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ranolazine and Myocardial Ischemia

ranolazine has been researched along with Myocardial Ischemia in 87 studies

*Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). [MeSH]

Research

Studies (87)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (11.49)	18.2507
2000's	33 (37.93)	29.6817
2010's	40 (45.98)	24.3611
2020's	4 (4.60)	2.80

Authors

Authors	Studies
Arrhenius, T; Barr, R; Brown, S; Chen, M; Cheng, JF; Dyck, JR; Haramura, M; Harmon, C; Liu, B; Lopaschuk, GD; Mak, CC; Nadzan, AM; Reily, S; Thorn, V; Tith, S; Wallace, D	1
Cuisiat, F; Le Grand, B; Létienne, R; Mas, A; Pignier, C; Rolland, F; Vacher, B	1
Ayyasamy, L; Bagepally, BS	1
Chen, T; Fang, X; Huang, J; Xu, X; Zhao, Q; Zheng, J; Zhu, H	1
Brilakis, E; Burnett, GM; Chaudhry, S; Corban, M; Eshtehardi, P; Gupta, S; Hosseini, H; Hung, OY; Koh, JS; Kumar, A; Kumar, S; Liu, C; Mehta, PK; Quyyumi, AA; Raad, M; Rabah, R; Sabbak, N; Samady, H	1
Patatanian, E; Sharp, RP; Sirajuddin, R	1
Anderson, RD; Bairey Merz, CN; Cook-Wiens, G; Handberg, EM; Pepine, CJ; Petersen, JW; Quesada, O; Samuels, B; Shufelt, C; Suppogu, N; Wei, J	1
Stone, PH	2
Graham, MM; Pearson, GJ; Turgeon, RD	1
Ren, Z; Teng, S; Zhao, K	1
Bairey Merz, CN; Berman, DS; Cook-Wiens, G; Elgendy, IY; Handberg, EM; Minissian, MB; Nelson, MD; Pepine, CJ; Rambarat, CA; Shaw, LJ; Thomson, LEJ; Wei, J	1
Turgeon, RD	1
Hartsfield, C; Kazi, DS; Koch, B; Meyer, N; Nguyen, L; Tran, O	1
Boden, WE; Rasalingam, R	1
Arnold, SV; Cohen, DJ; Grantham, JA; Hirai, T; Jones, P; Karmpaliotis, D; Lombardi, W; Moses, J; Nicholson, WJ; Patterson, C; Qintar, M; Salisbury, AC; Sapontis, J; Sheehy, J; Spertus, JA; Tang, Y	1
Jacobshagen, C	1
Bacchini, S; Barbieri, L; Bongo, AS; Cavallino, C; Degiovanni, A; Lazzero, M; Lupi, A; Nardi, F; Rametta, F; Rognoni, A; Veia, A	1
Astarita, C; Capuano, N; Caruso, A; Cirillo, T; Marinelli, U; Quaranta, G; Rigo, F; Romano, C; Tagliamonte, E	1
Rehberger-Likozar, A; Šebeštjen, M	1
Alexander, KP; Ben-Yehuda, O; Dressler, O; Farzaneh-Far, R; Généreux, P; Iñiguez, A; James, S; Ohman, EM; Osmukhina, A; Shechter, M; Stone, GW; Weisz, G; Zurakowski, A	1
Anderson, RD; Bairey Merz, CN; Berman, DS; Brown, GH; Cook-Wiens, G; Handberg, EM; Mehta, PK; Minissian, MB; Pepine, CJ; Petersen, JW; Rogatko, A; Shaw, LJ; Shufelt, CL; Shuster, JJ; Thomson, LE; Wei, J	1
Cacciapuoti, F	1
Grätzel, P	1
Colombo, A; Fragasso, G; Fumero, A; Giannini, F; Godino, C; Maranta, F; Margonato, A; Oppizzi, M; Slavich, M	1
Kaliebe, J; Murdock, DK; Overton, N	1
Conti, CR	2
Arora, R; Jawad, E	1
Barone, L; Crea, F; Di Monaco, A; Lamendola, P; Lanza, GA; Pisanello, C	1
Badger, T; Barry, WH; Kadono, T; Matsuoka, N; Rodesch, CK; Rollins, D; Yamada, S; Zhang, XQ	1
Braunwald, E; Buros, JL; Chaitman, BR; Karwatowska-Prokopczuk, E; Morrow, DA; Murphy, SA; Scirica, BM; Wilson, SR	1
Arcidi, JM; Belardinelli, L; Dhalla, AK; Hale, SL; Hwang, H; Kloner, RA; Shryock, JC; Simkhovich, BZ	1
