Compounds > raloxifene hydrochloride
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raloxifene hydrochloride and Disease Models, Animal

raloxifene hydrochloride has been researched along with Disease Models, Animal in 89 studies

Research

Studies (89)

TimeframeStudies, this research(%)All Research%
pre-19901 (1.12)18.7374
1990's5 (5.62)18.2507
2000's31 (34.83)29.6817
2010's42 (47.19)24.3611
2020's10 (11.24)2.80

Authors

AuthorsStudies
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV1
Chandal, N; Mahey, N; Nandanwar, H; Tambat, R; Thakur, KG; Verma, DK1
Jamdade, VS; Li, H1
Edemann-Callesen, H; Felgel-Farnholz, V; Garthe, A; Hadar, R; Hlusicka, EB; Winter, C1
Abdel-Salam, FS; Amer, MS; Basalious, EB; Elkasabgy, NA; Elkheshen, SA; Mahmoud, AA; Mostafa, AA2
Du, X; Hill, RA; Hudson, M; Jones, NC; Nakamura, JP; Schroeder, A; Sundram, S1
Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Nigar, S; Pottoo, FH; Sharma, S; Tabassum, N1
Kitade, M; Nagata, M; Shioyama, M; Takasugi, S; Yamaji, T1
Adikusuma, W; Chang, WC; Chou, PH; Chou, WH; Hung, KS; Lin, GH; Lu, HF; Mugiyanto, E; Wang, ST1
Casalena, G; Germain, D; Gomez, M; Jenkins, EC; Kenny, TC; Manfredi, G; Shah, N; Zhao, D1
Liu, F; Nan, XY; Ping, SH; Sun, Q; Tian, FM; Zhang, L; Zhou, Z1
Chen, SY; Cheng, PY; Chu, YJ; Huang, SY; Lam, KK; Lee, YM; Shen, HH1
Faverani, LP; Freire, AR; Gruber, R; Hassumi, JS; Luvizuto, ER; Momesso, GAC; Okamoto, R; Polo, TOB; Prado, FB; Ramalho-Ferreira, G; Rossi, AC1
Jou, D; Li, C; Li, H; Li, S; Lin, J; Lin, L; Liu, T; Lü, J; Ma, H; Wang, Y; Yan, D; Zhang, C; Zhao, C1
Allen, MR; Alvarez, MB; Bidwell, JP; Burr, DB; Childress, P; Condon, KW; Davis, H; He, Y; Hernandez-Buquer, S; Plotkin, LI; Robling, AG; Shao, Y; Stayrook, KR; Warden, SJ; Wek, RC; Yang, FC1
Hirata, M; Ichimaru, R; Inada, M; Matsumoto, C; Miyaura, C; Murphy, G; Nagase, H; Numabe, Y; Tominari, T; Watanabe, K; Yoshinouchi, S1
Faverani, LP; Freire, AR; Hassumi, JS; Momesso, GAC; Okamoto, R; Polo, TOB; Prado, FB; Ramalho-Ferreira, G; Rossi, AC; Yogui, FC1
Cho, DC; Gupta, R; Han, I; Kim, CH; Kim, KT; Kwon, JT; Lee, YS; Park, EK; Seo, YJ; Seu, SY; Sung, JK1
Alam, MS; Ansari, MA; Ashraf, GM; Barkat, MA; Barreto, GE; Javed, MN; Khan, A; Maqbool, A; Nigar, S; Pottoo, FH; Rasheed, R; Tabassum, N1
Bi, DD; Guo, YF; Han, MH; Hao, T; Liu, H; Qi, XY; Wang, XG; Wang, XT; Zhang, BX1
Duan, L; Huang, J; Li, X; Liang, Y; Ou, Y; Wang, D; Xiong, J; Xu, X1
Molloy, ME; Perez White, B; Tonetti, DA; Zhang, Y; Zhao, H1
Allen, MR; Aref, M; Brown, DM; Burr, DB; Gallant, MA; Newman, CL; Organ, JM; Wallace, JM1
Acaroglu, E; Akel, I; Dede, O; Demirkiran, G; Marcucio, R; Yalcin, N1
Chung, SH; Lambert, PF; Spurgeon, ME1
Gao, H; Xi, S; Xu, L1
Bao, J; Chen, Y; Dai, Y; Hu, X; Li, R; Lu, Z; Qiu, W; Shu, Y; Wu, A; Xu, W1
Amugongo, SK; Dai, W; Dave, NK; Jia, J; Jiang, L; Lane, NE; Lay, YA; Li, CS; Olivera, D; Panganiban, B; Ritchie, RO; Walsh, D; Yao, W1
Bhowmik, M; Pottoo, FH; Vohora, D1
Alvarez, P; Bogen, O; Levine, JD1
Cintra, LT; Dezan-Júnior, E; Dornelles, RC; Ervolino, E; Gomes-Filho, JE; Lodi, CS; Sivieri-Araújo, G; Wayama, MT; Yamanari, GH1
Achiwa, K; Goto, H; Hayashi, K; Honda, T; Ishigami, M; Ishikawa, T; Ishizu, Y; Katano, Y; Kuzuya, T; Luo, F1
Pávó, I; Pósa, A; Varga, C1
Allen, MR; Brown, DM; Chen, N; Creecy, A; Granke, M; Hammond, MA; Moe, SM; Newman, CL; Nyman, JS; Tian, N; Wallace, JM1
Ichimura, R; Inoue, K; Kuwata, K; Morikawa, T; Takahashi, M; Usuda, K; Watanabe, G; Yokosuka, M; Yoshida, M1
Bourque, M; Côté, M; Di Paolo, T; Morissette, M; Poirier, AA; Soulet, D1
Calignano, A; Corrado, B; Lama, A; Mattace Raso, G; Meli, R; Paciello, O; Pagano, TB; Pirozzi, C; Russo, S; Santoro, A1
Altavilla, D; Antoci, S; Armbruster, MA; Bitto, A; Burnett, BP; Di Stefano, V; Granese, R; Irrera, N; Levy, RM; Marini, H; Minutoli, L; Polito, F; Squadrito, F1
