reserpine has been researched along with Alloxan Diabetes in 16 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have compared the effects of the angiotensin converting enzyme inhibitor, perindopril, and a conventional antihypertensive regimen (triple therapy: hydralazine, reserpine and hydrochlorothiazide) on kidney function and albuminuria in hypertensive diabetic rats." | 3.68 | Antihypertensive therapy in a model combining spontaneous hypertension with diabetes. ( Allen, TJ; Cooper, ME; Doyle, AE; Jerums, G; O'Brien, RC; Rumble, JR, 1992) |
| "Also in a rat model of NIDDM, neonatally streptozotocin diabetic rats (STZ), the insulin response to glucose is profoundly suppressed when studied in vivo or in the perfused pancreas." | 1.29 | Release of catecholamines is increased but does not contribute to the impaired insulin secretion in the perfused pancreata of diabetic rats. ( Efendic, S; Hjemdahl, P; Ostenson, CG, 1993) |
| "Perindopril was associated with significantly lower AER than lacidipine, whereas lacidipine was more potent in preventing increases in ocular AVC." | 1.29 | Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat. ( Cooper, M; Gin, T; Jerums, G; Joon, TL; Panagiotopoulos, S; Taylor, H, 1996) |
| "Reserpine or tyramine treatment resulted in depletion of endogenous cardiac NE in control and diabetic rats." | 1.27 | Norepinephrine storage, distribution, and release in diabetic cardiomyopathy. ( Beamish, RE; Dhalla, KS; Dhalla, NS; Ganguly, PK; Innes, IR, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (50.00) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 1 (6.25) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Soliman, E | 1 |
| Essmat, N | 1 |
| Mahmoud, MF | 1 |
| Mahmoud, AAA | 1 |
| Sakano, D | 1 |
| Shiraki, N | 1 |
| Kikawa, K | 1 |
| Yamazoe, T | 1 |
| Kataoka, M | 1 |
| Umeda, K | 1 |
| Araki, K | 1 |
| Mao, D | 1 |
| Matsumoto, S | 1 |
| Nakagata, N | 1 |
| Andersson, O | 1 |
| Stainier, D | 1 |
| Endo, F | 1 |
| Kume, K | 1 |
| Uesugi, M | 1 |
| Kume, S | 1 |
| BRODY, MJ | 1 |
| DIXON, RL | 1 |
| Singal, A | 1 |
| Tirkey, N | 1 |
| Muragundla, A | 1 |
| Chopra, K | 1 |
| Jori, A | 1 |
| Bianchetti, A | 1 |
| Ostenson, CG | 1 |
| Hjemdahl, P | 1 |
| Efendic, S | 1 |
| O'Brien, RC | 2 |
| Cooper, ME | 2 |
| Jerums, G | 3 |
| Doyle, AE | 2 |
| Gin, T | 1 |
| Joon, TL | 1 |
| Panagiotopoulos, S | 1 |
| Cooper, M | 1 |
| Taylor, H | 1 |
| Tang, Z | 1 |
| Shou, I | 1 |
| Wang, LN | 1 |
| Fukui, M | 1 |
| Tomino, Y | 1 |
| Rumble, JR | 1 |
| Allen, TJ | 1 |
| Angel, I | 1 |
| Bidet, S | 1 |
| Langer, SZ | 1 |
| Ganguly, PK | 1 |
| Beamish, RE | 1 |
| Dhalla, KS | 1 |
| Innes, IR | 1 |
| Dhalla, NS | 1 |
| Verghease, S | 1 |
| Saraswathy, DK | 1 |
| Mäkeläinen, A | 1 |
| Nikki, P | 1 |
| Vapaatalo, H | 1 |
| Wiśniewski, K | 1 |
| Richter, W | 1 |
16 other studies available for reserpine and Alloxan Diabetes
| Article | Year |
|---|---|
Impact of some oral hypoglycemic agents on type 2 diabetes-associated depression and reserpine-induced depression in rats: the role of brain oxidative stress and inflammation.
Topics: Administration, Oral; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Antidepressive Agent | 2020 |
VMAT2 identified as a regulator of late-stage β-cell differentiation.
Topics: Adrenergic Uptake Inhibitors; Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Embryo | 2014 |
VASCULAR REACTIVITY IN EXPERIMENTAL DIABETES MELLITUS.
Topics: Angiotensins; Animals; Arginine Vasopressin; Blood Pressure; Catecholamines; Diabetes Mellitus, Expe | 1964 |
Green tea [Camellia sinensis (L.) O. Kuntze] extract reverses the despair behaviour in reserpinised and diabetic mice.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Camellia sinensis; Diabetes Mellitus, Experimental | 2006 |
Effect of benzyloxyguanidine (13958 RP) on the increase of blood glucose and plasma free fatty acids induced by various drugs in rats.
Topics: Animals; Blood Glucose; Body Temperature; Chlorpromazine; Diabetes Mellitus, Experimental; Diazoxide | 1967 |
Release of catecholamines is increased but does not contribute to the impaired insulin secretion in the perfused pancreata of diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Epinephrine; Female; Glucose; I | 1993 |
The effects of perindopril and triple therapy in a normotensive model of diabetic nephropathy.
Topics: Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressu | 1993 |
Organ specificity of antihypertensive therapy on ocular albumin vascular clearance and albuminuria in the hypertensive diabetic rat.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Press | 1996 |
Effects of antihypertensive drugs or glycemic control on antioxidant enzyme activities in spontaneously hypertensive rats with diabetes.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Glucose; Captopril; Catalase; Diabetes Mellitu | 1997 |
Antihypertensive therapy in a model combining spontaneous hypertension with diabetes.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Gluco | 1992 |
Pharmacological characterization of the hyperglycemia induced by alpha-2 adrenoceptor agonists.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; alpha-Methyltyrosine; Animals; Benzylamines; Blood Glucose | 1988 |
Norepinephrine storage, distribution, and release in diabetic cardiomyopathy.
Topics: Animals; Cardiomyopathies; Diabetes Mellitus, Experimental; Half-Life; Insulin; Male; Myocardium; No | 1987 |
Effect of serpasil on glycoprotein metabolism in deoxycorticoid acetate and salt administered alloxan diabetic rats.
Topics: Animals; Desoxycorticosterone; Diabetes Mellitus, Experimental; Glycoproteins; Male; Rats; Rats, Inb | 1986 |
Halothane-induced lipolysis in rats.
Topics: Adrenal Medulla; Anesthesia; Animals; Blood Glucose; Body Temperature; Carbohydrate Metabolism; Diab | 1973 |
[The studies on "nonspecific transport effect" of insulin].
Topics: Adenosine Triphosphatases; Animals; Biological Transport; Brain Chemistry; Cell Membrane Permeabilit | 1968 |
Increased vascular permeability in mice induced by dextran. A comparison with the anaphylactoid reaction in rats.
Topics: Animals; Blood Glucose; Cardiovascular System; Dextrans; Diabetes Mellitus, Experimental; Histamine; | 1969 |