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reserpine and Adrenal Cancer

reserpine has been researched along with Adrenal Cancer in 30 studies

Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.

Research Excerpts

ExcerptRelevanceReference
" In the VMAT-expressing NE tumour cell lines GOT1 and BON and in VMAT-expressing primary NE tumour cell cultures (carcinoids, n=4 and pheochromocytomas, n=4), reserpine significantly reduced the uptake of (123)I-MIBG."3.72Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters. ( Ahlman, H; Bernhardt, P; Forssell-Aronsson, E; Johanson, V; Kölby, L; Levin-Jakobsen, AM; Nilsson, O; Wängberg, B, 2003)
"Chronic administration of reserpine is associated with the development of pheochromocytomas in rats."3.69Sustained stimulation of rat adrenal chromaffin cell proliferation by reserpine. ( Downing, JC; McClain, RM; Tischler, AS; Ziar, J, 1995)
"Adrenomedullin (AM) is a vasorelaxant peptide that was recently isolated from human pheochromocytoma."3.69Vasopressor activities of N-terminal fragments of adrenomedullin in anesthetized rat. ( Inui, T; Itahara, Y; Nakajima, K; Sakakibara, S; Watanabe, TX; Yoshizawa-Kumagaye, K, 1996)
"To elucidate how the neuropeptide Y (NPY) gene is regulated by physiological/pharmacological changes in neural functions, the expression and regulation of the NPY gene were studied by measuring changes in the abundances of NPY and NPY mRNA in the adrenal gland and brain regions of rats in vivo and in PC12 rat pheochromocytoma cells after reserpine treatment."3.68Long lasting increase in neuropeptide Y gene expression in rat adrenal gland with reserpine treatment: positive regulation of transsynaptic activation and membrane depolarization. ( Higuchi, H; Iwasa, A; Miki, N; Yoshida, H, 1990)
"Mouse pheochromocytomas are a new tool for studying genes and signaling pathways that regulate cell growth and differentiation in adrenal medullary neoplasms and are a unique model for studying the regulation of PNMT expression."1.31Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice. ( Alroy, J; Bedri, S; Evinger, MJ; Powers, JF; Shahsavari, M; Tischler, AS; Tsokas, P, 2000)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199022 (73.33)18.7374
1990's5 (16.67)18.2507
2000's3 (10.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
KAPLAN, NM1
Kölby, L2
Bernhardt, P2
Levin-Jakobsen, AM1
Johanson, V1
Wängberg, B1
Ahlman, H2
Forssell-Aronsson, E2
Nilsson, O2
Jakobsen, AM1
Mallet, J1
Faucon Biguet, N1
Buda, M1
Lamouroux, A1
Samolyk, D1
Roisin, MP1
Isambert, MF1
Henry, JP1
Guillot, M1
Lenoir, G1
Wilson, SP1
Chang, KJ1
Viveros, OH1
Tischler, AS3
Ziar, J2
Downing, JC1
McClain, RM2
Watanabe, TX1
Itahara, Y1
Inui, T1
Yoshizawa-Kumagaye, K1
Nakajima, K1
Sakakibara, S1
Powers, JF2
Shahsavari, M2
Tsokas, P2
Downing, J1
Evinger, MJ1
Bedri, S1
Alroy, J1
Hengstmann, JH1
Dengler, HJ1
Romankiewicz, JA1
Becker, CE1
Benowitz, NL1
Gunby, P1
Rahn, KH1
van den Broek, PJ1
de Graeff, J1
Haas, Th1
Denkl, P1
Higuchi, H1
Iwasa, A1
Yoshida, H1
Miki, N1
McMahon, A1
Geertman, R1
Sabban, EL1
Shen, RS1
Zhang, YX1
Perez-Polo, JR1
Bräutigam, M1
Laschinski, G1
Kittner, B1
Herken, H1
Wagner, JA1
Perret, C1
Girardet, P1
Pichlmaier, H1
Werning, C1
Siegenthaler, W1
Koch-Weser, J1
Fernandes, M1
Kim, KE1
Moyer, JH1
Torikai, T1
Heinrich, F1
Schultis, K1
Fox, LP1
Grandi, J1
Johnson, AH1
Watrous, WG1
Johnson, MJ1

