Page last updated: 2024-08-24

ranolazine and Long QT Syndrome

ranolazine has been researched along with Long QT Syndrome in 38 studies

Research

Studies (38)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (34.21)	29.6817
2010's	18 (47.37)	24.3611
2020's	7 (18.42)	2.80

Authors

Authors	Studies
Arafune, T; Dobrev, D; Honjo, H; Kodama, I; Makita, N; Nattel, S; Niwa, R; Sakuma, I; Takanari, H; Tomii, N; Tsuji, Y; Tsuneyama, K; Yamazaki, M	1
Bodeau, S; Bourgain, M; Hermida, A; Hermida, JS; Jedraszak, G; Kubala, M	1
Abdala, AP; Charles, I; Cheng, H; Hancox, JC; James, AF	1
Kawai, T; Kuninishi, Y; Muraki, Y; Nogawa, H	1
Chan, CS; Chen, SA; Chen, YC; Chen, YJ; Higa, S; Lin, FJ; Lin, YK; Liu, CM; Lu, YY	1
Beserra, SS; Campos, DR; Miranda, VM	1
Li, SY; Lv, TT; Yang, Y; Zhang, P	1
Ahmad, S; Bengel, P; Sossalla, S	1
Abdelsayed, M; Ruben, PC; Ruprai, M	1
Trujillo, TC	1
Bankston, JR; Bers, DM; Clancy, CE; Grandi, E; Kass, RS; Moreno, JD; Yang, PC	1
van den Berg, MP; van den Heuvel, F; van Gelder, IC; van Tintelen, JP; Volders, PG	1
Arellano, AL; Cereza, G; Figueras, A; Montané, E; Tarapués, M	1
Mittal, SR	1
Cossarini, F; Kumthekar, A; Massera, D; Shih, JC; Taub, CC	1
Crumb, WJ; Johannesen, L; Mason, JW; Pueyo, E; Stockbridge, N; Strauss, DG; Vicente, J	1
Adler, A; Antzelevitch, C; Barajas-Martinez, H; Belardinelli, L; Benhorin, J; Chorin, E; Hochstadt, A; Hu, D; Rosso, R; Rozovski, U; Viskin, S; Zeltser, D	1
Kaufman, ES	1
McNitt, S; Moss, AJ; Robinson, JL; Rosero, S; Schwarz, KQ; Zareba, W	1
Hagen, BM; Kass, RS; Lederer, WJ; Lindegger, N; Marks, AR	1
Foster, NJ; Haines, DE	1
Baez-Escudero, JL; Beshai, JF; Burke, MC; Shah, DP; Weisberg, IL	1
Chahine, M; Huang, H; Napolitano, C; O'Leary, ME; Priori, SG	1
Belardinelli, L; Bers, DM; Grandi, E; Li, H; Luo, A; Ma, J; Shryock, JC; Wang, C; Wu, L; Zhang, P	1
Chartier, D; Comtois, P; Duverger, JE; Fabritz, L; Kirchhof, P; Lemoine, MD; Nattel, S; Naud, P; Qi, XY	1
Abramson, JJ; Kozhevnikov, D; Mantravadi, R; Owen, LJ; Parikh, A; Puglisi, JL; Roche, MA; Salama, G; Ye, Y	1
Chen, SA; Chen, YC; Chen, YJ; Cheng, CC; Lu, YY	1
Atack, TC; Hall, L; Lowe, JS; Roden, DM; Stroud, DM; Yang, T	1
Belardinelli, L; Crumb, W; Dhalla, AK; El-Bizri, N; Hirakawa, R; Hu, L; Karpinski, S; Koltun, D; Li, CH; Li, XJ; Liu, G; Rajamani, S; Shryock, JC; Smith-Maxwell, C; Wang, WQ; Wu, L; Yao, L; Zablocki, J	1
Belardinelli, L; Cheng, ML; Karwatowska-Prokopczuk, E; Schwartz, PJ; Wang, W; Zeng, D	1
Antzelevitch, C; Belardinelli, L; Li, Y; Shryock, JC; Song, Y; Wu, L	1
Belardinelli, L; Shryock, JC; Song, Y; Wu, L	1
Chaitman, BR	1
Antzelevitch, C; Belardinelli, L; Burashnikov, A; Cordeiro, JM; Di Diego, JM; Fish, JM; Fraser, H; Goodrow, RJ; Perez, G; Scornik, F; Wu, L; Zygmunt, AC	1
Makielski, JC; Valdivia, CR	1
Fredj, S; Kass, RS; Liu, H; Sampson, KJ	1
Conti, CR	1
Antzelevitch, C; Belardinelli, L; Glass, A; Goodrow, RJ; Sicouri, S; Timothy, KW; Zygmunt, AC	1