Banie, L; Lin, CS; Lin, G; Lue, TF; Ning, H; Wang, G1
Borges, CS; da Silva, BB; de Castro, JC; de Sousa, JM; dos Santos, AR; Lopes-Costa, PV; Pires, CG1
Frosch, KH; Rack, T; Sehmisch, S; Seidlova-Wuttke, D; Stuermer, EK; Stuermer, KM; Tezval, M; Wenda, E; Wuttke, W1
Armagan, G; Kanit, L; Sozmen, EY; Terek, CM; Yalcin, A1
Bavbek, M; Belen, D; Beşalti, O; Gürses, L; Oztürk, E; Seçkin, H; Senel, OO; Simşek, S; Yigitkanli, K1
Boekhoff, J; Herrmann, TR; Rack, T; Sehmisch, S; Seidlova-Wuttke, D; Stuermer, EK; Stuermer, KM; Tezval, H; Tezval, M; Wuttke, W1
Cegieła, U; Folwarczna, J; Kaczmarczyk-Sedlak, I; Nowińska, B; Pytlik, M; Sliwiński, L; Trzeciak, H; Trzeciak, HI1
Friedman, D; Harden, CL; Maclusky, NJ; Malthankar-Phatak, GH; McCloskey, DP; Pearce, P; Scharfman, HE1
Kida, Y; Marumo, K; Saito, M; Shinohara, A; Soshi, S; Ushiku, C1
Chung, SH; Lambert, PF1
Altintas, D; Cetinkaya, MB; Kandemir, B; Kokcu, A; Tosun, M1
Frye, CA; Walf, AA1
Adamo, EB; Altavilla, D; Bitto, A; Calò, M; Irrera, N; Marini, H; Minutoli, L; Polito, F; Squadrito, F; Vaccaro, M1
Enokida, M; Hagino, H; Hayashi, I; Okano, T; Teshima, R1
Carlsten, H; Engdahl, C; Erlandsson, M; Gjertsson, I; Holmdahl, R; Islander, U; Jochems, C; Lagerquist, M; Ohlsson, C1
Abedat, S; Beeri, R; Daher, S; Gal-Moscovici, A; Kott-Gutkowski, M; Lotan, C; Rajamannan, NM; Shuvy, M; Sosna, J; Valitsky, M1
Furuya, T1
Bhat, KM; Nampurath, GK; Potu, BK; Rao, MS1
Calmarza-Font, I; Garcia-Segura, LM; Lagunas, N1
Baker, SP; Boskey, AL; Brooks, DJ; Burket, JC; MacLeay, JM; van der Meulen, MC1
da Silva, BB; dos Santos, AR; Lopes-Costa, PV; Rodrigues-Junior, DM1
Ihoriya, C; Kadoya, H; Kashihara, N; Kidokoro, K; Nagasu, H; Nishi, Y; Sasaki, T; Satoh, M1
Ascaso, C; Casals, E; Castelo-Branco, C; Colodrón, M; Escaramís, G; Mercadé, I; Ordi, J; Sanjuán, A; Vanrell, JA; Vicente, JJ1
Liu, X; Menniti, FS; Ramirez, AD1
Ascaso, C; Blümel, JE; Casals, E; Castelo-Branco, C; Colodrón, M; Escaramís, G; Mercader, I; Ordi, J; Sanjuán, A; Vanrell, JA; Vicente, JJ1
Baracat, EC; de Deus, JM; Dietrich, CP; Girão, MJ; Nader, HB; Rodrigues de Lima, G; Sartori, MG1
Araki, S; Chin, M; Guo, B; Haneda, M; Isono, M; Isshiki, K; Kashiwagi, A; Koya, D; Sato, H; Sugimoto, T1
Iwamoto, J; Rowley, E; Sato, M; Schmidt, A; Stanfield, L; Takeda, T; Yeh, JK1
Hoane, MR; Kokiko, ON; Murashov, AK1
Ariazi, E; Bertucci, A; Grigg, R; Jordan, VC; Lee, ES; Meeke, K; Morris, C; O'Regan, RM; Osipo, C; Sarker, MA1
Asano, S; Kanematsu, M; Kikkawa, H; Kinoshita, M; Mitamura, M; Xiang, A1
Broulík, PD; Broulíková, K1
Guo, SW; Olive, DL1
Babayan, R; Dixon, A; Maric, C; Singh, S; Wells, CC1
Baetta, R; Bellosta, S; Cairoli, F; Canavesi, M; Comparato, C; Corsini, A; Eberini, I; Granata, A; Monetti, M; Puglisi, L1
Caeiro, JR; Cano, A; Dapía, S; del Val, R; García-Pérez, MA; Hermenegildo, C; Noguera, I; Pineda, B1
Badimon, JJ; Cardoso, L; Choi, BG; Fuster, V; Ibanez, B; Schaffler, MB; Tunstead, J; Vilahur, G; Viles-Gonzalez, JF; Yadegar, D; Zafar, MU1
Carlsten, H; Håkansson, C; Jochems, C; Lagerquist, M; Ohlsson, C1
Jordan, VC1
Best, KL; Counts, DF; Goode, RL; Hoover, DM; Jones, CD; Merriman, RL; Neubauer, BL; Sarosdy, MF; Shaar, CJ; Tanzer, LR1
Bryant, HU; Kim, J; Magee, D; McClintock, C; Sato, M; Slemenda, CW; Turner, CH1
Black, EC; Bryant, HU; Chandrasekhar, S; Frolik, CA; Magee, DE1
Carver, JM; Lundeen, SG; McKean, ML; Winneker, RC1
Bjarnason, NH; Byrjalsen, I; Christiansen, C; Haarbo, J; Kauffman, RF1
Yardley, DA1
Bélanger, A; Labrie, C; Labrie, F; Martel, C; Picard, S; Richard, V1
Bryant, HU; Gaynor, JS; Kaufman, L; Mallinckrodt, C; Monnet, E; Parker, D; Selzman, C; Turner, AS; Whitehill, T; Wrigley, R1
Lorraine, J1
Ang, WC; Farrell, E; Vollenhoven, B1
Blum, A; Cannon, RO1

