Page last updated: 2024-11-06

reserpine and Aging

reserpine has been researched along with Aging in 106 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."7.68The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
"In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)."7.67Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987)
"These suggest that the RES rat model of parkinsonism can be useful in improving our knowledge on the effect of aging on neurodegeneration."5.72Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. ( Bispo, JMM; Franco, HS; Gois, AM; Lins, LCRF; Marchioro, M; Melo, JEC; Mendonça, MS; Monteiro, MCN; Ribeiro, AM; Santos, JR; Santos, RS; Santos, TFO; Silva, RH, 2022)
"Epidermal growth factor (EGF) is one of the ErbB receptor ligands implicated in schizophrenia neuropathology as well as in dopaminergic development."3.77Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF. ( Aizawa, M; Iwakura, Y; Mizuno, M; Namba, H; Nawa, H; Shcherbakova, K; Sotoyama, H; Wang, R; Zheng, Y, 2011)
"In order to investigate the age-related changes in dopaminergic activity in rats, we have utilized the K(+)- and veratridine-stimulated [14C]dopamine release from striatum in vitro as a functional index of responsiveness to these stimuli in aging."3.69Restriction and functional changes of dopamine release in rat striatum from young adult and old rats. ( Andreas, K; Bergsträsser, E; Dobrev, D; Fischer, HD, 1995)
"This study was designed to determine the effect of neonatally-produced hypothyroidism on reserpine-elicited tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (D beta H) induction in the superior cervical ganglion (SCG) in rats."3.68Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats. ( Blouquit, MF; Chami, N; de Lonlay, A; Edwards, DA; Gripois, D; Valens, M, 1991)
" To determine if mechanisms that regulate gene expression are altered by aging, the effects of reserpine on induction of TH mRNA and TH activity were compared in another group of rats aged 2, 12 and 27 months."3.68Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine. ( Armbrecht, HJ; Hale, C; Moore, MA; Richardson, A; Strong, R; Wessels-Reiker, M, 1990)
"The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0."3.68The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991)
"In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)."3.67Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987)
"These suggest that the RES rat model of parkinsonism can be useful in improving our knowledge on the effect of aging on neurodegeneration."1.72Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. ( Bispo, JMM; Franco, HS; Gois, AM; Lins, LCRF; Marchioro, M; Melo, JEC; Mendonça, MS; Monteiro, MCN; Ribeiro, AM; Santos, JR; Santos, RS; Santos, TFO; Silva, RH, 2022)
"Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal."1.51Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019)
"Reserpine treatment significantly reduced total wheel-running activity and the monoamine levels in the hypothalamus, striatum and pons/medulla."1.29Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters. ( Penev, PD; Turek, FW; Zee, PC, 1993)
"Reserpine which promotes catecholamine release from the tissues, leads to the diminution of the rate of the MR of the shudder type in rats of the same age."1.27[Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period]. ( Praznikov, VP, 1984)
"Bromocriptine did not produce this behavior when administered alone."1.27Effects of age on behavioral responses to dopamine agonists in the rat. ( Hara, T; Kishimoto, O; Mizuki, Y; Soeda, K; Ushijima, I; Yamada, M, 1987)
"Reserpine treatment moderately increases the number of immunostainable LHRH cells, while ovariectomy is ineffective in this respect."1.26Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats. ( Horváth, J; Lengvári, I; Merchenthaler, I; Sétáló, G, 1980)
"The patterns in development of the two seizure types differ greatly in detail, further supporting the previously advanced inference that they represent neurological events that differ in kind rather than merely quantitatively."1.26Changes in CNS responses to high pressure during maturation of newborn mice. ( Brauer, RW; Gillen, HW; Mansfield, W; Nash, K, 1980)
"Using breast carcinoma in women as an example, it is shown that a carcinogenic effect cannot be demonstrated for two of the supposed carcinogenic factors, namely repeated diagnostic radiographic measures and administration of Rauwolfia-alkaloid containing drugs."1.25[Breast cancer in women as a paradigm for ageing as a hidden syncarcinogenic factor]. ( Fuchs, G; Oeser, H, 1975)

Research

Studies (106)

TimeframeStudies, this research(%)All Research%
pre-199073 (68.87)18.7374
1990's24 (22.64)18.2507
2000's4 (3.77)29.6817
2010's4 (3.77)24.3611
2020's1 (0.94)2.80

