reserpine and Aging
reserpine has been researched along with Aging in 106 studies
Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0." | 7.68 | The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991) |
| "In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)." | 7.67 | Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987) |
| "These suggest that the RES rat model of parkinsonism can be useful in improving our knowledge on the effect of aging on neurodegeneration." | 5.72 | Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. ( Bispo, JMM; Franco, HS; Gois, AM; Lins, LCRF; Marchioro, M; Melo, JEC; Mendonça, MS; Monteiro, MCN; Ribeiro, AM; Santos, JR; Santos, RS; Santos, TFO; Silva, RH, 2022) |
| "Epidermal growth factor (EGF) is one of the ErbB receptor ligands implicated in schizophrenia neuropathology as well as in dopaminergic development." | 3.77 | Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF. ( Aizawa, M; Iwakura, Y; Mizuno, M; Namba, H; Nawa, H; Shcherbakova, K; Sotoyama, H; Wang, R; Zheng, Y, 2011) |
| "In order to investigate the age-related changes in dopaminergic activity in rats, we have utilized the K(+)- and veratridine-stimulated [14C]dopamine release from striatum in vitro as a functional index of responsiveness to these stimuli in aging." | 3.69 | Restriction and functional changes of dopamine release in rat striatum from young adult and old rats. ( Andreas, K; Bergsträsser, E; Dobrev, D; Fischer, HD, 1995) |
| "This study was designed to determine the effect of neonatally-produced hypothyroidism on reserpine-elicited tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (D beta H) induction in the superior cervical ganglion (SCG) in rats." | 3.68 | Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats. ( Blouquit, MF; Chami, N; de Lonlay, A; Edwards, DA; Gripois, D; Valens, M, 1991) |
| " To determine if mechanisms that regulate gene expression are altered by aging, the effects of reserpine on induction of TH mRNA and TH activity were compared in another group of rats aged 2, 12 and 27 months." | 3.68 | Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine. ( Armbrecht, HJ; Hale, C; Moore, MA; Richardson, A; Strong, R; Wessels-Reiker, M, 1990) |
| "The effects of aging on heart rate and atrioventricular (AV) conduction responses to verapamil (0-100 ng/ml) were studied in Langendorff perfused hearts from 12 mature (4-6 months) and 12 senescent (24 months) male Fischer 344 rats and in hearts from 10 mature and 9 senescent rats after reserpine administration (0." | 3.68 | The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts. ( Garcia, J; Schmidlin, O; Schwartz, JB, 1991) |
| "In order to study the role of elastin in arteries with respect to hypertension and hypertensive arterial disease, aortic elastin content and elastase-like enzyme activity were examined and compared in stroke-prone spontaneously hypertensive rats (SHRSP), which show malignant hypertension, and Wistar-Kyoto normotensive rats (WKY)." | 3.67 | Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension. ( Daniel, EE; Ito, H; Kwan, CY, 1987) |
| "These suggest that the RES rat model of parkinsonism can be useful in improving our knowledge on the effect of aging on neurodegeneration." | 1.72 | Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism. ( Bispo, JMM; Franco, HS; Gois, AM; Lins, LCRF; Marchioro, M; Melo, JEC; Mendonça, MS; Monteiro, MCN; Ribeiro, AM; Santos, JR; Santos, RS; Santos, TFO; Silva, RH, 2022) |
| "Depression is a common psychiatric disease which pharmacological treatment relieves symptoms, but still far from ideal." | 1.51 | Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats. ( Burger, ME; de David Antoniazzi, CT; Duarte, MM; Duarte, T; Kronbauer, M; Milanesi, LH; Rosa, HZ; Rossato, DR; Roversi, K, 2019) |
| "Reserpine treatment significantly reduced total wheel-running activity and the monoamine levels in the hypothalamus, striatum and pons/medulla." | 1.29 | Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters. ( Penev, PD; Turek, FW; Zee, PC, 1993) |
