refludan and Hematuria

A 50-year-old patient presented with clinical symptoms of heart failure with orthopnoe and edema (NYHA IV).. Echocardiography revealed a dilated left ventricle with severely reduced left ventricular function and biventricular floating thrombi, due to dilatative cardiomyopathy.. With a heart failure medication clinical symptoms reduced and body weight decreased > 10 kg in 3 weeks. Due to the high-risk constellation, anticoagulation was performed with lepirudin and the biventricular thrombi were dissolved within 17 days. At this point in time, the patient suffered from petechial bleedings, hemoptysis and gross hematuria. Despite breaking anticoagulation and substitution of PPSB with not measurable fibrinogen, subarachnoid hemorrhage occurred leading to exitus letalis.. Lepirudin is a highly effective anticoagulant, that can induce severe hemorrhagic side effects in individual cases. The present case report demonstrates an immunological reaction as a rare cause with activation of prothrombin and formation of fibrin.

Topics: Antibody Formation; Cardiomyopathy, Dilated; Dose-Response Relationship, Drug; Echocardiography; Fatal Outcome; Fibrinolytic Agents; Heart Failure; Heart Ventricles; Hematuria; Hemoptysis; Hirudins; Humans; Male; Middle Aged; Prothrombin Time; Purpura; Recombinant Proteins; Subarachnoid Hemorrhage; Thrombosis