Authors

AuthorsStudies
Melo, JEC1
Santos, TFO1
Santos, RS1
Franco, HS1
Monteiro, MCN1
Bispo, JMM1
Mendonça, MS1
Ribeiro, AM1
Silva, RH2
Gois, AM1
Marchioro, M1
Lins, LCRF1
Santos, JR1
Roversi, K1
de David Antoniazzi, CT1
Milanesi, LH1
Rosa, HZ1
Kronbauer, M1
Rossato, DR1
Duarte, T1
Duarte, MM1
Burger, ME1
Tauffenberger, A1
Julien, C1
Parker, JA1
Sotoyama, H1
Zheng, Y1
Iwakura, Y1
Mizuno, M1
Aizawa, M1
Shcherbakova, K1
Wang, R1
Namba, H1
Nawa, H1
Saharia, K1
Arya, U1
Kumar, R1
Sahu, R1
Das, CK1
Gupta, K1
Dwivedi, H1
Subramaniam, JR1
DUBE, AH1
OSGOOD, CK1
NOTKIN, H1
FOUKS, L1
FREIS, ED2
COHEN, S1
LEONARD, CV1
FARBEROW, NL1
SHNEIDMAN, ES1
NUTTALL, FQ1
DOE, RP1
HECHT, K1
Abílio, VC1
Carvalho, RC1
Grassl, C1
Calzavara, MB1
Registro, S1
D'Almeida, V1
Ribeiro, Rde A1
Frussa-Filho, R1
Burger, M1
Fachinetto, R1
Calegari, L1
Paixão, MW1
Braga, AL1
Rocha, JB1
Lychkova, AE1
Burchinsky, SG1
Bareis, DL1
Slotkin, TA3
Ikeno, T1
Dickens, G1
Lloyd, T1
Guroff, G1
Praznikov, VP1
Ponzio, F1
Achilli, G1
Calderini, G1
Ferretti, P1
Perego, C1
Toffano, G1
Algeri, S1
Leff, SE1
Gariano, R1
Creese, I4
Merchenthaler, I1
Lengvári, I1
Horváth, J1
Sétáló, G1
Deguchi, T1
Goodrich, C1
Mansfield, W1
Brauer, RW1
Gillen, HW1
Nash, K1
Park, MK1
Sze, PY2
Dobrev, D1
Bergsträsser, E1
Fischer, HD1
Andreas, K1
Arnsten, AF2
Cai, JX2
Steere, JC1
Goldman-Rakic, PS2
Dose, JM1
Zolman, JF1
Murphy, BL1
Dopico, AM1
Zieher, LM1
Penev, PD2
Zee, PC2
Turek, FW2
Lechardeur, D1
Castel, MN1
Reibaud, M1
Scherman, D1
Laduron, PM1
Steinpreis, RE1
Salamone, JD1
Schwartz, JB3
Ahmed, NA1
Radwan, NM1
al-Zahaby, AS1
Abd el-Salam, MM1
Abete, P1
Testa, G1
Ferrara, N1
De Santis, D1
Capaccio, P1
Viati, L1
Calabrese, C1
Cacciatore, F1
Longobardi, G1
Condorelli, M1
Napoli, C1
Rengo, F1
Dörner, G2
Horita, A1
Janoff, AS1
Rosenberg, B1
Weiss, B2
Greenberg, L1
Cantor, E1
Greenberg, LH1
Consroe, P1
Picchioni, A1
Chin, L1
Baker, PC1
Hoff, KM1
Goodrich, CA1
Hinz, G1
Döcke, F1
Tönjes, R1
Da Prada, M1
Akimoto, M1
Okumura, S1
Kawai, H2
Bartolomé, J2
Lau, C1
Tissari, AH2
Raunu, EM1
Kellogg, C1
Oeser, H1
Fuchs, G1
Roffler-Tarlov, S1
Effendi, H1
Versprille, A1
Wise, ME1
Nieminen, L1
Möttönen, M1
Neckers, L1
Towle, AC1
Moody, CA1
Spear, LP1
Applegate, WB1
Bellavía, SL1
Sanz, EG1
Sereno, R1
Vermouth, NT1
Jahromi, SS1
Niesen, C1
Carlen, PL1
de Lonlay, A1
Blouquit, MF1
Valens, M1
Chami, N1
Edwards, DA1
Gripois, D1
Schmidlin, O2
Bharati, S1
Lev, M1
Strong, R1
Moore, MA1
Hale, C1
Wessels-Reiker, M1
Armbrecht, HJ1
Richardson, A1
de Avellar, MC1
Markus, RP1
Pellegrini, A2
Soldani, P2
Breschi, MC2
Martinotti, E1
Paparelli, A2
Yates, G1
Panksepp, J1
Ikemoto, S1
Nelson, E1
Conner, R1
Garcia, J1
Frolkis, VV1
Gorban, EN1
Moroz, EV1
Vlasova, D3
Borisova, I1
Kŭnchev, L3
Marks, RG1
Hale, WE1
Moore, MT1
May, FE1
Stewart, RB1
Borisov, I2
Partanen, M1
Waller, SB1
London, ED1
Hervonen, A1
Fine, MI1
Masserano, JM2
Weiner, N2
Ushijima, I1
Mizuki, Y1
Soeda, K1
Kishimoto, O2
Hara, T1
Yamada, M1
Harmon, JR1
Kimmel, GL1
Webb, PJ1
Delongchamp, RR1
Battaglia, G3
Norman, AB3
Vlk, J1
Disbrow, JK1
French, TA1
Ricciardi, MP1
Ito, H1
Kwan, CY1
Daniel, EE1
Rushkevich, IuE1
Finnen, MJ1
Hassall, KA1
Sket, D1
Pavlin, R1
Håkanson, R1
Larsson, LI1
Sundler, F1
Freeman, BM1
Manning, AC1
Pole, DS1
Mackay, AV1
Velkov, VA1
Matsunaga, R1
Hatotani, N1
Wegelius, U1
Schlesinger, K1
Uphouse, LL1
Mise, J1
Ragan, D1
Pillsbury, H1
Mathews, M1
Davidson, WJ1
Innes, IR1
Clemens, JA1
Amenomori, Y1
Jenkins, T1
Meites, J1
Kuttner, RE1
Lorincz, AB1
Sachs, C1
de Champlain, J1
Malmfors, T1
Olson, L1
Hinterberger, H1
Steele, RH1
Bartholomew, RJ1
Shibata, S1
Hattori, K1
Sakurai, I1
Mori, J1
Fujiwara, M1
Mueller, RA1
Shideman, FE2
Ignarro, LJ1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum[NCT02507206]Phase 2120 participants (Actual)Interventional2013-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for reserpine and Aging

