reserpine has been researched along with Cardiovascular Stroke in 60 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The experiments on anaesthetized dogs have shown that with artificial ventilation and open chest adrenalin in arrhythmogenic and nonarrythmogenic doses enhances glycogenolysis in the heart proportionally to the dose used Block of beta-adrenergic receptors by propranolol decreased the activation of glycogenolysis in the ischaemic zone and the frequency of ventricular fibrillation after occlusion of the coronary artery." | 7.66 | [Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation]. ( Dolgova, NP, 1982) |
| "Pretreatment with reserpine did not alter the dynamic changes of cardiac and liver MT content during myocardial infarction." | 5.28 | [Changes in metallothionein content of the heart and liver during acute myocardial infarction in rats]. ( Li, JH; Tang, CS; Wang, PJ, 1989) |
| " Some of this information includes: the unexpected yet very real hazards as well as benefits associated with the long-term use of powerful drugs, in particular the original description of hydralazine-induced lupus, its relation to genetic markers and its association with control of hypertension; the apparently decreasing need for antihypertensive drugs in subjects with well-controlled severe and moderate hypertension; the identification of risk factors for the complications of hypertension and the quantitation of their effects; the decrease in the incidence of hypertensive complications associated with the pharmacologic treatment of severe, moderate and, at least, the upper ranges of mild hypertension; the possibility of designing a chemical to block a specific reaction and the realization that it would have broader than expected effects; and the primary prevention of myocardial infarction in very high risk subjects." | 4.77 | The evolution of antihypertensive therapy. ( Perry, HM, 1985) |
| "The experiments on anaesthetized dogs have shown that with artificial ventilation and open chest adrenalin in arrhythmogenic and nonarrythmogenic doses enhances glycogenolysis in the heart proportionally to the dose used Block of beta-adrenergic receptors by propranolol decreased the activation of glycogenolysis in the ischaemic zone and the frequency of ventricular fibrillation after occlusion of the coronary artery." | 3.66 | [Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation]. ( Dolgova, NP, 1982) |
| "Myocardial infarction was induced by permanent ligation of the left coronary artery and ventricular tachyarrhythmias were evaluated from continuous electrocardiographic recordings." | 1.40 | Endothelin B-receptors and sympathetic activation: impact on ventricular arrhythmogenesis during acute myocardial infarction. ( Baibaki, ME; Barka, E; Kolettis, TM; Kontonika, M; Kyriakides, ZS; Oikonomidis, DL; Papalois, A; Tsalikakis, DG, 2014) |
| "Reserpine pretreatment attenuated this protective effect of preconditioning on reperfusion-induced arrhythmias." | 1.30 | The possible role of adrenergic component in ischemic preconditioning. ( Sharma, A; Singh, M, 1997) |
| "Reserpine pretreatment did not affect the response to ischaemia or to preconditioning, although LDH release tended to be greater than in normal hearts, especially in the non-preconditioned group." | 1.29 | Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart. ( Baird, AJ; Dzwonczyk, S; Grover, GJ; Murray, HN; Sleph, PG; Weselcouch, EO, 1995) |
| "Pretreatment with reserpine did not alter the dynamic changes of cardiac and liver MT content during myocardial infarction." | 1.28 | [Changes in metallothionein content of the heart and liver during acute myocardial infarction in rats]. ( Li, JH; Tang, CS; Wang, PJ, 1989) |
