racemetirosine and Parkinsonian Disorders studies

racemetirosine and Parkinsonian Disorders

alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)

Parkinsonian Disorders: A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.

Research Excerpts

Excerpt	Relevance	Reference
" In this study we seek to determine ventilation and its responses to hypoxia in a reserpine--alpha-methyl-tyrosine model of parkinsonism in the rat."	3.83	Breathing in Parkinsonism in the Rat. ( Bialkowska, M; Boguszewski, P; Pokorski, M, 2016)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	2 (40.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

3 (60.00)

29.6817

2010's

2 (40.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Bialkowska, M	1
Boguszewski, P	1
Pokorski, M	1
Fuentes, R	1
Petersson, P	1
Siesser, WB	1
Caron, MG	1
Nicolelis, MA	1
Charron, G	1
Doudnikoff, E	1
Laux, A	1
Berthet, A	1
Porras, G	1
Canron, MH	1
Barroso-Chinea, P	1
Li, Q	1
Qin, C	1
Nosten-Bertrand, M	1
Giros, B	1
Delalande, F	1
Van Dorsselaer, A	1
Vital, A	1
Goumon, Y	1
Bezard, E	1
Dong, Z	1
Ferger, B	1
Paterna, JC	1
Vogel, D	1
Furler, S	1
Osinde, M	1
Feldon, J	1
Büeler, H	1
Yavich, L	1
Oksman, M	1
Tanila, H	1
Kerokoski, P	1
Hiltunen, M	1
van Groen, T	1
Puoliväli, J	1
Männistö, PT	1
García-Horsman, A	1
MacDonald, E	1
Beyreuther, K	1
Hartmann, T	1
Jäkälä, P	1

Studies

Bialkowska, M

Boguszewski, P

Pokorski, M

Fuentes, R

Petersson, P

Siesser, WB

Caron, MG

Nicolelis, MA

Charron, G

Doudnikoff, E

Laux, A

Berthet, A

Porras, G

Canron, MH

Barroso-Chinea, P

Li, Q

Qin, C

Nosten-Bertrand, M

Giros, B

Delalande, F

Van Dorsselaer, A

Vital, A

Goumon, Y

Bezard, E

Dong, Z

Ferger, B

Paterna, JC

Vogel, D

Furler, S

Osinde, M

Feldon, J

Büeler, H

Yavich, L

Oksman, M

Tanila, H

Kerokoski, P

Hiltunen, M

van Groen, T

Puoliväli, J

Männistö, PT

García-Horsman, A

MacDonald, E

Beyreuther, K

Hartmann, T

Jäkälä, P

Clinical Trials (7)

Trial Overview

Trial	Enrollment	Study Type	Start Date	Status
Thoracic Dorsal Spinal Cord Stimulation for the Treatment of Gait and Balance Impairments in Parkinson Disease[NCT03079310]	15 participants (Anticipated)	Interventional	2016-02-29	Recruiting
Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.[NCT03526991]	10 participants (Anticipated)	Interventional	2021-08-01	Recruiting
STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease[NCT04956770]	2 participants (Actual)	Interventional	2021-06-14	Active, not recruiting
Effects of Repetitive Trans Spinal Magnetic Stimulation Associated With Treadmill Gait Training on Gait Disorders in Patients With Parkinson's Disease[NCT05938673]	76 participants (Anticipated)	Interventional	2023-11-30	Recruiting
Effects of Spinal Cord Stimulation on Gait in Patients With Parkinson´s Disease; a Randomized, Crossover, Double Blinded, Placebo-Controlled Study[NCT05148468]	12 participants (Anticipated)	Interventional	2021-11-30	Active, not recruiting
Spinal Cord Stimulation for the Treatment of Motor and Nonmotor Symptoms of Parkinson's Disease[NCT02388204]	20 participants (Anticipated)	Interventional	2014-06-30	Recruiting
Efficacy of Repetitive Trans-spinal Magnetic Stimulation on Gait Abnormalities in Parkinson's Disease Patients: A Double-blinded Randomized Controlled Trial[NCT05271513]	38 participants (Actual)	Interventional	2023-01-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial

Phase

Enrollment

Study Type

Start Date

Status

Thoracic Dorsal Spinal Cord Stimulation for the Treatment of Gait and Balance Impairments in Parkinson Disease[NCT03079310]

15 participants (Anticipated)

Interventional

2016-02-29

Recruiting

Exploring the Effects of Spinal Cord Stimulation in Parkinson's Disease.[NCT03526991]

10 participants (Anticipated)

Interventional

2021-08-01

Recruiting

STIMO-PARKINSON: Study on Feasibility of Targeted Epidural Spinal Stimulation (TESS) to Improve Mobility in Patients With Parkinson's Disease[NCT04956770]

2 participants (Actual)

Interventional

2021-06-14

Active, not recruiting

Effects of Repetitive Trans Spinal Magnetic Stimulation Associated With Treadmill Gait Training on Gait Disorders in Patients With Parkinson's Disease[NCT05938673]

76 participants (Anticipated)

Interventional

2023-11-30

Recruiting

Effects of Spinal Cord Stimulation on Gait in Patients With Parkinson´s Disease; a Randomized, Crossover, Double Blinded, Placebo-Controlled Study[NCT05148468]

12 participants (Anticipated)

Interventional

2021-11-30

Active, not recruiting

Spinal Cord Stimulation for the Treatment of Motor and Nonmotor Symptoms of Parkinson's Disease[NCT02388204]

20 participants (Anticipated)

Interventional

2014-06-30

Recruiting

Efficacy of Repetitive Trans-spinal Magnetic Stimulation on Gait Abnormalities in Parkinson's Disease Patients: A Double-blinded Randomized Controlled Trial[NCT05271513]

38 participants (Actual)

Interventional

2023-01-01

Completed

[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

5 other studies available for racemetirosine and Parkinsonian Disorders

Article	Year
Breathing in Parkinsonism in the Rat. Advances in experimental medicine and biology, 2016, Volume: 884 Topics: alpha-Methyltyrosine; Animals; Brain; Carotid Body; Disease Models, Animal; Dopamine; Dopamine Agoni	2016
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Spinal cord stimulation restores locomotion in animal models of Parkinson's disease. Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921 Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; Combined Modality Therapy; Corpus Striatum; Dopami	2009
Endogenous morphine-like compound immunoreactivity increases in parkinsonism. Brain : a journal of neurology, 2011, Volume: 134, Issue:Pt 8 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Aged; alpha-Methyltyrosine; Analysis of Variance; Anim	2011
Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1. Proceedings of the National Academy of Sciences of the United States of America, 2003, Oct-14, Volume: 100, Issue:21 Topics: alpha-Methyltyrosine; Animals; Animals, Genetically Modified; Base Sequence; Cell Cycle Proteins; Co	2003
Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein. Neurobiology of disease, 2005, Volume: 20, Issue:2 Topics: alpha-Methyltyrosine; alpha-Synuclein; Animals; Brain; Disease Models, Animal; Dopamine; Dopamine Pl	2005

Article

Year

Breathing in Parkinsonism in the Rat.

Advances in experimental medicine and biology, 2016, Volume: 884

Topics: alpha-Methyltyrosine; Animals; Brain; Carotid Body; Disease Models, Animal; Dopamine; Dopamine Agoni

2016

Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.

Science (New York, N.Y.), 2009, Mar-20, Volume: 323, Issue:5921