ArticleYear
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
    Experimental gerontology, 1984, Volume: 19, Issue:4

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph

1984
Neuropharmacology and aging.
    Advances in experimental medicine and biology, 1978, Volume: 97

    Topics: Acetylcholine; Aging; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biogenic Amin

1978
Audiogenic seizure susceptible rats.
    Federation proceedings, 1979, Volume: 38, Issue:10

    Topics: Acoustic Stimulation; Aging; Aluminum Hydroxide; Animals; Anticonvulsants; Behavior, Animal; Brain;

1979
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
    Medical biology, 1975, Volume: 53, Issue:1

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami

1975
Systolic hypertension in older persons.
    Advances in internal medicine, 1992, Volume: 37

    Topics: Aged; Aging; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Double-Blind Method;

1992
Pyridoxine dependency and central nervous system excitability.
    Advances in biochemical psychopharmacology, 1972, Volume: 4

    Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric S

1972
Pulmonary hypertension.
    Japanese circulation journal, 1974, Volume: 38, Issue:12

    Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary;

1974

Trials

1 trial available for reserpine and Aging

ArticleYear
Systolic hypertension in older persons.
    Advances in internal medicine, 1992, Volume: 37

    Topics: Aged; Aging; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Double-Blind Method;

1992

Other Studies

99 other studies available for reserpine and Aging

ArticleYear
Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism.
    Journal of chemical neuroanatomy, 2022, Volume: 125

    Topics: Aging; Animals; Catalepsy; Disease Models, Animal; Dopamine; Male; Motor Activity; Motor Disorders;

2022
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
    Molecular neurobiology, 2019, Volume: 56, Issue:9

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi

2019
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
    Neurobiology of aging, 2013, Volume: 34, Issue:9

    Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot

2013
Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Aging; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Biomarkers; Catalepsy; Dis

2011
Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans.
    Experimental gerontology, 2012, Volume: 47, Issue:2

    Topics: Acetylcholine; Aging; Aldicarb; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antihypertensive

2012
The effects of an analeptic (ritalin), an ataraxic (reserpine), and a placebo in senile states.
    Journal of chronic diseases, 1957, Volume: 5, Issue:2

    Topics: Aged; Aging; Central Nervous System Stimulants; Disease; Mental Disorders; Methylphenidate; Reserpin

1957
[The psychoanaleptic action of Disipal in the neuroleptic syndrome and in senile depression].
    Acta neurologica et psychiatrica Belgica, 1961, Volume: 61

    Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Anxiety; Depression; Depressive Disorder; Huma

1961
OFFICE EVALUATION OF THE HYPERTENSIVE PATIENT. II.
    Modern concepts of cardiovascular disease, 1963, Volume: 32

    Topics: Aging; Blood Pressure; Blood Pressure Determination; Central Nervous System; Diuretics; Fundus Oculi

