rebaudioside-a has been researched along with Overweight* in 3 studies
2 trial(s) available for rebaudioside-a and Overweight
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Biological effects of stevia, sucralose and sucrose in citrus-maqui juices on overweight subjects.
Topics: Adult; Anthocyanins; Antioxidants; Biomarkers; Citrus; Cytokines; Female; Fruit and Vegetable Juices; Humans; Inflammation; Lipids; Liver; Magnoliopsida; Male; Middle Aged; Non-Nutritive Sweeteners; Overweight; Stevia; Sucrose; Sweetening Agents | 2021 |
A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.
Low-calorie sweeteners (LCSs) provide sweetness with little or no energy. However, each LCS's unique chemical structure has potential to elicit different sensory, physiological, and behavioral responses that affect body weight.. The purpose of this trial was to compare the effects of consumption of 4 LCSs and sucrose on body weight, ingestive behaviors, and glucose tolerance over a 12-wk intervention in adults (18-60 y old) with overweight or obesity (body mass index 25-40 kg/m2).. In a parallel-arm design, 154 participants were randomly assigned to consume 1.25-1.75 L of beverage sweetened with sucrose (n = 39), aspartame (n = 30), saccharin (n = 29), sucralose (n = 28), or rebaudioside A (rebA) (n = 28) daily for 12 wk. The beverages contained 400-560 kcal/d (sucrose treatments) or <5 kcal/d (LCS treatments). Anthropometric indexes, energy intake, energy expenditure, appetite, and glucose tolerance were measured at baseline. Body weight was measured every 2 wk with energy intake, expenditure, and appetite assessed every 4 wk. Twenty-four-hour urine collections were completed every 4 wk to determine study compliance via para-aminobenzoic acid excretion.. Of the participants enrolled in the trial, 123 completed the 12-wk intervention. Sucrose and saccharin consumption led to increased body weight across the 12-wk intervention (Δweight = +1.85 ± 0.36 kg and +1.18 ± 0.36 kg, respectively; P ≤ 0.02) and did not differ from each other. There was no significant change in body weight with consumption of the other LCS treatments compared with baseline, but change in body weight for sucralose was negative and significantly lower compared with all other LCSs at week 12 (weight difference ≥ 1.37 ± 0.52 kg, P ≤ 0.008). Energy intake decreased with sucralose consumption (P = 0.02) and ingestive frequency was lower for sucralose than for saccharin (P = 0.045). Glucose tolerance was not significantly affected by any of the sweetener treatments.. Sucrose and saccharin consumption significantly increase body weight compared with aspartame, rebA, and sucralose, whereas weight change was directionally negative and lower for sucralose compared with saccharin, aspartame, and rebA consumption. LCSs should be categorized as distinct entities because of their differing effects on body weight. This trial was registered at clinicaltrials.gov as NCT02928653. Topics: Adult; Aspartame; Beverages; Body Mass Index; Body Weight; Diet; Dietary Sucrose; Diterpenes, Kaurane; Energy Intake; Feeding Behavior; Female; Humans; Male; Non-Nutritive Sweeteners; Obesity; Overweight; Saccharin; Stevia; Sucrose; Sweetening Agents; Weight Gain; Young Adult | 2019 |
1 other study(ies) available for rebaudioside-a and Overweight
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Effect of Sugar Replacement with Stevia-Based Tabletop Sweetener on Weight and Cardiometabolic Health among Indian Adults.
Added sugars contribute to caloric intake in the diet, which may lead to conditions like obesity. Replacing added sugar with a natural sugar substitute like zero-calorie stevia may help in reducing sugar and caloric intake.. An open-label, single-arm pilot study was conducted to evaluate the efficacy and safety of a stevia-based tabletop sweetener among overweight subjects with normal blood sugar levels (. When compared with the baseline, a significant reduction in weight (. Replacing added sugar in the daily diet with stevia-based tabletop sweetener, along with a physical activity regimen, promotes weight loss and reduction in waist circumference in overweight subjects with normal blood sugar levels and prediabetic subjects (CTRI/2019/12/022470). Topics: Adult; Blood Glucose; Body Mass Index; Cardiometabolic Risk Factors; Cardiovascular Diseases; Exercise; Glycated Hemoglobin; Humans; Non-Nutritive Sweeteners; Overweight; Pilot Projects; Prediabetic State; Stevia; Waist Circumference; Weight Loss | 2023 |