reserpine has been researched along with Cardiomegaly in 16 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study examined the effect of long-term administration of reserpine, an adrenergic blocking agent, on cardiac hypertrophy in animals with severe iron deficiency anaemia." | 3.66 | Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline. ( Carillo, SV; Rossi, MA, 1982) |
| "Reserpine treatment also produced stimulation of taurine influx with no effect on biosynthesis." | 1.26 | The effects of isoproterenol on taurine concentration in the rat heart. ( Chubb, J; Huxtable, R, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (75.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| BAUER, GE | 1 |
| MEERSON, FZ | 1 |
| ROZANOVA, LS | 1 |
| Rossi, MA | 1 |
| Carillo, SV | 1 |
| Donohoe, JA | 1 |
| Rosenfeldt, FL | 1 |
| Munsch, CM | 1 |
| Williams, JF | 1 |
| Mervaala, E | 1 |
| Müller, DN | 1 |
| Schmidt, F | 1 |
| Park, JK | 1 |
| Gross, V | 1 |
| Bader, M | 1 |
| Breu, V | 1 |
| Ganten, D | 1 |
| Haller, H | 1 |
| Luft, FC | 1 |
| Chen, H | 1 |
| Higashino, H | 1 |
| Maeda, K | 1 |
| Zhang, Z | 1 |
| Ohta, Y | 1 |
| Wang, Z | 1 |
| Su, DF | 1 |
| Yuan, WJ | 1 |
| Sole, MJ | 1 |
| Wurtman, RJ | 1 |
| Lo, CM | 1 |
| Kamble, AB | 1 |
| Sonnenblick, EH | 1 |
| Miyagishima, Y | 1 |
| Chubb, J | 1 |
| Huxtable, R | 1 |
| Manegold, C | 1 |
| Patzschke, U | 1 |
| Mill, JG | 1 |
| Leite, CM | 1 |
| Vassallo, DV | 1 |
| Lawrence, CB | 1 |
| Farquharson, C | 1 |
| Gilbert, JW | 1 |
| Berglund, E | 1 |
| Dahlgren, S | 1 |
| Ovenfors, CO | 1 |
| Barnes, R | 1 |
| Iwasaki, T | 1 |
| Poblete, PF | 1 |
| Kyle, MC | 1 |
| Pipberger, HV | 1 |
| Freis, ED | 1 |
| Cohen, J | 1 |
| Aroesty, JM | 1 |
| Rosenfeld, MG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT00005122] | 0 participants | Observational | 1958-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for reserpine and Cardiomegaly
| Article | Year |
|---|---|
Effect of treatment on morbidity in hypertension. Veterans Administration Cooperative Study on Antihypertensive Agents. Effect on the electrocardiogram.
Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Clinical Trials as Topi | 1973 |
15 other studies available for reserpine and Cardiomegaly
| Article | Year |
|---|---|
BUNDLE-BRANCH BLOCK UNDER VOLUNTARY CONTROL.
Topics: Atropine; Bundle-Branch Block; Cardiac Conduction System Disease; Cardiomegaly; Carotid Sinus; Diagn | 1964 |
[EFFECT OF CHANGES IN MEDIATOR METABOLISM ON THE DEVELOPMENT OF HEART HYPERTROPHY].
Topics: Aortic Coarctation; Aortic Valve Stenosis; Cardiomegaly; Catecholamines; Iproniazid; Monoamine Oxida | 1964 |
Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline.
Topics: Anemia, Hypochromic; Animals; Body Weight; Cardiomegaly; Male; Myocardium; Norepinephrine; Organ Siz | 1982 |
The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carbohydrate Metabo | 1993 |
Blood pressure-independent effects in rats with human renin and angiotensinogen genes.
Topics: Albuminuria; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Antihypertensi | 2000 |
Reduction of cardiac norepinephrine improves postischemic heart function in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Cardiac Output; Cardiomegaly; Coronary Circulation; Creatine Kinase; Heart Rate; Hemodynami | 2001 |
Tyrosine hydroxylase activity in the heart of the cardiomyopathic syrian hamster.
Topics: Animals; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Female; Heart Failure; | 1977 |
[Catecholamine in the myocardium; a fluorescence histochemical study].
Topics: Animals; Atrioventricular Node; Cardiomegaly; Catecholamines; Dogs; Heart Atria; Heart Block; Heart | 1975 |
The effects of isoproterenol on taurine concentration in the rat heart.
Topics: Amino Acids; Animals; Biological Transport; Cardiomegaly; Heart; Isoproterenol; Male; Myocardium; Ra | 1978 |
[Regression of left ventricular hypertophy in the ECG during antihypertensive treatment: preliminary observations (author's transl)].
Topics: Adult; Aged; Cardiomegaly; Chlorthalidone; Electrocardiography; Female; Humans; Hydralazine; Hyperte | 1979 |
[Effects of sympathetic block on post-infarction cardiac hypertrophy and their impact on myocardial contractility].
Topics: Animals; Autonomic Nerve Block; Cardiomegaly; Male; Myocardial Contraction; Myocardial Infarction; P | 1991 |
The effects of reserpine upon the cardiac enlargement of copper deficiency.
Topics: Age Factors; Animals; Body Weight; Cardiomegaly; Copper; Cytochrome c Group; Female; Myocardium; Nor | 1988 |
Experimental pulmonary hypertension in the dog. A preparation involving repeated air embolism.
Topics: Animals; Ascites; Blood Pressure; Cardiac Catheterization; Cardiomegaly; Dogs; Embolism, Air; Heart | 1968 |
Studies on the mechanism of cardiotonics with reference to cardiac glycoside, calcium ion and myocardial catecholamine in the canine heart.
Topics: Animals; Aortic Valve Insufficiency; Calcium; Cardiomegaly; Catecholamines; Dogs; Drug Synergism; El | 1968 |
Determinants of thyroxine-induced cardiac hypertrophy in mice.
Topics: Animals; Blood Circulation; Cardiomegaly; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; My | 1966 |