racemetirosine has been researched along with Blood Pressure, High in 24 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To identify the mechanism of cyclosporine-induced hypertension, we studied the effect of cyclosporine on the catecholamine synthetic pathway in rats." | 7.71 | Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension. ( Kobayashi, S; Kumai, T; Shimizu, H, 2001) |
| " Dose-response curves for methoxamine and vasopressin were not significantly different between groups." | 5.28 | Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats? ( Chow, KY; Kline, RL; Mercer, PF, 1990) |
| " We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patients with pheochromocytoma undergoing surgical resection." | 5.06 | Surgical management of pheochromocytoma with the use of metyrosine. ( Keiser, HR; Linehan, WM; Norton, JA; Pass, HI; Perry, RR; Robertson, CN; Travis, W; Wall, RT; Walther, MM, 1990) |
| " Significant hypertension (up to 201/110 mmHg) developed upon tumour manipulation and resolved with phentolamine administration and surgical isolation of the tumour." | 3.81 | Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report. ( Pollmann, AS; Schelew, B; Thanapaalasingham, K, 2015) |
| "To identify the mechanism of cyclosporine-induced hypertension, we studied the effect of cyclosporine on the catecholamine synthetic pathway in rats." | 3.71 | Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension. ( Kobayashi, S; Kumai, T; Shimizu, H, 2001) |
| "To evaluate the effects of metyrosine (alpha-methyl-p-tyrosine), a catecholamine synthesis inhibitor, and alpha-blockade with prazosin or phenoxybenzamine on cardiovascular morbidity during surgery for pheochromocytoma." | 3.69 | Metyrosine and pheochromocytoma. ( Bransome, ED; Carr, AA; Prisant, LM; Steinsapir, J, 1997) |
| "In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the alpha-adrenergic blocking agent, phenoxybenzamine hydrochloride." | 3.66 | Pheochromocytoma resistant to alpha-adrenergic blockade. ( Ertel, NH; Hauptman, JB; Modlinger, RS, 1983) |
| "Our objective was to study hypertension induced by chronic administration of synthetic glucocorticoid, dexamethasone (DEX), under nonstressful conditions and examine the role of catecholamine biosynthesis." | 1.43 | A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase. ( Franklin, C; Gottlieb, H; Hinojosa-Laborde, C; Rani, CS; Soto-Piña, AE; Strong, R, 2016) |
| "Biochemical studies confirmed its recurrence." | 1.29 | An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside. ( Acheson, LS; Anton, AH; Lina, AA; Sherman, BW, 1993) |
| " Dose-response curves for methoxamine and vasopressin were not significantly different between groups." | 1.28 | Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats? ( Chow, KY; Kline, RL; Mercer, PF, 1990) |
| "Pheochromocytoma is curable in 90% of cases, yet its diagnosis and localization are among the most challenging problems in clinical medicine." | 1.27 | Pheochromocytoma: diagnosis, localization, and treatment. ( Atuk, NO, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 2 (8.33) | 24.3611 |
| 2020's | 2 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, F | 1 |
| Ding, L | 1 |
| He, Q | 1 |
| Liu, M | 1 |
| Gruber, LM | 1 |
| Jasim, S | 1 |
| Ducharme-Smith, A | 1 |
| Weingarten, T | 1 |
| Young, WF | 1 |
| Bancos, I | 1 |
| Thanapaalasingham, K | 1 |
| Pollmann, AS | 1 |
| Schelew, B | 1 |
| Soto-Piña, AE | 1 |
| Franklin, C | 1 |
| Rani, CS | 1 |
| Gottlieb, H | 1 |
| Hinojosa-Laborde, C | 1 |
| Strong, R | 1 |
| Ionescu, CN | 1 |
| Sakharova, OV | 1 |
| Harwood, MD | 1 |
| Caracciolo, EA | 1 |
| Schoenfeld, MH | 1 |
| Donohue, TJ | 1 |
| Raizada, MK | 1 |
| Muther, TF | 1 |
| Sumners, C | 1 |
| Hauptman, JB | 1 |
| Modlinger, RS | 1 |
| Ertel, NH | 1 |
| Fujino, K | 1 |
| Atuk, NO | 1 |
| Anton, AH | 1 |
| Sherman, BW | 1 |
| Lina, AA | 1 |
| Acheson, LS | 1 |
| Watanabe, T | 1 |
| Noshiro, T | 1 |
| Akama, H | 1 |
| Kusakari, T | 1 |
| Shibukawa, S | 1 |
| Miura, W | 1 |
| Abe, K | 1 |
| Miura, Y | 1 |
| Steinsapir, J | 1 |
| Carr, AA | 1 |
| Prisant, LM | 1 |
| Bransome, ED | 1 |
| Misu, Y | 1 |
| Goshima, Y | 1 |
| Yue, JL | 1 |
| Miyamae, T | 1 |
| Akiyama, K | 1 |
| Sutoo, D | 1 |
| Kumai, T | 2 |
| Asoh, K | 1 |
| Tateishi, T | 1 |
| Tanaka, M | 1 |
| Watanabe, M | 1 |
| Shimizu, H | 2 |
| Kobayashi, S | 2 |
| Caballero, R | 1 |
| Pirmohamed, R | 1 |
| Wright, JA | 1 |
| Fujita, T | 1 |
| Sato, Y | 1 |
| Schuppert, F | 1 |
| Scheumann, GF | 1 |
| Schöber, C | 1 |
| Overbeck, J | 1 |
| Schürmeyer, TH | 1 |
| Schmoll, HJ | 1 |
| Dralle, H | 1 |
| von zur Mühlen, A | 1 |
| Kline, RL | 1 |
| Chow, KY | 1 |
| Mercer, PF | 1 |
| Perry, RR | 1 |
| Keiser, HR | 1 |
| Norton, JA | 1 |
| Wall, RT | 1 |
| Robertson, CN | 1 |
| Travis, W | 1 |
| Pass, HI | 1 |
| Walther, MM | 1 |
| Linehan, WM | 1 |
| Ram, CV | 1 |
| Meese, R | 1 |
| Hill, SC | 1 |
| Sautel, M | 1 |
| Sacquet, J | 1 |
| Vincent, M | 1 |
| Sassard, J | 1 |
| Cassis, LA | 1 |
| Stitzel, RE | 1 |
| Head, RJ | 1 |
2 reviews available for racemetirosine and Blood Pressure, High
| Article | Year |
|---|---|
Preoperative Management of Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; alpha-Methyltyro | 2020 |
The Role for Metyrosine in the Treatment of Patients With Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols; Drug | 2021 |
2 trials available for racemetirosine and Blood Pressure, High
| Article | Year |
|---|---|
Effect of dexamethasone on plasma free dopamine: dopaminergic modulation in hypertensive patients.