Reviews

7 reviews available for reserpine and Adrenal Cancer

ArticleYear
Opioid peptide synthesis in bovine and human adrenal chromaffin cells.
    Peptides, 1981, Volume: 2 Suppl 1

    Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Catecholamines; Cattle; Chromaffin System; Endorp

1981
[Influence of antihypertensive agents on catecholamine and metabolite excretion and its significance for the diagnosis of pheochromocytoma].
    Deutsche medizinische Wochenschrift (1946), 1975, Nov-07, Volume: 100, Issue:45

    Topics: Adrenal Gland Neoplasms; Adrenergic beta-Antagonists; Antihypertensive Agents; Catecholamines; Cloni

1975
Pharmacology and clinical use of drugs in hypertensive emergencies.
    American journal of hospital pharmacy, 1977, Volume: 34, Issue:2

    Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Aorta; Brain Diseases; Cerebral Hemorrhage; Diazox

1977
[Treatment of the hypertensive crisis].
    Schweizerische medizinische Wochenschrift, 1973, Nov-24, Volume: 103, Issue:47

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Antihypertensive Agents; Blood Pressure; Diaz

1973
Hypertensive emergencies.
    The New England journal of medicine, 1974, Jan-24, Volume: 290, Issue:4

    Topics: Adrenal Gland Neoplasms; Antihypertensive Agents; Brain Edema; Cerebrovascular Disorders; Coronary D

1974
Hypertensive emergencies.
    Pennsylvania medicine, 1974, Volume: 77, Issue:7

    Topics: Acute Kidney Injury; Adrenal Gland Neoplasms; Antihypertensive Agents; Aortic Aneurysm; Blood Volume

1974
[Aspect of hormones and hypertension].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1969, Jul-10, Volume: 58, Issue:7

    Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aldosterone; Blood Pressure; Catechol

1969

Other Studies

23 other studies available for reserpine and Adrenal Cancer

ArticleYear
PRIMARY ALDOSTERONISM WITH MALIGNANT HYPERTENSION.
    The New England journal of medicine, 1963, Dec-12, Volume: 269

    Topics: Adenoma; Adrenal Gland Neoplasms; Chlorothiazide; Corticosterone; Humans; Hydrocortisone; Hyperaldos

1963
Uptake of meta-iodobenzylguanidine in neuroendocrine tumours is mediated by vesicular monoamine transporters.
    British journal of cancer, 2003, Oct-06, Volume: 89, Issue:7

    Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Animals; Antineoplasti

2003
Importance of vesicle proteins in the diagnosis and treatment of neuroendocrine tumors.
    Annals of the New York Academy of Sciences, 2004, Volume: 1014

    Topics: 3-Iodobenzylguanidine; Adenocarcinoma; Adrenal Gland Neoplasms; Adrenergic Uptake Inhibitors; Biopsy

2004
Detection and regulation of the tyrosine hydroxylase mRNA levels in rat adrenal medulla and brain tissues.
    Cold Spring Harbor symposia on quantitative biology, 1983, Volume: 48 Pt 1

    Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Brain; Cell Line; Locus Coeruleus; Male; Pheochro

1983
Characterization of the monoamine uptake system in catecholamine storage vesicles isolated from a pheochromocytoma taken from a child.
    Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14

    Topics: Adenosine Triphosphate; Adolescent; Adrenal Gland Neoplasms; Biogenic Amines; Carbonyl Cyanide m-Chl

1984
Sustained stimulation of rat adrenal chromaffin cell proliferation by reserpine.
    Toxicology and applied pharmacology, 1995, Volume: 135, Issue:2

    Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Bromodeoxyuridine; Cell Count; Cell Division; Epi

1995
Vasopressor activities of N-terminal fragments of adrenomedullin in anesthetized rat.
    Biochemical and biophysical research communications, 1996, Feb-06, Volume: 219, Issue:1

