reamberin and Sepsis

The clinical efficacy of the preparation reamberin in correction of metabolic hypoxia in patients with severe thermal burn injury under septicotoxemia was studied. It was established high efficacy of the preparation in the correction of the antioxidant defense system, its considerable antitoxic activity. Established role of reamberin in maintaining the functioning of the humoral detoxication systems, and antimicrobial resistance in patients with severe thermal injury.

Topics: Adult; Aged; Antioxidants; Burns; Critical Care; Drug Therapy, Combination; Humans; Hypoxia; Lipid Peroxides; Meglumine; Middle Aged; Oxidative Stress; Sepsis; Succinates; Thiobarbituric Acid Reactive Substances; Young Adult

In 26 patients in complex of treatment of abdominal sepsis there was applied a 1.5% solution of reamberin intravenously in 400 ml dose during 5 days. The results of treatment were estimated, studying indices of systemic inflammatory reaction (SIR) and hepatic tests. Reamberin application have promoted rapid normalization of the parameters studied. The authors consider, that efficacy of reamberin is caused not only by positive impact on the SIR course, but by hepatoprotective action of the preparation as well.

Topics: Abdomen; Combined Modality Therapy; Humans; Injections, Intravenous; Interleukin-10; Interleukin-6; Liver; Liver Function Tests; Meglumine; Multiple Organ Failure; Sepsis; Succinates

The role of reamberin, a succinate-containing infusion preparation in correlation of pulmonary metabolic and respiratory disturbances in patients with obstetric puerperal sepsis was estimated. The prospective randomized study enrolled 43 patients with puerperal obstetric sepsis complicated by polyorganic deficiency (SOFA 8-10). Nineteen patients of the 1st group and 24 patients of the 2nd group were additionally treated with reamberin in a dose of 800 ml/day for 8 days. The venous and arterial difference by glucose, lactate, pyruvate, diene conjugates, malondialdehyde and ceruloplasmin was investigated. The blood gases were determined with the Ciba Corning 45 apparatus. Lower metabolic activity of the lungs with prevalence of the glucose anaerobic metabolism and lower activity of the intrapulmonary antioxidant protection were observed in the patients with obstetric sepsis. The use of reamberin in the complex therapy of obstetric sepsis promoted maintenance of the initial balance and anaeroibic and aerobic pulmonary metabolism, thus providing shorter terms of the decompensation and recovery of the lungs respiratory function.

Topics: Bacterial Infections; Blood Glucose; Ceruloplasmin; Female; Humans; Lactates; Lung; Malondialdehyde; Meglumine; Pregnancy; Puerperal Infection; Pyruvates; Respiratory Distress Syndrome; Sepsis; Succinates

The cytokine profile of blood (CPB) at the patients with chronic sepsis (CS) streptococcus or mixed (by a streptococcus and to staphylococcus etiology) was studied. To beginning of the treatment at intensifying of CS at the patients was detected the substantial increase of maintenance of proinflammatory (IL - 1β, IL - 2, IL - 6, TNF -α) cytokines (CК) in the blood serum at the moderate increase of antiinflammatory CK (IL-4). Thus, indexes, characterizing correlation pro- and antiinflammatory CК was rate, that testified to predominating of proinflammatory potencies of blood. Application in the complex treatment of the patients with CS combination of modern detoxic preparation reamberin and immunoactive preparation cycloferon promotes normalizations of CK maintenance in the blood and betweennesss by them. In a clinical plan the use of the reamberin and cycloferon combination provided acceleration of CS intensifying liquidation. Finding allow to consider pathogenetic reasonable and clinically perspective application of this preparations combination in treatment of the patients with CS.

Topics: Acridines; Adolescent; Adult; Chronic Disease; Cytokines; Drug Therapy, Combination; Female; Humans; Male; Meglumine; Middle Aged; Sepsis; Succinates

The use of reamberin and cycloferon combination for increasing the antibacterial therapy efficacy in patients with chronic sepsis (CS) was studied. It was shown that the combination provided more rapid elimination of the CS exacerbation symptoms, normalization of the hematologic indices, bacteriemia eradication and reduction of the cytokine blood profile--normal serum levels of proinflammatory (IL-1beta, IL-2, IL-6 and TNF-alpha) and antiinflammatory (IL-4) cytokines. The findings allowed to considered the use of the reamberin and cycloferon combination in the treatment of patients with CS pathogenetically reasonable and clinically perspective for increasing the antibacterial therapy efficacy.

Topics: Acridines; Adolescent; Adult; Anti-Bacterial Agents; Bacteremia; Cytokines; Drug Therapy, Combination; Female; Humans; Interferon Inducers; Interleukin-1beta; Interleukin-2; Interleukin-4; Interleukin-6; Male; Meglumine; Middle Aged; Sepsis; Streptococcus pyogenes; Succinates; Tumor Necrosis Factor-alpha