reamberin and Mouth-Neoplasms

The article discusses the practice of detoxication therapy to minimize undesirable toxic effects during chemo- and radiotherapy for locally advanced cancer of the oral mucosa in 88 patients treated with 1.5% solution of reamberine. There was a significant improvement in the parameters of liver function, as well as in the general wellbeing of patients. We analyzed the main symptoms of the toxicity of chemo- and radiotherapy in both groups. Inclusion of the reamberine solution as supportive therapy for cancer patients who were receiving chemo- and radiotherapy for cancer of the oral mucosa allowed reducing the number and severity of toxic complications.

Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Humans; Liver; Male; Meglumine; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Radiotherapy, Adjuvant; Severity of Illness Index; Stomatitis; Succinates; Treatment Outcome

The problems of prophylaxis of infectious complications in the treatment of oral local mucinous carcinoma are considered relevant to 204 respective cases. More favourable results of the combined and complex treatment of the patients were shown when a multidisciplinary approach was used with obligatory participation of stomatologists. Special stomatologic prophylactic and therapeutic procedures with using reamberin orally and intravenously in the chemo- and radiotherapy and adequate antibiotic therapy during the surgical operation resulted in less frequent infectious complications, that was in favour of the patients life quality. Intraosteal administration of antibiotics was shown preferable.

Topics: Adenocarcinoma, Mucinous; Adult; Aged; Anti-Bacterial Agents; Antineoplastic Agents; Drug Therapy, Combination; Female; Gamma Rays; Humans; Infusions, Intraosseous; Injections, Intravenous; Male; Mandible; Meglumine; Middle Aged; Mouth Neoplasms; Succinates; Treatment Outcome