| "Propranolol pretreatment decreased the infarct size but treatment after coronary ligation increased it." | 1.27 | Pharmacological interventions and myocardial infarct size in rat. ( Kumar, C; Singh, M, 1985) |
| " Three days post-AMI the dose-response curve for isoproterenol of right ventricular dP/dtmax was significantly depressed, while the inotropic effect of histamine was not impaired." | 1.26 | Impaired beta-adrenergic stimulation in the uninvolved ventricle post-acute myocardial infarction: reversible defect due to excessive circulating catecholamine-induced decline in number and affinity of beta-receptors. ( Baumann, G; Blömer, H; Blümel, G; Erhardt, WD; Felix, SB; Ludwig, L; Riess, G, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 52 (86.67) | 18.7374 |
| 1990's | 6 (10.00) | 18.2507 |
| 2000's | 1 (1.67) | 29.6817 |
| 2010's | 1 (1.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kolettis, TM | 1 |
| Oikonomidis, DL | 1 |
| Baibaki, ME | 1 |
| Barka, E | 1 |
| Kontonika, M | 1 |
| Tsalikakis, DG | 1 |
| Papalois, A | 1 |
| Kyriakides, ZS | 1 |
| Sieber, M | 1 |
| BULLE, PH | 1 |
| MENA, I | 1 |
| THOMSEN, P | 1 |
| RICHARDSON, JA | 1 |
| CHAMBERLIN, RT | 1 |
| PUTNAM, WS | 1 |
| BARRERA, F | 3 |
| LAUTSCH, EV | 3 |
| ASCANIO, G | 3 |
| OPPENHEIMER, MJ | 3 |
| BAUER, GE | 1 |
| TOGNELLA, S | 1 |
| BIGNOTTI, G | 1 |
| RAAB, W | 1 |
| DE MONCHAUX, RJ | 1 |
| WENZEL, DG | 1 |
| STARK, LG | 1 |
| Kedem, J | 1 |
| Zurovski, Y | 1 |
| Miller, H | 1 |
| Battler, A | 1 |
| Baumann, G | 1 |
| Riess, G | 1 |
| Erhardt, WD | 1 |
| Felix, SB | 1 |
| Ludwig, L | 1 |
| Blümel, G | 1 |
| Blömer, H | 1 |
| Dolgova, NP | 1 |
| Bernauer, W | 1 |
| Freis, E | 1 |
| Bender, F | 1 |
| Weselcouch, EO | 1 |
| Baird, AJ | 1 |
| Sleph, PG | 1 |
| Dzwonczyk, S | 1 |
| Murray, HN | 1 |
| Grover, GJ | 1 |
| Rongen, GA | 1 |
| Smits, P | 1 |
| Thien, T | 1 |
| Toombs, CF | 1 |
| Wiltse, AL | 1 |
| Shebuski, RJ | 1 |
| Vander Heide, RS | 1 |
| Schwartz, LM | 1 |
| Jennings, RB | 2 |
| Reimer, KA | 1 |
| Sharma, A | 1 |
| Singh, M | 2 |
| Miyagishima, Y | 1 |
| Spotnitz, HM | 1 |
| Golovtsev, IuIu | 1 |
| Perry, HM | 2 |
| Trappler, B | 1 |
| Forman, MB | 1 |
| Millar, RN | 1 |
| Obel, IW | 1 |
| Taguchi, J | 1 |
| Freis, ED | 3 |
| Mill, JG | 1 |
| Leite, CM | 1 |
| Vassallo, DV | 1 |
| Tang, CS | 1 |
| Wang, PJ | 1 |
| Li, JH | 1 |
| Kumar, C | 1 |
| Kattus, AA | 1 |
| Vollenberger, A | 1 |
| Shakhab, L | 1 |
| Alexander, S | 1 |
| Cernigliaro, C | 1 |
| Fedele, F | 1 |
| Malaspina, F | 1 |
| Minuco, G | 1 |
| Rossi, P | 1 |
| Peart, WS | 1 |
| Chasis, H | 1 |
| Fink, M | 1 |
| Abrams, R | 1 |
| Britov, AN | 1 |
| Siderskiĭ, AL | 1 |
| Stephan, E | 1 |
| Sommers, HM | 1 |
| Staszewska-Barczak, J | 1 |
| Brunaud, M | 1 |
| Vallée, E | 1 |
| Laborit, H | 1 |
| Feola, M | 1 |
| Haiderer, O | 1 |
| Kennedy, JH | 1 |
| Chung, EK | 1 |
| Morgan, EJ | 1 |
| Lewartowski, B | 1 |
| Sedek, G | 1 |
| Gawin, E | 1 |
| Levitsky, S | 1 |
| Mullin, EM | 1 |
| Sloane, RE | 1 |
| Morrow, AG | 1 |
| Leon, AS | 1 |
| Abrams, WB | 1 |
| Kiesewetter, E | 1 |
| Gillmann, H | 1 |
| Salonen, IS | 1 |
| Räsänen, O | 1 |
| Hueber, EF | 1 |
6 reviews available for reserpine and Cardiovascular Stroke
| Article | Year |
|---|---|
[CARDIOVASCULAR SYNDROMES IN POLYCYTHEMIA VERA].
Topics: Anti-Bacterial Agents; Anticoagulants; Bloodletting; Cerebrovascular Disorders; Electrocardiography; | 1964 |
NEUROGENIC MULTIFOCAL DESTRUCTION OF MYOCARDIAL TISSUE (PATHOGENIC MECHANISM AND ITS PREVENTION).
Topics: Adrenal Cortex Hormones; Catecholamines; Epinephrine; Heart Diseases; Hypoxia; Myocardial Infarction | 1963 |
Elderly hypertensive patient. Epidemiologic review.
