reamberin and Systemic-Inflammatory-Response-Syndrome

The aim of the work was to study characteristics of endogenous intoxication (EI) associated with salmonellosis under conditions of basal therapy and its supplementation by detoxicant reamberin. The study included 66 patients with the gastroenteric variant of moderately severe S. enteriditis infection. The infection was accompanied by well-apparent manifestations of EI (increased leukocyte index, elevated level of medium weight molecules, and reduced detoxification potency of albumin) Persistent EI promotes development of secondary immunodeficiency; the recovery from the disease does not exclude long-term carriage of the pathogen and the development of chronic gastrointestinal diseases. It requires new approaches to the treatment of salmonellosis, such as the use of detoxicants like reamberin that decrease the severity of EI. It is concluded that introduction of reamberin in the combined treatment of salmonellosis can be recommended as a promising option for the management of infectious diseases.

Topics: Adolescent; Adult; Female; Humans; Male; Meglumine; Middle Aged; Salmonella enteritidis; Salmonella Infections; Succinates; Systemic Inflammatory Response Syndrome; Treatment Outcome; Young Adult

A group of 66 patients with purulent-septic surgical pathology on the background of type 2 diabetes mellitus (in the compensation phase) and atherosclerosis of vessels in lower extremities (in the decompensation phase) have been studied. The status of all patients has been determined by the syndrome of systemic inflammation reaction (rated 12.4 +/- 2.2 on the APACHE II scale). Group I (n = 30) included 19 men aged 53.7 +/-7.7 and 11 women aged 54.4 +/- 9.1, which were administered reamberin (single daily dose of 500 ml for three days after operation). Group II (n = 36) included 24 men aged 56.1 +/- 9.2 and 12 women aged 51.9 +/- 8.8 with analogous pathology and general status, which received infusion therapy without reamberin. It is established that the administration of reamberin in patients with purulent-septic surgical pathology on the background of type 2 diabetes mellitus and atherosclerosis of vessels in lower extremities is patho-. genetically justified and allows the reperfusion syndrome upon various operations to be prevented and the critical state in post-operation regime to be eliminated.

Topics: Adult; Aged; Atherosclerosis; Diabetes Mellitus, Type 2; Female; Humans; Male; Meglumine; Middle Aged; Succinates; Systemic Inflammatory Response Syndrome; Time Factors