    Topics: Adrenal Gland Neoplasms; Adrenomedullin; Anesthesia, General; Animals; Blood Pressure; Consciousness

1996
Comparative studies of chromaffin cell proliferation in the adrenal medulla of rats and mice.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1997, Volume: 35, Issue:2

    Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Antihypertensive Agents; Antimetabolites; Bromode

1997
Pheochromocytoma cell lines from heterozygous neurofibromatosis knockout mice.
    Cell and tissue research, 2000, Volume: 302, Issue:3

    Topics: Adrenal Gland Neoplasms; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic

2000
Hypertensive emergencies.
    The Medical clinics of North America, 1979, Volume: 63, Issue:1

    Topics: Adrenal Gland Neoplasms; Angiotensin II; Animals; Aortic Aneurysm; Aortic Dissection; Brain Diseases

1979
More on the subject of reserpine.
    JAMA, 1979, Jun-15, Volume: 241, Issue:24

    Topics: Adrenal Gland Neoplasms; Animals; Breast Neoplasms; Female; Humans; Hypertension; Male; Mice; Rats;

1979
[Therapy of hypertensive crisis].
    Verhandlungen der Deutschen Gesellschaft fur Kreislaufforschung, 1977, Volume: 43

    Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine

1977
Prolonged survival in a patient with pulmonary metastases of a malignant pheochromocytoma.
    The Netherlands journal of medicine, 1978, Volume: 21, Issue:6

    Topics: Adrenal Gland Neoplasms; Adult; Drug Therapy, Combination; Female; Humans; Lung Neoplasms; Middle Ag

1978
[Therapy of hypertensive crises].
    Fortschritte der Medizin, 1977, Apr-21, Volume: 95, Issue:15

    Topics: Acute Disease; Adrenal Gland Neoplasms; Antihypertensive Agents; Clonidine; Diazoxide; Dihydralazine

1977
Long lasting increase in neuropeptide Y gene expression in rat adrenal gland with reserpine treatment: positive regulation of transsynaptic activation and membrane depolarization.
    Molecular pharmacology, 1990, Volume: 38, Issue:5

    Topics: Actins; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Blotting, Northern; Cerebral Cortex; Chrom

1990
Rat dopamine beta-hydroxylase: molecular cloning and characterization of the cDNA and regulation of the mRNA by reserpine.
    Journal of neuroscience research, 1990, Volume: 25, Issue:3

    Topics: Adrenal Gland Neoplasms; Adrenal Glands; Amino Acid Sequence; Animals; Base Sequence; DNA; Dopamine

1990
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
    Journal of enzyme inhibition, 1989, Volume: 3, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animal

1989
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115).
    Biochemical pharmacology, 1985, Apr-01, Volume: 34, Issue:7

    Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani

1985
Structure of catecholamine secretory vesicles from PC12 cells.
    Journal of neurochemistry, 1985, Volume: 45, Issue:4

    Topics: Adrenal Gland Neoplasms; Animals; Catecholamines; Cell Line; Centrifugation, Density Gradient; Cytop

1985
[Surgery in hypertension (author's transl)].
    MMW, Munchener medizinische Wochenschrift, 1974, Mar-22, Volume: 116, Issue:12

    Topics: Adrenal Gland Neoplasms; Guanethidine; Humans; Hydralazine; Hypertension; Methyldopa; Pheochromocyto

1974
[Therapy of phenochromocytoma].
    Deutsche medizinische Wochenschrift (1946), 1971, Jan-15, Volume: 96, Issue:3

    Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Humans; Neoplasm

1971
[Therapy of hypertension].
    Die Medizinische Welt, 1971, Jan-16, Volume: 3

    Topics: Adrenal Gland Neoplasms; Aniline Compounds; Antihypertensive Agents; Diuretics; Female; Guanethidine

1971
Pheochromocytoma associated with pregnancy. Specialty team management and review.
    American journal of obstetrics and gynecology, 1969, May-15, Volume: 104, Issue:2

    Topics: Adrenal Gland Neoplasms; Adult; Anesthesia, Intravenous; Female; Fetal Death; Humans; Hypertension;

1969