reamberin and Disease-Models--Animal

To evaluate antidepressant activity of domestic derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin and mexidol) in rats.. The influence of emoxipine, reamberin and mexidol on duration of desperate behavior of rats in Porsolt forced swim test was studied. Additionally the effect of these substances on the animal's behavior in the open field was evaluated. Amitriptyline and alpha-lipoic acid were used as reference substances.. It was established that three administrations of any of the substances in doses corresponding to the therapeutic range in humans reduced the duration of desperate behavior in Porsolt test. Such effect of emoxipine, reamberin, mexidol and alpha-lipoic acid is indicative of their antidepressant activity. Intensity of this activity depends on the effect of these substances on the behavior in the open field.. Reamberin and alpha-lipoic acid that in maximal doses either had no effect on the orientation behavior in the open field (reamberin) or suppressed it (alpha-lipoic acid) matched amitriptyline in the extent of antidepressant activity. The derivatives of 3-oxypyridine (emoxipine and mexidol) with stimulatory effect on the behavior in the open field demonstrated significantly lower ability to reduce desperate behavior than that of amitriptyline.. Цель исследования - изучение антидепрессивной активности оригинальных отечественных производных 3-оксипиридина и янтарной кислоты (эмоксипин, реамберин и мексидол) в эксперименте на крысах. Материал и методы. Изучено влияние эмоксипина, реамберина и мексидола на длительность 'поведения отчаяния' у крыс в тесте принудительного плавания по Porsolt. Дополнительно проводилась оценка влияния изучаемых лекарственных средств (ЛС) на поведение животных в 'открытом поле'. В качестве ЛС сравнения использовали амитриптилин и α-липоевую кислоту (α-ЛК). Результаты и заключение. Установлено, что трехкратное введение всех изученных ЛС в оптимальных дозах, соответствующих терапевтическому диапазону для человека, сокращает длительность 'поведения отчаяния' в тесте Porsolt. Данный эффект эмоксипина, реамберина, мексидола и α-ЛК свидетельствует об их антидепрессивной активности, выраженность которой зависит от действия изученных ЛС на поведение в 'открытом поле'. Реамберин и α-ЛК, максимальные дозы которых либо не влияли на ориентировочную активность в 'открытом поле' (в случае реамберина), либо подавляли ее (в случае α-ЛК), не уступали амитриптилину по выраженности антидепрессивного эффекта. Производные 3-оксипиридина (эмоксипин и мексидол), обладавшие стимулирующим действием на активность в 'открытом поле', существенно уступали амитриптилину по способности сокращать 'поведение отчаяния'.

Topics: Animals; Behavior, Animal; Depressive Disorder; Disease Models, Animal; Female; Male; Meglumine; Picolines; Psychotropic Drugs; Pyridines; Rats; Succinates; Succinic Acid

The effect of domestic derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin, and mexidol) on obsessive-compulsive behavior of mice was studied in the marble-burying test. Additionally the effect of these drugs on the behavior of animals was assessed in the open field test. Amitriptylin and alpha-lipoic acid were used as reference drugs. It was established that single administration of the investigated drugs in optimal doses, corresponding to therapeutic range in humans, inhibits obsessive-compulsive behavior of mice in the marble-burying test. Amitriptylin and alpha-lipoic acid produced similar effects. It is established that emoxipine stimulates the behavior of mice in the open field after single administration. An increase in the emoxipine dose led to decrease of stimulation and gradual development of sedative effect. Reamberin and mexidol, as well as alpha-lipoic acid and amitriptyline, caused sedation in mice tested in the open field. Inhibiting effect of emoxipine, reamberin, mexidol and alpha-lipoic acid on the obsessive-compulsive behavior in mice directly depended on sedative action of these drugs.

Topics: Amitriptyline; Animals; Behavior, Animal; Disease Models, Animal; Female; Humans; Hypnotics and Sedatives; Male; Meglumine; Mice; Motor Activity; Obsessive-Compulsive Disorder; Picolines; Psychotropic Drugs; Succinates; Thioctic Acid

The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models.. We used 260 adult outbred mice. The drugs were introduced intraperitoneally 30 min before the modeling of acute brain ischemia. Each drug was used in 3 three doses: 1/2 of the calculated equivalent of mean treatment dose (EMTD), EMTD and double EMTD. A strangulation model with the assessment of mouse mortality latency and decapitation model with the assessment of agonal respiration (gasping) were used. The efficacy of the drugs was determined by comparison against alpha-lipoic acid that was used as a reference substance in previous studies of antihypoxic activity of emoxipine, reamberin and mexidol.. It was established that the derivatives of 3-oxipiridine and succinic acid protected against subtotal ischemia of rostral brain segments (of cerebral hemispheres) as evidenced by the increase in longevity. Emoxipine demonstrated the maximal effect thereby surpassing reamberin and mexidol in the intensity of antiischemic activity. Antiischemic effect of alpha-lipoic acid was comparable to emoxipine. In the model of total brain ischemia, the derivatives of 3-oxipiridine and succinic acid caused the opposite (proischemic) action on the bulbar respiratory center as evidenced by the reduction in duration of gasping. Alpha-lipoic acid did not affect the duration of gasping.. Цель исследования. Сравнительный анализ влияния оригинальных отечественных производных 3-оксипиридина и янтарной кислоты (эмоксипин, реамберин и мексидол) на устойчивость к острой ишемии головного мозга в эксперименте на мышах. Материал и методы. Исследование было проведено на 260 половозрелых беспородных мышах обоего пола. Изученные лекарственные средства вводили однократно внутрибрюшинно за 30 мин до моделирования острой церебральной ишемии. Каждое лекарственное средство применяли в трех дозах: 1/2 от расчетного эквивалента средней терапевтической дозы (ЭСТД), ЭСТД и удвоенный ЭСТД. Для моделирования острой ишемии головного мозга на мышах использовали странгуляционную модель с оценкой латентности гибели мышей и декапитационную модель с оценкой длительности агонального дыхания (гаспинга). Эффективность изученных препаратов была сопоставлена с результатами применения α-липоевой кислоты (α-ЛК), которая ранее использовалась в качестве препарата сравнения при изучении антигипоксической активности эмоксипина, реамберина и мексидола. Результаты и заключение. Было установлено, что производные 3-оксипиридина и янтарной кислоты оказывают протекторное действие при субтотальной ишемии ростральных отделов головного мозга (большие полушария) по критерию увеличения продолжительности жизни. Наибольшую эффективность продемонстрировал эмоксипин, превосходивший реамберин и мексидол по выраженности антиишемического действия. α-ЛК вызывала антиишемический эффект, сопоставимый с действием эмоксипина. При моделировании тотальной ишемии головного мозга производные 3-оксипиридина и янтарной кислоты оказывали противоположное (проишемическое) действие на бульбарный дыхательный центр по критерию уменьшения длительности гаспинга. α-ЛК не влияла на продолжительность гаспинга.

Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picolines; Pyridines; Succinates; Thioctic Acid

Topics: Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ileus; Injections, Intravenous; Intestine, Small; Ischemia; Meglumine; Succinates; Swine

Variations of the indices of endogenous intoxication, lipid peroxidation, oxidative modification of proteins, and antioxidant system operation have been studied in animals with acute experimental cholecystitis. The possibility and effectiveness of using succinate-containing drugs reamberin and mexidol for the correction of these impairments has been assessed. In the present study, reamberin effectively reduced the intensity of lipid peroxidation and protein modification in experimental animals.

Topics: Animals; Antioxidants; Blood Proteins; Catalase; Cholecystitis, Acute; Disease Models, Animal; Female; Guinea Pigs; Injections, Intramuscular; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Meglumine; Oxidation-Reduction; Oxidative Stress; Picolines; Succinates; Superoxide Dismutase

Combined application of photohemotherapy and antihypoxant reamberin for the treatment of endogenous intoxication favors fast (within one day) restoration of the functional condition of lungs and prevents the development of respiratory distress syndrome. High efficiency of the combined therapy is related to a fast stabilization of membranes, which is determined by the ability to correct lipid metabolism in lung tissues.

Topics: Animals; Disease Models, Animal; Dogs; Female; Lipid Metabolism; Lung; Male; Meglumine; Pancreatitis, Acute Necrotizing; Photochemotherapy; Respiratory Distress Syndrome; Succinates

The effects of original domestic derivatives of 3-oxypyridine and succinic acid (emoxipine, reamberin, and mexidol) on cellular composition of cortical and diencephalic structures in rat brain were studied in parallel with monitoring of behavioral, conditional learning, and metabolic disorders in acute phase of alloxan-induced diabetes in rats. The efficiency of 3-oxypyridine derivatives was compared to the results of alpha-lipoic acid administration. Single administration of emoxipine, reamberin, and mexidol in optimal doses prevented lipofuscin deposition in CA1 field neurocytes in hippocampus and/or increased the amount of terminally differentiated cells ofneuroectodermal lineage (oligodendrocytes, pyramid and basket cells) in this zone ofpaleocortex. Concurrently conditional learning capacity in morbid animals was restored. The cerebroprotective and nootropic effects of emoxipine and reamberin were associated with increased exploration motivation in the open field and were independent of their effects on carbohydrate and lipid metabolism dysfunction. On the contrary, the neuroprotective and nootropic effects of mexidol were associated with additional inhibition of morbid rat activity in the open field and a decrease in the level of circulating products of lipid peroxidation. It is established that 3-oxypyridine and succinic acid derivatives significantly exceed alpha-lipoic acid in terms of neuroprotective effects but exhibit significantly lower hypolipdemic activity in acute phase of alloxan diabetes.

Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Hippocampus; Learning; Lipid Metabolism; Lipid Peroxidation; Male; Meglumine; Motor Activity; Neurons; Neuroprotective Agents; Nootropic Agents; Picolines; Pyridines; Rats; Succinates; Succinic Acid; Thioctic Acid

The condition of the mucous membrane and lipid spectrum of tissue structures under the action of gastric ulcerogenic stress factors was studied on the background of administration of vitamin E, dimephosphon, and reamberin. The use of antioxidants, especially reamberin, led to the restoration of lipid metabolism and normalization of lipid peroxidation processes.

Topics: Animals; Antioxidants; Catalase; Chromatography, Thin Layer; Disease Models, Animal; Female; Lipid Peroxidation; Male; Malondialdehyde; Meglumine; Organophosphorus Compounds; Oxidative Stress; Phospholipases A2; Rats; Stomach Ulcer; Succinates; Superoxide Dismutase; Vitamin E

The effect of reamberin on morphofunctional changes in the small intestine mucous membrane due to stress ulcerogenesis was studied. Normalization of the lipid modifications in the tissue structure, evident of the drug antiulcerous properties, was observed.

Topics: Animals; Disease Models, Animal; Duodenal Ulcer; Female; Humans; Intestinal Mucosa; Intestine, Small; Lipid Peroxidation; Male; Meglumine; Oxidative Stress; Rats; Stomach Ulcer; Succinates