Page last updated: 2024-08-26

racecadotril and Diarrhea

racecadotril has been researched along with Diarrhea in 49 studies

Research

Studies (49)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (2.04)	18.7374
1990's	9 (18.37)	18.2507
2000's	17 (34.69)	29.6817
2010's	20 (40.82)	24.3611
2020's	2 (4.08)	2.80

Authors

Authors	Studies
Eser Faki, H; Ider, M; Ok, M; Ozdemir Kutahya, Z; Parlak, TM; Tras, B; Uney, K; Yildiz, R	1
Gordon, M; Liang, Y; Wen, J; Zeng, L; Zhang, L	1
Benninga, MA; Broekaert, IJ; Dolinsek, J; Mas, E; Miele, E; Orel, R; Pienar, C; Ribes-Koninckx, C; Thapar, N; Thomassen, RA; Thomson, M; Tzivinikos, C	1
Bui, T; Choy, RK; Glark-Deener, SG; Hualei, S; Kim, I; Li, G; Ramesh, AK; Twitchell, EL; Weiss, MD; Wen, K; Yang, X; Yuan, L	1
Chen, M; Däbritz, J; Eberlin, M; Mueck, T	1
Meißner, W; Pastrana, T	1
Jain, VK; Khandelwal, PD; Mehta, S; Sihag, M	1
Leemans, L	1
Heather, CS	1
Akobeng, A; Gordon, M	1
Cifuentes, L; Sáez, J	1
Arnett, SD; Bond, BR; Campbell, MA; Choy, RK; de Hostos, E; Griggs, DW; Ji, Y; Meyers, MJ; Neckermann, G; Oliva, J; Prinsen, MJ; Ruminski, PG; Tajfirouz, D; Yu, Y	1
Anbu, D; Bose, A; Kang, G; Parez, N; Sarkar, R; Sindhu, K; Srinivasan, R; Subashini, B; Svensson, L; Thuppal, SV; Venugopal, S	1
Ellis, D; Goldthorpe, J; Iglesias, N; Lazonby, G; Puntis, JW; Steele, J; Tran, LC; Vora, R; Zamvar, V	1
Haditsch, M; Jelinek, T; Nothdurft, HD; Weinke, T	1
Armellino, C; Buccigrossi, V; Guarino, A	1
Marañón, R; Miguez, C; Sánchez, C; Santos, M; Vázquez, P	1
Colosimo, M; Cucchiara, S; Curto, LS; De Sarro, G; Falcone, D; Gallelli, L; Luberto, L; Marigliano, NM; Mazzei, F; Rende, P; Tolotta, GA	1
Calatayud, GA; Castrellón, PG; Cézard, JP; Chéron, G; Garcia, JM; Lehert, P; Santos, M; Savitha, MR	1
Cuello García, CA; Pacheco Alvarado, KP; Pérez Gaxiola, G	1
Calero, C; Gutiérrez, C; López-Campos, JL	1
Tack, J	1
Duh, D; Tanret, I	1
Prado, D	1
Bocquet, N; Boursiquot, C; Chéron, G; Cojocaru, B; Garel, D; Marcombes, F; Sannier, N; Timsit, S; Wille, C	1
Awouters, F; Huighebaert, S; Tytgat, GN	1
Rao, SG	1
Bhan, MK; Bhatnagar, S	1
Liao, KF; Shieh, MJ; Wang, HH	1
Cezard, JP; Salazar-Lindo, E	1
Alam, S; Bhatnagar, S	1
Chmielewska, A; Ruszczyński, M; Szajewska, H; Wieczorek, J	1
Goulet, O; Polanco, I; Salazar-Lindo, E; Tormo, R	1
Abigerges, D; Armand, JP; de Costa, L; Gonçalves, E	1
Bérard, H; Dorval, ED; Gamelin, E; Picon, L; Regimbeau, C	1
Baumer, P; Berard, H; Lecomte, JM; Roge, J; Schwartz, JC	1
Bastian, G; Bonnay, M; Cote, C; Cvitkovic, E; Hagipantelli, R; Herait, P; Mahjoubi, M; Mignard, D; Misset, JL; Saliba, F; Vassal, G	1
Farthing, MJ	1
Berard, H; Fretault, N; Lecomte, JM; Vetel, JM	1
Baumer, P; Ben Khalifa, H; Berard, H; Hamza, H; Lecomte, JM	1
Berard, H; Fretault, N; Lecomte, JM; Turck, D	1
Schwartz, JC	1
Lecomte, JM	1
Chea-Woo, E; Gutierrez, M; Salazar-Lindo, E; Santisteban-Ponce, J	1
Awad, L; Bleiberg, H; Bugat, R; Culine, S; Droz, JP; Freyer, G; Herait, P; Marty, M; Mignard, D; Rougier, P; Trillet-Lenoir, V	1
Audrain, S; Bellaiche, M; Cézard, JP; Duhamel, JF; Ginies, JL; Girardet, JP; Lamireau, T; Lecomte, JM; Maurage, C; Meyer, M; Morali, A; Olives, JP; Pharaon, I; Poujol, A; Sarles, J; Vaillant, JM; Whately-Smith, C	1
Baumer, P; Bertrand, J; Danquechin Dorval, E; Lecomte, JM; Schwartz, JC; Vetel, JM	1
Costentin, J; Lecomte, JM; Marçais-Collado, H; Schwartz, JC; Uchida, G	1