| "Reserpine which promotes catecholamine release from the tissues, leads to the diminution of the rate of the MR of the shudder type in rats of the same age." | 1.27 | [Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period]. ( Praznikov, VP, 1984) |
| "Bromocriptine did not produce this behavior when administered alone." | 1.27 | Effects of age on behavioral responses to dopamine agonists in the rat. ( Hara, T; Kishimoto, O; Mizuki, Y; Soeda, K; Ushijima, I; Yamada, M, 1987) |
| "Reserpine treatment moderately increases the number of immunostainable LHRH cells, while ovariectomy is ineffective in this respect." | 1.26 | Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats. ( Horváth, J; Lengvári, I; Merchenthaler, I; Sétáló, G, 1980) |
| "The patterns in development of the two seizure types differ greatly in detail, further supporting the previously advanced inference that they represent neurological events that differ in kind rather than merely quantitatively." | 1.26 | Changes in CNS responses to high pressure during maturation of newborn mice. ( Brauer, RW; Gillen, HW; Mansfield, W; Nash, K, 1980) |
| "Using breast carcinoma in women as an example, it is shown that a carcinogenic effect cannot be demonstrated for two of the supposed carcinogenic factors, namely repeated diagnostic radiographic measures and administration of Rauwolfia-alkaloid containing drugs." | 1.25 | [Breast cancer in women as a paradigm for ageing as a hidden syncarcinogenic factor]. ( Fuchs, G; Oeser, H, 1975) |
Research
Studies (106)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 73 (68.87) | 18.7374 |
| 1990's | 24 (22.64) | 18.2507 |
| 2000's | 4 (3.77) | 29.6817 |
| 2010's | 4 (3.77) | 24.3611 |
| 2020's | 1 (0.94) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Melo, JEC | 1 |
| Santos, TFO | 1 |
| Santos, RS | 1 |
| Franco, HS | 1 |
| Monteiro, MCN | 1 |
| Bispo, JMM | 1 |
| Mendonça, MS | 1 |
| Ribeiro, AM | 1 |
| Silva, RH | 2 |
| Gois, AM | 1 |
| Marchioro, M | 1 |
| Lins, LCRF | 1 |
| Santos, JR | 1 |
| Roversi, K | 1 |
| de David Antoniazzi, CT | 1 |
| Milanesi, LH | 1 |
| Rosa, HZ | 1 |
| Kronbauer, M | 1 |
| Rossato, DR | 1 |
| Duarte, T | 1 |
| Duarte, MM | 1 |
| Burger, ME | 1 |
| Tauffenberger, A | 1 |
| Julien, C | 1 |
| Parker, JA | 1 |
| Sotoyama, H | 1 |
| Zheng, Y | 1 |
| Iwakura, Y | 1 |
| Mizuno, M | 1 |
| Aizawa, M | 1 |
| Shcherbakova, K | 1 |
| Wang, R | 1 |
| Namba, H | 1 |
| Nawa, H | 1 |
| Saharia, K | 1 |
| Arya, U | 1 |
| Kumar, R | 1 |
| Sahu, R | 1 |
| Das, CK | 1 |
| Gupta, K | 1 |
| Dwivedi, H | 1 |
| Subramaniam, JR | 1 |
| DUBE, AH | 1 |
| OSGOOD, CK | 1 |
| NOTKIN, H | 1 |
| FOUKS, L | 1 |
| FREIS, ED | 2 |
| COHEN, S | 1 |
| LEONARD, CV | 1 |
| FARBEROW, NL | 1 |
| SHNEIDMAN, ES | 1 |
| NUTTALL, FQ | 1 |
| DOE, RP | 1 |
| HECHT, K | 1 |
| Abílio, VC | 1 |
| Carvalho, RC | 1 |
| Grassl, C | 1 |
| Calzavara, MB | 1 |
| Registro, S | 1 |
| D'Almeida, V | 1 |
| Ribeiro, Rde A | 1 |
| Frussa-Filho, R | 1 |
| Burger, M | 1 |
| Fachinetto, R | 1 |
| Calegari, L | 1 |
| Paixão, MW | 1 |
| Braga, AL | 1 |
| Rocha, JB | 1 |
| Lychkova, AE | 1 |
| Burchinsky, SG | 1 |
| Bareis, DL | 1 |
| Slotkin, TA | 3 |
| Ikeno, T | 1 |
| Dickens, G | 1 |
| Lloyd, T | 1 |
| Guroff, G | 1 |
| Praznikov, VP | 1 |
| Ponzio, F | 1 |
| Achilli, G | 1 |
| Calderini, G | 1 |
| Ferretti, P | 1 |
| Perego, C | 1 |
| Toffano, G | 1 |
| Algeri, S | 1 |
| Leff, SE | 1 |
| Gariano, R | 1 |
| Creese, I | 4 |
| Merchenthaler, I | 1 |
| Lengvári, I | 1 |
| Horváth, J | 1 |
| Sétáló, G | 1 |
| Deguchi, T | 1 |
| Goodrich, C | 1 |
| Mansfield, W | 1 |
| Brauer, RW | 1 |
| Gillen, HW | 1 |
| Nash, K | 1 |
| Park, MK | 1 |
| Sze, PY | 2 |
| Dobrev, D | 1 |
| Bergsträsser, E | 1 |
| Fischer, HD | 1 |
| Andreas, K | 1 |
| Arnsten, AF | 2 |
| Cai, JX | 2 |
| Steere, JC | 1 |
| Goldman-Rakic, PS | 2 |
| Dose, JM | 1 |
| Zolman, JF | 1 |
