reamberin and Acute-Disease

Comparative study of efficacy of the official therapy of acute gastro-intestinal infections (65 patients) and a complex therapy using a succinic acid derivative reamberin (71 patients) has been carried out. It is established that the introduction of reamberin into infusion therapy in patients with acute gastro-intestinal infections leads to a faster reduction of basic symptoms of intoxication and gastroenteritis, normalization of leukocyte intoxication index, and correction of basic indices of thrombocytes aggregation. These results allow reamberin 1.5% infusion to be recommended for the treatment of patients with acute gastro-intestinal infections.

Topics: Acute Disease; Adolescent; Adult; Antioxidants; Bacterial Infections; Blood Platelets; Endotoxins; Female; Gastrointestinal Tract; Humans; Leukocytes; Male; Meglumine; Middle Aged; Platelet Aggregation; Succinates; Treatment Outcome

Reamberin was shown to improve the efficacy of the treatment of acute intestinal infections caused by opportunistic bacteria. Its introduction into combined therapy accelerated normalization of the patients' general conditions, improved their well-being, eliminated syndrome of infectious toxicosis, diarrheic and abdominal pain syndromes, decreased duration of postinfectious asthenia, had beneficial effect on biochemical and immune parameters. Reamberin reduced the level of medium-sized molecules and malonic dialdehyde to the upper normal value which suggests elimination of endogenous "metabolic" intoxication syndrome, normalization of the level of circulating immune complexes and their fractional composition. The study showed that introduction of reamberin in combined therapy of acute intestinal infections is pathogenetically justified.

Topics: Acute Disease; Adult; Bacterial Infections; Female; Humans; Intestinal Diseases; Male; Meglumine; Middle Aged; Opportunistic Infections; Succinates; Treatment Outcome; Young Adult

Efficiency of reamberin and cycloferon application combination at the patients with the heavy form of acute tonsillitis was investigated. It is set that cycloferon and reamberin application in the complex of treatment of the patients with this pathology is instrumental in normalization of the general state and feel of patients, liquidation of both commontoxic syndrome and local inflammatory displays in pharynx, and also normalization of the studied biochemical and immunological indexes. Application of cycloferon and reamberin provides the decline of "average molecules" and malon dialdehyde level to norm, that testifies about liquidation endogenous "metabolic" intoxication syndrome, and also instrumental in normalization of phagocytes activity of monocytes indexes, that describe normalize operating of the indicated preparation on the macrophage phagocytes system.

Topics: Acridines; Acute Disease; Adult; Antioxidants; Drug Therapy, Combination; Female; Humans; Interferon Inducers; Male; Meglumine; Middle Aged; Severity of Illness Index; Succinates; Tonsillitis; Treatment Outcome; Young Adult

The study including 427 patients with acute and chronic viral hepatitis was designed to assess results of clinical and laboratory diagnostics of hepatic problems and the state of thiosulfide antioxidative system. It was shown that infusion of succinate-containing preparation reamberin (400 ml/day for 10 days) took less time to eliminate clinical manifestation of the disease (dispeptic and asthenovegetative syndromes) than conventional therapy. Simultaneously the levels of biochemical markers of hepatic cytolysis and cholestasis significantly decreased while serum antioxidative potential recovered. The normal size of the liver was achieved 3.4 times more frequently than in control. No side effects or adverse reactions other than listed in the instruction for use of reamberin occurred. The preparation had to be withdrawn only in one patient.

Topics: Acute Disease; Adolescent; Adult; Biomarkers; Chronic Disease; Cytoprotection; Female; Hepatitis, Viral, Human; Humans; Length of Stay; Male; Meglumine; Middle Aged; Succinates; Treatment Outcome; Young Adult