Reviews

4 review(s) available for ranolazine and Long QT Syndrome

Article	Year
Sodium channel blockers in the management of long QT syndrome types 3 and 2: A system review and meta-analysis. Journal of cardiovascular electrophysiology, 2021, Volume: 32, Issue:11 Topics: Adrenergic beta-Antagonists; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Mexiletine; Ranolazine; Sodium Channel Blockers	2021
Inhibition of Late Sodium Current as an Innovative Antiarrhythmic Strategy. Current heart failure reports, 2017, Volume: 14, Issue:3 Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Heart Failure; Humans; Long QT Syndrome; Ranolazine; Sodium Channel Blockers; Sodium Channels	2017
The antiarrhythmic effects of ranolazine. Reviews in cardiovascular medicine, 2009, Volume: 10 Suppl 1 Topics: Acetanilides; Acute Coronary Syndrome; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Heart Conduction System; Humans; Long QT Syndrome; Piperazines; Potassium Channel Blockers; Ranolazine; Sick Sinus Syndrome; Sodium Channel Blockers; Treatment Outcome	2009
Electrophysiologic properties and antiarrhythmic actions of a novel antianginal agent. Journal of cardiovascular pharmacology and therapeutics, 2004, Volume: 9 Suppl 1 Topics: Acetanilides; Action Potentials; Angina Pectoris; Animals; Electrophysiologic Techniques, Cardiac; Humans; Ion Channels; Long QT Syndrome; Piperazines; Ranolazine; Stereoisomerism; Torsades de Pointes	2004

Trials

3 trial(s) available for ranolazine and Long QT Syndrome

Article	Year
Comprehensive T wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil. Journal of the American Heart Association, 2015, Apr-13, Volume: 4, Issue:4 Topics: Adult; Calcium Channel Blockers; Cross-Over Studies; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart; Humans; Long QT Syndrome; Male; Phenethylamines; Quinidine; Ranolazine; Sodium Channel Blockers; Sulfonamides; Verapamil	2015
Ranolazine for Congenital Long-QT Syndrome Type III: Experimental and Long-Term Clinical Data. Circulation. Arrhythmia and electrophysiology, 2016, Volume: 9, Issue:10 Topics: Adolescent; Adult; Aged; Electrocardiography; Female; Humans; Israel; Long QT Syndrome; Male; Middle Aged; NAV1.5 Voltage-Gated Sodium Channel; Phenotype; Ranolazine; Sodium Channel Blockers; Treatment Outcome	2016
Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:12 Topics: Acetanilides; Adolescent; Adult; Electrocardiography; Enzyme Inhibitors; Female; Genetic Predisposition to Disease; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Sodium; Sodium Channels; Treatment Outcome; Young Adult	2008