| Murphy, BL | 1 |
| Dopico, AM | 1 |
| Zieher, LM | 1 |
| Penev, PD | 2 |
| Zee, PC | 2 |
| Turek, FW | 2 |
| Lechardeur, D | 1 |
| Castel, MN | 1 |
| Reibaud, M | 1 |
| Scherman, D | 1 |
| Laduron, PM | 1 |
| Steinpreis, RE | 1 |
| Salamone, JD | 1 |
| Schwartz, JB | 3 |
| Ahmed, NA | 1 |
| Radwan, NM | 1 |
| al-Zahaby, AS | 1 |
| Abd el-Salam, MM | 1 |
| Abete, P | 1 |
| Testa, G | 1 |
| Ferrara, N | 1 |
| De Santis, D | 1 |
| Capaccio, P | 1 |
| Viati, L | 1 |
| Calabrese, C | 1 |
| Cacciatore, F | 1 |
| Longobardi, G | 1 |
| Condorelli, M | 1 |
| Napoli, C | 1 |
| Rengo, F | 1 |
| Dörner, G | 2 |
| Horita, A | 1 |
| Janoff, AS | 1 |
| Rosenberg, B | 1 |
| Weiss, B | 2 |
| Greenberg, L | 1 |
| Cantor, E | 1 |
| Greenberg, LH | 1 |
| Consroe, P | 1 |
| Picchioni, A | 1 |
| Chin, L | 1 |
| Baker, PC | 1 |
| Hoff, KM | 1 |
| Goodrich, CA | 1 |
| Hinz, G | 1 |
| Döcke, F | 1 |
| Tönjes, R | 1 |
| Da Prada, M | 1 |
| Akimoto, M | 1 |
| Okumura, S | 1 |
| Kawai, H | 2 |
| Bartolomé, J | 2 |
| Lau, C | 1 |
| Tissari, AH | 2 |
| Raunu, EM | 1 |
| Kellogg, C | 1 |
| Oeser, H | 1 |
| Fuchs, G | 1 |
| Roffler-Tarlov, S | 1 |
| Effendi, H | 1 |
| Versprille, A | 1 |
| Wise, ME | 1 |
| Nieminen, L | 1 |
| Möttönen, M | 1 |
| Neckers, L | 1 |
| Towle, AC | 1 |
| Moody, CA | 1 |
| Spear, LP | 1 |
| Applegate, WB | 1 |
| Bellavía, SL | 1 |
| Sanz, EG | 1 |
| Sereno, R | 1 |
| Vermouth, NT | 1 |
| Jahromi, SS | 1 |
| Niesen, C | 1 |
| Carlen, PL | 1 |
| de Lonlay, A | 1 |
| Blouquit, MF | 1 |
| Valens, M | 1 |
| Chami, N | 1 |
| Edwards, DA | 1 |
| Gripois, D | 1 |
| Schmidlin, O | 2 |
| Bharati, S | 1 |
| Lev, M | 1 |
| Strong, R | 1 |
| Moore, MA | 1 |
| Hale, C | 1 |
| Wessels-Reiker, M | 1 |
| Armbrecht, HJ | 1 |
| Richardson, A | 1 |
| de Avellar, MC | 1 |
| Markus, RP | 1 |
| Pellegrini, A | 2 |
| Soldani, P | 2 |
| Breschi, MC | 2 |
| Martinotti, E | 1 |
| Paparelli, A | 2 |
| Yates, G | 1 |
| Panksepp, J | 1 |
| Ikemoto, S | 1 |
| Nelson, E | 1 |
| Conner, R | 1 |
| Garcia, J | 1 |
| Frolkis, VV | 1 |
| Gorban, EN | 1 |
| Moroz, EV | 1 |
| Vlasova, D | 3 |
| Borisova, I | 1 |
| Kŭnchev, L | 3 |
| Marks, RG | 1 |
| Hale, WE | 1 |
| Moore, MT | 1 |
| May, FE | 1 |
| Stewart, RB | 1 |
| Borisov, I | 2 |
| Partanen, M | 1 |
| Waller, SB | 1 |
| London, ED | 1 |
| Hervonen, A | 1 |
| Fine, MI | 1 |
| Masserano, JM | 2 |
| Weiner, N | 2 |
| Ushijima, I | 1 |
| Mizuki, Y | 1 |
| Soeda, K | 1 |
| Kishimoto, O | 2 |
| Hara, T | 1 |
| Yamada, M | 1 |
| Harmon, JR | 1 |
| Kimmel, GL | 1 |
| Webb, PJ | 1 |
| Delongchamp, RR | 1 |
| Battaglia, G | 3 |
| Norman, AB | 3 |
| Vlk, J | 1 |
| Disbrow, JK | 1 |
| French, TA | 1 |
| Ricciardi, MP | 1 |
| Ito, H | 1 |
| Kwan, CY | 1 |
| Daniel, EE | 1 |
| Rushkevich, IuE | 1 |
| Finnen, MJ | 1 |
| Hassall, KA | 1 |
| Sket, D | 1 |
| Pavlin, R | 1 |
| Håkanson, R | 1 |
| Larsson, LI | 1 |
| Sundler, F | 1 |
| Freeman, BM | 1 |
| Manning, AC | 1 |
| Pole, DS | 1 |
| Mackay, AV | 1 |
| Velkov, VA | 1 |
| Matsunaga, R | 1 |
| Hatotani, N | 1 |
| Wegelius, U | 1 |
| Schlesinger, K | 1 |
| Uphouse, LL | 1 |
| Mise, J | 1 |
| Ragan, D | 1 |
| Pillsbury, H | 1 |
| Mathews, M | 1 |
| Davidson, WJ | 1 |
| Innes, IR | 1 |
| Clemens, JA | 1 |
| Amenomori, Y | 1 |
| Jenkins, T | 1 |
| Meites, J | 1 |
| Kuttner, RE | 1 |
| Lorincz, AB | 1 |
| Sachs, C | 1 |
| de Champlain, J | 1 |
| Malmfors, T | 1 |
| Olson, L | 1 |
| Hinterberger, H | 1 |
| Steele, RH | 1 |
| Bartholomew, RJ | 1 |
| Shibata, S | 1 |
| Hattori, K | 1 |
| Sakurai, I | 1 |
| Mori, J | 1 |
| Fujiwara, M | 1 |
| Mueller, RA | 1 |
| Shideman, FE | 2 |
| Ignarro, LJ | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A D1 Agonist For Working Memory Enhancement In The Schizophrenia Spectrum[NCT02507206] | Phase 2 | 120 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Reviews
7 reviews available for reserpine and Aging
| Article | Year |
|---|---|
Neurotransmitter receptors in the central nervous system and aging: pharmacological aspect (review).
