rada16-i and Intervertebral-Disc-Degeneration

rada16-i has been researched along with Intervertebral-Disc-Degeneration* in 1 studies

Other Studies

1 other study(ies) available for rada16-i and Intervertebral-Disc-Degeneration

Article	Year
Functional Self-Assembled Peptide Nanofibers for Bone Marrow Mesenchymal Stem Cell Encapsulation and Regeneration in Nucleus Pulposus. Artificial organs, 2016, Volume: 40, Issue:6 Low back pain (LBP) is mainly caused by intervertebral disc degeneration (IDD). Recent studies have demonstrated that the transplantation of mesenchymal stem cells (MSCs) can regenerate regions that have undergone degeneration, and the regenerative effect can be enhanced by using a hydrogel carrier. This article describes an injectable functional hydrogel system manufactured by combining RADA16-I and RADA-KPSS (RADA-KPSS was manufactured by conjugating a bioactive motif derived from BMP-7 [KPSS] onto the C terminal of RADA16-I) at a volume ratio of 1:1. This hydrogel system can enhance the proliferation, differentiation, and chemotactic migration of BMSCs. In addition, the encapsulation of BMSCs with this system maintains cell viability for a long period after transplantation into an ex vivo cultured disc model. In conclusion, KPSS-conjugated RADKPS is an ideal encapsulation system for BMSCs in intervertebral disc (IVD) regeneration. Topics: Animals; Bone Morphogenetic Protein 7; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Cells, Immobilized; Injections; Intervertebral Disc Degeneration; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nanofibers; Nucleus Pulposus; Peptides; Rabbits; Regeneration; Tissue Scaffolds	2016

Article

Year

Functional Self-Assembled Peptide Nanofibers for Bone Marrow Mesenchymal Stem Cell Encapsulation and Regeneration in Nucleus Pulposus.

Artificial organs, 2016, Volume: 40, Issue:6

Low back pain (LBP) is mainly caused by intervertebral disc degeneration (IDD). Recent studies have demonstrated that the transplantation of mesenchymal stem cells (MSCs) can regenerate regions that have undergone degeneration, and the regenerative effect can be enhanced by using a hydrogel carrier. This article describes an injectable functional hydrogel system manufactured by combining RADA16-I and RADA-KPSS (RADA-KPSS was manufactured by conjugating a bioactive motif derived from BMP-7 [KPSS] onto the C terminal of RADA16-I) at a volume ratio of 1:1. This hydrogel system can enhance the proliferation, differentiation, and chemotactic migration of BMSCs. In addition, the encapsulation of BMSCs with this system maintains cell viability for a long period after transplantation into an ex vivo cultured disc model. In conclusion, KPSS-conjugated RADKPS is an ideal encapsulation system for BMSCs in intervertebral disc (IVD) regeneration.

Topics: Animals; Bone Morphogenetic Protein 7; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Cells, Immobilized; Injections; Intervertebral Disc Degeneration; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nanofibers; Nucleus Pulposus; Peptides; Rabbits; Regeneration; Tissue Scaffolds

2016