Other Studies

31 other study(ies) available for ranolazine and Long QT Syndrome

Article	Year
Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm. Heart rhythm, 2022, Volume: 19, Issue:2 Topics: Action Potentials; Animals; Atrioventricular Block; Defibrillators, Implantable; Disease Models, Animal; Long QT Syndrome; Rabbits; Ranolazine; Tachycardia, Ventricular; Torsades de Pointes	2022
Use of ranolazine as rescue therapy in a patient with Timothy syndrome type 2. Revista espanola de cardiologia (English ed.), 2022, Volume: 75, Issue:5 Topics: Autistic Disorder; Humans; Long QT Syndrome; Ranolazine; Syndactyly	2022
Delayed Ventricular Repolarization and Sodium Channel Current Modification in a Mouse Model of Rett Syndrome. International journal of molecular sciences, 2022, May-20, Volume: 23, Issue:10 Topics: Animals; Disease Models, Animal; Long QT Syndrome; Male; Mice; Ranolazine; Rett Syndrome; Sodium; Sodium Channels	2022
Pharmacological characterisation of electrocardiogram J-T European journal of pharmacology, 2022, Jul-15, Volume: 927 Topics: Animals; DNA-Binding Proteins; Electrocardiography; Flecainide; Guinea Pigs; Long QT Syndrome; Nifedipine; Quinidine; Quinine; Ranolazine; Sotalol; Torsades de Pointes; Verapamil	2022
Modulation of post-pacing action potential duration and contractile responses on ventricular arrhythmogenesis in chloroquine-induced long QT syndrome. European journal of pharmacology, 2023, Feb-15, Volume: 941 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Azithromycin; Long QT Syndrome; Rabbits; Ranolazine; Sodium; Tachycardia, Ventricular	2023
Inotropic and Antiarrhythmic Transmural Actions of Ranolazine in a Cellular Model of Type 3 Long QT Syndrome. Arquivos brasileiros de cardiologia, 2020, Volume: 114, Issue:4 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiac Conduction System Disease; Humans; Long QT Syndrome; Ranolazine	2020
The efficacy of Ranolazine on E1784K is altered by temperature and calcium. Scientific reports, 2018, 02-26, Volume: 8, Issue:1 Topics: Action Potentials; Brugada Syndrome; Calcium; Cardiac Conduction System Disease; HEK293 Cells; Humans; Long QT Syndrome; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Ranolazine; Sodium; Temperature	2018
Advances in the management of stable angina. Journal of managed care pharmacy : JMCP, 2006, Volume: 12, Issue:8 Suppl Topics: Acetanilides; Angina, Stable; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chronic Disease; Cytochrome P-450 CYP3A; Drug Interactions; Enzyme Inhibitors; Humans; Long QT Syndrome; Piperazines; Ranolazine	2006
Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation research, 2013, Sep-13, Volume: 113, Issue:7 Topics: Acetanilides; Action Potentials; Anti-Arrhythmia Agents; Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Long QT Syndrome; Mutation; Piperazines; Ranolazine; Sodium Channel Blockers; Sodium Channels	2013
Successful treatment of a patient with symptomatic long QT syndrome type 3 using ranolazine combined with a beta-blocker. International journal of cardiology, 2014, Jan-15, Volume: 171, Issue:1 Topics: Acetanilides; Adrenergic beta-Antagonists; Adult; Cardiac Conduction System Disease; Drug Therapy, Combination; Electrocardiography, Ambulatory; Female; Humans; Long QT Syndrome; Piperazines; Ranolazine; Sodium Channel Blockers; Treatment Outcome	2014
Serious QT interval prolongation with ranolazine and amiodarone. International journal of cardiology, 2014, Mar-01, Volume: 172, Issue:1 Topics: Acetanilides; Aged; Amiodarone; Electrocardiography; Female; Humans; Long QT Syndrome; Piperazines; Ranolazine; Sodium Channel Blockers; Torsades de Pointes	2014
Slow junctional rhythm, QTc prolongation and transient torsades de-pointes following combined use of Ivabradine, Diltiazem and Ranolazine. The Journal of the Association of Physicians of India, 2014, Volume: 62, Issue:5 Topics: Acetanilides; Aged, 80 and over; Angina, Unstable; Benzazepines; Bradycardia; Diltiazem; Drug Interactions; Drug Substitution; Drug Therapy, Combination; Electrocardiography; Female; Humans; Ivabradine; Long QT Syndrome; Piperazines; Ranolazine; Torsades de Pointes	2014
