Page last updated: 2024-08-24

ranolazine and Torsade de Pointes

ranolazine has been researched along with Torsade de Pointes in 14 studies

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (35.71)29.6817
2010's7 (50.00)24.3611
2020's2 (14.29)2.80

Authors

AuthorsStudies
Arafune, T; Dobrev, D; Honjo, H; Kodama, I; Makita, N; Nattel, S; Niwa, R; Sakuma, I; Takanari, H; Tomii, N; Tsuji, Y; Tsuneyama, K; Yamazaki, M1
Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H1
Arellano, AL; Cereza, G; Figueras, A; Montané, E; Tarapués, M1
Lüthje, L; Maier, LS; Seegers, J; Sohns, C; Sossalla, S; Toischer, K; Vollmann, D; Wallisch, N; Zabel, M1
Mittal, SR1
Belardinelli, L; January, CT; Li, H; Rajamani, S; Shryock, JC; Wu, L1
Antoons, G; Beekman, JD; Belardinelli, L; Engelen, MA; Houtman, MJ; Oros, A; Stengl, M; Vos, MA1
Guo, D; Jia, S; Lian, J; Ma, A; Patel, C; Xue, X; Yan, GX; Yang, L; Yuan, Z1
Belardinelli, L; Bers, DM; Grandi, E; Li, H; Luo, A; Ma, J; Shryock, JC; Wang, C; Wu, L; Zhang, P1
Abramson, JJ; Kozhevnikov, D; Mantravadi, R; Owen, LJ; Parikh, A; Puglisi, JL; Roche, MA; Salama, G; Ye, Y1
Antzelevitch, C; Belardinelli, L; Burashnikov, A; Cordeiro, JM; Di Diego, JM; Fish, JM; Fraser, H; Goodrow, RJ; Perez, G; Scornik, F; Wu, L; Zygmunt, AC1
Rosovski, U; Viskin, S1
Antzelevitch, C; Belardinelli, L; Glass, A; Goodrow, RJ; Sicouri, S; Timothy, KW; Zygmunt, AC1
Belardinelli, L; Dhalla, AK; Robertson, C; Wang, WQ1

Reviews

1 review(s) available for ranolazine and Torsade de Pointes

ArticleYear
Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent.
    Journal of cardiovascular pharmacology and therapeutics, 2004, Volume: 9 Suppl 1

    Topics: Acetanilides; Action Potentials; Angina Pectoris; Animals; Electrophysiologic Techniques, Cardiac; Humans; Ion Channels; Long QT Syndrome; Piperazines; Ranolazine; Stereoisomerism; Torsades de Pointes

2004

Other Studies

13 other study(ies) available for ranolazine and Torsade de Pointes

ArticleYear
Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm.
    Heart rhythm, 2022, Volume: 19, Issue:2

    Topics: Action Potentials; Animals; Atrioventricular Block; Defibrillators, Implantable; Disease Models, Animal; Long QT Syndrome; Rabbits; Ranolazine; Tachycardia, Ventricular; Torsades de Pointes

2022
Pharmacological characterisation of electrocardiogram J-T
    European journal of pharmacology, 2022, Jul-15, Volume: 927

    Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil

2022
Serious QT interval prolongation with ranolazine and amiodarone.
    International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1

    Topics: Acetanilides; Aged; Amiodarone; Electrocardiography; Female; Humans; Long QT Syndrome; Piperazines; Ranolazine; Sodium Channel Blockers; Torsades de Pointes

2014
Effects of ranolazine on torsades de pointes tachycardias in a healthy isolated rabbit heart model.
    Cardiovascular therapeutics, 2014, Volume: 32, Issue:4

    Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Dose-Response Relationship, Drug; Heart Conduction System; Heart Rate; In Vitro Techniques; Perfusion; Piperazines; Potassium; Rabbits; Ranolazine; Sotalol; Time Factors; Torsades de Pointes

2014
Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine.
    The Journal of the Association of Physicians of India, 2014, Volume: 62, Issue:5

    Topics: Acetanilides; Aged, 80 and over; Angina, Unstable; Benzazepines; Bradycardia; Diltiazem; Drug Interactions; Drug Substitution; Drug Therapy, Combination; Electrocardiography; Female; Humans; Ivabradine; Long QT Syndrome; Piperazines; Ranolazine; Torsades de Pointes

2014
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.
    American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:3

    Topics: 4-Aminopyridine; Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Barium Compounds; Cell Line; Chlorides; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Conduction System; Humans; Kidney; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Tetrodotoxin; Torsades de Pointes

2009
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
    Journal of the American College of Cardiology, 2010, Feb-23, Volume: 55, Issue:8

    Topics: Acetanilides; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Dogs; Lidocaine; Models, Animal; Phenethylamines; Piperazines; Potassium Channel Blockers; Ranolazine; Sodium Channels; Sulfonamides; Torsades de Pointes

2010
Modulation of the late sodium current by ATX-II and ranolazine affects the reverse use-dependence and proarrhythmic liability of IKr blockade.
    British journal of pharmacology, 2011, Volume: 164, Issue:2

    Topics: Acetanilides; Animals; Anti-Arrhythmia Agents; Clarithromycin; Cnidarian Venoms; Heart Ventricles; Piperazines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Rabbits; Ranolazine; Sodium Channels; Sotalol; Torsades de Pointes

2011
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization.
    Circulation, 2011, Apr-26, Volume: 123, Issue:16

    Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Enzyme Inhibitors; Female; Heart Rate; Long QT Syndrome; Models, Cardiovascular; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Piperidines; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Torsades de Pointes

2011
Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2.
    Heart rhythm, 2012, Volume: 9, Issue:6

    Topics: Acetanilides; Action Potentials; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Enzyme Inhibitors; Female; Follow-Up Studies; Long QT Syndrome; Myocardium; Piperazines; Rabbits; Ranolazine; Ryanodine Receptor Calcium Release Channel; Torsades de Pointes; Treatment Outcome

2012
The degree of potassium channel blockade and the risk of torsade de pointes: the truth, nothing but the truth, but not the whole truth.
    European heart journal, 2005, Volume: 26, Issue:6

    Topics: Acetanilides; Amiodarone; Anti-Arrhythmia Agents; Humans; Piperazines; Potassium Channel Blockers; Ranolazine; Research Design; Torsades de Pointes; Verapamil

2005
Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine.
    Heart rhythm, 2007, Volume: 4, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetanilides; Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Calcium Channel Agonists; Disease Models, Animal; Dogs; Electrocardiography; Endocardium; Enzyme Inhibitors; Heart Ventricles; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Pericardium; Piperazines; Ranolazine; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Premature Complexes

2007
Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits.
    The Journal of pharmacology and experimental therapeutics, 2008, Volume: 325, Issue:3

    Topics: Acetanilides; Action Potentials; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Anti-Arrhythmia Agents; Blood Pressure; Electrocardiography; Female; Heart Rate; Lidocaine; Methoxamine; Phenylephrine; Piperazines; Potassium Channel Blockers; Prazosin; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Torsades de Pointes

2008