reamberin and Endotoxemia

Endointoxication's syndrome and manifestations of immune deficiency observed among elderly patients with acute exacerbations of ENT diseases and concomitant cerebrovascular pathology. Reamberin in pathogenetic therapy arrests manifestations of intoxication and optimizes immunobiological homeostasis.

Topics: Aged; Chronic Disease; Drug Monitoring; Endotoxemia; Female; Homeostasis; Humans; Hypertension; Hypoxia-Ischemia, Brain; Immunologic Factors; Infusions, Intravenous; Male; Meglumine; Neuroprotective Agents; Otorhinolaryngologic Diseases; Patient Acuity; Succinates; Treatment Outcome

Experiments on Wistar rats showed the development of endotoxicosis 12 h after severe compression injury. Endotoxicosis manifested in disorders in bromosulfaleine excretion from the blood, increase of blood urea, uric acid, creatinine, and potassium levels and aminotransferase activities. Injection of succinate-containing antihypoxants (reamberine, cytoflavin, metaprot plus, succinamic acid 2-amino-4-acetylthiasolo[5,4-b]indole) directly after decompression promoted recovery of liver function, prevented the development of hyperfermentemia and renal failure as a result of reduced blood levels of potassium and non-protein nitrogen. The protective effect of the drugs in traumatic toxicosisdecreased in the following order: metaprot plus>cytoflavin>2-amino-4-acetylthiasolo[5,4-b]indole succinaminic acid>reamberine.

Topics: Animals; Antioxidants; Drug Combinations; Endotoxemia; Flavin Mononucleotide; Inosine Diphosphate; Ischemia; Male; Meglumine; Niacinamide; Nitrogen; Potassium; Rats; Rats, Wistar; Succinates