Ranolazine-induced Repolarization Changes: A Case Report. The American journal of medicine, 2015, Volume: 128, Issue:7 Topics: Acetanilides; Action Potentials; Chest Pain; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Electrocardiography; Female; Follow-Up Studies; Heart Conduction System; Humans; Long QT Syndrome; Middle Aged; Piperazines; Ranolazine; Risk Assessment; Sodium Channel Blockers; Stents; Takotsubo Cardiomyopathy	2015
Use of ranolazine in long-QT syndrome type 3. Journal of cardiovascular electrophysiology, 2008, Volume: 19, Issue:12 Topics: Acetanilides; Adolescent; Adult; Electrocardiography; Enzyme Inhibitors; Female; Genetic Predisposition to Disease; Heart Conduction System; Heart Rate; Humans; Long QT Syndrome; Male; Middle Aged; Muscle Proteins; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Sodium; Sodium Channels; Treatment Outcome; Young Adult	2008
Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine. Journal of molecular and cellular cardiology, 2009, Volume: 47, Issue:2 Topics: Acetanilides; Animals; Calcium; Calcium Signaling; Diastole; Dose-Response Relationship, Drug; Ion Channel Gating; Long QT Syndrome; Mice; Mutation; Myocytes, Cardiac; Piperazines; Ranolazine	2009
Ranolazine safely decreases ventricular and atrial fibrillation in Timothy syndrome (LQT8). Pacing and clinical electrophysiology : PACE, 2012, Volume: 35, Issue:3 Topics: Acetanilides; Adult; Anti-Arrhythmia Agents; Atrial Fibrillation; Autistic Disorder; Drug Therapy, Combination; Humans; Long QT Syndrome; Male; Piperazines; Ranolazine; Syndactyly; Treatment Outcome; Ventricular Fibrillation; Verapamil	2012
Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels. American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:1 Topics: Acetanilides; Adolescent; DNA Mutational Analysis; Electrophysiology; Enzyme Inhibitors; Genotype; Humans; Ion Channel Gating; Long QT Syndrome; Muscle Proteins; Mutation; NAV1.5 Voltage-Gated Sodium Channel; Phenotype; Piperazines; Ranolazine; Sodium Channels	2011
Late sodium current contributes to the reverse rate-dependent effect of IKr inhibition on ventricular repolarization. Circulation, 2011, Apr-26, Volume: 123, Issue:16 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Enzyme Inhibitors; Female; Heart Rate; Long QT Syndrome; Models, Cardiovascular; Myocardial Contraction; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Piperidines; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin; Torsades de Pointes	2011
Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model. Cardiovascular research, 2011, Oct-01, Volume: 92, Issue:1 Topics: Acetanilides; Action Potentials; Animals; Arrhythmias, Cardiac; Disease Models, Animal; Heart Atria; Long QT Syndrome; Male; Mice; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Sodium Channels	2011
Ranolazine stabilizes cardiac ryanodine receptors: a novel mechanism for the suppression of early afterdepolarization and torsades de pointes in long QT type 2. Heart rhythm, 2012, Volume: 9, Issue:6 Topics: Acetanilides; Action Potentials; Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Enzyme Inhibitors; Female; Follow-Up Studies; Long QT Syndrome; Myocardium; Piperazines; Rabbits; Ranolazine; Ryanodine Receptor Calcium Release Channel; Torsades de Pointes; Treatment Outcome	2012
ATX-II-induced pulmonary vein arrhythmogenesis related to atrial fibrillation and long QT syndrome. European journal of clinical investigation, 2012, Volume: 42, Issue:8 Topics: Acetanilides; Action Potentials; Analysis of Variance; Animals; Atrial Fibrillation; Cardiac Conduction System Disease; Cardiotonic Agents; Cnidarian Venoms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Atria; Humans; Long QT Syndrome; Models, Animal; Piperazines; Pulmonary Veins; Rabbits; Ranolazine	2012
Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice. Cardiovascular research, 2012, Aug-01, Volume: 95, Issue:3 Topics: Acetanilides; Action Potentials; Animals; Cnidarian Venoms; Disease Models, Animal; Electrocardiography; Female; Genetic Predisposition to Disease; Humans; Long QT Syndrome; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Risk Factors; Sex Factors; Tachycardia, Ventricular; Time Factors	2012