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Desipramine; Dopamine; Dopamine Antagonists; Female; Fluph | 1984 |
Neuropharmacology and aging.
Topics: Acetylcholine; Aging; Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Biogenic Amin | 1978 |
Audiogenic seizure susceptible rats.
Topics: Acoustic Stimulation; Aging; Aluminum Hydroxide; Animals; Anticonvulsants; Behavior, Animal; Brain; | 1979 |
Pharmacological and ultrastructural maturation of serotonergic synapses during ontogeny.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Biological Transport, Active; Brain; Imiprami | 1975 |
Systolic hypertension in older persons.
Topics: Aged; Aging; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Double-Blind Method; | 1992 |
Pyridoxine dependency and central nervous system excitability.
Topics: Acoustic Stimulation; Aging; Aminobutyrates; Animals; Brain Chemistry; Drug Interactions; Electric S | 1972 |
Pulmonary hypertension.
Topics: Adult; Aging; Cardiac Output; Chronic Disease; Electrocardiography; Humans; Hypertension, Pulmonary; | 1974 |
Trials
1 trial available for reserpine and Aging
| Article | Year |
|---|---|
Systolic hypertension in older persons.
Topics: Aged; Aging; Antihypertensive Agents; Atenolol; Blood Pressure; Chlorthalidone; Double-Blind Method; | 1992 |
Other Studies
99 other studies available for reserpine and Aging
| Article | Year |
|---|---|
Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism.
Topics: Aging; Animals; Catalepsy; Disease Models, Animal; Dopamine; Male; Motor Activity; Motor Disorders; | 2022 |
Tactile Stimulation on Adulthood Modifies the HPA Axis, Neurotrophic Factors, and GFAP Signaling Reverting Depression-Like Behavior in Female Rats.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Behavior, Animal; Body Weight; Corticosterone; Depressi | 2019 |
Evaluation of longevity enhancing compounds against transactive response DNA-binding protein-43 neuronal toxicity.
Topics: Aging; Animals; Caenorhabditis elegans; Chromans; DNA-Binding Proteins; Ethosuximide; Longevity; Mot | 2013 |
Pallidal hyperdopaminergic innervation underlying D2 receptor-dependent behavioral deficits in the schizophrenia animal model established by EGF.
Topics: Aging; Animals; Animals, Newborn; Antipsychotic Agents; Behavior, Animal; Biomarkers; Catalepsy; Dis | 2011 |
Reserpine modulates neurotransmitter release to extend lifespan and alleviate age-dependent Aβ proteotoxicity in Caenorhabditis elegans.
Topics: Acetylcholine; Aging; Aldicarb; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antihypertensive | 2012 |
The effects of an analeptic (ritalin), an ataraxic (reserpine), and a placebo in senile states.
Topics: Aged; Aging; Central Nervous System Stimulants; Disease; Mental Disorders; Methylphenidate; Reserpin | 1957 |
[The psychoanaleptic action of Disipal in the neuroleptic syndrome and in senile depression].
Topics: Aged; Aged, 80 and over; Aging; Antipsychotic Agents; Anxiety; Depression; Depressive Disorder; Huma | 1961 |
OFFICE EVALUATION OF THE HYPERTENSIVE PATIENT. II.
Topics: Aging; Blood Pressure; Blood Pressure Determination; Central Nervous System; Diuretics; Fundus Oculi | 1963 |
TRANQUILIZERS AND SUICIDE IN THE SCHIZOPHRENIC PATIENT.
Topics: Aging; Alcoholism; Biomedical Research; Chlorpromazine; Drug Therapy; Marriage; Perphenazine; Prochl | 1964 |
THE ACHILLES REFLEX IN THYROID DISORDERS; A CRITICAL EVALUATION.
Topics: Achilles Tendon; Adrenocorticotropic Hormone; Aging; Anemia; Anemia, Pernicious; Aspirin; Cold Tempe | 1964 |
[The age-dependent effect of reserpine (0.1 mg/kg) on the course of conditioned reactions of the first and second order in rats].
Topics: Aging; Animals; Conditioning, Classical; Nervous System Physiological Phenomena; Rats; Reflex; Reser | 1960 |
Important role of striatal catalase in aging- and reserpine-induced oral dyskinesia.