Topics: Adult; Aldosterone; alpha-Methyltyrosine; Dexamethasone; Dopamine; Dopamine Agents; Epinephrine; Hum | 1995 |
Surgical management of pheochromocytoma with the use of metyrosine.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Drug Therapy, Combination; Female; Humans; Hyp | 1990 |
20 other studies available for racemetirosine and Blood Pressure, High
| Article | Year |
|---|---|
Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.
Topics: alpha-Methyltyrosine; Catecholamines; Enzyme Inhibitors; Humans; Hypertension; Intraoperative Compli | 2015 |
A Novel Model of Dexamethasone-Induced Hypertension: Use in Investigating the Role of Tyrosine Hydroxylase.
Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Disease Models, Anima | 2016 |
Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.
Topics: alpha-Methyltyrosine; Antihypertensive Agents; Antithyroid Agents; Catecholamines; Enzyme Inhibitors | 2008 |
Increased angiotensin II receptors in neuronal cultures from hypertensive rat brain.
Topics: alpha-Methyltyrosine; Angiotensin II; Animals; Binding Sites; Brain; Cells, Cultured; Dopamine; Hype | 1984 |
Pheochromocytoma resistant to alpha-adrenergic blockade.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Drug Resistance; Humans | 1983 |
Brain catecholamines in spontaneously hypertensive and DOCA-salt hypertensive rats.
Topics: alpha-Methyltyrosine; Animals; Brain; Brain Stem; Desoxycorticosterone; Dopamine; Epinephrine; Hyper | 1984 |
Pheochromocytoma: diagnosis, localization, and treatment.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Diagnosis, Differential; Humans; Hype | 1983 |
An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Drug Resistance; Echocardiography; Fe | 1993 |
Metyrosine and pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; alph | 1997 |
Is L-DOPA a neurotransmitter of the primary baroreceptor afferents terminating in the nucleus tractus solitarii of rats?
Topics: Afferent Pathways; alpha-Methyltyrosine; Animals; gamma-Aminobutyric Acid; Hypertension; Levodopa; M | 1998 |
Rectifying effect of exercise on hypertension in spontaneously hypertensive rats via a calcium-dependent dopamine synthesizing system in the brain.
Topics: alpha-Methyltyrosine; Animals; Blood Pressure; Brain; Calcium; Dopamine; Dopamine Antagonists; Edeti | 1999 |
Involvement of tyrosine hydroxylase up regulation in dexamethasone-induced hypertension of rats.
Topics: Actins; Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Dexamethasone; Drug Interact | 2000 |
Involvement of tyrosine hydroxylase upregulation in cyclosporine-induced hypertension.
Topics: Adrenal Medulla; alpha-Methyltyrosine; Animals; Blood Pressure; Blotting, Northern; Calcineurin; Cat | 2001 |
Use of alpha-methyl-tyrosine for refractory hypertension in a child with neuroblastoma.
Topics: Abdominal Neoplasms; alpha-Methyltyrosine; Blood Pressure; Combined Modality Therapy; Dose-Response | 1992 |
Role of hypothalamic-renal noradrenergic systems in hypotensive action of potassium.
Topics: alpha-Methyltyrosine; Analysis of Variance; Animals; Blood Pressure; Body Weight; Cold Temperature; | 1992 |
[Therapy of a malignant sympathetic paraganglioma of the organ of Zuckerkandl--a case report].
Topics: Adult; alpha-Methyltyrosine; Aorta, Abdominal; Combined Modality Therapy; Dopamine; Epinephrine; Hum | 1991 |
Does enhanced sympathetic tone contribute to angiotensin II hypertension in rats?
Topics: Adrenergic alpha-Agonists; alpha-Methyltyrosine; Angiotensin II; Animals; Arginine Vasopressin; Bloo | 1990 |
Failure of alpha-methyltyrosine to prevent hypertensive crisis in pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Catecholamines; Female; Humans; Hypertension; | 1985 |
NE turnover in genetically hypertensive rats of Lyon strain. I. Brain nuclei.
Topics: Aging; alpha-Methyltyrosine; Animals; Blood Pressure; Body Weight; Brain; Heart Rate; Hypertension; | 1988 |
Influence of cold-induced increases in sympathetic nerve activity on norepinephrine content in the vasculature of the spontaneously hypertensive rat.
Topics: alpha-Methyltyrosine; Animals; Cold Temperature; Hypertension; Methyltyrosines; Norepinephrine; Rats | 1988 |