raltegravir-potassium and Cytomegalovirus-Infections

raltegravir-potassium has been researched along with Cytomegalovirus-Infections* in 1 studies

Other Studies

1 other study(ies) available for raltegravir-potassium and Cytomegalovirus-Infections

ArticleYear
The Association of Human Cytomegalovirus with Biomarkers of Inflammation and Immune Activation in HIV-1-Infected Women.
    AIDS research and human retroviruses, 2016, Volume: 32, Issue:2

    Three groups of cytomegalovirus (CMV)-seropositive women (total n = 164) were selected from the Chicago Women's Interagency HIV-1 Study to investigate the association between CMV coinfection and immune activation: (1) HIV-1 viremic, (2) HIV-1 aviremic, and (3) HIV-1 uninfected. Quantitative measures of CMV serum IgG, CMV DNA, and serum biomarkers interleukin (IL)-6, soluble CD163 (sCD163), soluble CD14 (sCD14), and interferon gamma-induced protein (IP10) were obtained. Levels of CMV IgG and the serum biomarkers were significantly higher in the HIV-1 viremic group compared to the aviremic and uninfected groups (p < 0.001). No significant associations with CMV IgG levels were found for HIV-uninfected women. When each of the HIV-infected groups was analyzed, sCD14 levels in the viremic women were significantly associated with CMV IgG levels with p < 0.02 when adjusted for age, CD4 count, and HIV viral load. There was also a modest association (p = 0.036) with IL-6 from plasma and cervical vaginal lavage specimens both unadjusted and adjusted for CD4 count and HIV viral load. The association of CMV IgG level with sCD14 implicates the monocyte as a potential site for interaction of the two viruses, which eventually may lead to non-AIDS-defining pathological conditions.

    Topics: Adult; Anti-HIV Agents; Antibodies, Viral; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Biomarkers; Coinfection; Cytomegalovirus; Cytomegalovirus Infections; Female; HIV Infections; HIV-1; Humans; Immunoglobulin G; Inflammation; Interferon-gamma; Interleukin-6; Lipopolysaccharide Receptors; Middle Aged; Raltegravir Potassium; Receptors, Cell Surface; Viral Load; Viremia

2016