Topics: Aging; Amitrole; Animals; Catalase; Dopamine Agonists; Dyskinesia, Drug-Induced; Enzyme Inhibitors; | 2004 |
Effects of age on reserpine-induced orofacial dyskinesia and possible protection of diphenyl diselenide.
Topics: Age Factors; Aging; Animals; Antioxidants; Antipsychotic Agents; Behavior, Animal; Benzene Derivativ | 2004 |
Balance of activity of sympathetic, parasympathetic, and serotoninergic divisions of the autonomic nervous system in rabbits.
Topics: Aging; Animals; Autonomic Nervous System; Bradycardia; Catecholamines; Heart; Muscles; Myocardium; R | 2005 |
Maturation of sympathetic neurotransmission in the rat heart--III. Developmental changes in reserpine inhibition of norepinephrine uptake into isolated synaptic vesicles.
Topics: Aging; Animals; Body Weight; Heart; In Vitro Techniques; Norepinephrine; Organ Size; Rats; Reserpine | 1980 |
The receptor-mediated activation of tyrosine hydroxylation in the superior cervical ganglion of the rat.
Topics: Aging; Animals; Bucladesine; Carbachol; Dopamine; Ganglia, Spinal; Hydroxylation; Kinetics; Pterins; | 1981 |
[Adrenergic mechanisms regulating the motor reactions of rats in the early postnatal period].
Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Levodopa; Motor Activity; Rats; Receptors, Adrener | 1984 |
Depletion and recovery of neuronal monoamine storage in rats of different ages treated with reserpine.
Topics: Aging; Animals; Biogenic Amines; Brain; Dopamine; Epinephrine; Male; Norepinephrine; Rats; Reserpine | 1984 |
Dopamine receptor turnover rates in rat striatum are age-dependent.
Topics: Aging; Animals; Corpus Striatum; Cycloheximide; Kinetics; Male; Quinolines; Rats; Receptors, Dopamin | 1984 |
Immunohistochemical study of the LHRH-synthesizing neuron system of aged female rats.
Topics: Aging; Animals; Axons; Brain; Castration; Female; Gonadotropin-Releasing Hormone; Immunoenzyme Techn | 1980 |
Sympathetic regulation of circadian rhythm of serotonin N-acetyltransferase activity in pineal gland of infant rat.
Topics: Acetyltransferases; Aging; Animals; Animals, Newborn; Arylamine N-Acetyltransferase; Circadian Rhyth | 1982 |
Reserpine effects on body temperature in maturing mice.
Topics: Aging; Animals; Biogenic Amines; Body Temperature; Body Temperature Regulation; Brain; Ethanol; Mice | 1982 |
Changes in CNS responses to high pressure during maturation of newborn mice.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Female; | 1980 |
Ouabain-induced inotropism of isolated newborn and adult rabbit myocardium.
Topics: Aging; Animals; Animals, Newborn; Electric Stimulation; Heart; In Vitro Techniques; Myocardial Contr | 1981 |
Developmental-regulatory aspects of brain tryptophan hydroxylase.
Topics: Adrenalectomy; Aging; Animals; Brain; Corticosterone; Enzyme Induction; Glucocorticoids; Mesencephal | 1981 |
Restriction and functional changes of dopamine release in rat striatum from young adult and old rats.
Topics: Age Factors; Aging; Animals; Calcium; Corpus Striatum; Dopamine; Male; Ouabain; Potassium; Rats; Rat | 1995 |
Dopamine D2 receptor mechanisms contribute to age-related cognitive decline: the effects of quinpirole on memory and motor performance in monkeys.
Topics: Aging; Animals; Dopamine Agonists; Dose-Response Relationship, Drug; Ergolines; Female; Hallucinatio | 1995 |
Separate and combined effects of dopamine D1 and D2 receptor agonists on key pecking in the developing chick.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Chickens; Conditioning, | 1994 |
Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; Animals; Behavior, Animal; Benzaz | 1994 |
Neurochemical characterization of the alterations in the noradrenergic afferents to the cerebellum of adult rats exposed to X-irradiation at birth.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Afferent Pat | 1993 |
Monoamine depletion blocks triazolam-induced phase advances of the circadian clock in hamsters.
Topics: Aging; Animals; Arousal; Biogenic Monoamines; Brain Chemistry; Circadian Rhythm; Cricetinae; Male; M | 1994 |
Axonal transport of dopamine-containing vesicles labelled in vivo with [3H]reserpine.
Topics: Aging; Animals; Axons; Binding Sites; Biological Transport; Colchicine; Corpus Striatum; Dopamine; M | 1993 |
Effects of acute haloperidol and reserpine administration on vacuous jaw movements in three different age groups of rats.
Topics: Aging; Animals; Haloperidol; Jaw; Male; Mastication; Motor Activity; Rats; Rats, Sprague-Dawley; Res | 1993 |
Monoamine depletion alters the entrainment and the response to light of the circadian activity rhythm in hamsters.
Topics: Aging; Animals; Biogenic Monoamines; Brain Chemistry; Circadian Rhythm; Cricetinae; Male; Mesocricet | 1993 |
Dopaminergic responses in the Fischer 344 rat heart: preserved chronotropic and dromotropic responses with aging.
