heart Valve Diseases; Humans; Mitral Valve; Reserpine; Rhe | 1957 |
[Research on chronic morphine poisoning. II. Effects of reserpine, chlorpromazine & N-allylnormorphine on activity manifestations induced by morphine].
Topics: Chlorpromazine; Chronic Disease; Drug-Related Side Effects and Adverse Reactions; Morphine; Nalorphi | 1959 |
Analgesia in phasic and tonic pain tests in a pharmacological model of autotomy.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Amphetamine; Analgesia; Animals; Behavio | 2002 |
Effect of reserpine on the lesser circulation in chronic pulmonary diseases.
Topics: Chronic Disease; Humans; Hypertension; Hypertension, Pulmonary; Lung Abscess; Lung Diseases; Reserpi | 1962 |
[The effect of therapeutic and subtoxic doses of serpasil on the brain and internal organs of animals in chronic experimental conditions].
Topics: Brain; Central Nervous System; Chronic Disease; Intestines; Kidney; Liver; Reserpine | 1961 |
[Research on catecholamines in chronic hepatitis following epidemic hepatitis].
Topics: Adolescent; Adult; Catecholamines; Chronic Disease; Female; Hepatitis; Hepatitis A; Humans; Male; Mi | 1967 |
[Effects of reserpine on pulmonary circulation and respiratory function, especially on pulmonary hypertension].
Topics: Adolescent; Adult; Aged; Blood Gas Analysis; Blood Pressure; Bronchial Diseases; Chronic Disease; Fe | 1967 |
Effect of reserpine-kanamycin treatment on chronic vasospasm after platelet-enriched subarachnoid hemorrhage in primates.
Topics: Animals; Blood Platelets; Chronic Disease; Drug Therapy, Combination; Female; Ischemic Attack, Trans | 1984 |
[Characteristics of the action of gemiton, adelfan and dopegit on cerebral circulation in arterial hypertension].
Topics: Aged; Antihypertensive Agents; Cerebrovascular Circulation; Cerebrovascular Disorders; Chronic Disea | 1984 |
[Changes in the hemodynamic indices of hypertension patients].
Topics: Adult; Aged; Antihypertensive Agents; Chronic Disease; Drug Combinations; Drug Evaluation; Female; H | 1983 |
Reserpine and breast cancer.
Topics: Breast Neoplasms; Chronic Disease; Female; Humans; Hypertension; Reserpine | 1980 |
Influence of reserpine on all-night sleep pattern in nonlobotomized and lobotomized chronic schizophrenic patients.
Topics: Chronic Disease; Dreams; Electrocardiography; Electroencephalography; Electromyography; Female; Huma | 1975 |
[Hypertension and pregnancy].
Topics: Adult; Antihypertensive Agents; Benzothiadiazines; Chronic Disease; Diuretics; Female; Humans; Hyper | 1977 |
The chronically reserpinized rat as a possible animal model for cystic fibrosis. IV. The protein composition of pulmonary lavage fluid.
Topics: Adult; Animals; Child; Chronic Disease; Cystic Fibrosis; Disease Models, Animal; Glycoproteins; Huma | 1976 |
Reserpine in hypertension: present status.
Topics: Animals; Benzothiadiazines; Breast Neoplasms; Chronic Disease; Depression; Diuretics; Drug Therapy, | 1975 |
Coordinate regulation of the cyclic AMP system with firing rate and expression of tyrosine hydroxylase in the rat locus coeruleus: effects of chronic stress and drug treatments.
Topics: Adrenalectomy; Animals; Antidepressive Agents; Chronic Disease; Cyclic AMP; Electrophysiology; Locus | 1992 |
Neurochemical changes associated with the persistence of spontaneous oral dyskinesia in rats following chronic reserpine treatment.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Brain; Caudat | 1991 |
[The Kristepin and obzidan treatment of patients with hypertension].
Topics: Adult; Antihypertensive Agents; Chronic Disease; Clopamide; Dihydroergotoxine; Drug Combinations; Dr | 1989 |
Role of oxygen-derived free radicals in the mechanism of chronic gastric ulceration in the rat: implications for cytoprotection.
Topics: Allopurinol; Animals; Chronic Disease; Dimethyl Sulfoxide; Female; Free Radicals; Gastric Acid; Hydr | 1989 |
Possible enhancing effects of diazepam with reserpine in a chronic schizophrenic patient with tardive dyskinesia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Diazepam; Drug Therapy, Combination; Dyskinesia, Drug- | 1989 |
Effect of oral fluphenazine on Huntington's chorea.
Topics: Age Factors; Aged; Chronic Disease; Female; Fluphenazine; Humans; Huntington Disease; Male; Mental P | 1968 |
[Internal therapy of peripheral arterial blood circulation disorders].
Topics: Adenosine Triphosphate; Aged; Angiotensin II; Anti-Bacterial Agents; Blood Pressure; Chlorpromazine; | 1970 |
Do antihypertensive drugs really cause depression?
Topics: Acute Disease; Antihypertensive Agents; Chronic Disease; Depression; Guanethidine; Humans; Hypertens | 1974 |
Letter: Methyldopa and depression.
Topics: Chronic Disease; Depression; Humans; Methyldopa; Reserpine; Time Factors | 1973 |
[Apparent cure of arterial hypertension].
Topics: Adult; Chronic Disease; Drug Therapy, Combination; Female; Guanethidine; Humans; Hydrochlorothiazide | 1974 |
The medical treatment of dissecting aortic aneurysms.
Topics: Acute Disease; Adult; Aged; Aortic Aneurysm; Aortic Rupture; Aortography; Chronic Disease; Female; F | 1972 |
Dissecting aortic aneurysm.
Topics: Acute Disease; Administration, Oral; Aortic Aneurysm; Chronic Disease; Guanethidine; Humans; Injecti | 1971 |
[Treatment of chronic glomerulonephritis and pyelonephritis].
Topics: Anti-Bacterial Agents; Benzimidazoles; Chloroquine; Chronic Disease; Diet Therapy; Glomerulonephriti | 1971 |
[The high dosage reserpine cure in the treatment of chronic schizophrenics. A clinical and statistical analysis].
Topics: Adolescent; Adult; Age Factors; Aged; Autonomic Nervous System; Chronic Disease; Female; Humans; Mal | 1968 |
[Behavior of urinary 5-hydroxyindolacetic acid before and after administration of a serotonin depleting agent in chronic bronchitis patients].
Topics: Adult; Aged; Bronchitis; Chronic Disease; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Reser | 1969 |
[Therapy of chronic glomerulonephritis].
Topics: Acidosis; Blood Pressure; Child; Chronic Disease; Cyclophosphamide; Diet, Sodium-Restricted; Dietary | 1970 |
[Very high reserpine dosage in the treatment of chronic schizophrenia].
Topics: Chronic Disease; Female; Humans; Male; Orphenadrine; Reserpine; Schizophrenia | 1967 |
[Effects of reserpine on respiratory functions, with special reference to the increase of anoxemia in cardiac and pulmonary diseases].
Topics: Aortic Valve Stenosis; Asthma; Blood Gas Analysis; Bronchiectasis; Bronchitis; Carbon Dioxide; Cardi | 1968 |
Control of renin release in experimental hypertension.
Topics: Acetylcholine; Animals; Arteries; Blood Flow Velocity; Blood Pressure; Catheterization; Chronic Dise | 1969 |