reamberin and Postoperative-Complications

Topics: Administration, Intravenous; Adult; Aged; Antioxidants; Digestive System Surgical Procedures; Drug Monitoring; Female; Free Radicals; Humans; Intestinal Obstruction; Male; Meglumine; Middle Aged; Postoperative Care; Postoperative Complications; Reperfusion Injury; Succinates; Treatment Outcome

The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period. Significant free radical production occurred both in preoperative period and after surgical intervention. This was the reason to include antioxidant therapy using Reamberin (STPF «POLYSAN») in addition to basic treatment. The drug is approved for use by Central Formulary Committee of the Ministry of Health of Ukraine. All patients were divided into 2 groups depending on the treatment scheme. Group I consisted of 100 patients with acute small bowel obstruction who underwent the comprehensive treatment according to recommendations of the Ministry of Health of Ukraine № 297 dated 02.04.2010 (Standards of medical care for patients with urgent surgical diseases of the abdominal cavity). 102 patients of group II received the comprehensive treatment of antihypoxant and antioxidant therapy with Reamberin added to basic scheme. The main active ingredient of Reamberin is succinic acid. The drug was administered intravenously by drop infusion in a dose of 400 ml a day during 7-day period. Administration rate did not exceed 90 drops per minute. The medicine administration was started during complex preoperative preparation and then was done immediately after the completion of surgical treatment under resuscitation conditions. It was shown that the use of Reamberin promotes effective correction of free radical imbalance, reduction of endogenous intoxication and postoperative complications.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Female; Humans; Intestinal Obstruction; Intestine, Small; Length of Stay; Lipid Peroxidation; Male; Meglumine; Middle Aged; Postoperative Complications; Solutions; Succinates; Young Adult

The purpose of this study was to evaluate the effectiveness of combined surgical and medical treatment of infective endocarditis in patients with congenital valvular heart disease when included in a regimen of the drug Reamberin. In this regard, the analysis of the effectiveness of a combination regimen of 74 patients with valvular congenital heart diseases complicated with infective endocarditis. Given the indications for surgical correction operative technique features and possible technical difficulties in carrying out such operations, due to the inflammatory changes and tissue destruction, and ways to overcome them. For the correction of metabolic disorders in the postoperative period, 47 patients (main group) was appointed Reamberin: once, intravenous drip 400 ml/day during the first 5 days after surgery. 27 patients (control group) was conducted infusion therapy depending on the severity of the condition according to the classical scheme. In addition to standard clinical and laboratory examination, to assess the effectiveness of Reamberin was investigated catalase activity of CPK in blood serum in the dynamics of observation (1, 3 and 5 days after surgery). It is revealed that surgical approach, used in complex treatment of patients with valvular congenital heart diseases, including reorganization of the cavities of the heart, increasing the frequency of joints and the use of reinforcing strips of synthetic material that prevents the cutting of sutures through the inflamed tissue has achieved good short-and long-term results. Infective endocarditis and destruction of the valvular annulus fibrosus the use of a frame of strips of polytetrafluoroethylene allows you to restore its integrity and to implant a mechanical prosthesis. The inclusion in the regimen of patients with infective endocarditis complicated by cardiac insufficiency in the early postoperative period the drug Reamberin improves the efficiency of treatment by a more rapid restoration of the normal metabolism of cardiomyocytes and accelerates elimination of signs of heart failure.. Цель исследования - оценка эффективности препарата реамберин в послеоперационной терапии больных с врожденными пороками клапанов сердца. Проведен анализ эффективности комбинированной схемы терапии 74 пациентов с клапанными врожденными пороками сердца, осложненными инфекционным эндокардитом. Приведены показания к хирургическому лечению, особенности оперативной техники и возникающие технические сложности при выполнении подобных операций, обусловленные воспалительными изменениями и деструкцией тканей, а также пути их преодоления. Для коррекции метаболических расстройств в послеоперационный период 47 пациентам (основная группа) был назначен реамберин: 400 мл/сут однократно внутривенно капельно в течение первых 5 дней после операции. 27 пациентам (контрольная группа) проведена инфузионная терапия по классической схеме в зависимости от тяжести состояния. Помимо стандартного клинико-лабораторного обследования, для оценки эффективности применения реамберина исследовалась активность каталазы, креатинфосфокиназы в сыворотке крови в динамике (1, 3 и 5-е сутки после операции). Хирургическая тактика в комплексном лечении больных с клапанными врожденными пороками сердца, включающая санацию полостей сердца, увеличение частоты швов и применение укрепляющих прокладок из синтетического материала, предотвращающего травмирование швами воспаленных тканей, позволяет достигнуть хороших ближайших и отдаленных результатов. Используя каркасные полоски из политетрафторэтилена, удается восстановить целостность деструктированного клапанного фиброзного кольца и имплантировать механический протез. Включение препарата реамберин в схему терапии инфекционного эндокардита в раннем послеоперационном периоде ускоряет восстановление нормального метаболизма кардиомиоцитов, что ведет к более раннему купированию признаков сердечной недостаточности и повышает общую эффективность лечения.

Topics: Adolescent; Adult; Antioxidants; Creatine Kinase; Endocarditis; Female; Heart Failure; Heart Valve Diseases; Heart Valve Prosthesis Implantation; Humans; Infusions, Intravenous; Male; Meglumine; Metabolic Diseases; Middle Aged; Postoperative Complications; Succinates; Treatment Outcome