Topics: Adult; Age Factors; Aged; Cerebrovascular Disorders; Female; Humans; Hydrochlorothiazide; Hypertensi | 1978 |
The evolution of antihypertensive therapy.
Topics: Antihypertensive Agents; Bis-Trimethylammonium Compounds; Blood Pressure; Calcium Channel Blockers; | 1985 |
Effectiveness of drug therapy in hypertension: present status. A review.
Topics: Antihypertensive Agents; Cerebrovascular Disorders; Coronary Disease; Eye Diseases; Ganglionic Block | 1971 |
[Gastro-duodenal disorders in patients with cardiovascular diseases].
Topics: Adrenal Cortex Hormones; Animals; Arteriosclerosis; Cardiovascular Diseases; Cats; Cerebrovascular D | 1971 |
5 trials available for reserpine and Cardiovascular Stroke
| Article | Year |
|---|---|
[Current state of the treatment of arterial hypertension].
Topics: Adult; Aged; Cerebrovascular Disorders; Clinical Trials as Topic; Heart Failure; Humans; Hydralazine | 1980 |
[Use of strophathin and rausedil in the 1st days of uncomplicated myocardial infarct].
Topics: Aged; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Hemodynamics; Humans; Mi | 1979 |
Partial versus complete control of blood pressure in the prevention of hypertensive complications.
Topics: Atrial Fibrillation; Blood Pressure; Cardiovascular Diseases; Clinical Trials as Topic; Follow-Up St | 1975 |
The organization of a multi-centre randomized control therapeutic trial for mild to moderate hypertension.
Topics: Adult; Blood Pressure Determination; Clinical Trials as Topic; Female; Guanethidine; Humans; Hyperte | 1973 |
Appraisal of antihypertensive drug therapy.
Topics: Antihypertensive Agents; Arteriosclerosis; Clinical Trials as Topic; Coronary Disease; Diabetes Comp | 1974 |
49 other studies available for reserpine and Cardiovascular Stroke
| Article | Year |
|---|---|
Endothelin B-receptors and sympathetic activation: impact on ventricular arrhythmogenesis during acute myocardial infarction.
Topics: Action Potentials; Adrenal Glands; Adrenalectomy; Animals; Arrhythmias, Cardiac; Heart Ventricles; M | 2014 |
[Identification of risk factors (the method of logistic regression)].
Topics: Aged; Breast Neoplasms; Confidence Intervals; Female; Humans; Logistic Models; Male; Middle Aged; My | 2008 |
Chlorpromazine and reserpine prevention of myocardial damage by histamine and serotonin.
Topics: Chlorpromazine; Histamine; Myocardial Infarction; Myocardium; Reserpine; Serotonin | 1957 |
[Determination of the coronary index by means of various radioactive isotopes].
Topics: Coronary Disease; Iodine Isotopes; Myocardial Infarction; Radioisotopes; Radiometry; Reserpine; Rubi | 1962 |
CIRCULATING LEVELS OF CATECHOLAMINES IN ACUTE MYOCARDIAL INFARCTION AND ANGINA PECTORIS.
Topics: Acute Disease; Adrenalectomy; Angina Pectoris; Blood Chemical Analysis; Cardiovascular Diseases; Cat | 1963 |
PROLONGED CARDIOGENIC SHOCK. REPORT OF A CASE IN WHICH PREVIOUS PROLONGED THERAPY WITH A RESERPINE-LIKE DRUG MAY HAVE PLAYED A ROLE.
Topics: Humans; Hypertension; Metaraminol; Myocardial Infarction; Norepinephrine; Rauwolfia; Reserpine; Shoc | 1963 |
CARDIOGENIC SHOCK AS INFLUENCED BY RESERPINE.
Topics: Animals; Cardiovascular Diseases; Catecholamines; Dogs; Myocardial Infarction; Research; Reserpine; | 1964 |
BUNDLE-BRANCH BLOCK UNDER VOLUNTARY CONTROL.
Topics: Atropine; Bundle-Branch Block; Cardiac Conduction System Disease; Cardiomegaly; Carotid Sinus; Diagn | 1964 |
A CASE OF WOLFF-PARKINSON-WHITE SYNDROME COMPLICATED BY MYOCARDIAL INFARCTION.
Topics: Digoxin; Drug Therapy; Electrocardiography; Heart Block; Heart Conduction System; Humans; Myocardial | 1965 |
EFFECT OF NICOTINE ON CARDIAC NECROSIS INDUCED BY CORTICOSTEROID-ELECTROLYTE-STRESS.
