reamberin and Pneumonia--Bacterial

To evaluate the tolerance and therapeutic effectiveness of 1.5% reamberine (RB) solution infusions in complex therapy for pneumonia-complicated pneumonia and acute respiratory diseases (ARD).. 133 patients aged 18 to 60 years with pneumonia-complicated influenza and ARD were examined. The investigators measured the dynamic serum levels of metalloproteins (MP), such as transferrin, lactoferrin, and ceruloplasmin, and the activity of superoxide dismutase. They also studied the concentration of secondary lipid peroxidation products (malondialdehyde) by the so-called thiobarbituric acid test.. Dropwise intravenous RB infusions exerted a modifying effect on MP content, contributed to more pronounced stabilization of a serum antioxidant potential (versus olifen, vitamin E, and basic therapy) and to enhanced nonspecific protection, which was accompanied by a significant clinical improvement.. The study revealed the high clinical efficacy of 1.5% RB solution infusions (300 ml for 4-5 days) in the treatment of 74 patients with pneumonia-complicated influenza, stabilized serum antioxidant potential, and the body's enhanced nonspecific resistance.

Topics: Adolescent; Adult; Antioxidants; Drug Therapy, Combination; Female; Humans; Influenza, Human; Infusions, Intravenous; Lipid Peroxides; Male; Malondialdehyde; Meglumine; Metalloproteins; Middle Aged; Pneumonia, Bacterial; Succinates; Superoxide Dismutase; Treatment Outcome; Young Adult

The purpose of the study was to improve efficiency of treatment of the patients with severe community-acquired pneumonia at the expense of optimization of schemes of intensive therapy using immunomodulators, antioxidants and antihypoxants. The study involved 142 patients with severe community-acquired pneumonia who were divided into 4 groups. The properties of the erythrocytes membranes, some indicators of immune system and endotoxicosis were examined. It has been determined, that the use of Cycloferonum increases the functionale state of active link of T-immunity. It has been established that the use of Reamberinum while applying the complex therapy results in accelerating the normalization of endotoxicosis indices, it favourably effects the properties of the erythrocytes membranes. The positive influence of Cycloferonum and Reamberinum has been proved. The inclusion of the preparations Reamberinum and Cycloferonum into the complex of intensive therapy to the patients with severe community-acquired pneumonia reduces the bed-staying at the department of intensive care unit.

Topics: Acridines; Adult; Aged; B-Lymphocytes; Combined Modality Therapy; Community-Acquired Infections; Critical Care; Female; Humans; Interferon Inducers; Lymphocyte Count; Male; Meglumine; Middle Aged; Pneumonia, Bacterial; Republic of Belarus; Succinates; T-Lymphocytes; Young Adult