Page last updated: 2024-11-06

reserpine and Cardiomegaly

reserpine has been researched along with Cardiomegaly in 16 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Cardiomegaly: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Research Excerpts

ExcerptRelevanceReference
"This study examined the effect of long-term administration of reserpine, an adrenergic blocking agent, on cardiac hypertrophy in animals with severe iron deficiency anaemia."3.66Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline. ( Carillo, SV; Rossi, MA, 1982)
"Reserpine treatment also produced stimulation of taurine influx with no effect on biosynthesis."1.26The effects of isoproterenol on taurine concentration in the rat heart. ( Chubb, J; Huxtable, R, 1978)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-199012 (75.00)18.7374
1990's2 (12.50)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BAUER, GE1
MEERSON, FZ1
ROZANOVA, LS1
Rossi, MA1
Carillo, SV1
Donohoe, JA1
Rosenfeldt, FL1
Munsch, CM1
Williams, JF1
Mervaala, E1
Müller, DN1
Schmidt, F1
Park, JK1
Gross, V1
Bader, M1
Breu, V1
Ganten, D1
Haller, H1
Luft, FC1
Chen, H1
Higashino, H1
Maeda, K1
Zhang, Z1
Ohta, Y1
Wang, Z1
Su, DF1
Yuan, WJ1
Sole, MJ1
Wurtman, RJ1
Lo, CM1
Kamble, AB1
Sonnenblick, EH1
Miyagishima, Y1
Chubb, J1
Huxtable, R1
Manegold, C1
Patzschke, U1
Mill, JG1
Leite, CM1
Vassallo, DV1
Lawrence, CB1
Farquharson, C1
Gilbert, JW1
Berglund, E1
Dahlgren, S1
Ovenfors, CO1
Barnes, R1
Iwasaki, T1
Poblete, PF1
Kyle, MC1
Pipberger, HV1
Freis, ED1
Cohen, J1
Aroesty, JM1
Rosenfeld, MG1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
[NCT00005122]0 participants Observational1958-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

1 trial available for reserpine and Cardiomegaly

ArticleYear
Effect of treatment on morbidity in hypertension. Veterans Administration Cooperative Study on Antihypertensive Agents. Effect on the electrocardiogram.
    Circulation, 1973, Volume: 48, Issue:3

    Topics: Antihypertensive Agents; Arrhythmias, Cardiac; Blood Pressure; Cardiomegaly; Clinical Trials as Topi

1973

Other Studies

15 other studies available for reserpine and Cardiomegaly

ArticleYear
BUNDLE-BRANCH BLOCK UNDER VOLUNTARY CONTROL.
    British heart journal, 1964, Volume: 26

    Topics: Atropine; Bundle-Branch Block; Cardiac Conduction System Disease; Cardiomegaly; Carotid Sinus; Diagn

1964
[EFFECT OF CHANGES IN MEDIATOR METABOLISM ON THE DEVELOPMENT OF HEART HYPERTROPHY].
    Biulleten' eksperimental'noi biologii i meditsiny, 1964, Volume: 57

    Topics: Aortic Coarctation; Aortic Valve Stenosis; Cardiomegaly; Catecholamines; Iproniazid; Monoamine Oxida

1964
Pathogenesis of cardiac hypertrophy in iron deficiency anaemia: the role of noradrenaline.
    British journal of experimental pathology, 1982, Volume: 63, Issue:3

    Topics: Anemia, Hypochromic; Animals; Body Weight; Cardiomegaly; Male; Myocardium; Norepinephrine; Organ Siz

1982
The effect of orotic acid treatment on the energy and carbohydrate metabolism of the hypertrophying rat heart.
    The International journal of biochemistry, 1993, Volume: 25, Issue:2

    Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Carbohydrate Metabo

1993
Blood pressure-independent effects in rats with human renin and angiotensinogen genes.
    Hypertension (Dallas, Tex. : 1979), 2000, Volume: 35, Issue:2

    Topics: Albuminuria; Angiotensin II; Angiotensinogen; Animals; Animals, Genetically Modified; Antihypertensi

2000
Reduction of cardiac norepinephrine improves postischemic heart function in stroke-prone spontaneously hypertensive rats.
    Journal of cardiovascular pharmacology, 2001, Volume: 38, Issue:6

    Topics: Animals; Cardiac Output; Cardiomegaly; Coronary Circulation; Creatine Kinase; Heart Rate; Hemodynami

2001
Tyrosine hydroxylase activity in the heart of the cardiomyopathic syrian hamster.
    Journal of molecular and cellular cardiology, 1977, Volume: 9, Issue:3

    Topics: Animals; Cardiomegaly; Cardiomyopathies; Cricetinae; Disease Models, Animal; Female; Heart Failure;

1977
[Catecholamine in the myocardium; a fluorescence histochemical study].
    Japanese circulation journal, 1975, Volume: 39, Issue:3

    Topics: Animals; Atrioventricular Node; Cardiomegaly; Catecholamines; Dogs; Heart Atria; Heart Block; Heart

1975
The effects of isoproterenol on taurine concentration in the rat heart.
    European journal of pharmacology, 1978, Apr-15, Volume: 48, Issue:4

    Topics: Amino Acids; Animals; Biological Transport; Cardiomegaly; Heart; Isoproterenol; Male; Myocardium; Ra

1978
[Regression of left ventricular hypertophy in the ECG during antihypertensive treatment: preliminary observations (author's transl)].
    Deutsche medizinische Wochenschrift (1946), 1979, Jun-08, Volume: 104, Issue:23

    Topics: Adult; Aged; Cardiomegaly; Chlorthalidone; Electrocardiography; Female; Humans; Hydralazine; Hyperte

1979
[Effects of sympathetic block on post-infarction cardiac hypertrophy and their impact on myocardial contractility].
    Arquivos brasileiros de cardiologia, 1991, Volume: 57, Issue:6

    Topics: Animals; Autonomic Nerve Block; Cardiomegaly; Male; Myocardial Contraction; Myocardial Infarction; P

1991
The effects of reserpine upon the cardiac enlargement of copper deficiency.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 189, Issue:2

    Topics: Age Factors; Animals; Body Weight; Cardiomegaly; Copper; Cytochrome c Group; Female; Myocardium; Nor

1988
Experimental pulmonary hypertension in the dog. A preparation involving repeated air embolism.
    The Journal of thoracic and cardiovascular surgery, 1968, Volume: 55, Issue:4

    Topics: Animals; Ascites; Blood Pressure; Cardiac Catheterization; Cardiomegaly; Dogs; Embolism, Air; Heart

1968
Studies on the mechanism of cardiotonics with reference to cardiac glycoside, calcium ion and myocardial catecholamine in the canine heart.
    Japanese circulation journal, 1968, Volume: 32, Issue:9

    Topics: Animals; Aortic Valve Insufficiency; Calcium; Cardiomegaly; Catecholamines; Dogs; Drug Synergism; El

1968
Determinants of thyroxine-induced cardiac hypertrophy in mice.
    Circulation research, 1966, Volume: 18, Issue:4

    Topics: Animals; Blood Circulation; Cardiomegaly; Injections, Subcutaneous; Male; Mice; Mice, Inbred ICR; My

1966