Reviews

6 review(s) available for raloxifene hydrochloride and Disease Models, Animal

ArticleYear
[Bone and calcium metabolism in patients with rheumatoid arthritis].
    Clinical calcium, 2011, Volume: 21, Issue:9

    Topics: Animals; Arthritis, Rheumatoid; Bone and Bones; Calcium; Disease Models, Animal; Disease Progression; Estrogen Replacement Therapy; Estrogens; Female; Humans; Inflammation Mediators; Joints; Male; Menopause; Osteoporosis; Pregnancy; Pregnancy Complications; Raloxifene Hydrochloride

2011
Two unsuccessful clinical trials on endometriosis and a few lessons learned.
    Gynecologic and obstetric investigation, 2007, Volume: 64, Issue:1

    Topics: Adult; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Endometriosis; Estradiol; Female; Follow-Up Studies; Fulvestrant; Humans; Middle Aged; Needs Assessment; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Severity of Illness Index; Species Specificity; Treatment Failure

2007
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications.
    Breast cancer research and treatment, 1983, Volume: 3 Suppl

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes

1983
In pursuit of the prevention of breast cancer.
    The American journal of the medical sciences, 2000, Volume: 320, Issue:4

    Topics: Age Factors; Animals; Anticarcinogenic Agents; Breast Neoplasms; Cohort Studies; Confounding Factors, Epidemiologic; Contraceptives, Oral, Hormonal; Disease Models, Animal; Emigration and Immigration; Estrogen Receptor Modulators; Estrogen Replacement Therapy; Female; Humans; Italy; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Factors; Tamoxifen; Twin Studies as Topic; United Kingdom

2000
Effect of hormone replacement therapies and selective estrogen receptor modulators in postmenopausal women with uterine leiomyomas: a literature review.
    Climacteric : the journal of the International Menopause Society, 2001, Volume: 4, Issue:4

    Topics: Animals; Disease Models, Animal; Estrogen Replacement Therapy; Female; Humans; Leiomyoma; Norpregnenes; Postmenopause; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Uterine Neoplasms

2001
Selective estrogen receptor modulator effects on serum lipoproteins and vascular function in postmenopausal women and in hypercholesterolemic men.
    Annals of the New York Academy of Sciences, 2001, Volume: 949

    Topics: Animals; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Lipoproteins; Male; Nitric Oxide; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators

2001

Other Studies

83 other study(ies) available for raloxifene hydrochloride and Disease Models, Animal

ArticleYear
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49

    Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

2020
Repurposing Approved Drugs as Fluoroquinolone Potentiators to Overcome Efflux Pump Resistance in Staphylococcus aureus.
    Microbiology spectrum, 2021, 12-22, Volume: 9, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Bacterial Proteins; Biofilms; Carrier Proteins; Ciprofloxacin; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Repositioning; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Female; Fluoroquinolones; Humans; Mice; Mice, Inbred BALB C; Molecular Docking Simulation; Multidrug Resistance-Associated Proteins; Norfloxacin; Pyrvinium Compounds; Raloxifene Hydrochloride; Staphylococcal Infections; Staphylococcus aureus

2021
Raloxifene impedes cisplatin-induced nephrotoxicity through inhibition of Proinflammatory cytokines in female wistar rats.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Blood Urea Nitrogen; Cisplatin; Creatinine; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Kidney; Kidney Diseases; Raloxifene Hydrochloride; Rats, Wistar

2021
Adolescent raloxifene treatment in females prevents cognitive deficits in a neurodevelopmental rodent model of schizophrenia.
    Behavioural brain research, 2023, 03-12, Volume: 441

    Topics: Animals; Behavior, Animal; Cognition; Disease Models, Animal; Female; Humans; Male; Poly I-C; Prenatal Exposure Delayed Effects; Raloxifene Hydrochloride; Rodentia; Schizophrenia

2023
Long lasting in-situ forming implant loaded with raloxifene HCl: An injectable delivery system for treatment of bone injuries.
    International journal of pharmaceutics, 2019, Nov-25, Volume: 571

    Topics: Animals; Bone and Bones; Bone Density Conservation Agents; Chemistry, Pharmaceutical; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Evaluation, Preclinical; Drug Implants; Drug Liberation; Humans; Injections, Intralesional; Male; Osteoporotic Fractures; Polylactic Acid-Polyglycolic Acid Copolymer; Porosity; Raloxifene Hydrochloride; Rats; Surface Properties

2019
Raloxifene recovers effects of prenatal immune activation on cognitive task-induced gamma power.
    Psychoneuroendocrinology, 2019, Volume: 110

    Topics: Animals; Behavior, Animal; Biological Clocks; Cognition; Disease Models, Animal; Female; Gamma Rhythm; Immune System; Lymphocyte Activation; Male; Mice; Mice, Inbred C57BL; Poly I-C; Pregnancy; Prenatal Exposure Delayed Effects; Psychomotor Performance; Raloxifene Hydrochloride; Schizophrenia

2019
Raloxifene potentiates the effect of fluoxetine against maximal electroshock induced seizures in mice.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2020, Apr-15, Volume: 146

    Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Electroshock; Fluoxetine; Glutamic Acid; Hippocampus; Mice; Neuropeptide Y; Oxidative Stress; Raloxifene Hydrochloride; Receptors, Dopamine; Receptors, Serotonin; Seizures; Signal Transduction

2020
In-situ forming chitosan implant-loaded with raloxifene hydrochloride and bioactive glass nanoparticles for treatment of bone injuries: Formulation and biological evaluation in animal model.
    International journal of pharmaceutics, 2020, Apr-30, Volume: 580

    Topics: Animals; Bone Density Conservation Agents; Bone Regeneration; Chitosan; Disease Models, Animal; Drug Carriers; Drug Compounding; Drug Evaluation, Preclinical; Drug Implants; Glass; Male; Nanoparticles; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Tibia; Treatment Outcome

2020
Involvement of estrogen in phosphorus-induced nephrocalcinosis through fibroblast growth factor 23.
    Scientific reports, 2020, 03-17, Volume: 10, Issue:1

    Topics: Animals; Aorta; Bone Density; Calcium; Disease Models, Animal; Estrogens; Female; Fibroblast Growth Factors; Nephrocalcinosis; Ovariectomy; Phosphorus; Pyrimidines; Raloxifene Hydrochloride; Rats; Receptor, Fibroblast Growth Factor, Type 1

2020
Pharmacogenomics Study for Raloxifene in Postmenopausal Female with Osteoporosis.
    Disease markers, 2020, Volume: 2020

    Topics: Aged; Aged, 80 and over; Animals; Bone Density Conservation Agents; Disease Models, Animal; Epoxide Hydrolases; Female; Genotyping Techniques; Humans; Membrane Proteins; Mice; Middle Aged; Osteoporosis, Postmenopausal; Pharmacogenomic Variants; Raloxifene Hydrochloride; Receptors, Neuropeptide; Receptors, Pituitary Hormone-Regulating Hormone; Serine Endopeptidases; Treatment Outcome

2020
Raloxifene is a Female-specific Proteostasis Therapeutic in the Spinal Cord.
    Endocrinology, 2021, 02-01, Volume: 162, Issue:2

    Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Male; Mice; Neurodegenerative Diseases; Proteasome Endopeptidase Complex; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Sex Characteristics; Spinal Cord; Ubiquitination

2021
Raloxifene retards the progression of adjacent segmental intervertebral disc degeneration by inhibiting apoptosis of nucleus pulposus in ovariectomized rats.
    Journal of orthopaedic surgery and research, 2021, Jun-09, Volume: 16, Issue:1

    Topics: Animals; Apoptosis; Bone Density; Disease Models, Animal; Disease Progression; Female; Intervertebral Disc Degeneration; Lumbar Vertebrae; Nucleus Pulposus; Osteoporosis; Ovariectomy; Postoperative Complications; Raloxifene Hydrochloride; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Spinal Fusion

2021
Involvement of HSP70 and HO-1 in the protective effects of raloxifene on multiple organ dysfunction syndrome by endotoxemia in ovariectomized rats.
    Menopause (New York, N.Y.), 2017, Volume: 24, Issue:8