Belardinelli, L; Bhandari, A; Dhalla, AK; Dow, J; Kloner, RA; Shryock, JC; Wang, WQ	1
Gong, S; Guan, T; Li, Y; Sun, H; Wu, X; Yao, Z	1
Belardinelli, L; Blackburn, B; Heo, J; Iskandrian, AE; Venkataraman, R	1
Klocke, FJ	1
Hochman, JS; McCabe, CH; Mega, JL; Merlini, P; Morrow, DA; Murphy, SA; Scirica, BM; Sloan, S	1
Chirkov, YY; Horowitz, JD; Kennedy, JA; Sverdlov, AL	1
Dey, T; Martinez, MW; Nanda, S	1
Chaitman, BR; DeVault, A; Koch, GG; Sano, J; Stocke, K; Stone, PH	1
Boden, WE	1
Aljaroudi, W; Belardinelli, L; Heo, J; Iskandrian, AE; Venkataraman, R	1
Madias, JE	1
Ayalloore, SG; LeLorier, P	1
Bairey Merz, CN; Berman, DS; Gill, E; Goykhman, P; Mehta, PK; Minissian, M; Shaw, LJ; Shufelt, C; Slivka, M; Slomka, PJ; Thomson, LE; Wei, J; Yang, Y	1
Anderson, JL; Bair, TL; Bunch, TJ; Crandall, BG; Day, JD; Lappe, DL; Mader, KM; Mahapatra, S; May, HT; Molden, J; Muhlestein, JB; Murdock, D; Osborn, JS; Weiss, JP	1
Zaza, A	1
Boden, WE; Friedewald, VE; Roberts, WC; Stone, GW; Yancy, CW	1
Cingolani, E; Lepor, NE; Singh, BN	1
Belardinelli, L; Crumb, W; Dhalla, AK; El-Bizri, N; Hirakawa, R; Hu, L; Karpinski, S; Koltun, D; Li, CH; Li, XJ; Liu, G; Rajamani, S; Shryock, JC; Smith-Maxwell, C; Wang, WQ; Wu, L; Yao, L; Zablocki, J	1
Brambilla, G; Dei Cas, L; Della Pina, P; Gavazzoni, M; Gorga, E; Raddino, R; Regazzoni, V	1
Thadani, U	1
Cocco, G	1
Bauersachs, J	1
Di Monaco, A; Sestito, A	1
Belardinelli, L; Kumar, K; Nieminen, T; Verrier, RL	1
Stone, PH; Wimmer, NJ	1
Binding, P; Fairman, DA; Haddock, PS; Karran, EH; MacInnes, A; Phelan, A; Rhodes, Ja; Wyatt, MJ	1
Hill, JA; Schofield, RS	1
Chaitman, BR; Chumakova, G; Kuch, J; Parker, JO; Pepine, CJ; Skettino, SL; Skopal, J; Wang, W; Wolff, AA	1
Frenneaux, M; Horowitz, J; Lee, L	1
Pauly, DF; Pepine, CJ	1
Cocco, G; Pouleur, H; Rousseau, MF; Wolff, AA	1
Arora, R; Parang, P; Singh, B	1
Braunwald, E; Karwatowska-Prokopczuk, E; McCabe, CH; Morrow, DA; Scirica, BM; Skene, A	1
Belardinelli, L; Clanachan, AS; Fraser, H; Light, PE; McVeigh, JJ; Wang, L	1
Hale, SL; Kloner, RA	1
Braunwald, E; Budaj, A; Karwatowska-Prokopczuk, E; McCabe, CH; Morrow, DA; Murphy, SA; Scirica, BM; Skene, A; Varshavsky, S; Wolff, AA	1
Belardinelli, L; Braunwald, E; Gersh, BJ; Hedgepeth, CM; Hod, H; McCabe, CH; Molhoek, P; Morrow, DA; Murphy, SA; Scirica, BM; Verheugt, FW	1
Braunwald, E; Giugliano, RP	1
Hasenfuss, G; Maier, LS	1
Belardinelli, L; Shryock, JC	1
Saint, DA	1
Chaitman, BR; Sano, J	1
Barry, WH; Yamada, S; Zhang, XQ	1
Allely, MC; Brown, CM; Kenny, BA; Kilpatrick, AT; Martin, A; Spedding, M	1
Ribeiro, C	1
Hayashida, W; Pouleur, H; Rousseau, MF; van Eyll, C	1
Black, SC; Driscoll, EM; Gralinski, MR; Lucchesi, BR; McCormack, JG	1
Black, SC; Chou, AY; Gralinski, MR; Kilgore, KS; Lucchesi, BR; McCormack, JG	1
Clarke, B; McCormack, JG; Patmore, L; Spedding, M	1
Barr, RL; Lopaschuk, GD; McCormack, JG; Wolff, AA	1
Iliceto, S; Marangelli, V; Rizzon, P	1
Abiko, Y; Hara, A; Hashizume, H; Maruyama, K; Matsumura, H	1
Akahane, M; Endo, T; Komatsu, H; Maruyama, K; Murakami, M; Wang, JX	1