Topics: Adrenal Cortex Hormones; Desoxycorticosterone; Dexamethasone; Humans; Mecamylamine; Myocardial Infar | 1965 |
Effect of reserpine upon the haemodynamic course of recovery following experimental myocardial infarction.
Topics: Animals; Blood Pressure; Cardiac Output; Disease Models, Animal; Dogs; Electrocardiography; Heart; H | 1980 |
Impaired beta-adrenergic stimulation in the uninvolved ventricle post-acute myocardial infarction: reversible defect due to excessive circulating catecholamine-induced decline in number and affinity of beta-receptors.
Topics: Adenylyl Cyclases; Animals; Catecholamines; Coronary Circulation; Female; Guinea Pigs; Isoproterenol | 1981 |
[Role of catecholamine in activating glycogenolysis in experimental myocardial infarct complicated by ventricular fibrillation].
Topics: Animals; Arrhythmias, Cardiac; Dogs; Epinephrine; Glycogen; Male; Myocardial Infarction; Myocardium; | 1982 |
The metabolic role of endogenous catecholamines in acute myocardial infarction: effects of reserpinization and of infused noradrenaline.
Topics: Adenosine Triphosphate; Animals; Catecholamines; Coronary Vessels; Glucose-6-Phosphate; Glucosephosp | 1983 |
Acute hypertensive crises.
Topics: Acute Disease; Adult; Aged; Clonidine; Diazoxide; Heart Block; Humans; Hypertension; Injections, Int | 1980 |
Endogenous catecholamines are not necessary for ischaemic preconditioning in the isolated perfused rat heart.
Topics: Animals; Catecholamines; L-Lactate Dehydrogenase; Male; Myocardial Infarction; Myocardial Ischemia; | 1995 |
Role of norepinephrine in ischemic preconditioning in rabbit myocardium.
Topics: Animals; Myocardial Infarction; Myocardial Ischemia; Norepinephrine; Phenylephrine; Rabbits; Reserpi | 1994 |
Ischemic preconditioning fails to limit infarct size in reserpinized rabbit myocardium. Implication of norepinephrine release in the preconditioning effect.
Topics: Animals; Blood Pressure; Female; Heart Rate; Male; Myocardial Infarction; Myocardial Stunning; Myoca | 1993 |
Effect of catecholamine depletion on myocardial infarct size in dogs: role of catecholamines in ischemic preconditioning.
Topics: Adrenergic Uptake Inhibitors; Animals; Collateral Circulation; Dogs; Female; Male; Myocardial Infarc | 1995 |
The possible role of adrenergic component in ischemic preconditioning.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Blood Pressure; Catecholamines; | 1997 |
[Catecholamine in the myocardium; a fluorescence histochemical study].
Topics: Animals; Atrioventricular Node; Cardiomegaly; Catecholamines; Dogs; Heart Atria; Heart Block; Heart | 1975 |
Treatment of mild hypertension. Preliminary results of a two-year feasibility trial.
Topics: Adult; Blood Pressure; Chlorthalidone; Death, Sudden; Humans; Hypertension; Male; Mass Screening; Mi | 1977 |
Reserpine therapy and shock in myocardial infarction.
Topics: Dextrans; Humans; Myocardial Infarction; Reserpine; Shock, Cardiogenic | 1977 |
[Effects of sympathetic block on post-infarction cardiac hypertrophy and their impact on myocardial contractility].
Topics: Animals; Autonomic Nerve Block; Cardiomegaly; Male; Myocardial Contraction; Myocardial Infarction; P | 1991 |
[Changes in metallothionein content of the heart and liver during acute myocardial infarction in rats].
Topics: Animals; Liver; Male; Metallothionein; Myocardial Infarction; Myocardium; Rats; Rats, Inbred Strains | 1989 |
Pharmacological interventions and myocardial infarct size in rat.
Topics: Animals; Imidazoles; Myocardial Infarction; Nitroblue Tetrazolium; Oxidoreductases; Propranolol; Rat | 1985 |
Results of treatment of hypertension.
Topics: Acute Kidney Injury; Antihypertensive Agents; Cardiovascular Diseases; Coronary Disease; Female; Hum | 1971 |
When a drug is the culprit.
Topics: Adult; Aged; Angina Pectoris; Arrhythmias, Cardiac; Clofibrate; Depression; Drug-Related Side Effect | 1973 |
Exercise electrocardiography: recognition of the ischemic response, false positive and negative patterns.
Topics: Action Potentials; Angina Pectoris; Arteriosclerosis; Chlorothiazide; Coronary Disease; Diagnostic E | 1974 |
[Neuro-humoral regulation of anaerobic formation of energy in the ischemic myocardium].