1963
TRANQUILIZERS AND SUICIDE IN THE SCHIZOPHRENIC PATIENT.
    Archives of general psychiatry, 1964, Volume: 11

    Topics: Aging; Alcoholism; Biomedical Research; Chlorpromazine; Drug Therapy; Marriage; Perphenazine; Prochl

1964
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION.
    Annals of internal medicine, 1964, Volume: 61

    Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe

1964
[The age-dependent effect of reserpine (0.1 mg/kg) on the course of conditioned reactions of the first and second order in rats].
    Acta biologica et medica Germanica, 1960, Volume: 4

    Topics: Aging; Animals; Conditioning, Classical; Nervous System Physiological Phenomena; Rats; Reflex; Reser

1960
Important role of striatal catalase in aging- and reserpine-induced oral dyskinesia.
    Neuropharmacology, 2004, Volume: 47, Issue:2

    Topics: Aging; Amitrole; Animals; Catalase; Dopamine Agonists; Dyskinesia, Drug-Induced; Enzyme Inhibitors;

2004
Effects of age on reserpine-induced orofacial dyskinesia and possible protection of diphenyl diselenide.
    Brain research bulletin, 2004, Dec-15, Volume: 64, Issue:4

    Topics: Age Factors; Aging; Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Benzene Derivativ

2004
Balance of activity of sympathetic, parasympathetic, and serotoninergic divisions of the autonomic nervous system in rabbits.
    Bulletin of experimental biology and medicine, 2005, Volume: 140, Issue:5

    Topics: Aging; Animals; Autonomic Nervous System; Bradycardia; Catecholamines; Heart; Muscles; Myocardium; R

2005
Maturation of sympathetic neurotransmission in the rat heart--III. Developmental changes in reserpine inhibition of norepinephrine uptake into isolated synaptic vesicles.
    Biochemical pharmacology, 1980, Jun-01, Volume: 29, Issue:11

    Topics: Aging; Animals; Body Weight; Heart; In Vitro Techniques; Norepinephrine; Organ Size; Rats; Reserpine

1980
The receptor-mediated activation of tyrosine hydroxylation in the superior cervical ganglion of the rat.
    Journal of neurochemistry, 1981, Volume: 36, Issue:5

    Topics: Aging; Animals; Bucladesine; Carbachol; Dopamine; Ganglia, Spinal; Hydroxylation; Kinetics; Pterins;

1981
[Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period].
    Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 98, Issue:9

    Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Levodopa; Motor Activity; Rats; Receptors, Adrener

1984
Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine.
    Neurobiology of aging, 1984,Summer, Volume: 5, Issue:2

    Topics: Aging; Animals; Biogenic Amines; Brain; Dopamine; Epinephrine; Male; Norepinephrine; Rats; Reserpine

1984
Dopamine receptor turnover rates in rat striatum are age-dependent.
    Proceedings of the National Academy of Sciences of the United States of America, 1984, Volume: 81, Issue:12

    Topics: Aging; Animals; Corpus Striatum; Cycloheximide; Kinetics; Male; Quinolines; Rats; Receptors, Dopamin

1984
Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats.
    Cell and tissue research, 1980, Volume: 209, Issue:3

    Topics: Aging; Animals; Axons; Brain; Castration; Female; Gonadotropin-Releasing Hormone; Immunoenzyme Techn

1980
Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat.
    Journal of neurochemistry, 1982, Volume: 38, Issue:3

    Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Circadian Rhyth

1982
Reserpine effects on body temperature in maturing mice.
    General pharmacology, 1982, Volume: 13, Issue:1

    Topics: Aging; Animals; Biogenic Amines; Body Temperature; Body Temperature Regulation; Brain; Ethanol; Mice

1982
Changes in CNS responses to high pressure during maturation of newborn mice.
    Journal of applied physiology: respiratory, environmental and exercise physiology, 1980, Volume: 49, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Female;

1980
Ouabain-induced inotropism of isolated newborn and adult rabbit myocardium.
    Developmental pharmacology and therapeutics, 1981, Volume: 2, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Heart; In Vitro Techniques; Myocardial Contr

1981
Developmental-regulatory aspects of brain tryptophan hydroxylase.
    Advances in experimental medicine and biology, 1981, Volume: 133

    Topics: Adrenalectomy; Aging; Animals; Brain; Corticosterone; Enzyme Induction; Glucocorticoids; Mesencephal

1981
Restriction and functional changes of dopamine release in rat striatum from young adult and old rats.
    Mechanisms of ageing and development, 1995, May-12, Volume: 80, Issue:2

    Topics: Age Factors; Aging; Animals; Calcium; Corpus Striatum; Dopamine; Male; Ouabain; Potassium; Rats; Rat