Reviews

15 review(s) available for racecadotril and Diarrhea

Article	Year
Racecadotril for acute diarrhoea in children. The Cochrane database of systematic reviews, 2019, 12-19, Volume: 12 Topics: Child, Preschool; Diarrhea; Fluid Therapy; Humans; Infant; Length of Stay; Randomized Controlled Trials as Topic; Thiorphan; Treatment Outcome	2019
Racecadotril in the treatment of acute diarrhea in children: a systematic, comprehensive review and meta-analysis of randomized controlled trials. BMC pediatrics, 2018, 04-03, Volume: 18, Issue:1 Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Randomized Controlled Trials as Topic; Thiorphan	2018
[Treatment of diarrhea with loperamide in palliative medicine. A systematic review]. Schmerz (Berlin, Germany), 2013, Volume: 27, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Antidiarrheals; Controlled Clinical Trials as Topic; Diarrhea; Diphenoxylate; Drug Therapy, Combination; Humans; Loperamide; Octreotide; Palliative Care; Thiorphan	2013
What place for ▾racecadotril? Drug and therapeutics bulletin, 2013, Volume: 51, Issue:5 Topics: Antidiarrheals; Diarrhea; Humans; Neprilysin; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Thiorphan; United Kingdom; World Health Organization	2013
[The treatment of acute diarrhea]. Journal de pharmacie de Belgique, 2013, Issue:3 Topics: Adult; Anti-Bacterial Agents; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Loperamide; Probiotics; Thiorphan	2013
Travellers' diarrhoea. BMJ clinical evidence, 2015, Apr-30, Volume: 2015 Topics: Anti-Bacterial Agents; Antidiarrheals; Bismuth; Diarrhea; Diet; Fluid Therapy; Humans; Organometallic Compounds; Salicylates; Thiorphan; Travel-Related Illness	2015
Racecadotril for acute diarrhoea in children: systematic review and meta-analyses. Archives of disease in childhood, 2016, Volume: 101, Issue:3 Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Humans; Thiorphan; Treatment Outcome	2016
Is racecadotril effective for acute diarrhea in children? -First update. Medwave, 2015, Dec-16, Volume: 15 Suppl 3 Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Gastroenteritis; Humans; Randomized Controlled Trials as Topic; Thiorphan; Time Factors; Treatment Outcome	2015
Racecadotril for childhood gastroenteritis: an individual patient data meta-analysis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver, 2011, Volume: 43, Issue:9 Topics: Adolescent; Adult; Antidiarrheals; Child; Combined Modality Therapy; Dehydration; Diarrhea; Feces; Female; Gastroenteritis; Humans; Male; Randomized Controlled Trials as Topic; Rehydration Solutions; Rotavirus; Thiorphan; Young Adult	2011
Functional diarrhea. Gastroenterology clinics of North America, 2012, Volume: 41, Issue:3 Topics: Antidepressive Agents, Tricyclic; Antidiarrheals; Bismuth; Carbon; Cholestyramine Resin; Chronic Disease; Clonidine; Diarrhea; Humans; Octreotide; Organometallic Compounds; Oxides; Probiotics; Receptors, Opioid; Salicylates; Serotonin 5-HT3 Receptor Antagonists; Thiorphan	2012
Racecadotril versus loperamide: antidiarrheal research revisited. Digestive diseases and sciences, 2003, Volume: 48, Issue:2 Topics: Adolescent; Adult; Antidiarrheals; Child; Child, Preschool; Controlled Clinical Trials as Topic; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant; Loperamide; Male; Middle Aged; Severity of Illness Index; Thiorphan; Treatment Outcome	2003
Systematic review: racecadotril in the treatment of acute diarrhoea in children. Alimentary pharmacology & therapeutics, 2007, Sep-15, Volume: 26, Issue:6 Topics: Acute Disease; Antidiarrheals; Child, Preschool; Diarrhea; Female; Gastroenteritis; Humans; Infant; Male; Randomized Controlled Trials as Topic; Thiorphan; Treatment Outcome	2007
Acute infectious diarrhoea in children: new insights in antisecretory treatment with racecadotril. Acta paediatrica (Oslo, Norway : 1992), 2008, Volume: 97, Issue:8 Topics: Acute Disease; Antidiarrheals; Bacterial Infections; Breast Feeding; Child; Dehydration; Diarrhea; Fluid Therapy; Humans; Malabsorption Syndromes; Thiorphan; Virus Diseases	2008
Racecadotril: a new approach to the treatment of diarrhoea. International journal of antimicrobial agents, 2000, Volume: 14, Issue:1 Topics: Animals; Antidiarrheals; Diarrhea; Dogs; Rats; Thiorphan	2000
An overview of clinical studies with racecadotril in adults. International journal of antimicrobial agents, 2000, Volume: 14, Issue:1 Topics: Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Humans; Randomized Controlled Trials as Topic; Thiorphan	2000