    Topics: Administration, Oral; Animals; Disease Models, Animal; Endotoxemia; Female; Heme Oxygenase-1; HSP70 Heat-Shock Proteins; Multiple Organ Failure; Ovariectomy; Raloxifene Hydrochloride; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators

2017
Raloxifene but not alendronate can compensate the impaired osseointegration in osteoporotic rats.
    Clinical oral investigations, 2018, Volume: 22, Issue:1

    Topics: Alendronate; Animals; Bone Density; Dental Implants; Disease Models, Animal; Female; Immunoenzyme Techniques; Implants, Experimental; Microscopy, Confocal; Osseointegration; Osteoporosis; Ovariectomy; Raloxifene Hydrochloride; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Tibia; X-Ray Microtomography

2018
Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling.
    Oncotarget, 2017, May-16, Volume: 8, Issue:20

    Topics: Animals; Antineoplastic Agents, Hormonal; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cytokine Receptor gp130; Cytokines; Disease Models, Animal; Humans; Interleukin-6; Leukemia Inhibitory Factor; Liver Neoplasms; Mice; Phosphorylation; Protein Transport; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; STAT6 Transcription Factor; Xenograft Model Antitumor Assays

2017
Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism.
    Endocrinology, 2017, 09-01, Volume: 158, Issue:9

    Topics: Animals; Bone and Bones; Bone Resorption; Diphosphonates; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Imidazoles; Mice; Mice, Knockout; Nuclear Matrix-Associated Proteins; Osteoporosis; Parathyroid Hormone; Raloxifene Hydrochloride; Transcription Factors; Zoledronic Acid

2017
Raloxifene reduces the risk of local alveolar bone destruction in a mouse model of periodontitis combined with systemic postmenopausal osteoporosis.
    Archives of oral biology, 2018, Volume: 85

    Topics: Alveolar Bone Loss; Animals; Bone Density; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Female; Humans; Mice; Osteoblasts; Osteoporosis, Postmenopausal; Raloxifene Hydrochloride

2018
A SERM increasing the expression of the osteoblastogenesis and mineralization-related proteins and improving quality of bone tissue in an experimental model of osteoporosis.
    Journal of applied oral science : revista FOB, 2018, Volume: 26

    Topics: Animals; beta Catenin; Core Binding Factor Alpha 1 Subunit; Disease Models, Animal; Female; Gene Expression; Immunohistochemistry; Osteoblasts; Osteocalcin; Osteogenesis; Osteopontin; Osteoporosis; Ovariectomy; Polymerase Chain Reaction; Proteins; Raloxifene Hydrochloride; Rats, Wistar; Reference Values; Reproducibility of Results; Selective Estrogen Receptor Modulators; Time Factors; Treatment Outcome; Wnt Proteins; X-Ray Microtomography

2018
Effect of a bisphosphonate and selective estrogen receptor modulator on bone remodeling in streptozotocin-induced diabetes and ovariectomized rat model.
    The spine journal : official journal of the North American Spine Society, 2018, Volume: 18, Issue:10

    Topics: Alendronate; Animals; Biomarkers; Bone Density; Bone Remodeling; Collagen Type I; Diabetes Mellitus, Experimental; Diphosphonates; Disease Models, Animal; Female; Humans; Lumbar Vertebrae; Osteocalcin; Osteoporosis, Postmenopausal; Ovariectomy; Peptides; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Streptozocin; X-Ray Microtomography

2018
The Synergistic Effect of Raloxifene, Fluoxetine, and Bromocriptine Protects Against Pilocarpine-Induced Status Epilepticus and Temporal Lobe Epilepsy.
    Molecular neurobiology, 2019, Volume: 56, Issue:2

    Topics: Animals; Anticonvulsants; Bromocriptine; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Epilepsy, Temporal Lobe; Female; Fluoxetine; Hippocampus; Male; Mice; Neurons; Oxidative Stress; Pilocarpine; Raloxifene Hydrochloride; Status Epilepticus

2019
Combined administration on You-Gui Yin and low-dose Raloxifene partially attenuates the bone loss in ovariectomized mice through the proliferation and osteogenic differentiation of bone marrow stromal cells.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2019, Volume: 53

    Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Resorption; Cell Differentiation; Cell Proliferation; Disease Models, Animal; Drug Synergism; Drugs, Chinese Herbal; Female; Mesenchymal Stem Cells; Mice, Inbred C57BL; Osteogenesis; Osteoporosis; Ovariectomy; Raloxifene Hydrochloride; Tibia

2019
Estrogen Modulates Cartilage and Subchondral Bone Remodeling in an Ovariectomized Rat Model of Postmenopausal Osteoarthritis.
    Medical science monitor : international medical journal of experimental and clinical research, 2019, Apr-29, Volume: 25

    Topics: Animals; Anterior Cruciate Ligament; Bone and Bones; Bone Density; Bone Remodeling; Cartilage; Cartilage, Articular; Disease Models, Animal; Estrogens; Extracellular Matrix; Female; Knee Joint; MicroRNAs; Osteoarthritis; Ovariectomy; Postmenopause; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen

2019
Extranuclear ERα is associated with regression of T47D PKCα-overexpressing, tamoxifen-resistant breast cancer.
    Molecular cancer, 2013, May-01, Volume: 12

    Topics: Animals; Antineoplastic Agents, Hormonal; Breast Neoplasms; Caveolin 1; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Models, Animal; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Gene Expression; Humans; Mice; Protein Binding; Protein Kinase C-alpha; Protein Transport; Raloxifene Hydrochloride; Tamoxifen; Xenograft Model Antitumor Assays

2013
In vivo reference point indentation reveals positive effects of raloxifene on mechanical properties following 6 months of treatment in skeletally mature beagle dogs.
    Bone, 2013, Volume: 56, Issue:2

    Topics: Animals; Bone Density Conservation Agents; Bone Remodeling; Disease Models, Animal; Dogs; Female; Osteoporosis; Raloxifene Hydrochloride

2013
Selective estrogen receptor modulation prevents scoliotic curve progression: radiologic and histomorphometric study on a bipedal C57Bl6 mice model.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2014, Volume: 23, Issue:2

    Topics: Animals; Bone Density; Disease Models, Animal; Disease Progression; Female; Mice; Mice, Inbred C57BL; Raloxifene Hydrochloride; Scoliosis; Selective Estrogen Receptor Modulators; Tamoxifen

2014
Recurrence of cervical cancer in mice after selective estrogen receptor modulator therapy.
    The American journal of pathology, 2014, Volume: 184, Issue:2