Reviews

27 review(s) available for ranolazine and Myocardial Ischemia

Article	Year
Cost-utility of Ranolazine for Chronic Stable Angina Pectoris: Systematic Review and Meta-analysis. Clinical therapeutics, 2023, Volume: 45, Issue:5 Topics: Acetanilides; Angina, Stable; Cost-Benefit Analysis; Humans; Myocardial Ischemia; Ranolazine	2023
Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials. Clinical therapeutics, 2019, Volume: 41, Issue:10 Topics: Angina Pectoris; Cardiovascular Agents; Coronary Artery Disease; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Randomized Controlled Trials as Topic; Ranolazine; Treatment Outcome	2019
Use of Ranolazine for the Treatment of Coronary Microvascular Dysfunction. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2021, Volume: 21, Issue:5 Topics: Cardiovascular Agents; Humans; Myocardial Ischemia; Ranolazine	2021
Pharmacologic Treatment of Patients With Myocardial Ischemia With No Obstructive Coronary Artery Disease. The American journal of cardiology, 2018, 04-01, Volume: 121, Issue:7 Topics: Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Cardiovascular Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Myocardial Ischemia; Nicorandil; Nitrates; Quality of Life; Ranolazine; Vasodilator Agents	2018
[Late sodium current and calcium overload--pathogenesis and adequate treatment]. Deutsche medizinische Wochenschrift (1946), 2013, Volume: 138, Issue:16 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Atrial Fibrillation; Benzazepines; Calcium; Calcium Channel Blockers; Cardiovascular Agents; Coronary Artery Disease; Electrocardiography; Endothelium, Vascular; Heart Failure, Diastolic; Humans; Hypercalcemia; Ivabradine; Myocardial Ischemia; Nitrates; Piperazines; Ranolazine; Sodium; Sodium Channels; Sodium-Calcium Exchanger	2013
Ranolazine: effects on ischemic heart. Recent patents on cardiovascular drug discovery, 2013, Volume: 8, Issue:3 Topics: Acetanilides; Angina, Stable; Animals; Arrhythmias, Cardiac; Clinical Trials as Topic; Diabetes Mellitus; Drug Interactions; Heart Failure; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium Channel Blockers	2013
Ranolazine and Ivabradine: two different modalities to act against ischemic heart disease. Therapeutic advances in cardiovascular disease, 2016, Volume: 10, Issue:2 Topics: Angina, Stable; Benzazepines; Cardiovascular Agents; Heart Rate; Humans; Ivabradine; Myocardial Ischemia; Oxygen Consumption; Ranolazine	2016
Chronic stable angina pectoris. Disease-a-month : DM, 2008, Volume: 54, Issue:9 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetanilides; Angina Pectoris; Antihypertensive Agents; Benzazepines; Bosentan; Chronic Disease; Counterpulsation; Cyclic Nucleotide-Gated Cation Channels; Exercise Test; Heart Murmurs; Humans; Ivabradine; Myocardial Contraction; Myocardial Ischemia; Myocardial Revascularization; Myocardium; Nicorandil; Oxygen Consumption; Perhexiline; Piperazines; Protein Kinase Inhibitors; Ranolazine; Sulfonamides; Trimetazidine; Vasodilator Agents	2008
Ranolazine: new paradigm for management of myocardial ischemia, myocardial dysfunction, and arrhythmias. Cardiology clinics, 2008, Volume: 26, Issue:4 Topics: Acetanilides; Angina Pectoris; Animals; Arrhythmias, Cardiac; Cardiomyopathies; Drug Therapy, Combination; Heart Failure; Humans; Myocardial Ischemia; Piperazines; Ranolazine	2008
[Mechanisms of myocardial cell protection from ischemia/reperfusion injury and potential clinical implications]. Giornale italiano di cardiologia (2006), 2009, Volume: 10, Issue:1 Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Animals; Apoptosis; Cell Death; Collateral Circulation; Disease Models, Animal; Humans; Ischemic Preconditioning, Myocardial; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Oxygen Consumption; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents	2009
Modulation of myocardial metabolism: an emerging therapeutic principle. Current opinion in cardiology, 2010, Volume: 25, Issue:4 Topics: Acetanilides; Amiodarone; Cardiovascular Agents; Heart Failure; Humans; Hypertrophy, Left Ventricular; Myocardial Ischemia; Myocardial Perfusion Imaging; Myocardial Reperfusion; Myocardium; Perhexiline; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	2010
[The late sodium current: pathophysiology and pharmacology of a new therapeutic target]. Giornale italiano di cardiologia (2006), 2011, Volume: 12, Issue:10 Suppl 2 Topics: Acetanilides; Arrhythmias, Cardiac; Disease Progression; Enzyme Inhibitors; Heart Conduction System; Heart Diseases; Humans; Muscle Cells; Myocardial Contraction; Myocardial Ischemia; Piperazines; Ranolazine; Sodium; Sodium Channels; Treatment Outcome	2011
The electrophysiological properties of ranolazine: a metabolic anti-ischemic drug or an energy-efficient antiarrhythmic agent? Reviews in cardiovascular medicine, 2011, Volume: 12, Issue:3 Topics: Acetanilides; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Energy Metabolism; Heart Conduction System; Humans; Myocardial Ischemia; Myocardium; Piperazines; Ranolazine	2011
Should ranolazine be used for all patients with ischemic heart disease or only for symptomatic patients with stable angina or for those with refractory angina pectoris? A critical appraisal. Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:17 Topics: Acetanilides; Cardiotonic Agents; Humans; Myocardial Ischemia; Piperazines; Product Surveillance, Postmarketing; Ranolazine; Sodium Channel Blockers; Treatment Outcome	2012
