racemetirosine has been researched along with Hypertension in 24 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify the mechanism of cyclosporine-induced hypertension, we studied the effect of cyclosporine on the catecholamine synthetic pathway in rats." | 7.71 | Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension. ( Kobayashi, S; Kumai, T; Shimizu, H, 2001) |
| " Dose-response curves for methoxamine and vasopressin were not significantly different between groups." | 5.28 | Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats? ( Chow, KY; Kline, RL; Mercer, PF, 1990) |
| " We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patients with pheochromocytoma undergoing surgical resection." | 5.06 | Surgical management of pheochromocytoma with the use of metyrosine. ( Keiser, HR; Linehan, WM; Norton, JA; Pass, HI; Perry, RR; Robertson, CN; Travis, W; Wall, RT; Walther, MM, 1990) |
| " Significant hypertension (up to 201/110 mmHg) developed upon tumour manipulation and resolved with phentolamine administration and surgical isolation of the tumour." | 3.81 | Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report. ( Pollmann, AS; Schelew, B; Thanapaalasingham, K, 2015) |
| "To identify the mechanism of cyclosporine-induced hypertension, we studied the effect of cyclosporine on the catecholamine synthetic pathway in rats." | 3.71 | Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension. ( Kobayashi, S; Kumai, T; Shimizu, H, 2001) |
| "To evaluate the effects of metyrosine (alpha-methyl-p-tyrosine), a catecholamine synthesis inhibitor, and alpha-blockade with prazosin or phenoxybenzamine on cardiovascular morbidity during surgery for pheochromocytoma." | 3.69 | Metyrosine and pheochromocytoma. ( Bransome, ED; Carr, AA; Prisant, LM; Steinsapir, J, 1997) |
| "In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the alpha-adrenergic blocking agent, phenoxybenzamine hydrochloride." | 3.66 | Pheochromocytoma resistant to alpha-adrenergic blockade. ( Ertel, NH; Hauptman, JB; Modlinger, RS, 1983) |
| "Our objective was to study hypertension induced by chronic administration of synthetic glucocorticoid, dexamethasone (DEX), under nonstressful conditions and examine the role of catecholamine biosynthesis." | 1.43 | A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase. ( Franklin, C; Gottlieb, H; Hinojosa-Laborde, C; Rani, CS; Soto-Piña, AE; Strong, R, 2016) |
| "Biochemical studies confirmed its recurrence." | 1.29 | An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside. ( Acheson, LS; Anton, AH; Lina, AA; Sherman, BW, 1993) |
| " Dose-response curves for methoxamine and vasopressin were not significantly different between groups." | 1.28 | Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats? ( Chow, KY; Kline, RL; Mercer, PF, 1990) |
| "Pheochromocytoma is curable in 90% of cases, yet its diagnosis and localization are among the most challenging problems in clinical medicine." | 1.27 | Pheochromocytoma: diagnosis, localization, and treatment. ( Atuk, NO, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, F | 1 |
| Ding, L | 1 |
| He, Q | 1 |
| Liu, M | 1 |
| Gruber, LM | 1 |
| Jasim, S | 1 |
| Ducharme-Smith, A | 1 |
| Weingarten, T | 1 |
| Young, WF | 1 |
| Bancos, I | 1 |
| Thanapaalasingham, K | 1 |
| Pollmann, AS | 1 |
| Schelew, B | 1 |
| Soto-Piña, AE | 1 |
| Franklin, C | 1 |
| Rani, CS | 1 |
| Gottlieb, H | 1 |
| Hinojosa-Laborde, C | 1 |
| Strong, R | 1 |
| Ionescu, CN | 1 |
| Sakharova, OV | 1 |
| Harwood, MD | 1 |
| Caracciolo, EA | 1 |
| Schoenfeld, MH | 1 |
| Donohue, TJ | 1 |
| Raizada, MK | 1 |
| Muther, TF | 1 |
| Sumners, C | 1 |
| Hauptman, JB | 1 |
| Modlinger, RS | 1 |
| Ertel, NH | 1 |
| Fujino, K | 1 |
| Atuk, NO | 1 |
| Anton, AH | 1 |
| Sherman, BW | 1 |
| Lina, AA | 1 |
| Acheson, LS | 1 |
| Watanabe, T | 1 |
| Noshiro, T | 1 |
| Akama, H | 1 |
| Kusakari, T | 1 |
| Shibukawa, S | 1 |
| Miura, W | 1 |
| Abe, K | 1 |
| Miura, Y | 1 |
| Steinsapir, J | 1 |
| Carr, AA | 1 |
| Prisant, LM | 1 |
| Bransome, ED | 1 |
| Misu, Y | 1 |
| Goshima, Y | 1 |
| Yue, JL | 1 |
| Miyamae, T | 1 |
| Akiyama, K | 1 |
| Sutoo, D | 1 |
| Kumai, T | 2 |
| Asoh, K | 1 |
| Tateishi, T | 1 |
| Tanaka, M | 1 |
| Watanabe, M | 1 |
| Shimizu, H | 2 |
| Kobayashi, S | 2 |
| Caballero, R | 1 |
| Pirmohamed, R | 1 |
| Wright, JA | 1 |
| Fujita, T | 1 |
| Sato, Y | 1 |
| Schuppert, F | 1 |
| Scheumann, GF | 1 |
| Schöber, C | 1 |
| Overbeck, J | 1 |
| Schürmeyer, TH | 1 |
| Schmoll, HJ | 1 |
| Dralle, H | 1 |
| von zur Mühlen, A | 1 |
| Kline, RL | 1 |
| Chow, KY | 1 |
| Mercer, PF | 1 |
| Perry, RR | 1 |
| Keiser, HR | 1 |
| Norton, JA | 1 |
| Wall, RT | 1 |
| Robertson, CN | 1 |
| Travis, W | 1 |
| Pass, HI | 1 |
| Walther, MM | 1 |
| Linehan, WM | 1 |
| Ram, CV | 1 |
| Meese, R | 1 |
| Hill, SC | 1 |
| Sautel, M | 1 |
| Sacquet, J | 1 |
| Vincent, M | 1 |
| Sassard, J | 1 |
| Cassis, LA | 1 |
| Stitzel, RE | 1 |
| Head, RJ | 1 |
2 reviews available for racemetirosine and Hypertension
| Article | Year |
|---|---|
Preoperative Management of Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; alpha-Methyltyro | 2020 |
The Role for Metyrosine in the Treatment of Patients With Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols; Drug | 2021 |
2 trials available for racemetirosine and Hypertension
| Article | Year |
|---|---|
Effect of dexamethasone on plasma free dopamine: dopaminergic modulation in hypertensive patients.
