reamberin and Shock

A 51-year-old severely burned woman had hospitalized at the Clinic of Thermal Injuries of the S.M. Kirov Military Medical Academy with a diagnosis: flame burn in a surface area of 40% (11%)/II-III b degrees of head, neck, trunk, limbs. Inhalation injury of moderate severity. The infusion drug of the combined action reamberin, which has a volemic and antihypoxic effect, had added to the complex antishock therapy. The presented clinical observation demonstrates the favorable course of burn shock: stopping of burn shock 28 hours after injury.. В клинику термических поражений ФГБВОУ ВО 'Военно-медицинская академия имени С.М. Кирова' МО РФ была госпитализирована пострадавшая 51 года по поводу ожога пламенем на S=40% (11%)/II-IIIб ст. головы, шеи, туловища, конечностей, ингаляционного поражения средней степени тяжести. В комплексную противошоковую терапию был добавлен инфузионный препарат комбинированного действия реамберин, обладающий волемическим и антигипоксическим действием. Представленное клиническое наблюдение демонстрирует благоприятное течение ожогового шока: выход из состояния ожогового шока через 28 часов после получения травмы.

Topics: Burns; Female; Fluid Therapy; Humans; Meglumine; Middle Aged; Military Personnel; Shock; Succinates

Efficacy of reamberin infusion therapy was estimated in 38 patients with severe acetic acid intoxication. Reamberin was shown to have positive effect on certain end-points of the treatment, viz. caused a 2-fold decrease in duration of exotoxic shock (which allowed to use smaller volumes of infusion solutions), 3-fold decrease in the frequency of pneumonia, 5-fold reduction in the frequency of delirium and acute renal insufficiency in the early post-traumatic period. The use of reamberin allowed to reduce duration of patients' stay in intensive therapy and resuscitation wards by 1.2 times and mortality rate by 18.5%.

Topics: Acetic Acid; Female; Humans; Infusion Pumps; Male; Meglumine; Severity of Illness Index; Shock; Succinates; Treatment Outcome

Preclinical safety of reamberin, a preparation of succinic acid intended for the treatment of patients with shock conditions of different etiology, and remaxol a drug intended for the treatment of patients with liver dysfunction caused by acute intoxication was performed. Both medicines belong to the 5th class of practically non-toxic drugs. Their administration to experimental animals for 30 days did not cause toxic effects on the functional and morphological state of main systems and organs. Both medicines do not affect specific (humoral and cellular) and non-specific immune response and do not cause sensibilization, mutagenic, embryotoxic and teratogenic effects, and also do no alter parameters of reproductive functions of rats.

Topics: Animals; Dogs; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Female; Male; Meglumine; Rats; Shock; Succinates