reserpine has been researched along with Catatonic Rigidity in 24 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity." | 7.74 | Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008) |
| "The aim of the present study was to assess the efficacy of pramipexole (2-amino-4,5,6, 7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochloride), a new dopamine D(2)/D(3) receptor agonist, to attenuate parkinsonian-like muscle rigidity in rats." | 7.70 | Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats. ( Lorenc-Koci, E; Wolfarth, S, 1999) |
| " The extract at both the doses displayed a significant reduction in postural flexion, moderate decrease in tremor, muscular rigidity and postural immobility scores but do not exhibit significant lowering of hypokinesia score in reserpine induced Parkinsonian model." | 4.12 | Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates. ( Kadiri, SK; Karkar, VV; Pal Roy, S; Rao Konijeti, S, 2022) |
| " Although rigidity was reduced by efaroxan (an imidazoline I(1) receptor and alpha(2)-adrenoceptor antagonist) and idazoxan (an imidazoline I(1) and I(2) receptor and alpha(2)-adrenoceptor antagonist), SKF86466 and yohimbine, both of which are alpha(2)-adrenoceptor antagonists with no affinity for imidazoline receptors, also suppressed rigidity, suggesting that activation rather than blockade of imidazoline I(1) receptors contributes to reduction of reserpine-induced muscle rigidity." | 3.74 | Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease. ( Hashimoto, M; Ono, H; Tanabe, M, 2008) |
| "The aim of the present study was to assess the efficacy of pramipexole (2-amino-4,5,6, 7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochloride), a new dopamine D(2)/D(3) receptor agonist, to attenuate parkinsonian-like muscle rigidity in rats." | 3.70 | Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats. ( Lorenc-Koci, E; Wolfarth, S, 1999) |
| " The aim of this study was to examine the influence of MK-801 on the reserpine-induced muscle rigidity." | 3.69 | Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: a mechanomyographic analysis. ( Lorenc-Koci, E; Ossowska, K; Wolfarth, S, 1994) |
| "Reserpine was injected in a dose of 10 mg/kg alone or with alpha-methyl-p-tyrosine (250 mg/kg) 1, 4 and 27." | 1.29 | Does reserpine induce parkinsonian rigidity? ( Lorenc-Koci, E; Ossowska, K; Wardas, J; Wolfarth, S, 1995) |
| "Apomorphine was used as a test substance to reduce reserpine rigidity by stimulation of dopamine receptors." | 1.27 | Reserpine-induced rigidity in rats: drug effects on muscle tone from corpus striatum and nucleus accumbens. ( Johnels, B, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (58.33) | 18.7374 |
| 1990's | 7 (29.17) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Pal Roy, S | 1 |
| Kadiri, SK | 1 |
| Karkar, VV | 1 |
| Rao Konijeti, S | 1 |
| Tanabe, M | 1 |
| Hashimoto, M | 1 |
| Ono, H | 1 |
| Wagner, BH | 1 |
| Anderson, RJ | 1 |
| Johnels, B | 4 |
| Bräutigam, M | 2 |
| Flosbach, CW | 2 |
| Herken, H | 2 |
| Torrini, M | 1 |
| Masini, E | 1 |
| Ledda, F | 1 |
| Mannaioni, PF | 1 |
| Steg, G | 3 |
| Dreesen, R | 1 |
| Ossowska, K | 3 |
| Lorenc-Koci, E | 5 |
| Wolfarth, S | 4 |
| Wardas, J | 2 |
| Schulze, G | 1 |
| Hernández-López, S | 1 |
| Flores, G | 1 |
| Rosales, MG | 1 |
| Sierra, A | 1 |
| Martínez-Fong, D | 1 |
| Aceves, J | 1 |
| Nickel, B | 1 |
| Kolasiewicz, W | 1 |
| Szelenyi, I | 1 |
| Konieczny, J | 1 |
| Jurna, I | 1 |
| Ungerstedt, U | 1 |
| Andén, NE | 1 |
| Goldstein, JM | 1 |
| Barnett, A | 1 |
| Malick, JB | 1 |
| Klockgether, T | 1 |
| Turski, L | 1 |
| Aley, KO | 1 |
| Kulkarni, SK | 1 |
| Colpaert, FC | 1 |
| Meinck, HM | 1 |
| Conrad, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| a Pilot Study of Pramipexole to Treat Extrapyramidal Symptoms Induced by Antipsychotics[NCT03430596] | Early Phase 1 | 50 participants (Actual) | Interventional | 2018-05-01 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for reserpine and Catatonic Rigidity
| Article | Year |
|---|---|
[Acute drug-induced extrapyramidal syndrome: case studies of a decade at the autonomous toxicology department of the Arcispedale].
Topics: Adolescent; Adult; Aged; Basal Ganglia Diseases; Benzamides; Butyrophenones; Child; Drug-Related Sid | 1981 |
Striatal monoamines and reserpine and chlorpromazine rigidity.
Topics: Animals; Biogenic Amines; Cats; Chlorpromazine; Corpus Striatum; Dopamine; Humans; Mice; Motor Neuro | 1976 |
Pathological aspects on Parkinson's syndrome.