The incidence of intestinal fistulas after laparotomy for various reasons (peritonitis, acute pancreatitis or trauma) is 1.5%. Fistula formation in patients with chronic gastrointestinal diseases has a rapid onset, severe course, and poor prognosis. Against the background of a long course of the disease and depletion of the body, there is a decrease in the activity of reparative processes, which leads to the manifestation of postoperative complications: the formation of fistulas, insolvency of intestinal anastomoses, peritonitis. Vacuum drainage is a treatment method aimed at eliminating exudate, reducing the area of the wound and its epithelization. The inclusion of a succinate-containing solution in the treatment regimen improves metabolic processes and improves the prognosis of the disease. As an illustration, a description of the clinical observation of patients with similar pathology and different treatment regimens is given.. Частота возникновения кишечных свищей после лапаротомий по поводу разных причин (перитонит, острый панкреатит или травма) составляет 1,5%. Образование свищей у пациентов с хроническими заболеваниями желудочно-кишечного тракта имеет стремительное начало, характеризуется тяжелым течением и неблагоприятным прогнозом. На фоне длительного течения заболевания и истощения организма происходит снижение активности репаративных процессов, что приводит к проявлению послеоперационных осложнений: образованию свищей, несостоятельности кишечных анастомозов, перитонита. Вакуумное дренирование является методом лечения, направленным на элиминацию экссудата, уменьшение площади раны и ее эпителизацию. Включение в схему лечения сукцинатсодержащего раствора способствует улучшению метаболических процессов и прогноза заболевания. В качестве иллюстрации в статье приведено описание клинического наблюдения пациентов со сходной патологией и разными схемами терапии.

Topics: Acute Disease; Humans; Intestinal Fistula; Negative-Pressure Wound Therapy; Pancreatitis; Peritonitis; Succinates

The objective of this research was to study changes in parameters, characterizing endogenous intoxication in patients with acute small bowel obstruction with Reamberin included into therapy scheme. Full physical examination and surgical treatment of 202 patients with acute small bowel obstruction were conducted. The control group included 30 healthy individuals. Dynamics of such clinical biochemical parameters as medium mass molecules (MMM), malondialdehyde (MDA), diene conjugates (DC) in blood serum were analyzed in preoperative period and on the 1st, 5th and 14th day of postoperative period. Significant free radical production occurred both in preoperative period and after surgical intervention. This was the reason to include antioxidant therapy using Reamberin (STPF «POLYSAN») in addition to basic treatment. The drug is approved for use by Central Formulary Committee of the Ministry of Health of Ukraine. All patients were divided into 2 groups depending on the treatment scheme. Group I consisted of 100 patients with acute small bowel obstruction who underwent the comprehensive treatment according to recommendations of the Ministry of Health of Ukraine № 297 dated 02.04.2010 (Standards of medical care for patients with urgent surgical diseases of the abdominal cavity). 102 patients of group II received the comprehensive treatment of antihypoxant and antioxidant therapy with Reamberin added to basic scheme. The main active ingredient of Reamberin is succinic acid. The drug was administered intravenously by drop infusion in a dose of 400 ml a day during 7-day period. Administration rate did not exceed 90 drops per minute. The medicine administration was started during complex preoperative preparation and then was done immediately after the completion of surgical treatment under resuscitation conditions. It was shown that the use of Reamberin promotes effective correction of free radical imbalance, reduction of endogenous intoxication and postoperative complications.

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antioxidants; Case-Control Studies; Female; Humans; Intestinal Obstruction; Intestine, Small; Length of Stay; Lipid Peroxidation; Male; Meglumine; Middle Aged; Postoperative Complications; Solutions; Succinates; Young Adult

The purpose of this study was to evaluate the efficacy of Reamberin as a component of intensive care edematous form of acute pancreatitis in elderly and senile patients. There were analysed the treatment data of 78 patients of this category diagnosed with «acute pancreatitis edematous form». Based on the regimens, patients were divided into 2 groups: 42 patients of the main group received Reamberin in addition to the standard treatment; patients in the control group (36 patients) received standard basic therapy. Inclusion in Reamberin regimens edematous form of acute pancreatitis in patients older than 60 years increases the effectiveness of treatment due to more rapid relief of symptoms of endogenous intoxication. The drug has a membrane stabilizing action, on the one hand, preventing the progression of the destruction of the pancreas and hence increase endogenous intoxication, the other - limiting structural disorders of the liver, normalizes its detoxification function. In addition, increasing the effectiveness of anticoagulant and fibrinolytic systems Reamberin corrects disturbances in the hemostatic system, contributing to the improvement of organ blood flow hepatopancreatoduodenal zone.. Целью исследования явилась оценка эффективности препарата «Реамберин» в качестве компонента интенсивной терапии отечной формы острого панкреатита у пациентов пожилого и старческого возраста. Проведен анализ данных лечения 78 пациентов данной категории с диагнозом острого панкреатита, отечной формы. Пациенты были разделены на две группы: основную — 42 человека, дополнительно к стандартному лечению они получали Реамберин; контрольную — 36 человек, получавших стандартную базисную терапию. Включение Реамберина в схемы терапии отечной формы острого панкреатита у пациентов старше 60 лет повышает эффективность лечения за счет более быстрого купирования признаков эндогенной интоксикации. Препарат оказывает мембраностабилизирующее действие, что, с одной стороны, предупреждает прогрессирование деструкции поджелудочной железы и, соответственно, нарастание эндогенной интоксикации, а с другой, ограничивая структурные нарушения печени, нормализует ее детоксикационную функцию. Кроме того, повышая активность антикоагулянтной и фибринолитической систем, Реамберин корригирует нарушения в системе гемостаза, способствуя улучшению органного кровотока гепатопанкреатодуоденальной зоны.

