racemetirosine has been researched along with Depressive Disorder, Major in 6 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The pathophysiologic mechanism of major depressive disorder (MDD) has been consistently associated with altered catecholaminergic function, especially with decreased dopamine neurotransmission, by various sources of largely indirect evidence." | 2.73 | Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects. ( Carlson, PJ; Charney, DS; Drevets, WC; Fromm, S; Geraci, M; Hasler, G; Luckenbaugh, DA; Meyers, N; Neumeister, A; Roiser, JP; Waldeck, T, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Homan, P | 3 |
| Drevets, WC | 5 |
| Hasler, G | 5 |
| Mondillo, K | 1 |
| Blair, JR | 1 |
| Fromm, S | 1 |
| Carlson, PJ | 1 |
| Luckenbaugh, DA | 1 |
| Waldeck, T | 1 |
| Geraci, M | 1 |
| Roiser, JP | 1 |
| Neumeister, A | 1 |
| Meyers, N | 1 |
| Charney, DS | 2 |
| Berman, RM | 1 |
| Sanacora, G | 1 |
| Anand, A | 1 |
| Roach, LM | 1 |
| Fasula, MK | 1 |
| Finkelstein, CO | 1 |
| Wachen, RM | 1 |
| Oren, DA | 1 |
| Heninger, GR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuronal Correlates of Catecholamine Depletion in Patients With Bulimia Nervosa Off Medication and Healthy Controls[NCT02179814] | 60 participants (Anticipated) | Interventional | 2012-02-20 | Suspended (stopped due to Conduct of the first analyses) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for racemetirosine and Depressive Disorder, Major
| Article | Year |
|---|---|
Neural correlates of free T3 alteration after catecholamine depletion in subjects with remitted major depressive disorder and in controls.
Topics: Adolescent; Adult; alpha-Methyltyrosine; Case-Control Studies; Catecholamines; Cross-Over Studies; D | 2014 |
Growth hormone response to catecholamine depletion in unmedicated, remitted subjects with major depressive disorder and healthy controls.
Topics: Administration, Oral; Adult; alpha-Methyltyrosine; Catecholamines; Cross-Over Studies; Depressive Di | 2013 |
The effects of catecholamine depletion on the neural response to fearful faces in remitted depression.
Topics: Adolescent; Adult; alpha-Methyltyrosine; Amphetamine; Catecholamines; Central Nervous System Stimula | 2014 |
Impairments of probabilistic response reversal and passive avoidance following catecholamine depletion.
Topics: Adolescent; Adult; alpha-Methyltyrosine; Avoidance Learning; Brain; Catecholamines; Conditioning, Op | 2009 |
Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects.
Topics: Adolescent; Adult; alpha-Methyltyrosine; Brain; Catecholamines; Corpus Striatum; Cross-Over Studies; | 2008 |
Monoamine depletion in unmedicated depressed subjects.
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Depressive Disorder, Major; Diphenhydramine; Dopamine; | 2002 |