Topics: Adult; Aldosterone; alpha-Methyltyrosine; Dexamethasone; Dopamine; Dopamine Agents; Epinephrine; Hum | 1995 |
Surgical management of pheochromocytoma with the use of metyrosine.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Drug Therapy, Combination; Female; Humans; Hyp | 1990 |
20 other studies available for racemetirosine and Hypertension
| Article | Year |
|---|---|
Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.
Topics: alpha-Methyltyrosine; Catecholamines; Enzyme Inhibitors; Humans; Hypertension; Intraoperative Compli | 2015 |
A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.
Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Disease Models, Anima | 2016 |
Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.
Topics: alpha-Methyltyrosine; Antihypertensive Agents; Antithyroid Agents; Catecholamines; Enzyme Inhibitors | 2008 |
Increased angiotensin II receptors in neuronal cultures from hypertensive rat brain.
Topics: alpha-Methyltyrosine; Angiotensin II; Animals; Binding Sites; Brain; Cells, Cultured; Dopamine; Hype | 1984 |
Pheochromocytoma resistant to alpha-adrenergic blockade.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Drug Resistance; Humans | 1983 |
Brain catecholamines in spontaneously hypertensive and DOCA-salt hypertensive rats.
Topics: alpha-Methyltyrosine; Animals; Brain; Brain Stem; Desoxycorticosterone; Dopamine; Epinephrine; Hyper | 1984 |
Pheochromocytoma: diagnosis, localization, and treatment.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Diagnosis, Differential; Humans; Hype | 1983 |
An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Drug Resistance; Echocardiography; Fe | 1993 |
Metyrosine and pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; alph | 1997 |
Is L-DOPA a neurotransmitter of the primary baroreceptor afferents terminating in the nucleus tractus solitarii of rats?
Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; gamma-Aminobutyric Acid; Hypertension; Levodopa; M | 1998 |
Rectifying effect of exercise on hypertension in spontaneously hypertensive rats via a calcium-dependent dopamine synthesizing system in the brain.
Topics: alpha-Methyltyrosine; Animals; Blood Pressure; Brain; Calcium; Dopamine; Dopamine Antagonists; Edeti | 1999 |
Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
Topics: Actins; Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Drug Interact | 2000 |
Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension.
Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Blotting, Northern; Calcineurin; Cat | 2001 |
Use of alpha-methyl-tyrosine for refractory hypertension in a child with neuroblastoma.
Topics: Abdominal Neoplasms; alpha-Methyltyrosine; Blood Pressure; Combined Modality Therapy; Dose-Response | 1992 |
Role of hypothalamic-renal noradrenergic systems in hypotensive action of potassium.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Blood Pressure; Body Weight; Cold Temperature; | 1992 |
[Therapy of a malignant sympathetic paraganglioma of the organ of Zuckerkandl--a case report].
Topics: Adult; alpha-Methyltyrosine; Aorta, Abdominal; Combined Modality Therapy; Dopamine; Epinephrine; Hum | 1991 |
Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats?
Topics: Adrenergic alpha-Agonists; alpha-Methyltyrosine; Angiotensin II; Animals; Arginine Vasopressin; Bloo | 1990 |
Failure of alpha-methyltyrosine to prevent hypertensive crisis in pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Catecholamines; Female; Humans; Hypertension; | 1985 |
NE turnover in genetically hypertensive rats of Lyon strain. I. Brain nuclei.
Topics: Aging; alpha-Methyltyrosine; Animals; Blood Pressure; Body Weight; Brain; Heart Rate; Hypertension; | 1988 |
Influence of cold-induced increases in sympathetic nerve activity on norepinephrine content in the vasculature of the spontaneously hypertensive rat.
Topics: alpha-Methyltyrosine; Animals; Cold Temperature; Hypertension; Methyltyrosines; Norepinephrine; Rats | 1988 |