reamberin and Bacterial-Infections

Comparative study of efficacy of the official therapy of acute gastro-intestinal infections (65 patients) and a complex therapy using a succinic acid derivative reamberin (71 patients) has been carried out. It is established that the introduction of reamberin into infusion therapy in patients with acute gastro-intestinal infections leads to a faster reduction of basic symptoms of intoxication and gastroenteritis, normalization of leukocyte intoxication index, and correction of basic indices of thrombocytes aggregation. These results allow reamberin 1.5% infusion to be recommended for the treatment of patients with acute gastro-intestinal infections.

Topics: Acute Disease; Adolescent; Adult; Antioxidants; Bacterial Infections; Blood Platelets; Endotoxins; Female; Gastrointestinal Tract; Humans; Leukocytes; Male; Meglumine; Middle Aged; Platelet Aggregation; Succinates; Treatment Outcome

Reamberin was shown to improve the efficacy of the treatment of acute intestinal infections caused by opportunistic bacteria. Its introduction into combined therapy accelerated normalization of the patients' general conditions, improved their well-being, eliminated syndrome of infectious toxicosis, diarrheic and abdominal pain syndromes, decreased duration of postinfectious asthenia, had beneficial effect on biochemical and immune parameters. Reamberin reduced the level of medium-sized molecules and malonic dialdehyde to the upper normal value which suggests elimination of endogenous "metabolic" intoxication syndrome, normalization of the level of circulating immune complexes and their fractional composition. The study showed that introduction of reamberin in combined therapy of acute intestinal infections is pathogenetically justified.

Topics: Acute Disease; Adult; Bacterial Infections; Female; Humans; Intestinal Diseases; Male; Meglumine; Middle Aged; Opportunistic Infections; Succinates; Treatment Outcome; Young Adult

The role of reamberin, a succinate-containing infusion preparation in correlation of pulmonary metabolic and respiratory disturbances in patients with obstetric puerperal sepsis was estimated. The prospective randomized study enrolled 43 patients with puerperal obstetric sepsis complicated by polyorganic deficiency (SOFA 8-10). Nineteen patients of the 1st group and 24 patients of the 2nd group were additionally treated with reamberin in a dose of 800 ml/day for 8 days. The venous and arterial difference by glucose, lactate, pyruvate, diene conjugates, malondialdehyde and ceruloplasmin was investigated. The blood gases were determined with the Ciba Corning 45 apparatus. Lower metabolic activity of the lungs with prevalence of the glucose anaerobic metabolism and lower activity of the intrapulmonary antioxidant protection were observed in the patients with obstetric sepsis. The use of reamberin in the complex therapy of obstetric sepsis promoted maintenance of the initial balance and anaeroibic and aerobic pulmonary metabolism, thus providing shorter terms of the decompensation and recovery of the lungs respiratory function.

Topics: Bacterial Infections; Blood Glucose; Ceruloplasmin; Female; Humans; Lactates; Lung; Malondialdehyde; Meglumine; Pregnancy; Puerperal Infection; Pyruvates; Respiratory Distress Syndrome; Sepsis; Succinates