reamberin and Inflammation

The efficacy of a 1.5% reamberin solution possessing detoxicating, antihypoxant, antioxidant, and membrane-protective properties, used as a component of the complex infusion therapy in children with acute Epstein-Barr virus infection, has been estimated. The dynamics of the inflammatory process in children treated by the drug complex including reamberin is characterized by rapid relief of general symptoms, improvement of state, and reduction in length of the febrile period of disease as compared to patients treated with glucose-saline solutions and basic therapy. The administration of reamberin in children contributed to the early elimination of metabolic shifts by the period of convalescence, as evidenced by improvement in some laboratory parameters, including protein-synthesis function of the liver.

Topics: Adolescent; Antiviral Agents; Child; Child, Preschool; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Infant; Inflammation; Liver; Male; Meglumine; Protein Biosynthesis; Succinates

The effect of domestic 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin and mexidol) included in the complex treatment of recrudescence of inflammatory diseases of the uterus and its appendages, as manifested in endometrial leucocyte infiltration (ELI) compared to lipid peroxidation products concentration in blood serum, was assessed in a short-term, prospective placebo-controlled single-blind randomized trial. It has been found that two-week infusions of emoxipin (single dose, 150 mg), reamberin (single dose, 400 ml), and mexidol (single dose, 300 mg) favor a decrease in ELI and influence ambiguously on lipid peroxidation - antioxidant (LPA) system condition in blood serum of patients. It has been found that 3-oxypyridine derivative (emoxipin) decreases the intensity of ELI, but does not affect LPA system condition. Succinic acid derivative (reamberin) is inferior to emoxipin in the degree of decreasing ELI, but reduces the concentration of the antioxidant protein ceruloplasmin. Mexidol, being 3-oxipyridine and succinic acid derivative simultaneously, exceeds reamberin in decreasing ELI, increases concentration of blood antioxidant components (alpha-tocopherol and ceruloplasmin), and decreases the level of primary isopropanol-soluble products of lipid peroxidation.

Topics: Adolescent; Adult; alpha-Tocopherol; Antioxidants; Ceruloplasmin; Endometrium; Female; Humans; Inflammation; Lipid Peroxidation; Meglumine; Middle Aged; Picolines; Prospective Studies; Pyridines; Single-Blind Method; Succinates; Ureteral Diseases

Two-week-long, prospective, placebo-controlled, single-blind randomized study of the effects of intravenous emoxipin (150 mg daily), reamberin (400 ml daily) and mexidol (300 mg daily) infusion on the dynamics of clinical symptoms of non-complicated recrudescence of inflammatory diseases of the uterus and its appendages (IDUA) in comparison to the standard therapy was performed. It was established that emoxipin, reamberin and mexidol administration appreciably improved the clinical state dynamics of women with recrudescence of IDUA. The effect was associated with more pronounced decrease in severity of genital and abdominal symptoms versus standard therapy results.

Topics: Adult; Antioxidants; Female; Humans; Inflammation; Meglumine; Middle Aged; Pelvic Inflammatory Disease; Picolines; Prospective Studies; Succinates; Uterine Diseases

Short-term, prospective placebo-controlled simple blind randomized study of the effects of 3-oxypyridine and succinic acid derivatives (emoxipin, reamberin, mexidol) on the affective status of females with recrudescence of the inflammatory diseases of uterus and its appendages (IDUA) in comparison to changes of systemic inflammatory response (SIR) markers level in the blood has been conducted. It is established that the inclusion of emoxipin, reamberin and mexidol in complex treatment of IDUA recrudescence reduce depression, anxiety and SIR laboratory signs. Mexidol being both 3-oxypyridine and succinic acid derivative showed the best influence on the dynamics of affective disorders and SIR changes.

Topics: Adnexa Uteri; Adolescent; Adult; Antioxidants; Brain; Depressive Disorder; Female; Genital Diseases, Female; Humans; Inflammation; Interleukin-1beta; Meglumine; Middle Aged; Phagocytosis; Picolines; Prospective Studies; Pyridines; Recurrence; Succinates; Succinic Acid; Tumor Necrosis Factor-alpha; Uterus

There were examined 54 patients, in whom peritonitis of various etiology was diagnosed. Clinical, biochemical, immunological and other investigations were conducted for estimation of the enteral insufficiency syndrome severity. Basing on the analysis of the data obtained and criterions of the patient common state there was determined the occurrence risk for inflammatory complications (IC). Complex of prophylactic and therapeutic measures for reduction of the IC rate was proposed.

Topics: Adult; Endotoxins; Enterosorption; Female; Humans; Inflammation; Interleukin-6; Intubation, Gastrointestinal; Male; Meglumine; Middle Aged; Peritonitis; Severity of Illness Index; Silicates; Succinates; Tumor Necrosis Factor-alpha