Topics: Acute Disease; Aged; Antioxidants; Blood Coagulation; Drug Monitoring; Female; Humans; Male; Meglumine; Middle Aged; Multiple Organ Failure; Pancreatitis; Pharmaceutical Solutions; Retrospective Studies; Succinates; Treatment Outcome

The study was aimed to investigate the influence of drug reamberin inclusion in the treatment regimen of patients with acute Epstein-Barr virus (EBV) infection on the effectiveness of therapy. Treatment results were analyzed in a group of 70 children aged 4-15 with a diagnosis of moderate to severe EBV infection. By the method of random sampling distribution, patients were divided into two comparable groups of 35 children, which were representative with respect to gender, age, date of admission, and conducted basic therapy. Patients in the control group were treated by the conventional scheme, while the main group received basic therapy with antibacterial drug (according to indication) and symptomatic agents (antipyretics, desensitizing agents, and local antiseptics for the treatment of rotor and nasopharynx) and, in addition, obtained 1.5% reamberin solution intravenously, 10 mL/kg body weight once a day at a rate of 3-4 mL/min (the treatment course did not exceed 3 days). Treatment efficacy was assessed by a decrease in the duration of intoxication symptoms, relief of their clinical manifestations, and normalization of laboratory data (including, in addition to commonly accepted data, the levels of malonic dialdehyde, ferritin, transferrin and catalase before and after treatment).The inclusion of reamberin in the therapy of acute EBV infection in children favors (in comparison to conventional treatment regimen) more pronounced and rapid decrease the intensity of the oxidative process and improves the functioning of the antioxidant system. This was manifested by normalization of immunobiochemical indicators (reduction of malonic dialdehyde and ferritin and increase in the level of catalase) and decrease in the inflammatory response (leukocytosis, ESR, and the number of atypical mononuclear cells in the blood), This resulted in more rapid relief of the clinical manifestations of infection (sore throat, hyperthermia, lymphadenopathy, and hepatomegaly) and shortened the hospital stay by 38.5% (p < 0.05).

Topics: Acute Disease; Adolescent; Child; Child, Preschool; Epstein-Barr Virus Infections; Female; Herpesvirus 4, Human; Humans; Male; Meglumine; Metabolic Diseases; Succinates