The patient with chronic ischemic heart disease. Role of ranolazine in the management of stable angina. European review for medical and pharmacological sciences, 2012, Volume: 16, Issue:12 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina, Stable; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Chronic Disease; Coronary Artery Bypass; Disease Management; Heart Function Tests; Humans; Membrane Transport Modulators; Myocardial Ischemia; Nitrates; Percutaneous Coronary Intervention; Piperazines; Platelet Aggregation Inhibitors; Ranolazine	2012
Mechanisms of ranolazine's dual protection against atrial and ventricular fibrillation. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2013, Volume: 15, Issue:3 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Coronary Artery Disease; Electrocardiography; Heart Conduction System; Heart Failure; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium; Sodium Channel Blockers; Treatment Outcome; Ventricular Fibrillation	2013
Anti-anginal and anti-ischemic effects of late sodium current inhibition. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:1 Topics: Acetanilides; Angina, Stable; Clinical Trials as Topic; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium Channel Blockers; Sodium Channels; Treatment Outcome	2013
Role of metabolically active drugs in the management of ischemic heart disease. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2001, Volume: 1, Issue:1 Topics: Acetanilides; Animals; Cardiovascular Agents; Carnitine; Clinical Trials as Topic; Dichloroacetic Acid; Energy Metabolism; Fatty Acids; Glucose; Humans; Insulin; Myocardial Ischemia; Myocardium; Piperazines; Potassium; Ranolazine; Trimetazidine	2001
Metabolic manipulation in ischaemic heart disease, a novel approach to treatment. European heart journal, 2004, Volume: 25, Issue:8 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Cardiovascular Agents; Drug Therapy, Combination; Enzyme Inhibitors; Epoxy Compounds; Glucose; Humans; Hypoglycemic Agents; Insulin; Myocardial Ischemia; Myocardium; Perhexiline; Piperazines; Potassium; Ranolazine; Trimetazidine	2004
Ischemic heart disease: metabolic approaches to management. Clinical cardiology, 2004, Volume: 27, Issue:8 Topics: Acetanilides; Cardiovascular Agents; Carnitine; Dichloroacetic Acid; Energy Metabolism; Humans; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine; Ribose; Trimetazidine	2004
Metabolic modulators for chronic cardiac ischemia. Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10, Issue:4 Topics: Acetanilides; Animals; Carnitine; Chronic Disease; Drug Evaluation, Preclinical; Enzyme Inhibitors; Heart; Humans; Lipid Metabolism; Myocardial Ischemia; Myocardium; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Trimetazidine; Vasodilator Agents; Vitamin B Complex	2005
Inhibition of sodium-dependent calcium overload to treat myocardial ischemia. Clinical cardiology, 2006, Volume: 29, Issue:4 Topics: Acetanilides; Angina Pectoris; Enzyme Inhibitors; Homeostasis; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium Channel Blockers; Sodium-Calcium Exchanger	2006
The year in non-ST-segment elevation acute coronary syndrome. Journal of the American College of Cardiology, 2007, Oct-02, Volume: 50, Issue:14 Topics: Acetanilides; Acute Disease; Age Factors; Aged; Biomarkers; Bone Morphogenetic Proteins; Cardiac Catheterization; Cardiology; Coronary Disease; Electrocardiography; Enzyme Inhibitors; Female; Fibrinolytic Agents; Glucose Metabolism Disorders; Growth Differentiation Factor 15; Hemorrhage; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Myocardial Ischemia; Piperazines; Practice Guidelines as Topic; Quality Assurance, Health Care; Ranolazine; Risk Assessment; Sex Factors	2007
Mechanism of action of the new anti-ischemia drug ranolazine. Clinical research in cardiology : official journal of the German Cardiac Society, 2008, Volume: 97, Issue:4 Topics: Acetanilides; Animals; Calcium; Clinical Trials as Topic; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium; Sodium Channels; Water-Electrolyte Balance	2008
The cardiac persistent sodium current: an appealing therapeutic target? British journal of pharmacology, 2008, Volume: 153, Issue:6 Topics: Acetanilides; Animals; Controlled Clinical Trials as Topic; Drug Delivery Systems; Drug Therapy, Combination; Electrophysiology; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Potassium Channel Blockers; Ranolazine; Sodium Channel Blockers; Sodium Channels	2008
Novel therapeutic approaches to treating chronic angina in the setting of chronic ischemic heart disease. Clinical cardiology, 2007, Volume: 30, Issue:2 Suppl 1 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Angiotensin-Converting Enzyme Inhibitors; Benzazepines; Calcium Channel Blockers; Chronic Disease; Enzyme Inhibitors; Humans; Ivabradine; Myocardial Ischemia; Nicorandil; Nitro Compounds; Piperazines; Ranolazine; rho-Associated Kinases; Sinoatrial Node; Trimetazidine; Vasodilator Agents	2007
Metabolic approach to myocardial ischemia: a novel therapeutic strategy for patients with coronary artery disease? Cardiologia (Rome, Italy), 1995, Volume: 40, Issue:10 Topics: Acetanilides; Carnitine; Clinical Trials as Topic; Coenzymes; Coronary Disease; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Superoxide Dismutase; Trimetazidine; Ubiquinone; Vasodilator Agents	1995