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias. The Journal of pharmacology and experimental therapeutics, 2013, Volume: 344, Issue:1 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Cnidarian Venoms; Female; Flecainide; Heart Conduction System; Long QT Syndrome; Mutation; Myocardial Ischemia; Myocytes, Cardiac; Patch-Clamp Techniques; Piperazines; Potassium Channel Blockers; Pyridines; Quaternary Ammonium Compounds; Rabbits; Ranolazine; Sodium Channel Blockers; Triazoles	2013
The risk of sudden cardiac death in patients with non-ST elevation acute coronary syndrome and prolonged QTc interval: effect of ranolazine. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2013, Volume: 15, Issue:3 Topics: Acetanilides; Acute Coronary Syndrome; Aged; Cardiovascular Agents; Death, Sudden, Cardiac; Electrocardiography; Female; Humans; Incidence; Kaplan-Meier Estimate; Long QT Syndrome; Male; Multivariate Analysis; Piperazines; Proportional Hazards Models; Randomized Controlled Trials as Topic; Ranolazine; Retrospective Studies; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome	2013
Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:2 Topics: Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Female; Guinea Pigs; In Vitro Techniques; Long QT Syndrome; Male; Piperazines; Ranolazine	2004
Antagonism by ranolazine of the pro-arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:2 Topics: Acetanilides; Action Potentials; Animals; Chromans; Cnidarian Venoms; Delayed Rectifier Potassium Channels; Drug Synergism; Drug Therapy, Combination; Female; Guinea Pigs; Heart Conduction System; Heart Ventricles; Ion Channel Gating; Long QT Syndrome; Male; Myocytes, Cardiac; Piperazines; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Potassium Channels, Voltage-Gated; Pyridines; Ranolazine; Sodium Channels; Sulfonamides; Tetrodotoxin; Time Factors	2004
Efficacy and safety of a metabolic modulator drug in chronic stable angina: review of evidence from clinical trials. Journal of cardiovascular pharmacology and therapeutics, 2004, Volume: 9 Suppl 1 Topics: Acetanilides; Administration, Oral; Aged; Angina Pectoris; Aryl Hydrocarbon Hydroxylases; Chronic Disease; Clinical Trials as Topic; Cross-Over Studies; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Interactions; Electrocardiography; Energy Metabolism; Exercise Test; Female; Humans; Long QT Syndrome; Male; Piperazines; Randomized Controlled Trials as Topic; Ranolazine; Single-Blind Method; Survival Analysis; Time Factors; Treatment Outcome	2004
Ranolazine and late cardiac sodium current--a therapeutic target for angina, arrhythmia and more? British journal of pharmacology, 2006, Volume: 148, Issue:1 Topics: Acetanilides; Angina Pectoris; Animals; Arrhythmias, Cardiac; Long QT Syndrome; Mutation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels	2006
Molecular basis of ranolazine block of LQT-3 mutant sodium channels: evidence for site of action. British journal of pharmacology, 2006, Volume: 148, Issue:1 Topics: Acetanilides; Action Potentials; Anesthetics, Local; Animals; Anti-Arrhythmia Agents; Binding Sites; Cell Line; Computer Simulation; Dose-Response Relationship, Drug; Humans; Lidocaine; Long QT Syndrome; Mice; Mice, Transgenic; Models, Cardiovascular; Models, Molecular; Mutation; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Piperazines; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Time Factors; Transfection	2006
Inherited long QT syndrome: phenotype and therapy to use and avoid. Clinical cardiology, 2006, Volume: 29, Issue:10 Topics: Acetanilides; Adrenergic beta-Antagonists; Contraindications; Defibrillators, Implantable; Drug Therapy; Humans; Long QT Syndrome; Phenotype; Piperazines; Ranolazine	2006
Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine. Heart rhythm, 2007, Volume: 4, Issue:5 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Acetanilides; Action Potentials; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Calcium Channel Agonists; Disease Models, Animal; Dogs; Electrocardiography; Endocardium; Enzyme Inhibitors; Heart Ventricles; Long QT Syndrome; Myocytes, Cardiac; Patch-Clamp Techniques; Pericardium; Piperazines; Ranolazine; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Premature Complexes	2007