racemetirosine has been researched along with Depressive Disorder in 8 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Diphenhydramine was used as an active control because of the significant sedation associated with AMPT." | 2.68 | Effects of alpha-methyl-para-tyrosine (AMPT) in drug-free depressed patients. ( Charney, DS; Delgado, PL; Heninger, GR; Miller, HL; Salomon, RM, 1996) |
| " Overall, the dose-response and time-of-recovery relationships for altered NET expression matched those for production of antidepressant-like effects on behavior." | 1.35 | Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine. ( Baros, AM; Bondi, CO; Lapiz, MD; Morilak, DA; O'Donnell, JM; Zhang, HT; Zhao, Z, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pałucha-Poniewiera, A | 1 |
| Podkowa, K | 1 |
| Lenda, T | 1 |
| Pilc, A | 1 |
| Bremner, JD | 1 |
| Vythilingam, M | 1 |
| Ng, CK | 1 |
| Vermetten, E | 1 |
| Nazeer, A | 1 |
| Oren, DA | 2 |
| Berman, RM | 2 |
| Charney, DS | 3 |
| Nathan, PJ | 1 |
| Zhao, Z | 1 |
| Baros, AM | 1 |
| Zhang, HT | 1 |
| Lapiz, MD | 1 |
| Bondi, CO | 1 |
| Morilak, DA | 1 |
| O'Donnell, JM | 1 |
| Kraemer, GW | 1 |
| Ebert, MH | 1 |
| Lake, CR | 1 |
| McKinney, WT | 1 |
| Miller, HL | 2 |
| Delgado, PL | 1 |
| Salomon, RM | 1 |
| Heninger, GR | 2 |
| Narasimhan, M | 1 |
| Anand, A | 1 |
| Cappiello, A | 1 |
| Csernansky, JG | 1 |
| Posener, JA | 1 |
3 trials available for racemetirosine and Depressive Disorder
| Article | Year |
|---|---|
Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression.
Topics: Adrenergic Uptake Inhibitors; Adult; alpha-Methyltyrosine; Antidepressive Agents, Tricyclic; Brain; | 2003 |
Effects of alpha-methyl-para-tyrosine (AMPT) in drug-free depressed patients.
Topics: Adult; Aged; alpha-Methyltyrosine; Depressive Disorder; Diphenhydramine; Enzyme Inhibitors; Female; | 1996 |
Transient depressive relapse induced by catecholamine depletion: potential phenotypic vulnerability marker?
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Cross-Over Studies; Depressive Disorder; Double-Blind M | 1999 |
5 other studies available for racemetirosine and Depressive Disorder
| Article | Year |
|---|---|
The involvement of monoaminergic neurotransmission in the antidepressant-like action of scopolamine in the tail suspension test.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents; Citalopram; Depressive Disorder; Disease Model | 2017 |
Neurochemical aspects of susceptibility to depression.
Topics: alpha-Methyltyrosine; Antidepressive Agents; Brain; Depressive Disorder; Female; Glucose; Humans; Ma | 2003 |
Norepinephrine transporter regulation mediates the long-term behavioral effects of the antidepressant desipramine.
Topics: alpha-Methyltyrosine; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Binding, Competit | 2008 |
Cerebrospinal fluid measures of neurotransmitter changes associated with pharmacological alteration of the despair response to social separation in rhesus monkeys.
Topics: alpha-Methyltyrosine; Animals; Anxiety, Separation; Behavior, Animal; Depressive Disorder; Disease M | 1984 |
Laboratory tests to aid in psychiatric diagnosis: are we making progress?
Topics: alpha-Methyltyrosine; Catecholamines; Clinical Laboratory Techniques; Depressive Disorder; Enzyme In | 1999 |