Topics: Aging; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Coronary Circulation; Dopamine; D | 1997 |
Reserpine effects on neurotransmitters in chick heart during growth.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Aspartic Acid; Chickens; gamma-Aminobutyric Acid; Inj | 1997 |
Cardioprotective effect of ischemic preconditioning is preserved in food-restricted senescent rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Aging; Animals; Blood Flow Velocity; Bod | 2002 |
Hormone dependent differentiation, maturation and function of the brain and sexual behavior.
Topics: Aging; Androgens; Animals; Brain; Cell Differentiation; Homosexuality; Humans; Luteinizing Hormone; | 1977 |
Chemically evoked hypothermia in the mouse: towards a method for investigating thermodynamic parameters of aging and death in mammals.
Topics: Adaptation, Physiological; Aging; Animals; Chlorpromazine; Drug Synergism; Female; Fenclonine; Hypot | 1978 |
Age-related alterations in the development of adrenergic denervation supersensitivity.
Topics: Adenylyl Cyclases; Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Light; Norepinephrine; Pineal | 1979 |
Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine.
Topics: Aging; Animals; Brain; Cerebellum; Cerebral Cortex; Desipramine; Male; Pineal Gland; Rats; Receptors | 1979 |
The effects of reserpine upon body weight, brain weight and brain indoleamine stores in maturing mice.
Topics: Aging; Animals; Animals, Newborn; Body Weight; Brain Chemistry; Hydroxyindoleacetic Acid; Mice; Orga | 1979 |
Effects of psychotrophic drugs on brain differentiation in female rats.
Topics: Aging; Animals; Animals, Newborn; Brain; Cell Differentiation; Estrus; Female; Male; Pargyline; Preg | 1977 |
Dopamine content and synthesis in retina and n. accumbens septi: pharmacological and light-induced modifications.
Topics: 2H-Benzo(a)quinolizin-2-ol, 2-Ethyl-1,3,4,6,7,11b-hexahydro-3-isobutyl-9,10-dimethoxy-; Adaptation, | 1977 |
[Studies of the hydrodynamic changes in the ureter--morphological changes of the rabbit ureter following internal pressure load and influence of aging and reserpine (author's transl)].
Topics: Aging; Animals; Pressure; Rabbits; Reserpine; Ureter | 1977 |
Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturation.
Topics: Adrenal Medulla; Aging; Animals; Animals, Newborn; Body Weight; Brain; Carboxy-Lyases; Chlorisondami | 1977 |
Effects of postnatal reserpine administration on sympatho-adrenal development in the rat.
Topics: Adrenal Glands; Aging; Animals; Animals, Newborn; Catecholamines; Chlorisondamine; Female; Methyltyr | 1976 |
Subcellular distribution of 5-hydroxytryptamine in rat brain during development: effect of drugs and fasting.
Topics: 5-Hydroxytryptophan; Aging; Animals; Animals, Newborn; Brain; Fasting; Pargyline; Rats; Reserpine; S | 1975 |
Audiogenic seizures: relation to age and mechanisms of monoamine neurotransmission.
Topics: 5-Hydroxytryptophan; Acoustic Stimulation; Aging; Animals; Benserazide; Brain; Catecholamines; Dihyd | 1976 |
[Breast cancer in women as a paradigm for ageing as a hidden syncarcinogenic factor].
Topics: Age Factors; Aging; Breast Neoplasms; Carcinogens; Female; Humans; Radiography; Reserpine; Secologan | 1975 |
Differences between the effects of acute and long-term treatment with desmethylimipramine on reserpine-induced release of amines from rat brain.
Topics: Administration, Oral; Aging; Animals; Brain; Brain Chemistry; Catecholamines; Desipramine; Dopamine; | 1975 |
The negative inotropic effect of secobarbital on the heart of reserpinised newborn and adult guinea pigs.
Topics: Aging; Animals; Animals, Newborn; Depression, Chemical; Guinea Pigs; In Vitro Techniques; Myocardial | 1975 |
The pain aggression induced by bronopol in the rat.
Topics: Aggression; Aging; Animals; Behavior, Animal; Drug Interactions; Female; Humans; Pain; Peritonitis; | 1975 |
Glucocorticoids as a regulatory factor for brain tryptophan hydroxylase.
Topics: Adrenalectomy; Aging; Animals; Animals, Newborn; Brain; Corticosterone; Male; Mice; Mice, Inbred C57 | 1976 |
Effects of acute dopamine depletion on responsiveness to D1 and D2 receptor agonists in infant and weanling rat pups.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aging; alpha-Methyltyrosine; Analysis of | 1992 |
Alpha-amylase circadian rhythm of young rat parotid gland: an endogenous rhythm with maternal coordination.
Topics: Aging; alpha-Amylases; alpha-Methyltyrosine; Animals; Circadian Rhythm; Female; Food Deprivation; Li | 1992 |
Amphetamine actions on pre- and postpubertal rat hippocampal dentate granule neurons.
Topics: Aging; Animals; Atenolol; Calcium Channels; Cocaine; Dextroamphetamine; Evoked Potentials; Haloperid | 1991 |
Tyrosine hydroxylase and dopamine beta-hydroxylase inductions evoked by reserpine in the superior cervical ganglion of developing eu- and hypothyroid rats.