Trials

17 trial(s) available for ranolazine and Myocardial Ischemia

Article	Year
Microvascular Assessment of Ranolazine in Non-Obstructive Atherosclerosis: The MARINA Randomized, Double-Blinded, Controlled Pilot Trial. Circulation. Cardiovascular interventions, 2020, Volume: 13, Issue:12 Topics: Atherosclerosis; Cardiovascular Agents; Double-Blind Method; Fractional Flow Reserve, Myocardial; Humans; Myocardial Ischemia; Pilot Projects; Ranolazine; Treatment Outcome	2020
Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study. International journal of cardiology, 2019, Feb-01, Volume: 276 Topics: Adult; Aged; Angina Pectoris; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Cross-Over Studies; Double-Blind Method; Female; Humans; Microcirculation; Middle Aged; Myocardial Ischemia; Myocardial Perfusion Imaging; Ranolazine; Severity of Illness Index; Sodium Channel Blockers	2019
Effects of ranolazine on noninvasive coronary flow reserve in patients with myocardial ischemia but without obstructive coronary artery disease. Echocardiography (Mount Kisco, N.Y.), 2015, Volume: 32, Issue:3 Topics: Cardiovascular Agents; Coronary Stenosis; Double-Blind Method; Echocardiography; Female; Fractional Flow Reserve, Myocardial; Humans; Male; Myocardial Ischemia; Placebo Effect; Ranolazine; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome	2015
Influence of trimetazidine and ranolazine on endothelial function in patients with ischemic heart disease. Coronary artery disease, 2015, Volume: 26, Issue:8 Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Double-Blind Method; Endothelium, Vascular; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Ranolazine; Sodium Channel Blockers; Treatment Outcome; Trimetazidine; Ultrasonography, Doppler; Vasodilation; Vasodilator Agents	2015
Ranolazine in patients with incomplete revascularisation after percutaneous coronary intervention (RIVER-PCI): a multicentre, randomised, double-blind, placebo-controlled trial. Lancet (London, England), 2016, Jan-09, Volume: 387, Issue:10014 Topics: Aged; Angina Pectoris; Coronary Artery Disease; Coronary Stenosis; Double-Blind Method; Female; Hospitalization; Humans; Ischemic Attack, Transient; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Revascularization; Percutaneous Coronary Intervention; Ranolazine; Sodium Channel Blockers; Stroke	2016
A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): impact on angina and myocardial perfusion reserve. European heart journal, 2016, 05-14, Volume: 37, Issue:19 Topics: Administration, Oral; Angina Pectoris; Coronary Disease; Cross-Over Studies; Double-Blind Method; Drug Administration Schedule; Female; Hemodynamics; Humans; Magnetic Resonance Angiography; Male; Medication Adherence; Microvessels; Middle Aged; Myocardial Ischemia; Quality of Life; Ranolazine; Sodium Channel Blockers; Treatment Outcome	2016
Efficacy of ranolazine in patients with chronic angina observations from the randomized, double-blind, placebo-controlled MERLIN-TIMI (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Segment Elevation Acute Coronary Syndromes) 36 Trial. Journal of the American College of Cardiology, 2009, Apr-28, Volume: 53, Issue:17 Topics: Acetanilides; Acute Coronary Syndrome; Aged; Angina Pectoris; Chronic Disease; Cohort Studies; Confidence Intervals; Double-Blind Method; Enzyme Inhibitors; Exercise Test; Exercise Tolerance; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Piperazines; Proportional Hazards Models; Ranolazine	2009
A study of the effects of ranolazine using automated quantitative analysis of serial myocardial perfusion images. JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:11 Topics: Acetanilides; Aged; Angina Pectoris; Automation, Laboratory; Cardiovascular Agents; Coronary Artery Disease; Coronary Circulation; Exercise Test; Exercise Tolerance; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Perfusion Imaging; Pilot Projects; Piperazines; Ranolazine; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon; Treatment Outcome	2009
Clinical features and outcomes of women with unstable ischemic heart disease: observations from metabolic efficiency with ranolazine for less ischemia in non-ST-elevation acute coronary syndromes-thrombolysis in myocardial infarction 36 (MERLIN-TIMI 36). Circulation, 2010, Apr-27, Volume: 121, Issue:16 Topics: Acetanilides; Acute Coronary Syndrome; Aged; Angina, Unstable; Death; Electrocardiography; Enzyme Inhibitors; Female; Hospitalization; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Prospective Studies; Ranolazine; Risk Factors; Sex Characteristics; Sex Distribution; Surveys and Questionnaires; Thrombolytic Therapy	2010
The anti-ischemic mechanism of action of ranolazine in stable ischemic heart disease. Journal of the American College of Cardiology, 2010, Sep-14, Volume: 56, Issue:12 Topics: Acetanilides; Adult; Aged; Aged, 80 and over; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Enzyme Inhibitors; Exercise Test; Female; Heart Rate; Humans; Male; Middle Aged; Myocardial Ischemia; Piperazines; Ranolazine; Time Factors	2010
Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease. JACC. Cardiovascular imaging, 2011, Volume: 4, Issue:5 Topics: Acetanilides; Adenosine; Aged; Cardiovascular Agents; Coronary Circulation; Cross-Over Studies; Double-Blind Method; Feasibility Studies; Female; Humans; Los Angeles; Magnetic Resonance Imaging; Microvascular Angina; Middle Aged; Myocardial Ischemia; Myocardial Perfusion Imaging; Pilot Projects; Piperazines; Placebo Effect; Quality of Life; Ranolazine; Surveys and Questionnaires; Time Factors; Treatment Outcome; Vasodilator Agents	2011
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA, 2004, Jan-21, Volume: 291, Issue:3 Topics: Acetanilides; Adrenergic beta-Antagonists; Aged; Amlodipine; Angina Pectoris; Atenolol; Calcium Channel Blockers; Cardiovascular Agents; Chronic Disease; Diltiazem; Double-Blind Method; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Ischemia; Nitroglycerin; Physical Exertion; Piperazines; Ranolazine; Survival Analysis	2004
Comparative efficacy of ranolazine versus atenolol for chronic angina pectoris. The American journal of cardiology, 2005, Feb-01, Volume: 95, Issue:3 Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Aged; Analysis of Variance; Angina Pectoris; Atenolol; Blood Pressure; Chronic Disease; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Exercise Test; Female; Heart Rate; Humans; Linear Models; Male; Middle Aged; Myocardial Ischemia; Piperazines; Ranolazine; Treatment Outcome	2005
Evaluation of a novel anti-ischemic agent in acute coronary syndromes: design and rationale for the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST-elevation acute coronary syndromes (MERLIN)-TIMI 36 trial. American heart journal, 2006, Volume: 151, Issue:6 Topics: Acetanilides; Acute Disease; Aged; Angina, Unstable; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Ranolazine; Syndrome	2006
Effects of ranolazine on recurrent cardiovascular events in patients with non-ST-elevation acute coronary syndromes: the MERLIN-TIMI 36 randomized trial. JAMA, 2007, Apr-25, Volume: 297, Issue:16 Topics: Acetanilides; Aged; Angina Pectoris; Cardiovascular Agents; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Proportional Hazards Models; Ranolazine; Recurrence	2007
Effect of ranolazine, an antianginal agent with novel electrophysiological properties, on the incidence of arrhythmias in patients with non ST-segment elevation acute coronary syndrome: results from the Metabolic Efficiency With Ranolazine for Less Ischem Circulation, 2007, Oct-09, Volume: 116, Issue:15 Topics: Acetanilides; Acute Disease; Aged; Angina Pectoris; Arrhythmias, Cardiac; Coronary Disease; Diabetic Angiopathies; Electrocardiography; Electrophysiology; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Placebos; Ranolazine; Tachycardia; Thrombolytic Therapy	2007
Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease. Cardiovascular drugs and therapy, 1994, Volume: 8, Issue:5 Topics: Acetanilides; Angina Pectoris; Blood Pressure; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Infarction; Myocardial Ischemia; Piperazines; Ranolazine; Ventricular Function, Left	1994