1995
Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1995, Volume: 15, Issue:5 Pt 1

    Topics: Aging; Animals; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Female; Hallucinatio

1995
Separate and combined effects of dopamine D1 and D2 receptor agonists on key pecking in the developing chick.
    Pharmacology, biochemistry, and behavior, 1994, Volume: 49, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chickens; Conditioning,

1994
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.
    Psychopharmacology, 1994, Volume: 116, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz

1994
Neurochemical characterization of the alterations in the noradrenergic afferents to the cerebellum of adult rats exposed to X-irradiation at birth.
    Journal of neurochemistry, 1993, Volume: 61, Issue:2

    Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Afferent Pat

1993
Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters.
    Brain research, 1994, Feb-21, Volume: 637, Issue:1-2

    Topics: Aging; Animals; Arousal; Biogenic Monoamines; Brain Chemistry; Circadian Rhythm; Cricetinae; Male; M

1994
Axonal transport of dopamine-containing vesicles labelled in vivo with [3H]reserpine.
    The European journal of neuroscience, 1993, May-01, Volume: 5, Issue:5

    Topics: Aging; Animals; Axons; Binding Sites; Biological Transport; Colchicine; Corpus Striatum; Dopamine; M

1993
Effects of acute haloperidol and reserpine administration on vacuous jaw movements in three different age groups of rats.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:2

    Topics: Aging; Animals; Haloperidol; Jaw; Male; Mastication; Motor Activity; Rats; Rats, Sprague-Dawley; Res

1993
Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters.
    Brain research, 1993, May-28, Volume: 612, Issue:1-2

    Topics: Aging; Animals; Biogenic Monoamines; Brain Chemistry; Circadian Rhythm; Cricetinae; Male; Mesocricet

1993
Dopaminergic responses in the Fischer 344 rat heart: preserved chronotropic and dromotropic responses with aging.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 1997, Volume: 52, Issue:1

    Topics: Aging; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Coronary Circulation; Dopamine; D

1997
Reserpine effects on neurotransmitters in chick heart during growth.
    Journal of physiology, Paris, 1997, Volume: 91, Issue:2

    Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Inj

1997
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
    American journal of physiology. Heart and circulatory physiology, 2002, Volume: 282, Issue:6

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod

2002
Hormone dependent differentiation, maturation and function of the brain and sexual behavior.
    Endokrinologie, 1977, Volume: 69, Issue:3

    Topics: Aging; Androgens; Animals; Brain; Cell Differentiation; Homosexuality; Humans; Luteinizing Hormone;

1977
Chemically evoked hypothermia in the mouse: towards a method for investigating thermodynamic parameters of aging and death in mammals.
    Mechanisms of ageing and development, 1978, Volume: 7, Issue:5

    Topics: Adaptation, Physiological; Aging; Animals; Chlorpromazine; Drug Synergism; Female; Fenclonine; Hypot

1978
Age-related alterations in the development of adrenergic denervation supersensitivity.
    Federation proceedings, 1979, Volume: 38, Issue:5

    Topics: Adenylyl Cyclases; Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Light; Norepinephrine; Pineal

1979
Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine.
    The Journal of pharmacology and experimental therapeutics, 1979, Volume: 211, Issue:2

    Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Desipramine; Male; Pineal Gland; Rats; Receptors

1979
The effects of reserpine upon body weight, brain weight and brain indoleamine stores in maturing mice.
    General pharmacology, 1979, Volume: 10, Issue:3

    Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Orga

1979
Effects of psychotrophic drugs on brain differentiation in female rats.
    Endokrinologie, 1977, Volume: 70, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg

1977
Dopamine content and synthesis in retina and n. accumbens septi: pharmacological and light-induced modifications.
    Advances in biochemical psychopharmacology, 1977, Volume: 16

    Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Adaptation,

1977
[Studies of the hydrodynamic changes in the ureter--morphological changes of the rabbit ureter following internal pressure load and influence of aging and reserpine (author's transl)].
    Nihon Hinyokika Gakkai zasshi. The japanese journal of urology, 1977, Volume: 68, Issue:10

    Topics: Aging; Animals; Pressure; Rabbits; Reserpine; Ureter

1977
Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation.
    The Journal of pharmacology and experimental therapeutics, 1977, Volume: 202, Issue:3

    Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Chlorisondami

1977
Effects of postnatal reserpine administration on sympatho-adrenal development in the rat.
    Biochemical pharmacology, 1976, Jul-01, Volume: 25, Issue:13

    Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Catecholamines; Chlorisondamine; Female; Methyltyr

1976
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
    Journal of neurochemistry, 1975, Volume: 24, Issue:6

    Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S

1975
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
    Brain research, 1976, Apr-16, Volume: 106, Issue:1

    Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd

1976
[Breast cancer in women as a paradigm for ageing as a hidden syncarcinogenic factor].
    Deutsche medizinische Wochenschrift (1946), 1975, Mar-07, Volume: 100, Issue:10

    Topics: Age Factors; Aging; Breast Neoplasms; Carcinogens; Female; Humans; Radiography; Reserpine; Secologan

1975
Differences between the effects of acute and long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain.
    Biochemical pharmacology, 1975, Jul-15, Volume: 24, Issue:13-14

    Topics: Administration, Oral; Aging; Animals; Brain; Brain Chemistry; Catecholamines; Desipramine; Dopamine;

1975
The negative inotropic effect of secobarbital on the heart of reserpinised newborn and adult guinea pigs.
    Archives internationales de pharmacodynamie et de therapie, 1975, Volume: 215, Issue:2

    Topics: Aging; Animals; Animals, Newborn; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Myocardial

1975
The pain aggression induced by bronopol in the rat.
    Acta pharmacologica et toxicologica, 1975, Volume: 37, Issue:3

    Topics: Aggression; Aging; Animals; Behavior, Animal; Drug Interactions; Female; Humans; Pain; Peritonitis;

1975
Glucocorticoids as a regulatory factor for brain tryptophan hydroxylase.
    Journal of neurochemistry, 1976, Volume: 26, Issue:1

    Topics: Adrenalectomy; Aging; Animals; Animals, Newborn; Brain; Corticosterone; Male; Mice; Mice, Inbred C57

1976
Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups.
    Psychopharmacology, 1992, Volume: 107, Issue:1

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; alpha-Methyltyrosine; Analysis of

1992
Alpha-amylase circadian rhythm of young rat parotid gland: an endogenous rhythm with maternal coordination.
    Archives of oral biology, 1992, Volume: 37, Issue:5

    Topics: Aging; alpha-Amylases; alpha-Methyltyrosine; Animals; Circadian Rhythm; Female; Food Deprivation; Li

1992
Amphetamine actions on pre- and postpubertal rat hippocampal dentate granule neurons.
    Brain research, 1991, Aug-09, Volume: 556, Issue:1

    Topics: Aging; Animals; Atenolol; Calcium Channels; Cocaine; Dextroamphetamine; Evoked Potentials; Haloperid

1991
Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats.
    Journal of the autonomic nervous system, 1991, Volume: 36, Issue:1

    Topics: Aging; Animals; Dopamine beta-Hydroxylase; Ganglia, Sympathetic; Hypothyroidism; Rats; Rats, Inbred

1991
Effects of physiological aging on cardiac electrophysiology in perfused Fischer 344 rat hearts.
    The American journal of physiology, 1992, Volume: 262, Issue:1 Pt 2

    Topics: Aging; Animals; Atrioventricular Node; Bundle of His; Dose-Response Relationship, Drug; Electrophysi

1992
Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine.
    Brain research, 1990, Aug-13, Volume: 525, Issue:1

    Topics: Adrenal Glands; Aging; Animals; DNA; Dopamine; Gene Expression Regulation, Enzymologic; Male; Nuclei

1990
Neuronal uptake of noradrenaline in the rat isolated trachea: effect of ageing.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1990, Volume: 96, Issue:2

    Topics: Aging; Animals; Cocaine; Drug Resistance; In Vitro Techniques; Kinetics; Male; Neurons; Norepinephri

1990
Adrenergic innervation of the ductus deferens in young and aging rats: a morpho-functional investigation.
    Acta histochemica, 1990, Volume: 89, Issue:1

    Topics: Adrenergic alpha-Agonists; Aging; Animals; Epididymis; Histocytochemistry; Male; Methoxamine; Norepi

1990
Social isolation effects on the "behavioral despair" forced swimming test: effect of age and duration of testing.
    Physiology & behavior, 1991, Volume: 49, Issue:2

    Topics: Aging; Animals; Arousal; Body Temperature Regulation; Escape Reaction; Female; Food Deprivation; Mal

1991
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts.
    The Journal of pharmacology and experimental therapeutics, 1991, Jul-01, Volume: 258, Issue:1

    Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperi

1991
Peculiarities of neural regulation of the thyroid, adrenocortical and testicular functions in old age.
    Mechanisms of ageing and development, 1990, Volume: 51, Issue:1

    Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Atropine; Dibenzylchlorethamine; Ketost

1990
[The effect of estradiol and reserpine on cortisol formation in sexually immature rats].
    Akusherstvo i ginekologiia, 1990, Volume: 29, Issue:3