Topics: Animals; Basal Ganglia; Basal Ganglia Diseases; Central Nervous System; Chlorpromazine; Corpus Stria | 1972 |
21 other studies available for reserpine and Catatonic Rigidity
| Article | Year |
|---|---|
Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adjuvants, Immunologic; Animals; Antioxidants; Antipar | 2022 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines | 2008 |
Prevention of reserpine rigidity by alpha-2 adrenergic antagonists.
Topics: Adrenergic alpha-Antagonists; Animals; Clonidine; Extrapyramidal Tracts; Male; Motor Activity; Muscl | 1982 |
Reserpine-induced rigidity in rats: drug effects on muscle tone from corpus striatum and nucleus accumbens.
Topics: 5-Hydroxytryptophan; Animals; Apomorphine; Carbidopa; Corpus Striatum; Male; Muscle Rigidity; Nucleu | 1983 |
Depression of reserpine-induced muscular rigidity in rats after administration of lisuride into the spinal subarachnoid space.
Topics: Animals; Catheterization; Electromyography; Ergolines; Injections, Spinal; Lisuride; Male; Muscle Ri | 1980 |
A mechanographic method for measurement of muscle tone in the conscious rat. The calf muscle stretch response in reserpine-induced rigidity.
Topics: Animals; Apomorphine; Biomechanical Phenomena; Disease Models, Animal; Haloperidol; Male; Muscle Con | 1982 |
Action of lisuride on reserpine-induced muscular rigidity in rats after local application into the striatum, ventricular space or the spinal subarachnoid space.
Topics: Animals; Corpus Striatum; Electromyography; Ergolines; Hydrogen-Ion Concentration; Injections; Injec | 1982 |
Antiparkinsonian action of MK-801 on the reserpine-induced rigidity: a mechanomyographic analysis.
Topics: Animals; Dizocilpine Maleate; Foot; Male; Muscle Rigidity; Muscle Tonus; Parkinson Disease; Rats; Ra | 1994 |
Does reserpine induce parkinsonian rigidity?
Topics: Adrenergic Uptake Inhibitors; alpha-Methyltyrosine; Animals; Electromyography; Enzyme Inhibitors; Hi | 1995 |
The influence of dizocilpine (MK-801) on the reserpine-enhanced electromyographic stretch reflex in rats.
Topics: Animals; Dizocilpine Maleate; Dopamine; Electromyography; Excitatory Amino Acid Antagonists; Male; M | 1996 |
Muscarinic antagonists microinjected into the subthalamic nucleus decrease muscular rigidity in reserpinized rats.
Topics: Anesthetics, Intravenous; Animals; Chloral Hydrate; Cholinergic Antagonists; Electromyography; Locom | 1996 |
Quantification of rigidity and tremor activity in rats by using a new device and its validation by different classes of drugs.
Topics: Analgesics, Opioid; Animals; Antiparkinson Agents; Central Nervous System Depressants; Male; Muscari | 1997 |
Efficacy of pramipexole, a new dopamine receptor agonist, to relieve the parkinsonian-like muscle rigidity in rats.
Topics: alpha-Methyltyrosine; Animals; Benzothiazoles; Dopamine Agonists; Dose-Response Relationship, Drug; | 1999 |
SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats.
Topics: Adrenergic Uptake Inhibitors; Animals; Ankle Joint; Dopamine Agents; Dopamine Antagonists; Drug Comb | 2001 |
A method for mechanographical recording of muscle tone in the rat: the effect of some antiparkinsonian drugs on rigidity induced by reserpine.
Topics: Animals; Antiparkinson Agents; Apomorphine; Bromocriptine; Carbidopa; Drug Evaluation, Preclinical; | 1978 |
Effect of local application of apomorphine to the corpus striatum and to the nucleus accumbens on the reserpine-induced rigidity in rats.
Topics: Animals; Apomorphine; Corpus Striatum; Disease Models, Animal; Dopamine; Dose-Response Relationship, | 1977 |
The evaluation of anti-parkinson drugs on reserpine-induced rigidity in rats.
Topics: Amantadine; Animals; Antiparkinson Agents; Apomorphine; Benztropine; Carbidopa; Hindlimb; Levodopa; | 1975 |
NMDA antagonists potentiate antiparkinsonian actions of L-dopa in monoamine-depleted rats.
Topics: Animals; Dizocilpine Maleate; Drug Synergism; Electromyography; Levodopa; Male; Methyltyrosines; Mot | 1990 |
Anticatatonic effect of venoruton.
Topics: Animals; Anticoagulants; Antipsychotic Agents; Catatonia; Female; Haloperidol; Hydroxyethylrutoside; | 1988 |
Pharmacological characteristics of tremor, rigidity and hypokinesia induced by reserpine in rat.
Topics: Animals; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Female; Haloperidol; Levodop | 1987 |
Neuropharmacological investigations in the stiff-man syndrome.
Topics: Adrenergic Fibers; Central Nervous System Diseases; Clonidine; Diazepam; Female; Humans; Methampheta | 1986 |