Topics: Aging; Animals; Dopamine beta-Hydroxylase; Ganglia, Sympathetic; Hypothyroidism; Rats; Rats, Inbred | 1991 |
Effects of physiological aging on cardiac electrophysiology in perfused Fischer 344 rat hearts.
Topics: Aging; Animals; Atrioventricular Node; Bundle of His; Dose-Response Relationship, Drug; Electrophysi | 1992 |
Modulation of tyrosine hydroxylase gene expression in the rat adrenal gland by age and reserpine.
Topics: Adrenal Glands; Aging; Animals; DNA; Dopamine; Gene Expression Regulation, Enzymologic; Male; Nuclei | 1990 |
Neuronal uptake of noradrenaline in the rat isolated trachea: effect of ageing.
Topics: Aging; Animals; Cocaine; Drug Resistance; In Vitro Techniques; Kinetics; Male; Neurons; Norepinephri | 1990 |
Adrenergic innervation of the ductus deferens in young and aging rats: a morpho-functional investigation.
Topics: Adrenergic alpha-Agonists; Aging; Animals; Epididymis; Histocytochemistry; Male; Methoxamine; Norepi | 1990 |
Social isolation effects on the "behavioral despair" forced swimming test: effect of age and duration of testing.
Topics: Aging; Animals; Arousal; Body Temperature Regulation; Escape Reaction; Female; Food Deprivation; Mal | 1991 |
The effects of aging on the electrophysiologic responses to verapamil in isolated perfused rat hearts.
Topics: Aging; Animals; Drug Interactions; Electrophysiology; Heart Conduction System; Injections, Intraperi | 1991 |
Peculiarities of neural regulation of the thyroid, adrenocortical and testicular functions in old age.
Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aging; Animals; Atropine; Dibenzylchlorethamine; Ketost | 1990 |
[The effect of estradiol and reserpine on cortisol formation in sexually immature rats].
Topics: Aging; Animals; Estradiol; Female; Hydrocortisone; Rats; Rats, Inbred Strains; Reserpine; Sexual Mat | 1990 |
Resting heart rates in an ambulatory elderly population: an evaluation of age, sex, symptoms, and medication.
Topics: Aged; Aging; Blood Pressure; Digoxin; Female; Heart Rate; Humans; Male; Nitroglycerin; Propranolol; | 1989 |
[Changes in the progesterone serum concentration of sexually immature rat pups treated with estradiol and reserpine].
Topics: Aging; Animals; Drug Interactions; Estradiol; Progesterone; Rats; Rats, Inbred Strains; Reserpine; S | 1989 |
[Participation of the catecholaminergic system in estrogen formation in sexually immature rats].
Topics: Aging; Animals; Estradiol; Estrogens; Estrus; Feedback; Female; Pregnancy; Rats; Rats, Inbred Strain | 1988 |
Indices of neurotransmitter synthesis and release in aging sympathetic nervous system.
Topics: Adrenal Glands; Aging; Animals; Catecholamines; Choline O-Acetyltransferase; Dopamine beta-Hydroxyla | 1985 |
The effects of reserpine and haloperidol on tyrosine hydroxylase activity in the brains of aged rats.
Topics: Aging; Animals; Brain; Brain Mapping; Haloperidol; Male; Pterins; Rats; Reserpine; Tyrosine 3-Monoox | 1986 |
Effects of age on behavioral responses to dopamine agonists in the rat.
Topics: Aging; alpha-Methyltyrosine; Animals; Apomorphine; Behavior, Animal; Bromocriptine; Dopamine; Male; | 1987 |
Effect of prenatal reserpine exposure on development of the postnatal rat heart.
Topics: Aging; Animals; Body Weight; Female; Heart; Male; Organ Size; Pregnancy; Rats; Rats, Inbred Strains; | 1987 |
Differential serotonin2 receptor recovery in mature and senescent rat brain after irreversible receptor modification: effect of chronic reserpine treatment.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Brain; GTP-Binding Proteins; Guanylyl Imidodiphosphate | 1987 |
Age-related differential recovery rates of rat striatal D-1 dopamine receptors following irreversible inactivation.
Topics: Adrenergic alpha-Antagonists; Aging; Animals; Flupenthixol; Male; Mazindol; Quinolines; Rats; Rats, | 1988 |
Differential recovery rates of rat D2 dopamine receptors as a function of aging and chronic reserpine treatment following irreversible modification: a key to receptor regulatory mechanisms.
Topics: Aging; Animals; Apomorphine; Corpus Striatum; Guanylyl Imidodiphosphate; Haloperidol; In Vitro Techn | 1987 |
Postnatal development of chronotropic responses to chemical and electrical stimulation of adrenergic nerve endings in the sinoatrial node of the heart of the albino rat.
Topics: Aging; Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; Heart Rate; Piperazines; Ra | 1987 |
The influence of catecholamine systems and thyroid function on the actions of ethanol in long-sleep (LS) and short-sleep (SS) mice.