    Topics: Aging; Animals; Estradiol; Female; Hydrocortisone; Rats; Rats, Inbred Strains; Reserpine; Sexual Mat

1990
Resting heart rates in an ambulatory elderly population: an evaluation of age, sex, symptoms, and medication.
    Gerontology, 1989, Volume: 35, Issue:4

    Topics: Aged; Aging; Blood Pressure; Digoxin; Female; Heart Rate; Humans; Male; Nitroglycerin; Propranolol;

1989
[Changes in the progesterone serum concentration of sexually immature rat pups treated with estradiol and reserpine].
    Akusherstvo i ginekologiia, 1989, Volume: 28, Issue:2

    Topics: Aging; Animals; Drug Interactions; Estradiol; Progesterone; Rats; Rats, Inbred Strains; Reserpine; S

1989
[Participation of the catecholaminergic system in estrogen formation in sexually immature rats].
    Akusherstvo i ginekologiia, 1988, Volume: 27, Issue:5

    Topics: Aging; Animals; Estradiol; Estrogens; Estrus; Feedback; Female; Pregnancy; Rats; Rats, Inbred Strain

1988
Indices of neurotransmitter synthesis and release in aging sympathetic nervous system.
    Neurobiology of aging, 1985,Fall, Volume: 6, Issue:3

    Topics: Adrenal Glands; Aging; Animals; Catecholamines; Choline O-Acetyltransferase; Dopamine beta-Hydroxyla

1985
The effects of reserpine and haloperidol on tyrosine hydroxylase activity in the brains of aged rats.
    Life sciences, 1986, Jul-21, Volume: 39, Issue:3

    Topics: Aging; Animals; Brain; Brain Mapping; Haloperidol; Male; Pterins; Rats; Reserpine; Tyrosine 3-Monoox

1986
Effects of age on behavioral responses to dopamine agonists in the rat.
    European journal of pharmacology, 1987, Jun-12, Volume: 138, Issue:1

    Topics: Aging; alpha-Methyltyrosine; Animals; Apomorphine; Behavior, Animal; Bromocriptine; Dopamine; Male;

1987
Effect of prenatal reserpine exposure on development of the postnatal rat heart.
    Teratogenesis, carcinogenesis, and mutagenesis, 1987, Volume: 7, Issue:4

    Topics: Aging; Animals; Body Weight; Female; Heart; Male; Organ Size; Pregnancy; Rats; Rats, Inbred Strains;

1987
Differential serotonin2 receptor recovery in mature and senescent rat brain after irreversible receptor modification: effect of chronic reserpine treatment.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Brain; GTP-Binding Proteins; Guanylyl Imidodiphosphate

1987
Age-related differential recovery rates of rat striatal D-1 dopamine receptors following irreversible inactivation.
    European journal of pharmacology, 1988, Jan-19, Volume: 145, Issue:3

    Topics: Adrenergic alpha-Antagonists; Aging; Animals; Flupenthixol; Male; Mazindol; Quinolines; Rats; Rats,

1988
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1987, Volume: 7, Issue:5

    Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techn

1987
Postnatal development of chronotropic responses to chemical and electrical stimulation of adrenergic nerve endings in the sinoatrial node of the heart of the albino rat.
    Physiologia Bohemoslovaca, 1987, Volume: 36, Issue:5

    Topics: Aging; Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Heart Rate; Piperazines; Ra

1987
The influence of catecholamine systems and thyroid function on the actions of ethanol in long-sleep (LS) and short-sleep (SS) mice.
    Annals of the New York Academy of Sciences, 1987, Volume: 492

    Topics: Aging; alpha-Methyltyrosine; Animals; Catecholamines; Ethanol; Hydroxydopamines; Methyltyrosines; Mi

1987
Age-related changes in the recovery of noradrenaline content in sympathetic fibres after reserpine treatment.
    Acta histochemica, 1988, Volume: 84, Issue:2

    Topics: Aging; Animals; Fluorescent Antibody Technique; Intestine, Large; Kidney; Male; Nerve Fibers; Norepi

1988
[Age-related modification of dopaminergic-cholinergic neuronal interaction in rats].
    Yakubutsu, seishin, kodo = Japanese journal of psychopharmacology, 1988, Volume: 8, Issue:4

    Topics: Aging; Animals; Apomorphine; Drug Interactions; Male; Methyltyrosines; Physostigmine; Pilocarpine; R

1988
Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension.
    Experimental and molecular pathology, 1987, Volume: 47, Issue:1

    Topics: Aging; Animals; Aorta; Blood Pressure; Cell Membrane; Elastin; Hydralazine; Hypertension, Malignant;

1987
[Age characteristics of the development of a reserpine model of parkinsonism in rats].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 104, Issue:12