Other Studies

43 other study(ies) available for ranolazine and Myocardial Ischemia

Article	Year
Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. Journal of medicinal chemistry, 2006, Mar-09, Volume: 49, Issue:5 Topics: Animals; Carboxy-Lyases; Energy Metabolism; Fatty Acids; Glucose; In Vitro Techniques; Male; Malonyl Coenzyme A; Morpholines; Myocardial Ischemia; Myocardium; Oxidation-Reduction; Phenylurea Compounds; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Swine	2006
Sodium late current blockers in ischemia reperfusion: is the bullet magic? Journal of medicinal chemistry, 2008, Jul-10, Volume: 51, Issue:13 Topics: Animals; Dose-Response Relationship, Drug; Electrophysiology; Female; Guinea Pigs; Humans; Imaging, Three-Dimensional; Male; Models, Molecular; Molecular Structure; Myocardial Ischemia; Rabbits; Rats; Rats, Wistar; Reperfusion; Sodium Channel Blockers; Structure-Activity Relationship	2008
Angina relates to coronary flow in women with ischemia and no obstructive coronary artery disease. International journal of cardiology, 2021, 06-15, Volume: 333 Topics: Angina Pectoris; Coronary Artery Disease; Coronary Circulation; Coronary Vessels; Female; Humans; Ischemia; Microcirculation; Myocardial Ischemia; Ranolazine	2021
Ranolazine in Diabetics With Stable Ischemic Heart Disease: Greatest Efficacy Related to Greatest Metabolic Stress. Journal of the American College of Cardiology, 2017, 05-09, Volume: 69, Issue:18 Topics: Diabetes Mellitus; Humans; Myocardial Ischemia; Percutaneous Coronary Intervention; Ranolazine; Stress, Physiological	2017
Vagal Stimulation Facilitates Improving Effects of Ranolazine on Cardiac Function in Rats with Chronic Ischemic Heart Failure. Current molecular medicine, 2018, Volume: 18, Issue:1 Topics: Animals; Chronic Disease; Cytokines; Disease Models, Animal; Heart Failure; Male; Myocardial Ischemia; Nerve Tissue Proteins; Norepinephrine; Ranolazine; Rats; Rats, Sprague-Dawley; Vagus Nerve Stimulation; Ventricular Function, Left	2018
Treating Angina in Women: Improving Options and Outcomes. Journal of women's health (2002), 2019, Volume: 28, Issue:5 Topics: Angina Pectoris; Female; Humans; Myocardial Ischemia; Ranolazine	2019
Revascularization Rates and Associated Costs in Patients With Stable Ischemic Heart Disease Initiating Ranolazine Versus Traditional Antianginals as Add-on Therapy. The American journal of cardiology, 2019, 05-15, Volume: 123, Issue:10 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cost-Benefit Analysis; Delayed-Action Preparations; Female; Follow-Up Studies; Health Care Costs; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Revascularization; Nitroglycerin; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Treatment Outcome; United States; Vasodilator Agents; Young Adult	2019
Role of Ranolazine in Reducing Angina, Subsequent Revascularization, and Healthcare Expenditures in Stable Ischemic Heart Disease. The American journal of cardiology, 2019, 05-15, Volume: 123, Issue:10 Topics: Angina Pectoris; Health Expenditures; Humans; Myocardial Ischemia; Myocardial Revascularization; Ranolazine; Sodium Channel Blockers	2019
De-escalation of antianginal medications after successful chronic total occlusion percutaneous coronary intervention: Frequency and relationship with health status. American heart journal, 2019, Volume: 214 Topics: Aged; Angina Pectoris; Calcium Channel Blockers; Cardiovascular Agents; Chi-Square Distribution; Chronic Disease; Coronary Occlusion; Dyspnea; Female; Health Status; Health Surveys; Humans; Logistic Models; Male; Myocardial Ischemia; Nitro Compounds; Percutaneous Coronary Intervention; Prospective Studies; Quality of Life; Ranolazine; Registries; Time Factors	2019
[Drug therapy rarely fully utilized]. MMW Fortschritte der Medizin, 2016, Feb-04, Volume: 158, Issue:2 Topics: Angina Pectoris; Humans; Myocardial Ischemia; Quality of Life; Ranolazine	2016
Long-Term Preservation of Left Ventricular Systolic Function in Patients With Refractory Angina Pectoris and Inducible Myocardial Ischemia on Optimal Medical Therapy. The American journal of cardiology, 2016, 05-15, Volume: 117, Issue:10 Topics: Aged; Angina Pectoris; Benzazepines; Cardiovascular Agents; Echocardiography; Exercise Test; Female; Follow-Up Studies; Humans; Ivabradine; Male; Myocardial Ischemia; Ranolazine; Retrospective Studies; Sodium Channel Blockers; Stroke Volume; Systole; Time Factors; Tomography, Emission-Computed, Single-Photon; Trimetazidine; Vasodilator Agents; Ventricular Function, Left	2016
Ranolozine-induced suppression of ventricular tachycardia in a patient with nonischemic cardiomyopathy: a case report. Pacing and clinical electrophysiology : PACE, 2008, Volume: 31, Issue:6 Topics: Acetanilides; Aged; Cardiomyopathies; Enzyme Inhibitors; Humans; Male; Myocardial Ischemia; Piperazines; Ranolazine; Tachycardia, Ventricular; Treatment Outcome	2008
Expanding the understanding of the treatment of chronic angina: a 21st century approach-part II. Clinical cardiology, 2008, Volume: 31, Issue:7 Topics: Acetanilides; Angina Pectoris; Angioplasty, Balloon, Coronary; Chronic Disease; Enzyme Inhibitors; Humans; Myocardial Infarction; Myocardial Ischemia; Piperazines; Randomized Controlled Trials as Topic; Ranolazine	2008
Direct toxic effects of aqueous extract of cigarette smoke on cardiac myocytes at clinically relevant concentrations. Toxicology and applied pharmacology, 2009, Apr-01, Volume: 236, Issue:1 Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Acetanilides; Angina Pectoris; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glucose; Heart Ventricles; Mice; Mitochondria, Heart; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocytes, Cardiac; Nicotine; Piperazines; Rabbits; Ranolazine; Reactive Oxygen Species; Smoke; Smoking; Time Factors	2009
Ranolazine as a cardioplegia additive improves recovery of diastolic function in isolated rat hearts. Circulation, 2009, Sep-15, Volume: 120, Issue:11 Suppl Topics: Acetanilides; Angina Pectoris; Animals; Diastole; Female; Heart Arrest, Induced; Myocardial Contraction; Myocardial Ischemia; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium; Tetrodotoxin	2009
Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. American journal of physiology. Heart and circulatory physiology, 2009, Volume: 297, Issue:5 Topics: Acetanilides; Angina Pectoris; Animals; Anti-Arrhythmia Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Rate; Infusions, Intravenous; Injections, Intravenous; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation	2009
Synthesis of ranolazine metabolites and their anti-myocardial ischemia activities. Chemical & pharmaceutical bulletin, 2009, Volume: 57, Issue:11 Topics: Acetanilides; Animals; Cardiovascular Agents; Drug Evaluation, Preclinical; Electrocardiography; Female; Glucose; Isoproterenol; Male; Mice; Mice, Inbred Strains; Myocardial Ischemia; Oxidation-Reduction; Piperazines; Ranolazine	2009
Ranolazine and the myocardial demand-supply balance. JACC. Cardiovascular imaging, 2009, Volume: 2, Issue:11 Topics: Acetanilides; Angina Pectoris; Cardiovascular Agents; Coronary Artery Disease; Coronary Circulation; Exercise Test; Humans; Myocardial Ischemia; Myocardial Perfusion Imaging; Oxygen Consumption; Piperazines; Ranolazine; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon; Treatment Outcome	2009
Ranolazine is effective for acute or chronic ischemic dysfunction with heart failure. Journal of the American College of Cardiology, 2010, Aug-31, Volume: 56, Issue:10 Topics: Acetanilides; Cardiomyopathies; Enzyme Inhibitors; Heart Failure; Humans; Myocardial Ischemia; Piperazines; Ranolazine	2010
Ranolazine and its anti-ischemic effects: revisiting an old mechanistic paradigm anew? Journal of the American College of Cardiology, 2010, Sep-14, Volume: 56, Issue:12 Topics: Acetanilides; Blood Pressure; Dose-Response Relationship, Drug; Electrocardiography; Enzyme Inhibitors; Exercise Test; Heart Rate; Humans; Myocardial Ischemia; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Time Factors	2010
The effect of ranolazine on the vasodilator-induced myocardial perfusion abnormality. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2011, Volume: 18, Issue:3 Topics: Acetanilides; Enzyme Inhibitors; Exercise Test; False Negative Reactions; Female; Humans; Male; Middle Aged; Myocardial Ischemia; Myocardial Perfusion Imaging; Piperazines; Ranolazine; Reproducibility of Results; Sensitivity and Specificity; Treatment Outcome; Vasodilator Agents	2011
Letter by Madias regarding article, "Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the Metabolic Efficiency with Ranolazine for Less Ischemia in Non-ST- Circulation, 2011, Apr-12, Volume: 123, Issue:14 Topics: Acetanilides; Acute Coronary Syndrome; Death, Sudden, Cardiac; Electrocardiography; Enzyme Inhibitors; Heart Rate; Humans; Myocardial Infarction; Myocardial Ischemia; Piperazines; Predictive Value of Tests; Ranolazine; Risk Factors; Stroke Volume; Tachycardia, Ventricular; Thrombolytic Therapy	2011
Letter by Ayalloore and LeLorier regarding article, "Relationship between nonsustained ventricular tachycardia after non-ST-elevation acute coronary syndrome and sudden cardiac death: observations from the Metabolic Efficiency with Ranolazine for Less Isc Circulation, 2011, Apr-12, Volume: 123, Issue:14 Topics: Acetanilides; Acute Coronary Syndrome; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Electrocardiography; Enzyme Inhibitors; Heart Rate; Humans; Myocardial Infarction; Myocardial Ischemia; Piperazines; Predictive Value of Tests; Ranolazine; Risk Factors; Stroke Volume; Tachycardia, Ventricular; Thrombolytic Therapy	2011
Ranolazine reduces ventricular tachycardia burden and ICD shocks in patients with drug-refractory ICD shocks. Pacing and clinical electrophysiology : PACE, 2011, Volume: 34, Issue:12 Topics: Acetanilides; Aged; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cohort Studies; Defibrillators, Implantable; Drug Therapy, Combination; Electric Countershock; Electrocardiography; Female; Humans; Hypoglycemia; Lidocaine; Male; Mexiletine; Middle Aged; Myocardial Ischemia; Piperazines; Ranolazine; Sotalol; Stroke Volume; Tachycardia, Ventricular; Treatment Outcome	2011
The editor's roundtable: role of percutaneous coronary intervention and drug-eluting stents in patients with stable coronary heart disease. The American journal of cardiology, 2011, Nov-15, Volume: 108, Issue:10 Topics: Acetanilides; Acute Coronary Syndrome; Angina Pectoris; Angioplasty, Balloon, Coronary; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antithrombins; C-Reactive Protein; Cholesterol, LDL; Clinical Trials as Topic; Coronary Angiography; Coronary Artery Bypass; Coronary Circulation; Coronary Disease; Coronary Thrombosis; Cost-Benefit Analysis; Diabetes Mellitus; Drug-Eluting Stents; Enzyme Inhibitors; Heart; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Life Style; Medical History Taking; Medication Adherence; Multidetector Computed Tomography; Myocardial Ischemia; Piperazines; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Radionuclide Imaging; Ranolazine; Risk Factors; Troponin	2011
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Cnidarian Venoms; Female; Flecainide; Heart Conduction System; Long QT Syndrome; Mutation; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Pyridines; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Sodium Channel Blockers; Triazoles	2013
[New pharmacological approaches to ischemic heart disease]. Giornale italiano di cardiologia (2006), 2012, Volume: 13, Issue:10 Suppl 2 Topics: Acetanilides; Benzazepines; Humans; Ivabradine; Myocardial Ischemia; Piperazines; Ranolazine	2012
Management of myocardial ischemia. Is ranolazine needed? For all or some patients with myocardial ischemia? Expert opinion on pharmacotherapy, 2012, Volume: 13, Issue:17 Topics: Acetanilides; Cardiotonic Agents; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium Channel Blockers	2012
