reamberin and Intestinal-Obstruction

Topics: Administration, Intravenous; Adult; Aged; Antioxidants; Digestive System Surgical Procedures; Drug Monitoring; Female; Free Radicals; Humans; Intestinal Obstruction; Male; Meglumine; Middle Aged; Postoperative Care; Postoperative Complications; Reperfusion Injury; Succinates; Treatment Outcome

The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period. Significant free radical production occurred both in preoperative period and after surgical intervention. This was the reason to include antioxidant therapy using Reamberin (STPF «POLYSAN») in addition to basic treatment. The drug is approved for use by Central Formulary Committee of the Ministry of Health of Ukraine. All patients were divided into 2 groups depending on the treatment scheme. Group I consisted of 100 patients with acute small bowel obstruction who underwent the comprehensive treatment according to recommendations of the Ministry of Health of Ukraine № 297 dated 02.04.2010 (Standards of medical care for patients with urgent surgical diseases of the abdominal cavity). 102 patients of group II received the comprehensive treatment of antihypoxant and antioxidant therapy with Reamberin added to basic scheme. The main active ingredient of Reamberin is succinic acid. The drug was administered intravenously by drop infusion in a dose of 400 ml a day during 7-day period. Administration rate did not exceed 90 drops per minute. The medicine administration was started during complex preoperative preparation and then was done immediately after the completion of surgical treatment under resuscitation conditions. It was shown that the use of Reamberin promotes effective correction of free radical imbalance, reduction of endogenous intoxication and postoperative complications.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Female; Humans; Intestinal Obstruction; Intestine, Small; Length of Stay; Lipid Peroxidation; Male; Meglumine; Middle Aged; Postoperative Complications; Solutions; Succinates; Young Adult

Conducted a comprehensive examination and surgical treatment for acute obstruction of the small intestine (SI). It is established that, both before and after surgery to restore patency of SI is a significant violation of the functional state of the liver. This became the basis for the appointment of antioxidant therapy in the complex standard treatment. Using the solution reamberin promotes effective correction protein syntesis function disorders of the liver, reduces the severity of inflammation and stagnation in the hepatocytes, the severity of endogenous intoxication and the incidence of postoperative complications.

Topics: Adult; Aged; Aged, 80 and over; Antioxidants; Female; Humans; Intestinal Obstruction; Intestine, Small; Liver; Liver Function Tests; Male; Meglumine; Middle Aged; Severity of Illness Index; Succinates; Treatment Outcome

An analysis of efficacy of 1.5% reamberin solution usage was made in 80 patients for correction of blood rheological properties disorder in the case of peritonitis and bowel obstruction. It was established, that reamberin, which was administered in the dose of 500 ml after 12 hours of the beginning of intensive care during 48 hours, efficiently corrected the rheological disorders. It was because the erythron and reticulocyte production were activated, the hyposmolarity was removed, the intensity of free radical oxidation and peroxide oxidation of lipids was decreased and the antioxidant status was restored. This facilitated the hydrophily and erythrocyte volume decrease, the haemolysis reduction and qualitative gas exchange at the level of tissues.

Topics: Acute Disease; Anti-Bacterial Agents; Blood Viscosity; Critical Care; Follow-Up Studies; Humans; Intestinal Obstruction; Meglumine; Middle Aged; Peritonitis; Succinates; Treatment Outcome

Topics: Adult; Anti-Inflammatory Agents; Female; Humans; Intestinal Obstruction; Male; Meglumine; Peritonitis; Succinates