racemetirosine has been researched along with Depression in 7 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Caffeine-treated adolescent male rats were exposed to caffeine (0." | 1.56 | Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat. ( Abdulzahir, A; Hwang, K; Sanford, J; Turgeon, SM, 2020) |
| " The dose-response relationship shifted to the left following REMs deprivation (ED50 values in the group-housed, isolated, and REMs-deprived mice were 250, 200, and 27 micrograms/kg, respectively)." | 1.29 | Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test. ( Asakura, W; Matsumoto, K; Ohta, H; Watanabe, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (57.14) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Turgeon, SM | 1 |
| Abdulzahir, A | 1 |
| Hwang, K | 1 |
| Sanford, J | 1 |
| Udo, H | 1 |
| Hamasu, K | 1 |
| Furuse, M | 1 |
| Sugiyama, H | 1 |
| Kwon, S | 1 |
| Lee, B | 1 |
| Kim, M | 1 |
| Lee, H | 1 |
| Park, HJ | 1 |
| Hahm, DH | 1 |
| Homan, P | 1 |
| Grob, S | 1 |
| Milos, G | 1 |
| Schnyder, U | 1 |
| Hasler, G | 1 |
| Cunha, MP | 1 |
| Pazini, FL | 1 |
| Oliveira, Á | 1 |
| Bettio, LE | 1 |
| Rosa, JM | 1 |
| Machado, DG | 1 |
| Rodrigues, AL | 1 |
| Asakura, W | 1 |
| Matsumoto, K | 1 |
| Ohta, H | 1 |
| Watanabe, H | 1 |
| Caldecott-Hazard, S | 1 |
| Mazziotta, J | 1 |
| Phelps, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neuronal Correlates of Catecholamine Depletion in Patients With Bulimia Nervosa Off Medication and Healthy Controls[NCT02179814] | 60 participants (Anticipated) | Interventional | 2012-02-20 | Suspended (stopped due to Conduct of the first analyses) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for racemetirosine and Depression
| Article | Year |
|---|---|
Reduction in total plasma ghrelin levels following catecholamine depletion: relation to bulimic and depressive symptoms.
Topics: Adult; alpha-Methyltyrosine; Body Mass Index; Bulimia; Catecholamines; Convalescence; Cross-Over Stu | 2013 |
6 other studies available for racemetirosine and Depression
| Article | Year |
|---|---|
Pharmacological depletion of serotonin and norepinephrine with para-chlorophenylalanine and alpha-methyl-p-tyrosine reverses the antidepressant-like effects of adolescent caffeine exposure in the male rat.
Topics: Age Factors; alpha-Methyltyrosine; Animals; Antidepressive Agents; Anxiety; Anxiety Disorders; Behav | 2020 |
VEGF-induced antidepressant effects involve modulation of norepinephrine and serotonin systems.
Topics: alpha-Methyltyrosine; Animals; Brain; Depression; Disease Models, Animal; Enzyme Inhibitors; Fenclon | 2014 |
Antidepressant-like effect of the methanolic extract from Bupleurum falcatum in the tail suspension test.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Antidepressive Agents; Bupleurum; Depression; D | 2010 |
The activation of α1-adrenoceptors is implicated in the antidepressant-like effect of creatine in the tail suspension test.
Topics: Adrenergic Agents; alpha-Methyltyrosine; Analysis of Variance; Animals; Antidepressive Agents; Creat | 2013 |
Monoamine depletion attenuates the REM sleep deprivation-induced increase in clonidine response in the forced swimming test.
Topics: Adrenergic alpha-2 Receptor Antagonists; alpha-Methyltyrosine; Animals; Biogenic Monoamines; Brain C | 1994 |
Cerebral correlates of depressed behavior in rats, visualized using 14C-2-deoxyglucose autoradiography.
Topics: alpha-Methyltyrosine; Amphetamine; Animals; Autoradiography; Behavior, Animal; Brain; Carbon Radiois | 1988 |