    Topics: Animals; Biomarkers, Tumor; Cell Proliferation; Disease Models, Animal; Epithelium; Estrogen Receptor alpha; Estrogens; Female; Genitalia, Female; Humans; Mice; Mice, Transgenic; Neoplasm Recurrence, Local; Prognosis; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Treatment Outcome; Uterine Cervical Neoplasms

2014
[Effects of raloxifene combined with conjugated equine estrogen on prothrombotic state in ovariectomized rats].
    Zhonghua fu chan ke za zhi, 2013, Volume: 48, Issue:12

    Topics: Animals; Antithrombin III; Disease Models, Animal; Estrogens, Conjugated (USP); Female; Fibrinogen; Fibrinolysis; Ovariectomy; Plasminogen Activator Inhibitor 1; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Sprague-Dawley; Risk Factors; Selective Estrogen Receptor Modulators; Thrombosis

2013
Raloxifene suppresses experimental autoimmune encephalomyelitis and NF-κB-dependent CCL20 expression in reactive astrocytes.
    PloS one, 2014, Volume: 9, Issue:4

    Topics: Animals; Astrocytes; Cell Movement; Cells, Cultured; Chemokine CCL20; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Estradiol; Female; Fulvestrant; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Multiple Sclerosis; NF-kappa B; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Signal Transduction; Th17 Cells

2014
Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2014, Volume: 25, Issue:6

    Topics: Alendronate; Animals; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Female; Femur; Hormone Replacement Therapy; Lumbar Vertebrae; Osteoporosis; Osteoporotic Fractures; Ovariectomy; Parathyroid Hormone; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Weight-Bearing; X-Ray Microtomography

2014
Raloxifene protects against seizures and neurodegeneration in a mouse model mimicking epilepsy in postmenopausal woman.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2014, Dec-18, Volume: 65

    Topics: Animals; Bone Density; Cyclohexenes; Disease Models, Animal; Epilepsy, Temporal Lobe; Female; Hippocampus; Humans; Kainic Acid; Mice; Neurodegenerative Diseases; Neurons; Postmenopause; Raloxifene Hydrochloride; Seizures; Transforming Growth Factor beta3; Vinyl Compounds

2014
Role of nociceptor estrogen receptor GPR30 in a rat model of endometriosis pain.
    Pain, 2014, Volume: 155, Issue:12

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Endometriosis; Estradiol; Estrogen Antagonists; Female; Ganglia, Spinal; Gene Expression Regulation; Hyperalgesia; Nociceptors; Oligonucleotides, Antisense; Pain Threshold; Pelvic Pain; Protein Kinase C-epsilon; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; RNA, Messenger

2014
Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model.
    International endodontic journal, 2015, Volume: 48, Issue:11

    Topics: Alkaline Phosphatase; Animals; Biomarkers; Calcium; Disease Models, Animal; Estradiol; Female; Immunohistochemistry; Mandible; Neovascularization, Physiologic; Organ Size; Osteoclasts; Osteogenesis; Ovariectomy; Periapical Periodontitis; Phosphorus; Raloxifene Hydrochloride; Rats; Rats, Wistar

2015
Raloxifene Ameliorates Liver Fibrosis of Nonalcoholic Steatohepatitis Induced by Choline-Deficient High-Fat Diet in Ovariectomized Mice.
    Digestive diseases and sciences, 2015, Volume: 60, Issue:9

    Topics: Alanine Transaminase; Animals; Choline Deficiency; Disease Models, Animal; Estrogen Receptor alpha; Female; Gene Expression; Hepatic Stellate Cells; Liver; Liver Cirrhosis; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Organ Size; Ovariectomy; Raloxifene Hydrochloride; RNA, Messenger; Selective Estrogen Receptor Modulators

2015
Heme oxygenase contributes to estradiol and raloxifene-induced vasorelaxation in estrogen deficiency.
    International journal of cardiology, 2015, Volume: 189

    Topics: Analysis of Variance; Animals; Disease Models, Animal; Estradiol; Estrogens; Female; Heme Oxygenase (Decyclizing); Ovariectomy; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Wistar; Sensitivity and Specificity; Vasodilation

2015
Raloxifene improves skeletal properties in an animal model of cystic chronic kidney disease.
    Kidney international, 2016, Volume: 89, Issue:1

    Topics: Animals; Blood Urea Nitrogen; Bone Density Conservation Agents; Bone Remodeling; Collagen; Disease Models, Animal; Femur; Male; Mechanical Phenomena; Parathyroid Hormone; Polycystic Kidney, Autosomal Dominant; Raloxifene Hydrochloride; Rats; Renal Insufficiency, Chronic; Spine

2016
Neonatal exposure to SERMs disrupts neuroendocrine development and postnatal reproductive function through alteration of hypothalamic kisspeptin neurons in female rats.
    Neurotoxicology, 2016, Volume: 56

    Topics: Age Factors; Animals; Animals, Newborn; Body Weight; Developmental Disabilities; Disease Models, Animal; Endocrine System Diseases; Estradiol; Estrous Cycle; Female; Hormones; Hypothalamus; Kisspeptins; Neurons; Ovariectomy; Pregnancy; Progesterone; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Tamoxifen

2016
Neuroprotective and immunomodulatory effects of raloxifene in the myenteric plexus of a mouse model of Parkinson's disease.
    Neurobiology of aging, 2016, Volume: 48

    Topics: Animals; Anti-Inflammatory Agents; Benzodioxoles; Cells, Cultured; Cytokines; Disease Models, Animal; Dopaminergic Neurons; Inflammation Mediators; Macrophages; Myenteric Plexus; Neuroprotective Agents; NF-kappa B; Nitric Oxide; Parkinson Disease; Quinolines; Raloxifene Hydrochloride; Receptors, Estrogen; Receptors, G-Protein-Coupled; Selective Estrogen Receptor Modulators

2016
Extracorporeal shock waves alone or combined with raloxifene promote bone formation and suppress resorption in ovariectomized rats.
    PloS one, 2017, Volume: 12, Issue:2

    Topics: Adiponectin; Animals; Biomarkers; Bone and Bones; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Female; High-Energy Shock Waves; Osteogenesis; Osteoporosis; Ovariectomy; PPAR gamma; Raloxifene Hydrochloride; Rats; Transcription, Genetic

2017
Effects of genistein aglycone in osteoporotic, ovariectomized rats: a comparison with alendronate, raloxifene and oestradiol.
    British journal of pharmacology, 2008, Volume: 155, Issue:6

    Topics: Alendronate; Animals; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Female; Genistein; Osteoporosis; Ovariectomy; Phytoestrogens; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors

2008
Effects of estrogen, raloxifene and levormeloxifene on alpha1A-adrenergic receptor expression.
    The Journal of urology, 2008, Volume: 180, Issue:5

    Topics: Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Estrogens; Female; Fluorescent Antibody Technique; Gene Expression Regulation; Immunohistochemistry; Postpartum Period; Pregnancy; Pregnancy, Animal; Pyrrolidines; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Reference Values; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity

