reamberin and Liver-Cirrhosis

The clinical efficiency of a reamberin and cycloferon combination for the treatment of hepatic cirrhosis (HC) associated with chronic HCV infection has been studied. Immunological investigation of patients carried out before the treatment revealed a significant increase in the level of proinflammatory cytokines (CK) in serum, whereas the level of anti-inflammatory CK changed rather insignificantly. Use of the reamberin - cycloferon combination provided faster clinical-biochemical remission and, in respect of the pathogenetic state, ensured normalization of the CK profile in the blood. Based on these data, it can be considered as pathogenetically proved and clinically feasible and promising to use the reamberin - cycloferon combinations for a complex treatment of patients with HC associated with chronic HCV-infection.

Topics: Acridines; Antiviral Agents; Cytokines; Drug Therapy, Combination; Hepacivirus; Hepatitis C, Chronic; Humans; Interferon Inducers; Liver; Liver Cirrhosis; Meglumine; Remission Induction; Succinates; Th1-Th2 Balance; Treatment Outcome; Viral Load