rebaudioside-a has been researched along with Skin-Neoplasms* in 1 studies
1 other study(ies) available for rebaudioside-a and Skin-Neoplasms
| Article | Year |
|---|---|
Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
Four steviol (ent-kaurene-type diterpenoid) glycosides, stevioside, rebaudiosides A and C, and dulcoside A, have been isolated from Stevia rebaudiana BERTONI. These compounds showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 54.1-291.6 micro g/ear. Furthermore, at 1.0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 micro g/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50 micro g/mouse). Topics: Animals; Antineoplastic Agents, Phytogenic; Diterpenes; Diterpenes, Kaurane; Drug Screening Assays, Antitumor; Female; Glucosides; Mice; Mice, Inbred ICR; Skin Neoplasms; Stevia; Tetradecanoylphorbol Acetate | 2002 |