2008
Effects of raloxifene on the urethra of adult castrated female rats.
    Climacteric : the journal of the International Menopause Society, 2008, Volume: 11, Issue:6

    Topics: Animals; Disease Models, Animal; Female; Ovariectomy; Postmenopause; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Urethra; Urinary Bladder; Urinary Incontinence

2008
Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat.
    Langenbeck's archives of surgery, 2010, Volume: 395, Issue:2

    Topics: Analysis of Variance; Animals; Biomechanical Phenomena; Bone Density Conservation Agents; Disease Models, Animal; Drug Therapy, Combination; Estradiol; Female; Fluorescent Dyes; Fracture Fixation, Internal; Fracture Healing; Microradiography; Osteoporosis; Osteotomy; Ovariectomy; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Tibial Fractures

2010
The levels of glutathione and nitrite-nitrate and the expression of Bcl-2 mRNA in ovariectomized rats treated by raloxifene against kainic acid.
    The International journal of neuroscience, 2009, Volume: 119, Issue:2

    Topics: Animals; Apoptosis; Disease Models, Animal; Female; Glutathione; Kainic Acid; Nerve Degeneration; Neuroprotective Agents; Nitrates; Nitric Oxide; Nitrites; Ovariectomy; Oxidative Stress; Proto-Oncogene Proteins c-bcl-2; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; RNA, Messenger; Selective Estrogen Receptor Modulators; Treatment Outcome; Up-Regulation

2009
Effects of raloxifene on cerebral vasospasm after experimental Subarachnoid Hemorrhage in rabbits.
    Surgical neurology, 2009, Volume: 72, Issue:5

    Topics: Animals; Basilar Artery; Calcium Channels, L-Type; Cerebral Arteries; Cyclic GMP; Disease Models, Animal; Endothelial Cells; Estrogen Receptor alpha; Male; Muscle, Smooth, Vascular; Myosin Light Chains; Rabbits; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Subarachnoid Hemorrhage; Treatment Outcome; Vasodilation; Vasodilator Agents; Vasospasm, Intracranial

2009
Effect of testosterone, raloxifene and estrogen replacement on the microstructure and biomechanics of metaphyseal osteoporotic bones in orchiectomized male rats.
    World journal of urology, 2009, Volume: 27, Issue:4

    Topics: Administration, Oral; Animals; Biomechanical Phenomena; Bone and Bones; Bone Density; Bone Resorption; Disease Models, Animal; Estrogens; Hormone Replacement Therapy; Male; Orchiectomy; Osteoporosis; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Testosterone

2009
A comparative study of the effects of genistein, estradiol and raloxifene on the murine skeletal system.
    Acta biochimica Polonica, 2009, Volume: 56, Issue:2

    Topics: Animals; Body Weight; Bone and Bones; Bone Density; Bone Marrow Cells; Bone Resorption; Calcification, Physiologic; Calcium; Cell Count; Cells, Cultured; Disease Models, Animal; Drug Combinations; Estradiol; Estriol; Female; Gene Expression; Genistein; Humans; Mice; Mice, Inbred BALB C; Organ Size; Osteoblasts; Osteoclasts; Osteoporosis, Postmenopausal; Ovariectomy; Phytoestrogens; Raloxifene Hydrochloride; Rats; Rats, Wistar; RNA, Messenger; Selective Estrogen Receptor Modulators; Thymus Gland; Uterus

2009
A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures.
    Endocrinology, 2009, Volume: 150, Issue:9

    Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Estrous Cycle; Female; Pentobarbital; Pilocarpine; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus

2009
Raloxifene ameliorates detrimental enzymatic and nonenzymatic collagen cross-links and bone strength in rabbits with hyperhomocysteinemia.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2010, Volume: 21, Issue:4

    Topics: Animals; Arginine; Bone and Bones; Bone Density; Bone Density Conservation Agents; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycation End Products, Advanced; Hyperhomocysteinemia; Lysine; Methionine; Osteoporosis; Rabbits; Raloxifene Hydrochloride; Stress, Mechanical

2010
Prevention and treatment of cervical cancer in mice using estrogen receptor antagonists.
    Proceedings of the National Academy of Sciences of the United States of America, 2009, Nov-17, Volume: 106, Issue:46

    Topics: Animals; Antineoplastic Agents, Hormonal; Disease Models, Animal; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fulvestrant; Humans; Mice; Mice, Transgenic; Papillomavirus Infections; Raloxifene Hydrochloride; Uterine Cervical Neoplasms

2009
Comparison of the effects of raloxifene and anastrozole on experimental endometriosis.
    European journal of obstetrics, gynecology, and reproductive biology, 2010, Volume: 150, Issue:1

    Topics: Anastrozole; Animals; Aromatase Inhibitors; Disease Models, Animal; Endometriosis; Female; Nitriles; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Wistar; Single-Blind Method; Triazoles

2010
Raloxifene and/or estradiol decrease anxiety-like and depressive-like behavior, whereas only estradiol increases carcinogen-induced tumorigenesis and uterine proliferation among ovariectomized rats.
    Behavioural pharmacology, 2010, Volume: 21, Issue:3

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anxiety; Behavior, Animal; Carcinogens; Cell Proliferation; Depression; Disease Models, Animal; Drug Interactions; Estradiol; Estrogens; Female; Maze Learning; Neoplasms; Ovariectomy; Raloxifene Hydrochloride; Rats; Rats, Long-Evans; Regression Analysis; Sexual Behavior, Animal; Swimming; Time Factors; Uterus

2010
Genistein aglycone improves skin repair in an incisional model of wound healing: a comparison with raloxifene and oestradiol in ovariectomized rats.
    British journal of pharmacology, 2010, Volume: 160, Issue:5

    Topics: Animals; Dermatologic Surgical Procedures; Disease Models, Animal; Dose-Response Relationship, Drug; Ethinyl Estradiol; Female; Genistein; GTP-Binding Proteins; Ovariectomy; Phytoestrogens; Protein Glutamine gamma Glutamyltransferase 2; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Sprague-Dawley; Skin; Tensile Strength; Transforming Growth Factor beta1; Transglutaminases; Vascular Endothelial Growth Factor A; Wound Healing

2010
Effect of raloxifene on arthritis and bone mineral density in rats with collagen-induced arthritis.
    Calcified tissue international, 2011, Volume: 88, Issue:2

    Topics: Animals; Arthritis; Arthritis, Experimental; Bone Density; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Female; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley

2011
Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in B10.Q-ncf1*/* mice with collagen-induced chronic arthritis.
    BMC musculoskeletal disorders, 2010, Dec-16, Volume: 11

