raclopride and Infant--Premature--Diseases

Attention-deficit-hyperactivity disorder (ADHD), while largely thought to be a genetic disorder, has environmental factors that appear to contribute significantly to the aetiopathogenesis of the disorder. One such factor is pretern birth with vulnerable cerebrovascular homeostasis. We hypothesised that cerebral ischaemia at birth could contribute to persistent deficient dopaminergic neurotransmission, which is thought to be the pathophysiological basis of the disorder. We examined dopamine D(2/3) receptor binding with positron emission tomography (PET) using [11C] raclopride as a tracer, and continuous reaction times (RT) with a computerized test of variables (TOVA) in six adolescents (12-14 years of age, one female) who had been examined with cerebral blood flow (CBF) measurements at preterm birth and had a subsequent history of attention deficit. We found that high dopamine receptor availability ('empty receptors') was linked with increased RT and RT variability, supporting the concept of a dopaminergic role in symptomatology. High dopamine receptor availability was predicted by low neonatal CBF, supporting the hypothesis of cerebral ischaemia as a contributing factor in infants susceptible to ADHD.

Topics: Adolescent; Attention; Attention Deficit Disorder with Hyperactivity; Brain; Brain Ischemia; Carbon Radioisotopes; Child; Child, Preschool; Corpus Striatum; Female; Follow-Up Studies; Homeostasis; Humans; Infant, Newborn; Infant, Premature, Diseases; Male; Raclopride; Reaction Time; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Dopamine D3; Risk Factors; Tomography, Emission-Computed