reserpine has been researched along with Bipolar Disorder in 43 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A case is reported in which abrupt cessation of long term reserpine therapy for hypertension was followed by hallucinations and mania." | 3.66 | Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors. ( Kent, TA; Wilber, RD, 1982) |
| " A beneficial response was noted in most patients when reserpine was substituted for their currently prescribed standard neuroleptic; in some cases lithium dosage could then be reduced." | 1.26 | Lithium plus reserpine in refractory manic patients. ( Bacher, NM; Lewis, HA, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 42 (97.67) | 18.7374 |
| 1990's | 1 (2.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| LOEWE, S | 1 |
| STURTEVANT, FM | 1 |
| DRILL, VA | 1 |
| LAMBERT, PA | 1 |
| TOULET, M | 1 |
| DIEDERICHS, A | 1 |
| LEMONNIER, J | 1 |
| MAUREL, H | 1 |
| SPIELMANN, JP | 1 |
| WATT, DC | 1 |
| NAHUNEK, K | 1 |
| BARTOVA, D | 1 |
| FROGEL, M | 1 |
| GONZALEZ, JR | 1 |
| IMAHARA, JK | 1 |
| WEIDTMANN, W | 1 |
| LANTER, R | 1 |
| HEINRICH, JP | 1 |
| Johnson, JM | 1 |
| Anokhina, IP | 1 |
| Gamaleia, NB | 1 |
| Post, RM | 1 |
| Uhde, TW | 1 |
| Reches, A | 1 |
| Hassan, MN | 1 |
| Jackson, V | 1 |
| Fahn, S | 1 |
| Kent, TA | 1 |
| Wilber, RD | 1 |
| Lesch, KP | 1 |
| Gross, J | 1 |
| Wolozin, BL | 1 |
| Franzek, E | 1 |
| Bengel, D | 1 |
| Riederer, P | 1 |
| Murphy, DL | 2 |
| Leonard, BE | 1 |
| Lingjaerde, O | 1 |
| Luchins, D | 1 |
| Bacher, NM | 2 |
| Lewis, HA | 1 |
| Mikhalenko, IN | 1 |
| Kiseleva, LP | 1 |
| Lapin, IP | 1 |
| Arbuthnott, GW | 1 |
| Murray, LG | 1 |
| Stasiek, C | 1 |
| Zetin, M | 1 |
| Berlant, JL | 1 |
| Telner, JI | 1 |
| Lapierre, YD | 1 |
| Horn, E | 1 |
| Browne, M | 1 |
| Renwart, N | 1 |
| Frances, H | 1 |
| Simon, P | 1 |
| Schildkraut, JJ | 1 |
| Schanberg, SM | 1 |
| Breese, GR | 1 |
| Kopin, IJ | 1 |
| Dhasmana, KM | 1 |
| Dixit, KS | 1 |
| Jaju, BP | 1 |
| Gupta, ML | 1 |
| Shader, RI | 1 |
| King, DJ | 1 |
| Tissot, R | 1 |
| Haskovec, L | 1 |
| Rysánek, K | 2 |
| Stancer, HC | 1 |
| Quarrington, B | 1 |
| Cookson, BA | 1 |
| Brown, GM | 1 |
| Bonkalo, A | 1 |
| Lyall, WA | 1 |
| Davis, JM | 1 |
| Goodwin, FK | 1 |
| Brodie, HK | 1 |
| Bunney, WE | 1 |
| Fracchia, J | 1 |
| Sheppard, C | 1 |
| Merlis, S | 1 |
| Fischer, E | 1 |
| Spatz, H | 1 |
| Heller, B | 1 |
| Reggiani, H | 1 |
| Mashkovskii, MD | 1 |
| Polezhaeva, AI | 1 |
| Avrutskii, GIa | 1 |
| Vertozgadova, OP | 1 |
| Smulevich, AB | 1 |
| Lewis, WH | 1 |
| Varga, E | 1 |
| Haits, G | 1 |
| Rosenblatt, S | 1 |
| Chanley, JD | 1 |
| Leighton, WP | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cerebral Neuroinflammation During Major Depressive Episode: Multicentric Comparative Study.[NCT03314155] | 60 participants (Anticipated) | Interventional | 2018-12-07 | Recruiting | |||
| Cognitive Changes After Surgery in the Elderly: Does Minimally Invasive Surgery Influence the Incidence of Postoperative Cognitive Changes Compared to Open Colon Surgery?[NCT01623297] | 52 participants (Anticipated) | Observational | 2012-01-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for reserpine and Bipolar Disorder
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Neurochemical and neuropharmacological aspects of depression.
Topics: Addison Disease; Adrenal Cortex Hormones; Amphetamines; Animals; Antidepressive Agents, Tricyclic; B | 1975 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
[Monoamines and manic-depressive syndromes].