    Topics: Animals; Arthritis, Experimental; Cartilage; Disease Models, Animal; Disease Progression; Estradiol; Estrogens; Female; Interleukin-6; Mice; Mice, Inbred DBA; Mice, Mutant Strains; Mutation; NADPH Oxidases; Osteoarthritis; Ovariectomy; Prevalence; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators

2010
Raloxifene attenuates Gas6 and apoptosis in experimental aortic valve disease in renal failure.
    American journal of physiology. Heart and circulatory physiology, 2011, Volume: 300, Issue:5

    Topics: Animals; Aortic Valve; Apoptosis; Calcinosis; Disease Models, Animal; Female; Heart Valve Diseases; Intercellular Signaling Peptides and Proteins; Mitogen-Activated Protein Kinase Kinases; Proto-Oncogene Proteins c-akt; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Renal Insufficiency; Selective Estrogen Receptor Modulators; Signal Transduction; Uremia

2011
Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats.
    La Clinica terapeutica, 2011, Volume: 162, Issue:4

    Topics: Acid Phosphatase; Alkaline Phosphatase; Alkanes; Animals; Biomarkers; Bone Diseases, Metabolic; Bone Resorption; Calcium; Cissus; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Femur; Humans; Hydroxyproline; Isoenzymes; Osteoporosis, Postmenopausal; Ovariectomy; Phytotherapy; Plant Extracts; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Wistar; Tartrate-Resistant Acid Phosphatase

2011
Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to chronic unpredictable stress.
    Behavioural brain research, 2012, Feb-01, Volume: 227, Issue:1

    Topics: Animals; Anxiety; Depression; Disease Models, Animal; Female; Immobility Response, Tonic; Maze Learning; Mice; Ovariectomy; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Social Isolation; Stress, Psychological; Swimming; Tamoxifen

2012
Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment.
    Bone, 2013, Volume: 52, Issue:1

    Topics: Animals; Biomechanical Phenomena; Bone Density Conservation Agents; Diphosphonates; Disease Models, Animal; Imidazoles; Nanotechnology; Osteoporosis; Raloxifene Hydrochloride; Sheep; Spectrum Analysis, Raman; Zoledronic Acid

2013
Effects of tamoxifen and raloxifene on body and uterine weights of rats in persistent estrus.
    Clinical and experimental obstetrics & gynecology, 2012, Volume: 39, Issue:3

    Topics: Animals; Anovulation; Body Weight; Disease Models, Animal; Female; Organ Size; Raloxifene Hydrochloride; Rats; Rats, Wistar; Selective Estrogen Receptor Modulators; Tamoxifen; Uterus

2012
Selective estrogen receptor modulation attenuates proteinuria-induced renal tubular damage by modulating mitochondrial oxidative status.
    Kidney international, 2013, Volume: 83, Issue:4

    Topics: Animals; Apoptosis; Atrophy; Cells, Cultured; Cytokines; Disease Models, Animal; Female; Fibrosis; Gene Expression Regulation; Glomerulonephritis; Humans; Inflammasomes; Inflammation Mediators; Kidney Tubules, Proximal; Lipid Peroxidation; Macrophages; Mice; Mice, Inbred ICR; Mitochondria; Nephritis, Hereditary; NF-kappa B; Ovariectomy; Oxidation-Reduction; Oxidative Stress; Proteinuria; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators

2013
Effects of estradiol, cyproterone acetate, tibolone and raloxifene on uterus and aorta atherosclerosis in oophorectomized cholesterol-fed rabbits.
    Maturitas, 2003, May-30, Volume: 45, Issue:1

    Topics: Animals; Aorta; Arteriosclerosis; Cholesterol, Dietary; Cyproterone Acetate; Disease Models, Animal; Estradiol; Estrogen Replacement Therapy; Female; Norpregnenes; Ovariectomy; Rabbits; Raloxifene Hydrochloride; Uterus

2003
Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice.
    Neuroendocrinology, 2003, Volume: 77, Issue:4

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Estradiol; Male; Mice; Mice, Inbred C57BL; Neostriatum; Neuroprotective Agents; Parkinsonian Disorders; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators

2003
Raloxifene inhibits cholesterol aortic content but not atherosclerotic plaque size in oophorectomised cholesterol-fed rabbits.
    Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2004, Volume: 24, Issue:1

    Topics: Analysis of Variance; Animals; Aorta; Area Under Curve; Arteriosclerosis; Biopsy, Needle; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Female; Immunohistochemistry; Lipoproteins, LDL; Ovariectomy; Probability; Rabbits; Raloxifene Hydrochloride; Random Allocation; Reference Values; Selective Estrogen Receptor Modulators; Sensitivity and Specificity

2004
Glycosaminoglycan profile in bladder and urethra of castrated rats treated with estrogen, progestogen, and raloxifene.
    American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:6

    Topics: Analysis of Variance; Animals; Biomarkers; Disease Models, Animal; Electrophoresis, Agar Gel; Estrogens; Female; Glycosaminoglycans; Ovariectomy; Probability; Progesterone; Raloxifene Hydrochloride; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Urethra; Urinary Bladder

2003
Estrogen and raloxifene, a selective estrogen receptor modulator, ameliorate renal damage in db/db mice.
    The American journal of pathology, 2005, Volume: 166, Issue:6

    Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Disease Models, Animal; Estradiol; Female; Fibronectins; Glomerular Mesangium; Kidney; Mice; Mice, Mutant Strains; Ovariectomy; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators

2005
Raloxifene and vitamin K2 combine to improve the femoral neck strength of ovariectomized rats.
    Calcified tissue international, 2005, Volume: 77, Issue:2

    Topics: Administration, Oral; Animals; Bone Density; Compressive Strength; Disease Models, Animal; Drug Therapy, Combination; Female; Femur Neck; Lumbar Vertebrae; Osteocalcin; Osteogenesis; Osteoporosis; Ovariectomy; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Vitamin K 2

2005
Administration of raloxifene reduces sensorimotor and working memory deficits following traumatic brain injury.
    Behavioural brain research, 2006, Jun-30, Volume: 170, Issue:2

    Topics: Analysis of Variance; Animals; Behavior, Animal; Brain Injuries; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Motor Activity; Psychomotor Performance; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Reaction Time; Selective Estrogen Receptor Modulators; Sensation

2006
Development and therapeutic options for the treatment of raloxifene-stimulated breast cancer in athymic mice.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Apr-01, Volume: 12, Issue:7 Pt 1

    Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Neoplasm; Estradiol; Estrogen Receptor alpha; Female; Fulvestrant; Gefitinib; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Humans; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Quinazolines; Raloxifene Hydrochloride; RNA, Messenger; Structure-Activity Relationship; Transplantation, Heterologous; Trastuzumab; Xenograft Model Antitumor Assays

