raclopride and Sialorrhea

raclopride has been researched along with Sialorrhea* in 1 studies

Other Studies

1 other study(ies) available for raclopride and Sialorrhea

ArticleYear
Atypical antipsychotics--effects of amisulpride on salivary secretion and on clozapine-induced sialorrhea.
    Oral diseases, 2012, Volume: 18, Issue:7

    Amisulpride is suggested for treatment of clozapine-induced sialorrhea. However, objective measurements of its effectiveness are lacking and, preclinically, amisulpride has no effect. We currently hypothesise that amisulpride acts by reducing the nervous- rather than the clozapine-driven salivary secretion.. Effects of intravenous amisulpride (as well as of clozapine and raclopride, a dopamine D2/D3 antagonist) were investigated in rats, including those subjected to chronic preganglionic parasympathetic denervation (submandibular glands) or combined postganglionic parasympathetic and sympathetic denervation (parotid glands). In duct-cannulated glands, secretion was evoked reflexly, at low and maximum flow rates, and by electrical stimulation of the parasympathetic and sympathetic innervations, and administration of autonomimetics (including substance P).. Unlike clozapine, amisulpride had no effect on the reflexly evoked secretion at maximum rate. With respect to reflex secretion at low rate and to the secretion evoked by muscarinic, α-adrenergic, β-adrenergic and substance P receptors, amisulpride (in contrast to raclopride) dose dependently potentiated the responses. Amisulpride had no effect on gland blood flow.. No support for any inhibitory influence of amisulpride was found. Conversely, amisulpride universally enhanced secretion, suggesting that amisulpride is a potential drug for dry-mouth treatment. The mechanism behind the potentiation is currently unknown.

    Topics: Amisulpride; Amylases; Animals; Antipsychotic Agents; Autonomic Agents; Bethanechol; Clozapine; Denervation; Female; Isoproterenol; Methacholine Chloride; Parasympathetic Nervous System; Parotid Gland; Raclopride; Rats; Rats, Sprague-Dawley; Saliva; Salivation; Sialorrhea; Submandibular Gland; Substance P; Sulpiride; Sympathetic Nervous System

2012