Topics: Amines; Animals; Bipolar Disorder; Brain Chemistry; Cats; Dogs; Epinephrine; Humans; Hydroxyindoleac | 1967 |
[Relation of monoamines to mental disorders].
Topics: Amines; Animals; Bipolar Disorder; Catecholamines; Central Nervous System; Depression; Dihydroxyphen | 1970 |
Theories of biological etiology of affective disorders.
Topics: Adrenal Cortex Hormones; Affective Symptoms; Amines; Amphetamine; Antidepressive Agents; Bipolar Dis | 1970 |
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho | 1970 |
6 trials available for reserpine and Bipolar Disorder
| Article | Year |
|---|---|
Psychiatric uses of antiadrenergic and adrenergic blocking drugs.
Topics: Adult; Alcohol Amnestic Disorder; Antipsychotic Agents; Bipolar Disorder; Clinical Trials as Topic; | 1984 |
Biogenic amines and affective disorders. A critical analysis.
Topics: 5-Hydroxytryptophan; Affective Symptoms; Antidepressive Agents, Tricyclic; Biogenic Amines; Bipolar | 1976 |
The action of reserpine in imipramine-resistant depressive patients. Clinical and biochemical study.
Topics: Adult; Bipolar Disorder; Blood Pressure; Body Temperature; Clinical Trials as Topic; Depression; Dru | 1967 |
A longitudinal drug study and central amines.
Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Bipolar Disorder; Blood Pressure; Body Tempe | 1969 |
L-DOPA, catecholamines, and behavior: a clinical and biochemical study in depressed patients.
Topics: Aged; Aggression; Anger; Behavior; Bipolar Disorder; Brain; Brain Chemistry; Carboxy-Lyases; Catecho | 1970 |
Combination medications in psychiatric treatment: patterns in a group of elderly hospital patients.
Topics: Age Factors; Aged; Amitriptyline; Antidepressive Agents; Antihypertensive Agents; Antisocial Persona | 1971 |
33 other studies available for reserpine and Bipolar Disorder
| Article | Year |
|---|---|
Influence of chlorpromazine, reserpine, dibenzyline and desoxycorticosterone upon morphine-induced feline mania.
Topics: Animals; Bipolar Disorder; Cats; Chlorpromazine; Desoxycorticosterone; Mental Disorders; Morphine; P | 1956 |
Tranquilizing drugs and morphine-mania in cats.
Topics: Animals; Bipolar Disorder; Cats; Chlorpromazine; Morphine; Reserpine; Tranquilizing Agents | 1957 |
[24 Chronic mental patients treated successively with prolonged chlorpromazine therapy followed by reserpine; comparative results; superior effect of reserpine in hypomanic syndromes].
Topics: Bipolar Disorder; Chlorpromazine; Cyclothymic Disorder; Mental Disorders; Mentally Ill Persons; Psyc | 1957 |
[Severe chronic types of mania treated with reserpine; periodic recurrence in 2 of the cases].
Topics: Bipolar Disorder; Electroconvulsive Therapy; Psychotic Disorders; Reserpine | 1958 |
The effect of reserpine on the duration of manic attacks.
Topics: Bipolar Disorder; Humans; Mental Disorders; Psychotic Disorders; Reserpine; Social Behavior | 1958 |
[ON THE USE OF A COMBINATION OF RESERPINE AND TRIHEXYLPHENIDYL IN ENDOGENOUS DEPRESSIVE STATES].
Topics: Bipolar Disorder; Depressive Disorder; Humans; Mental Disorders; Psychotic Disorders; Reserpine; Tri | 1963 |
[EFFECT OF DRUG THERAPY ON REHOSPITALIZATIONS AT THE BEL AIR CLINIC OF PATIENTS WITH CHRONIC PSYCHOSES EXCEPT MANIC-DEPRESSIVE PSYCHOSES].
Topics: Bipolar Disorder; Chlorpromazine; Chlorprothixene; Convulsive Therapy; Drug Therapy; Haloperidol; Ho | 1964 |
ELECTROSHOCK THERAPY WITH THE PHENOTHIAZINES AND RESERPINE: A SURVEY AND REPORT.
Topics: Adolescent; Bipolar Disorder; Black People; Chlorpromazine; Depressive Disorder, Major; Drug Therapy | 1964 |
[SOMATOTHERAPY OF ENDOGENOUS PSYCHOSES AT MARBURG UNIVERSITY NEUROLOGIC CLINIC].
Topics: Bipolar Disorder; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Convulsive Therapy; Depression; | 1964 |
[Treatment of maniacal states by reserpine-thiopropemazine (RP-7843) association].