2006
Analysis of change patterns of microcomputed tomography 3-dimensional bone parameters as a high-throughput tool to evaluate antiosteoporotic effects of agents at an early stage of ovariectomy-induced osteoporosis in mice.
    Investigative radiology, 2006, Volume: 41, Issue:9

    Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Disease Models, Animal; Early Diagnosis; Estradiol; Female; Femur; Imaging, Three-Dimensional; Mice; Osteogenesis; Osteoporosis; Ovariectomy; Parathyroid Hormone; Peptide Fragments; Raloxifene Hydrochloride; Rolipram; Tomography, X-Ray Computed

2006
Raloxifen prevents bone loss in castrated male mice.
    Physiological research, 2007, Volume: 56, Issue:4

    Topics: Animals; Bone Density; Bone Density Conservation Agents; Bone Diseases, Metabolic; Disease Models, Animal; Femur; Male; Mice; Orchiectomy; Organ Size; Raloxifene Hydrochloride; Seminal Vesicles; Testosterone

2007
Renoprotective effects of a selective estrogen receptor modulator, raloxifene, in an animal model of diabetic nephropathy.
    American journal of nephrology, 2007, Volume: 27, Issue:2

    Topics: Animals; Diabetic Nephropathies; Disease Models, Animal; Female; Kidney; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators

2007
Raloxifene inhibits matrix metalloproteinases expression and activity in macrophages and smooth muscle cells.
    Pharmacological research, 2007, Volume: 56, Issue:2

    Topics: Animals; Atherosclerosis; Carotid Arteries; Cells, Cultured; CHO Cells; Cholesterol, Dietary; Cricetinae; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Humans; Macrophages; Macrophages, Peritoneal; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; NF-kappa B; Ovariectomy; Promoter Regions, Genetic; Protease Inhibitors; Rabbits; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Transcription, Genetic; Transfection

2007
Comparative effects of 17beta-estradiol, raloxifene and genistein on bone 3D microarchitecture and volumetric bone mineral density in the ovariectomized mice.
    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2008, Volume: 19, Issue:6

    Topics: Animals; Bone and Bones; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Estradiol; Female; Genistein; Mice; Mice, Inbred C57BL; Osteoporosis; Ovariectomy; Raloxifene Hydrochloride; Receptors, Estrogen; X-Ray Microtomography

2008
Selective estrogen receptor modulation influences atherosclerotic plaque composition in a rabbit menopause model.
    Atherosclerosis, 2008, Volume: 201, Issue:1

    Topics: Animals; Atherosclerosis; Chemokine CCL2; Cyclooxygenase 2; Disease Models, Animal; Female; Magnetic Resonance Imaging; Matrix Metalloproteinase 1; Menopause; Osteoporosis; Ovariectomy; Rabbits; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators

2008
Long-term anti-arthritic and anti-osteoporotic effects of raloxifene in established experimental postmenopausal polyarthritis.
    Clinical and experimental immunology, 2008, Volume: 152, Issue:3

    Topics: Animals; Arthritis, Experimental; Biomarkers; Bone Density; Bone Density Conservation Agents; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Humans; Interleukin-6; Mice; Osteoporosis, Postmenopausal; Ovariectomy; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Severity of Illness Index; Treatment Outcome

2008
Raloxifene (LY156758) produces antimetastatic responses and extends survival in the PAIII rat prostatic adenocarcinoma model.
    The Prostate, 1995, Volume: 27, Issue:4

    Topics: Adenocarcinoma; Adrenal Glands; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Fluorouracil; Incidence; Lung Neoplasms; Lymphatic Metastasis; Male; Organ Size; Piperidines; Prostate; Prostatic Neoplasms; Raloxifene Hydrochloride; Random Allocation; Rats; Rats, Wistar; Survival Rate; Testis; Weight Gain

1995
Dual-energy x-ray absorptiometry of raloxifene effects on the lumbar vertebrae and femora of ovariectomized rats.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1994, Volume: 9, Issue:5

    Topics: Absorptiometry, Photon; Animals; Bone Density; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Femur; Humans; Lumbar Vertebrae; Osteoporosis, Postmenopausal; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Reproducibility of Results

1994
Time-dependent changes in biochemical bone markers and serum cholesterol in ovariectomized rats: effects of raloxifene HCl, tamoxifen, estrogen, and alendronate.
    Bone, 1996, Volume: 18, Issue:6

    Topics: Alendronate; Amino Acids; Animals; Biomarkers; Body Weight; Bone Resorption; Cholesterol; Disease Models, Animal; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Humans; Organ Size; Osteoporosis, Postmenopausal; Ovariectomy; Piperidines; Radioimmunoassay; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Tamoxifen; Uterus

1996
Characterization of the ovariectomized rat model for the evaluation of estrogen effects on plasma cholesterol levels.
    Endocrinology, 1997, Volume: 138, Issue:4

    Topics: Animals; Cholesterol; Dexamethasone; Disease Models, Animal; Estradiol; Estrogen Antagonists; Estrogens; Ethinyl Estradiol; Female; Fulvestrant; Lipids; Ovariectomy; Piperidines; Progesterone; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Tamoxifen; Uterus

1997
Raloxifene inhibits aortic accumulation of cholesterol in ovariectomized, cholesterol-fed rabbits.
    Circulation, 1997, Sep-16, Volume: 96, Issue:6

    Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Disease Models, Animal; Estrogen Antagonists; Female; Organ Size; Ovariectomy; Piperidines; Rabbits; Raloxifene Hydrochloride; Uterus; Weight Gain

1997
Prevention of bone loss by EM-800 and raloxifene in the ovariectomized rat.
    The Journal of steroid biochemistry and molecular biology, 2000, Volume: 74, Issue:1-2

    Topics: Administration, Oral; Amino Acids; Animals; Benzopyrans; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Cholesterol; Disease Models, Animal; Epithelial Cells; Estradiol; Estrogens; Female; Femur; Lumbar Vertebrae; Organ Size; Ovariectomy; Postmenopause; Propionates; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Tibia; Time Factors; Triglycerides; Uterus

2000
The effect of raloxifene on coronary arteries in aged ovariectomized ewes.
    Journal of veterinary pharmacology and therapeutics, 2000, Volume: 23, Issue:3

    Topics: Animals; Cholesterol; Coronary Angiography; Coronary Vessels; Disease Models, Animal; Estradiol; Female; Injections, Subcutaneous; Nitroglycerin; Ovariectomy; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Sheep; Vasodilation; Vasodilator Agents

2000
Raloxifene and breast cancer.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2001, Oct-02, Volume: 165, Issue:7

    Topics: Animals; Breast Neoplasms; Disease Models, Animal; Estrogen Antagonists; Female; Humans; Mice; Raloxifene Hydrochloride; Tamoxifen; Tumor Cells, Cultured

2001