The effect of original domestic derivatives of 3-oxypiridine and succinic acid (emoxipine, reamberin and mexidol) on the resistance to acute brain ischemia was studied in an experimental mouse models.. We used 260 adult outbred mice. The drugs were introduced intraperitoneally 30 min before the modeling of acute brain ischemia. Each drug was used in 3 three doses: 1/2 of the calculated equivalent of mean treatment dose (EMTD), EMTD and double EMTD. A strangulation model with the assessment of mouse mortality latency and decapitation model with the assessment of agonal respiration (gasping) were used. The efficacy of the drugs was determined by comparison against alpha-lipoic acid that was used as a reference substance in previous studies of antihypoxic activity of emoxipine, reamberin and mexidol.. It was established that the derivatives of 3-oxipiridine and succinic acid protected against subtotal ischemia of rostral brain segments (of cerebral hemispheres) as evidenced by the increase in longevity. Emoxipine demonstrated the maximal effect thereby surpassing reamberin and mexidol in the intensity of antiischemic activity. Antiischemic effect of alpha-lipoic acid was comparable to emoxipine. In the model of total brain ischemia, the derivatives of 3-oxipiridine and succinic acid caused the opposite (proischemic) action on the bulbar respiratory center as evidenced by the reduction in duration of gasping. Alpha-lipoic acid did not affect the duration of gasping.. Цель исследования. Сравнительный анализ влияния оригинальных отечественных производных 3-оксипиридина и янтарной кислоты (эмоксипин, реамберин и мексидол) на устойчивость к острой ишемии головного мозга в эксперименте на мышах. Материал и методы. Исследование было проведено на 260 половозрелых беспородных мышах обоего пола. Изученные лекарственные средства вводили однократно внутрибрюшинно за 30 мин до моделирования острой церебральной ишемии. Каждое лекарственное средство применяли в трех дозах: 1/2 от расчетного эквивалента средней терапевтической дозы (ЭСТД), ЭСТД и удвоенный ЭСТД. Для моделирования острой ишемии головного мозга на мышах использовали странгуляционную модель с оценкой латентности гибели мышей и декапитационную модель с оценкой длительности агонального дыхания (гаспинга). Эффективность изученных препаратов была сопоставлена с результатами применения α-липоевой кислоты (α-ЛК), которая ранее использовалась в качестве препарата сравнения при изучении антигипоксической активности эмоксипина, реамберина и мексидола. Результаты и заключение. Было установлено, что производные 3-оксипиридина и янтарной кислоты оказывают протекторное действие при субтотальной ишемии ростральных отделов головного мозга (большие полушария) по критерию увеличения продолжительности жизни. Наибольшую эффективность продемонстрировал эмоксипин, превосходивший реамберин и мексидол по выраженности антиишемического действия. α-ЛК вызывала антиишемический эффект, сопоставимый с действием эмоксипина. При моделировании тотальной ишемии головного мозга производные 3-оксипиридина и янтарной кислоты оказывали противоположное (проишемическое) действие на бульбарный дыхательный центр по критерию уменьшения длительности гаспинга. α-ЛК не влияла на продолжительность гаспинга.

Topics: Acute Disease; Animals; Brain Ischemia; Disease Models, Animal; Female; Male; Meglumine; Mice; Picolines; Pyridines; Succinates; Thioctic Acid

Topics: Acute Disease; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Ileus; Injections, Intravenous; Intestine, Small; Ischemia; Meglumine; Succinates; Swine

Survival rate, average life expectancy of victims, parameters of the acid - base balance, gas composition of blood, and morphological structure of internal organs have been studied in acute experiments on a group of 120 rats with burn injury of IIIB degree (20% of body surface) against early introduction of antihypoxants reamberin and cytoflavin. It is established that the introduction of antihypoxants reliably prevents the development of typical pathologic processes and hypoxemia, reduces expressiveness of organ dysfunction and extent of mophological changes in internal organs, and increases 1.5 - 2.5 times the survival rate of heavily damaged animals in the acute period of burn injury.

Topics: Acute Disease; Animals; Burns; Drug Combinations; Drug Evaluation, Preclinical; Female; Flavin Mononucleotide; Hypoxia; Inosine Diphosphate; Male; Meglumine; Niacinamide; Rats; Succinates

The current paper presents the results of monitoring of 69 patients with acute respiratory viral infection, acetonemic syndrome. It was shown the effectiveness of inclusion of Reamberinum into complex therapy as a means for reduction of with acetonemic syndrome and for detoxic effect.

Topics: Acute Disease; Case-Control Studies; Child; Child, Preschool; Fluid Therapy; Humans; Infant; Infusions, Parenteral; Ketosis; Meglumine; Respiratory Tract Infections; Succinates; Syndrome; Toxemia

An analysis of efficacy of 1.5% reamberin solution usage was made in 80 patients for correction of blood rheological properties disorder in the case of peritonitis and bowel obstruction. It was established, that reamberin, which was administered in the dose of 500 ml after 12 hours of the beginning of intensive care during 48 hours, efficiently corrected the rheological disorders. It was because the erythron and reticulocyte production were activated, the hyposmolarity was removed, the intensity of free radical oxidation and peroxide oxidation of lipids was decreased and the antioxidant status was restored. This facilitated the hydrophily and erythrocyte volume decrease, the haemolysis reduction and qualitative gas exchange at the level of tissues.