Topics: Animals; Catecholamines; Coronary Disease; Denervation; Dogs; Ethanolamines; Glucosyltransferases; G | 1968 |
Effect of cold on the cardiovascular system.
Topics: Angina Pectoris; Blood Pressure; Canada; Cardiac Output; Cardiovascular Diseases; Cardiovascular Phy | 1974 |
[Medical treatment of dissecting acute aortic aneurysm complicated with myocardial infarct].
Topics: Acute Disease; Aged; Aortic Aneurysm; Female; Guanethidine; Humans; Male; Middle Aged; Myocardial In | 1974 |
Answers to questions frequently asked about ECT.
Topics: Age Factors; Anesthesia, Intravenous; Brain Damage, Chronic; Brain Neoplasms; Depression; Electrocon | 1972 |
Hypertension: challenge in preventive medicine.
Topics: Aged; Aneurysm; Cardiovascular Diseases; Cerebral Hemorrhage; Cerebrovascular Disorders; Drug Therap | 1973 |
[Slowing down of the heart over a long period by reserpine . (Remote results in a series of cases of irreducible chronic cardiac insufficiency following myocardial infarct)].
Topics: Adult; Heart Failure; Humans; Middle Aged; Myocardial Infarction; Reserpine | 1965 |
Ventricular fibrillation and myocardial necrosis after transient ischemia. Effect of treatment with oxygen, procainamide, reserpine, and propranolol.
Topics: Animals; Coronary Disease; Dogs; Injections, Intra-Arterial; Injections, Intramuscular; Injections, | 1972 |
The reflex stimulation of catecholamine secretion during the acute stage of myocardial infarction in the dog.
Topics: Acetylcholine; Adrenal Medulla; Animals; Bradykinin; Bretylium Compounds; Chlorisondamine; Dogs; Epi | 1971 |
[The action of 2-amino-4-(isothioureyl methyl)-thiazol dihydrochloride (Agr 307) on the catecholamines of the central nervous system in the rat. Possible inhibition of dopamine beta-hydroxylase].
Topics: Animals; Brain; Catecholamines; Dopamine; Hypertension; Male; Mixed Function Oxygenases; Monoamine O | 1971 |
Experimental graded "pump failure" of the left ventricle.
Topics: Animals; Aorta, Thoracic; Blood Flow Velocity; Blood Pressure; Carbon Dioxide; Cardiac Output; Cardi | 1971 |
Unusually marked sinus arrhythmia as a complication of acute diaphragmatic myocardial infarction.
Topics: Acute Disease; Arrhythmia, Sinus; Diaphragm; Digitalis Glycosides; Electrocardiography; Guanethidine | 1969 |
Factors in acute hypotension and ventricular fibrillation after cardiac necrosis.
Topics: Animals; Atropine; Blood Pressure; Bradycardia; Catecholamines; Dogs; Dye Dilution Technique; Electr | 1967 |
[Increase of contractility of the intact portions of the myocardium in the course of acute focal ischemia of the left ventricle in the dog].
Topics: Animals; Blood Pressure; Dogs; Heart; Muscle Contraction; Myocardial Infarction; Propranolol; Reserp | 1970 |
Experimental evaluation of pentazocine: effect on myocardial contractility and peripheral vascular resistance.
Topics: Animals; Aorta; Blood Flow Velocity; Blood Pressure; Catecholamines; Coronary Vessels; Dogs; Heart; | 1971 |
The role of catecholamines in producing arrhythmias.
Topics: Anesthetics; Antidepressive Agents; Arrhythmias, Cardiac; Atropine; Catecholamines; Digitalis Glycos | 1971 |
[Physiopathological deliberations on the significance of long-term therapy for hypertension].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Chlorothiazide; Fem | 1967 |
[Is the prevention of myocardial infarct using reserpine also possible in man?].
Topics: Humans; Myocardial Infarction; Reserpine | 1968 |
[Myocardial infarction caused by reserpine treatment].
Topics: Adult; Humans; Male; Myocardial Infarction; Reserpine; Schizophrenia | 1968 |
Role of reflexes following myocardial necrobiosis.
Topics: Animals; Atropine; Collateral Circulation; Dogs; Femoral Artery; Hydrocarbons, Halogenated; Myocardi | 1965 |
[On combined therapy of hypertension and heart insufficiency. Advantages and disadvantages].
Topics: Arrhythmias, Cardiac; Chlorthalidone; Digitoxin; Drug Synergism; Heart Function Tests; Humans; Hyper | 1966 |