Trials

18 trial(s) available for racecadotril and Diarrhea

Article	Year
A comparative study of racecadotril and single dose octreotide as an anti-secretory agent in acute infective diarrhoea. The Journal of the Association of Physicians of India, 2012, Volume: 60 Topics: Adolescent; Adult; Anti-Bacterial Agents; Antidiarrheals; Diarrhea; Drug Therapy, Combination; Dysentery; Female; Fluid Therapy; Humans; Male; Middle Aged; Octreotide; Thiorphan; Treatment Outcome; Young Adult	2012
Racecadotril in the Management of Rotavirus and Non-rotavirus Diarrhea in Under-five Children: Two Randomized, Double-blind, Placebo-controlled Trials. Indian pediatrics, 2016, Jul-08, Volume: 53, Issue:7 Topics: Antidiarrheals; Child, Preschool; Diarrhea; Female; Humans; Infant; Male; Rotavirus Infections; Thiorphan	2016
Use of racecadotril as outpatient treatment for acute gastroenteritis: a prospective, randomized, parallel study. The Journal of pediatrics, 2009, Volume: 155, Issue:1 Topics: Acute Disease; Ambulatory Care; Antidiarrheals; Dehydration; Diarrhea; Drug Therapy, Combination; Emergency Service, Hospital; Female; Gastroenteritis; Humans; Infant; Male; Prospective Studies; Rehydration Solutions; Thiorphan	2009
Prospective randomized double-blind trial of racecadotril compared with loperamide in elderly people with gastroenteritis living in nursing homes. European journal of clinical pharmacology, 2010, Volume: 66, Issue:2 Topics: Abdominal Pain; Aged; Aged, 80 and over; Aging; Antidiarrheals; Cytochrome P-450 Enzyme System; Dehydration; Diarrhea; Double-Blind Method; Female; Gastroenteritis; Homes for the Aged; Humans; Loperamide; Male; Nursing Homes; Polymorphism, Genetic; Statistics as Topic; Thiorphan	2010
Grading recommendations in clinical practice guidelines: randomised experimental evaluation of four different systems. Archives of disease in childhood, 2011, Volume: 96, Issue:8 Topics: Adult; Antidiarrheals; Attitude of Health Personnel; Child; Decision Making; Diarrhea; Evidence-Based Medicine; Female; Guideline Adherence; Humans; Male; Mexico; Middle Aged; Pediatrics; Practice Guidelines as Topic; Professional Practice; Thiorphan	2011
A multinational comparison of racecadotril and loperamide in the treatment of acute watery diarrhoea in adults. Scandinavian journal of gastroenterology, 2002, Volume: 37, Issue:6 Topics: Acute Disease; Administration, Oral; Adult; Antidiarrheals; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; International Cooperation; Loperamide; Male; Middle Aged; Multivariate Analysis; Probability; Single-Blind Method; Thiorphan; Treatment Outcome	2002
[Effect of racecadotril in the management of acute diarrhea in infants and children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:8 Topics: Acute Disease; Antidiarrheals; Child, Preschool; Dehydration; Diarrhea; Emergency Medical Services; Female; Fluid Therapy; Humans; Infant; Male; Thiorphan; Treatment Outcome; Water-Electrolyte Balance	2002
A blind, randomized comparison of racecadotril and loperamide for stopping acute diarrhea in adults. World journal of gastroenterology, 2005, Mar-14, Volume: 11, Issue:10 Topics: Acute Disease; Adult; Antidiarrheals; Constipation; Diarrhea; Female; Humans; Loperamide; Male; Middle Aged; Pruritus; Single-Blind Method; Thiorphan; Treatment Outcome	2005