    Topics: Aging; Animals; Caudate Nucleus; Dyskinesia, Drug-Induced; Globus Pallidus; Male; Parkinson Disease,

1987
Effects of neonatally administered chlorpromazine and reserpine on the responsiveness of rat hepatic drug-metabolising enzymes to testosterone in adult life.
    Biology of the neonate, 1986, Volume: 50, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Dieldrin; Female; Liver; Male; Microsomes, Liver;

1986
Cholinesterases in single nerve cells isolated from the locus ceruleus and from nucleus of the facial nerve of the rat: a microgasometric study.
    Journal of neurochemistry, 1985, Volume: 45, Issue:1

    Topics: Acetylcholinesterase; Aging; Animals; Cholinesterases; Facial Nerve; Locus Coeruleus; Male; Neurons;

1985
Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic study.
    Histochemistry, 1974, Mar-27, Volume: 39, Issue:1

    Topics: Aging; Animals; Chickens; Dihydroxyphenylalanine; Dopamine; Female; Histocytochemistry; Male; Micros

1974
Factors affecting plasma ceruloplasmin activity in Gallus domesticus.
    Comparative biochemistry and physiology. A, Comparative physiology, 1973, Jul-01, Volume: 45, Issue:3

    Topics: Adrenocorticotropic Hormone; Aging; Animals; Betamethasone; Ceruloplasmin; Chickens; Dose-Response R

1973
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
    British journal of pharmacology, 1974, Volume: 51, Issue:4

    Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo

1974
Gerontological changes of ATP content and K-Na-ATPase activity in rats brain.
    Folia morphologica, 1973, Volume: 21, Issue:4

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Animals; Brain; Female; Male; Parkinson Di

1973
[Characteristics of NAD metabolism in the brain--with reference to a comparison with the liver].
    Shinkei kenkyu no shimpo. Advances in neurological sciences, 1966, Volume: 10, Issue:2

    Topics: Aging; Animals; Brain; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Male; NAD; Niacinamide

1966
Angiography of the hand. Clinical and postmortem investigations.
    Acta radiologica. Supplementum, 1972, Volume: 315

    Topics: Adolescent; Adult; Aged; Aging; Angiography; Arteries; Arthritis, Rheumatoid; Blood Circulation Time

1972
Alteration of the course of hypertension in the spontaneously hypertensive rat.
    Circulation research, 1972, Volume: 31, Issue:1

    Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorothiazide; Environment; E

1972
Increased depletion of catecholamines by reserpine in immature cats.
    Canadian journal of physiology and pharmacology, 1972, Volume: 50, Issue:6

    Topics: Aging; Animals; Catecholamines; Cats; Heart; Myocardium; Reserpine; Spleen

1972
Effects of hypothalamic stimulation, hormones, and drugs on ovarian function in old female rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 132, Issue:2

    Topics: 17-Hydroxycorticosteroids; Aging; Animals; Castration; Electric Stimulation; Epinephrine; Female; Hy

1969
The effect of catechol amines on free amino acids in rat heart and other organs.
    Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 182, Issue:2

    Topics: Aging; Alanine; Amino Acids; Animals; Arginine; Epinephrine; Female; Glutamates; Glutamine; Heart; L

1969
The postnatal development of noradrenaline uptake in the adrenergic nerves of different tissues from the rat.
    European journal of pharmacology, 1970, Volume: 9, Issue:1

    Topics: Age Factors; Aging; Animals; Desipramine; Dopamine; Duodenum; Growth; Heart Atria; In Vitro Techniqu

1970
Content of catecholamines in the adrenal medulla in hypertension and other diseases.
    Biochemical medicine, 1970, Volume: 4, Issue:1

    Topics: Adolescent; Adrenal Medulla; Adult; Aged; Aging; Carcinoma; Child; Dopamine; Epinephrine; Female; Fe

1970
Adrenergic innervation and cocaine-induced potentiation of adrenergic responses of aortic strips from young and old rabbits.
    The Journal of pharmacology and experimental therapeutics, 1971, Volume: 177, Issue:3

    Topics: Aging; Animals; Aorta, Thoracic; Calcium; Cobalt; Cocaine; Cold Temperature; Drug Synergism; Histocy

1971
A comparison of the absorption, distribution and metabolism of reserpine in infant and adult rats.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 163, Issue:1

    Topics: Absorption; Aging; Animals; Brain Chemistry; Injections, Intraperitoneal; Injections, Subcutaneous;

1968
Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 159, Issue:1

    Topics: Aging; Animals; Chick Embryo; Cocaine; Cold Temperature; Egg Yolk; Epinephrine; Female; Microsomes;

1968