[Chronic ischemic heart diseases. Effectively alleviating ischemia symptoms]. MMW Fortschritte der Medizin, 2012, Oct-18, Volume: 154, Issue:18 Topics: Acetanilides; Angina Pectoris; Clinical Trials, Phase III as Topic; Coronary Circulation; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Practice Guidelines as Topic; Ranolazine	2012
[Relative improvement of the quality of life (interview by Philip Gräzel)]. MMW Fortschritte der Medizin, 2012, Oct-18, Volume: 154, Issue:18 Topics: Acetanilides; Angina Pectoris; Drug Therapy, Combination; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Quality of Life; Ranolazine	2012
The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase. Circulation research, 2003, Aug-08, Volume: 93, Issue:3 Topics: Acetanilides; Acetyl-CoA C-Acyltransferase; Animals; Cell Line; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Heart; Humans; In Vitro Techniques; Male; Mitochondria, Heart; Myocardial Ischemia; Myocardium; Myocytes, Cardiac; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Recombinant Proteins; Trimetazidine; Vasodilator Agents	2003
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. Journal of molecular and cellular cardiology, 2006, Volume: 41, Issue:6 Topics: Acetanilides; Animals; Calcium; Cnidarian Venoms; Diastole; Heart; In Vitro Techniques; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Sodium Channels; Ventricular Function, Left	2006
Ranolazine, an inhibitor of the late sodium channel current, reduces postischemic myocardial dysfunction in the rabbit. Journal of cardiovascular pharmacology and therapeutics, 2006, Volume: 11, Issue:4 Topics: Acetanilides; Animals; Blood Pressure; Disease Models, Animal; Heart Rate; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardial Stunning; Piperazines; Rabbits; Random Allocation; Ranolazine; Sodium Channel Blockers; Stroke Volume; Time Factors; Ventricular Function, Left; Ventricular Pressure	2006
Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium. British journal of pharmacology, 2008, Volume: 153, Issue:6 Topics: Acetanilides; Animals; Calcium; Controlled Clinical Trials as Topic; Drug Delivery Systems; Drug Design; Electrophysiology; Enzyme Inhibitors; Humans; Myocardial Ischemia; Piperazines; Ranolazine; Sodium Channel Blockers; Sodium Channels	2008
Ranolazine inhibits an oxidative stress-induced increase in myocyte sodium and calcium loading during simulated-demand ischemia. Journal of cardiovascular pharmacology, 2008, Volume: 51, Issue:5 Topics: Acetanilides; Animals; Calcium; Cations, Divalent; Cations, Monovalent; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; In Vitro Techniques; Myocardial Ischemia; Myocytes, Cardiac; Oxidative Stress; Piperazines; Rabbits; Ranolazine; Sodium; Thiourea	2008
Modulation of alpha 1-adrenoceptors in rat left ventricle by ischaemia and acyl carnitines: protection by ranolazine. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:6 Topics: Acetanilides; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Dihydroalprenolol; Dihydropyridines; In Vitro Techniques; Male; Myocardial Ischemia; Palmitoylcarnitine; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha	1993
[Therapeutic application of myocardial cytoprotection]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 1994, Volume: 13, Issue:9 Topics: Acetanilides; Adrenergic beta-Antagonists; Angina Pectoris; Calcium Channel Blockers; Carnitine; Humans; Myocardial Ischemia; Niacinamide; Nicorandil; Piperazines; Ranolazine; Trimetazidine; Vasodilator Agents	1994
Effect of ranolazine on infarct size in a canine model of regional myocardial ischemia/reperfusion. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:6 Topics: Acetanilides; Animals; Coronary Circulation; Creatine Kinase; Dogs; Hemodynamics; Infusions, Intravenous; Male; Models, Cardiovascular; Myocardial Infarction; Myocardial Ischemia; Piperazines; Ranolazine; Reperfusion Injury; Risk Factors	1994
Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart. Cardiovascular research, 1994, Volume: 28, Issue:8 Topics: Acetanilides; Adenosine Triphosphate; Angina Pectoris; Animals; Calcium; Creatine Kinase; Dose-Response Relationship, Drug; Heart; Microscopy, Electron; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Perfusion; Piperazines; Potassium; Rabbits; Ranolazine; Ventricular Pressure	1994
Protective effects of ranolazine in guinea-pig hearts during low-flow ischaemia and their association with increases in active pyruvate dehydrogenase. British journal of pharmacology, 1993, Volume: 109, Issue:3 Topics: Acetanilides; Adenosine Triphosphate; Angina Pectoris; Animals; Creatine Kinase; Female; Glycogen; Guinea Pigs; Heart; In Vitro Techniques; L-Lactate Dehydrogenase; Lactates; Lactic Acid; Myocardial Ischemia; Myocardium; Perfusion; Phosphocreatine; Piperazines; Pyruvate Dehydrogenase Complex; Ranolazine	1993
Ranolazine stimulates glucose oxidation in normoxic, ischemic, and reperfused ischemic rat hearts. Circulation, 1996, Jan-01, Volume: 93, Issue:1 Topics: Acetanilides; Animals; Fatty Acids; Glucose; Hemodynamics; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Oxidation-Reduction; Piperazines; Ranolazine; Rats; Rats, Sprague-Dawley	1996
Protective effects of ranolazine, a novel anti-ischemic drug, on the hydrogen peroxide-induced derangements in isolated, perfused rat heart: comparison with dichloroacetate. Japanese journal of pharmacology, 1998, Volume: 77, Issue:1 Topics: Acetanilides; Animals; Dichloroacetic Acid; Energy Metabolism; Enzyme Activation; Hydrogen Peroxide; Lipid Peroxidation; Male; Myocardial Ischemia; Piperazines; Pyruvate Dehydrogenase Complex; Ranolazine; Rats; Rats, Sprague-Dawley; Vascular Resistance	1998
Antianginal effects of ranolazine in various experimental models of angina. Arzneimittel-Forschung, 1999, Volume: 49, Issue:3 Topics: Acetanilides; Administration, Oral; Adrenergic beta-Antagonists; Anesthesia; Angina Pectoris; Animals; Atenolol; Dogs; Duodenum; Electrocardiography; Epinephrine; Female; Intubation, Gastrointestinal; Male; Myocardial Ischemia; Piperazines; Ranolazine; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasopressins	1999