Topics: Bipolar Disorder; Psychosurgery; Psychotic Disorders; Reserpine; Tranquilizing Agents | 1960 |
[Current biochemical conceptions of mental diseases. II. Role of changes in the biogenic amine system in the pathogenesis of affective disorders].
Topics: 3-Methoxy-4-hydroxyphenylethanol; Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; | 1980 |
Biological relationships between mania and melancholia.
Topics: Affective Disorders, Psychotic; Antidepressive Agents, Tricyclic; Bipolar Disorder; Carbamazepine; D | 1982 |
Lithium interferes with reserpine-induced dopamine depletion.
Topics: Adult; Animals; Bipolar Disorder; Corpus Striatum; Dopamine; Dopamine Antagonists; Dyskinesia, Drug- | 1983 |
Reserpine withdrawal psychosis: the possible role of denervation supersensitivity of receptors.
Topics: Affective Disorders, Psychotic; Aged; Basal Ganglia; Bipolar Disorder; Dopamine; Female; Hallucinati | 1982 |
Direct sequencing of the reserpine-sensitive vesicular monamine transporter complementary DNA in unipolar depression and manic depressive illness.
Topics: Adult; Aged; Base Sequence; Bipolar Disorder; Blood Platelets; Depressive Disorder; DNA, Complementa | 1994 |
[The role of serotonin in affective disorders (author's transl)].
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Brain; Depression; Humans; Hydroxyindoleacetic A | 1979 |
Lithium plus reserpine in refractory manic patients.
Topics: Adult; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; Lithiu | 1979 |
[Absecence of the antidepressant action of lithium under clinical and experimental conditions].
Topics: 5-Hydroxytryptophan; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Drug Interaction | 1976 |
Dopamine receptor agonists in psychiatric disease.
Topics: Bipolar Disorder; Dopamine; Humans; Parkinson Disease, Secondary; Piperazines; Piribedil; Receptors, | 1975 |
Organic manic disorders.
Topics: Adrenal Cortex Hormones; Adult; Antidepressive Agents, Tricyclic; Bipolar Disorder; Bronchodilator A | 1985 |
Neuroleptics and reserpine in refractory psychoses.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Drug Resistance; Drug Therapy, Combination; Fem | 1986 |
Atypical neuroleptics in mania.
Topics: Bipolar Disorder; Humans; Pimozide; Reserpine | 1988 |
Rapid reduction of mania by means of reserpine therapy.
Topics: Adult; Aged; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Psychot | 1986 |
The calcium entry blockers: anti-manic drugs?
Topics: Amphetamines; Animals; Bipolar Disorder; Calcium Channel Blockers; Diltiazem; Hyperkinesis; Male; Mi | 1986 |
Norepinephrine metabolism and drugs used in the affective disorders: a possible mechanism of action.
Topics: Animals; Antidepressive Agents; Bipolar Disorder; Brain; Central Nervous System Stimulants; Chlorpro | 1967 |
Role of central dopaminergic receptors in manic response of cats to morphine.
Topics: Animals; Atropine; Bipolar Disorder; Cats; Central Nervous System; Chlorpromazine; Dopamine; Drug An | 1972 |
The concept and phenomenology of depression, with special reference to the aged. Discussion.
Topics: Adult; Aged; Animals; Behavior, Animal; Biogenic Amines; Bipolar Disorder; Brain Chemistry; Depressi | 1974 |
Plasma cortisol-binding capacity in mental illness.
Topics: Adult; Anxiety; Binding Sites; Bipolar Disorder; Chlorpromazine; Chromatography, Gel; Depression; Di | 1973 |
Phenethylamine content of human urine and rat brain, its alterations in pathological conditions and after drug administration.
Topics: Adjustment Disorders; Animals; Antidepressive Agents; Bipolar Disorder; Brain Chemistry; Dementia; D | 1972 |
[The pharmacologic properties and therapeutic effectiveness of the new antidepressant preparation Azaphen].
Topics: Adult; Aged; Amphetamine; Animals; Antidepressive Agents; Bipolar Disorder; Cats; Depression; Depres | 1969 |
Iatrogenic psychotic depressive reaction in hypertensive patients.
Topics: Aged; Bipolar Disorder; Diuretics; Humans; Hypertension; Hyponatremia; Iatrogenic Disease; Imipramin | 1971 |
Therapeutic efficacy and the treatment of psychoses over the last three decades.
Topics: Adult; Bipolar Disorder; Convulsive Therapy; Electroconvulsive Therapy; Female; Humans; Imipramine; | 1968 |
The investigation of adrenergic metabolism with 7H3-norepinephrine in psychiatric disorders. I. Temporal changes in the distribution of urinary tritiated metabolites and the effects of drugs.
Topics: Amines; Bipolar Disorder; Chlorpromazine; Humans; Hydrogen-Ion Concentration; Injections, Intravenou | 1969 |