reserpine has been researched along with Bradykinesia in 7 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The extract at both the doses displayed a significant reduction in postural flexion, moderate decrease in tremor, muscular rigidity and postural immobility scores but do not exhibit significant lowering of hypokinesia score in reserpine induced Parkinsonian model." | 4.12 | Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates. ( Kadiri, SK; Karkar, VV; Pal Roy, S; Rao Konijeti, S, 2022) |
| "The mechanism underlying hypokinesia induction is not known, but depletion of monoamines induces behavior resembling venom-induced hypokinesia." | 1.38 | Biogenic amines in the nervous system of the cockroach, Periplaneta americana following envenomation by the jewel wasp, Ampulex compressa. ( Adams, ME; Banks, CN, 2012) |
| "In reserpine-treated rats, unilateral injection of L-SOP (2000 and 2500 nmol in 2." | 1.32 | Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat. ( Duty, S; MacInnes, N; Messenger, MJ, 2004) |
| "Ropinirole was weakly neuroprotective in this model." | 1.32 | S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole. ( Brocco, M; Brotchie, J; Crossman, A; Di Cara, B; Gobert, A; Hill, M; Jackson, M; Jenner, P; Joyce, JN; McGuire, S; Millan, MJ; Peglion, JL; Smith, L, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Pal Roy, S | 1 |
| Kadiri, SK | 1 |
| Karkar, VV | 1 |
| Rao Konijeti, S | 1 |
| Banks, CN | 1 |
| Adams, ME | 1 |
| Sutton, AC | 1 |
| Yu, W | 1 |
| Calos, ME | 1 |
| Smith, AB | 1 |
| Ramirez-Zamora, A | 1 |
| Molho, ES | 1 |
| Pilitsis, JG | 1 |
| Brotchie, JM | 1 |
| Shin, DS | 1 |
| Johnston, T | 1 |
| Duty, S | 2 |
| MacInnes, N | 1 |
| Messenger, MJ | 1 |
| Millan, MJ | 1 |
| Di Cara, B | 1 |
| Hill, M | 1 |
| Jackson, M | 1 |
| Joyce, JN | 1 |
| Brotchie, J | 1 |
| McGuire, S | 1 |
| Crossman, A | 1 |
| Smith, L | 1 |
| Jenner, P | 1 |
| Gobert, A | 1 |
| Peglion, JL | 1 |
| Brocco, M | 1 |
| Shiozaki, S | 1 |
| Ichikawa, S | 1 |
| Nakamura, J | 1 |
| Kitamura, S | 1 |
| Yamada, K | 1 |
| Kuwana, Y | 1 |
7 other studies available for reserpine and Bradykinesia
| Article | Year |
|---|---|
Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adjuvants, Immunologic; Animals; Antioxidants; Antipar | 2022 |
Biogenic amines in the nervous system of the cockroach, Periplaneta americana following envenomation by the jewel wasp, Ampulex compressa.
Topics: Animals; Biogenic Amines; Central Nervous System; Chromatography, High Pressure Liquid; Dopamine; Ho | 2012 |
Deep brain stimulation of the substantia nigra pars reticulata improves forelimb akinesia in the hemiparkinsonian rat.
Topics: Animals; Antipsychotic Agents; Beta Rhythm; Deep Brain Stimulation; Forelimb; Hypokinesia; Male; Oxi | 2013 |
GABA(B) receptor agonists reverse akinesia following intranigral or intracerebroventricular injection in the reserpine-treated rat.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; GABA-B Recepto | 2003 |
Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat.
Topics: Aminobutyrates; Animals; Cerebral Ventricles; Dose-Response Relationship, Drug; Globus Pallidus; Glu | 2004 |
S32504, a novel naphtoxazine agonist at dopamine D3/D2 receptors: II. Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole.
Topics: Acetylcholine; Animals; Callithrix; Cells, Cultured; Disease Models, Animal; Dopamine Agonists; Dopa | 2004 |
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adenosine; Animals; Antiparkinson Agents; Antipsychoti | 1999 |