Topics: Acute Disease; Anti-Bacterial Agents; Blood Viscosity; Critical Care; Follow-Up Studies; Humans; Intestinal Obstruction; Meglumine; Middle Aged; Peritonitis; Succinates; Treatment Outcome

Topics: Activities of Daily Living; Acute Disease; Child, Preschool; Conscience; Female; Humans; Infant; Male; Meglumine; Muscle Tonus; Psychotropic Drugs; Succinates; Treatment Outcome

To examine efficacy of a substrate antihypoxic drug reamberine in patients with cerebral insufficiency (CI) caused by severe forms of acute poisoning.. The study enrolled 60 patients (38 males, 22 females; mean age of the males 34.7 +/- 2.6 years, of the females - 28.4 +/- 3.2 years)admitted to the intensive care unit of St. Petersburg city center for treatment of acute poisoning for acute CI as a result of severe acute poisoning with neurotropic substances. The patients were divided into 2 groups matched by age, gender and severity of poisoning: group 1 (n = 32) received reamberin and standard treatment; group 2 (n = 28) received standard treatment alone.. The addition of reamberin to intensive treatment of acute CI alleviated severity of CI, enhanced recovery of functional activity of the brain, significantly reduced tissue hypoxia. All these positive effects improved clinical course of acute CI as shown by a shorter stay in the state of coma (reduction from 55 +/- 2.2 to 33 +/- 2.6 hours, shorter stay in the intensive care unit (reduction from 69.1 +/- 3.6 to 53.4 +/- 4.3 hours), reduced cost of the treatment.. In severe poisoning with neurotropic substances reamberin enhances correction of CI and increases tissue oxygen utilization.

Topics: Acute Disease; Adult; Combined Modality Therapy; Female; Humans; Hypoxia, Brain; Intensive Care Units; Male; Meglumine; Neurotoxicity Syndromes; Severity of Illness Index; Succinates; Treatment Outcome

The level of endogenous S-adenosyl-L-methionine (SAM) production during pharmacological correction of acute toxic (tetrachloromethane) and chronic drug-induced liver injury treated by remaxol, exogenous ademethionine, and reamberin has been studied on 118 outbred male rats. It is established that, upon a single introduction of tetrachlormethane (acute toxic injury model), remaxol and exogenous SAM produced a gain in the endogenous SAM level in hepatocytes. At the same time, in the case of chronic drug-induced injury (antituberculosis drugs), only remaxol caused authentic growth of the endogenous SAM level that was comparable with a compensatory growth of SAM at nontreated animals. Considering the improvement of laboratory indicators and the histological pattern of liver in animals treated by remaxol, it is possible to conclude on the important role of succinic acid along with the induction of SAM, in the hepatoprotective effect of drugs. This is confirmed by the effect of reamberin, which contains only succinic acid without methionine and does not cause induction of endogenous SAM.

Topics: Acute Disease; Animals; Animals, Outbred Strains; Antitubercular Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury, Chronic; Hepatocytes; Liver; Male; Meglumine; Methionine; Protective Agents; Rats; S-Adenosylmethionine; Succinates; Succinic Acid

The current health conditions dictate the need to reduce the time of patient treatment in hospital and require rational use of drugs. Reduction of the duration of intoxication syndrome in severe forms of intestinal infections in children depends on infusion therapy and choice of solutions for intravenous administration. Reamberin is generation IV infusion preparation for intensive care, representing a balanced isotonic detoxicant infusion solution based on succinic acid. Using reamberin ensures a significant decrease in the time of stay in hospital for children with severe forms of intestinal infections, which is achieved by reducing the duration of endogenous intoxication.

Topics: Acid-Base Equilibrium; Acute Disease; Blood Chemical Analysis; Case-Control Studies; Child; Child, Preschool; Communicable Diseases; Critical Care; Hemodynamics; Humans; Infant; Injections, Intravenous; Intestines; Intraabdominal Infections; Meglumine; Protective Agents; Russia; Succinates