Topics: Aging; alpha-Methyltyrosine; Animals; Catecholamines; Ethanol; Hydroxydopamines; Methyltyrosines; Mi | 1987 |
Age-related changes in the recovery of noradrenaline content in sympathetic fibres after reserpine treatment.
Topics: Aging; Animals; Fluorescent Antibody Technique; Intestine, Large; Kidney; Male; Nerve Fibers; Norepi | 1988 |
[Age-related modification of dopaminergic-cholinergic neuronal interaction in rats].
Topics: Aging; Animals; Apomorphine; Drug Interactions; Male; Methyltyrosines; Physostigmine; Pilocarpine; R | 1988 |
Elastin and elastase-like enzyme change in aorta of rat with malignant hypertension.
Topics: Aging; Animals; Aorta; Blood Pressure; Cell Membrane; Elastin; Hydralazine; Hypertension, Malignant; | 1987 |
[Age characteristics of the development of a reserpine model of parkinsonism in rats].
Topics: Aging; Animals; Caudate Nucleus; Dyskinesia, Drug-Induced; Globus Pallidus; Male; Parkinson Disease, | 1987 |
Effects of neonatally administered chlorpromazine and reserpine on the responsiveness of rat hepatic drug-metabolising enzymes to testosterone in adult life.
Topics: Aging; Animals; Animals, Newborn; Chlorpromazine; Dieldrin; Female; Liver; Male; Microsomes, Liver; | 1986 |
Cholinesterases in single nerve cells isolated from the locus ceruleus and from nucleus of the facial nerve of the rat: a microgasometric study.
Topics: Acetylcholinesterase; Aging; Animals; Cholinesterases; Facial Nerve; Locus Coeruleus; Male; Neurons; | 1985 |
Peptide and amine producing endocrine-like cells in the chicken thymus. A chemical, histochemical and electron microscopic study.
Topics: Aging; Animals; Chickens; Dihydroxyphenylalanine; Dopamine; Female; Histocytochemistry; Male; Micros | 1974 |
Factors affecting plasma ceruloplasmin activity in Gallus domesticus.
Topics: Adrenocorticotropic Hormone; Aging; Animals; Betamethasone; Ceruloplasmin; Chickens; Dose-Response R | 1973 |
The long-term regulation of tyrosine hydroxylase activity in cultured sympathetic ganglia: role of ganglionic noradrenaline content.
Topics: Acetylesterase; Aging; Animals; Animals, Newborn; Bucladesine; Carbachol; Choline; Cyclic AMP; Cyclo | 1974 |
Gerontological changes of ATP content and K-Na-ATPase activity in rats brain.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Aging; Animals; Brain; Female; Male; Parkinson Di | 1973 |
[Characteristics of NAD metabolism in the brain--with reference to a comparison with the liver].
Topics: Aging; Animals; Brain; Carbon Tetrachloride Poisoning; Chlorpromazine; Liver; Male; NAD; Niacinamide | 1966 |
Angiography of the hand. Clinical and postmortem investigations.
Topics: Adolescent; Adult; Aged; Aging; Angiography; Arteries; Arthritis, Rheumatoid; Blood Circulation Time | 1972 |
Alteration of the course of hypertension in the spontaneously hypertensive rat.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chlorothiazide; Environment; E | 1972 |
Increased depletion of catecholamines by reserpine in immature cats.
Topics: Aging; Animals; Catecholamines; Cats; Heart; Myocardium; Reserpine; Spleen | 1972 |
Effects of hypothalamic stimulation, hormones, and drugs on ovarian function in old female rats.
Topics: 17-Hydroxycorticosteroids; Aging; Animals; Castration; Electric Stimulation; Epinephrine; Female; Hy | 1969 |
The effect of catechol amines on free amino acids in rat heart and other organs.
Topics: Aging; Alanine; Amino Acids; Animals; Arginine; Epinephrine; Female; Glutamates; Glutamine; Heart; L | 1969 |
The postnatal development of noradrenaline uptake in the adrenergic nerves of different tissues from the rat.
Topics: Age Factors; Aging; Animals; Desipramine; Dopamine; Duodenum; Growth; Heart Atria; In Vitro Techniqu | 1970 |
Content of catecholamines in the adrenal medulla in hypertension and other diseases.
Topics: Adolescent; Adrenal Medulla; Adult; Aged; Aging; Carcinoma; Child; Dopamine; Epinephrine; Female; Fe | 1970 |
Adrenergic innervation and cocaine-induced potentiation of adrenergic responses of aortic strips from young and old rabbits.
Topics: Aging; Animals; Aorta, Thoracic; Calcium; Cobalt; Cocaine; Cold Temperature; Drug Synergism; Histocy | 1971 |
A comparison of the absorption, distribution and metabolism of reserpine in infant and adult rats.
Topics: Absorption; Aging; Animals; Brain Chemistry; Injections, Intraperitoneal; Injections, Subcutaneous; | 1968 |
Norepinephrine and epinephrine in the embryo and embryonic heart of the chick: uptake and subcellular distribution.
Topics: Aging; Animals; Chick Embryo; Cocaine; Cold Temperature; Egg Yolk; Epinephrine; Female; Microsomes; | 1968 |