[Treatment of acute chemically induced diarrhea by inhibition of enkephalinase. Results of a pilot study]. Gastroenterologie clinique et biologique, 1995, Volume: 19, Issue:1 Topics: Acute Disease; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; Combined Modality Therapy; Diarrhea; Female; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Metastasis; Neprilysin; Prospective Studies; Thiorphan	1995
The enkephalinase inhibitor, acetorphan, in acute diarrhoea. A double-blind, controlled clinical trial versus loperamide. Scandinavian journal of gastroenterology, 1993, Volume: 28, Issue:4 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Thiorphan	1993
Pathophysiology and therapy of irinotecan-induced delayed-onset diarrhea in patients with advanced colorectal cancer: a prospective assessment. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1998, Volume: 16, Issue:8 Topics: Adult; Aged; Antidiarrheals; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Diarrhea; Female; Humans; Irinotecan; Loperamide; Male; Middle Aged; Prospective Studies; Thiorphan	1998
Comparison of racecadotril and loperamide in adults with acute diarrhoea. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Adult; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Protease Inhibitors; Thiorphan	1999
Racecadotril versus placebo in the treatment of acute diarrhoea in adults. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Adult; Antidiarrheals; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Aged; Neprilysin; Protease Inhibitors; Thiorphan	1999
Comparison of racecadotril and loperamide in children with acute diarrhoea. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Antidiarrheals; Child; Child, Preschool; Diarrhea; Double-Blind Method; Female; Humans; Loperamide; Male; Neprilysin; Protease Inhibitors; Recurrence; Thiorphan	1999
Racecadotril in the treatment of acute watery diarrhea in children. The New England journal of medicine, 2000, Aug-17, Volume: 343, Issue:7 Topics: Acute Disease; Antidiarrheals; Child, Preschool; Combined Modality Therapy; Developing Countries; Diarrhea; Double-Blind Method; Feces; Fluid Therapy; Hospitalization; Humans; Infant; Male; Neprilysin; Rotavirus; Thiorphan; Time Factors	2000
Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups. British journal of cancer, 2000, Volume: 83, Issue:4 Topics: Adult; Aged; Antidiarrheals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials, Phase II as Topic; Colorectal Neoplasms; Diarrhea; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Fluorouracil; Humans; Irinotecan; Male; Middle Aged; Multicenter Studies as Topic; Multivariate Analysis; Neoplasm Metastasis; Neutropenia; Predictive Value of Tests; Randomized Controlled Trials as Topic; Risk Factors; Thiorphan	2000
Efficacy and tolerability of racecadotril in acute diarrhea in children. Gastroenterology, 2001, Volume: 120, Issue:4 Topics: Acute Disease; Antidiarrheals; Child, Preschool; Defecation; Diarrhea; Double-Blind Method; Female; Humans; Infant; Male; Thiorphan; Time Factors	2001
Effects of acetorphan, an enkephalinase inhibitor, on experimental and acute diarrhoea. Gut, 1992, Volume: 33, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Castor Oil; Diarrhea; Double-Blind Method; Female; Humans; Male; Middle Aged; Neprilysin; Thiorphan; Time Factors	1992

Other Studies

16 other study(ies) available for racecadotril and Diarrhea

Article	Year
Can diarrhea affect the pharmacokinetics of racecadotril in neonatal calves? Journal of veterinary pharmacology and therapeutics, 2022, Volume: 45, Issue:5 Topics: Animals; Antidiarrheals; Cattle; Cattle Diseases; Cryptosporidiosis; Cryptosporidium; Diarrhea; Thiorphan	2022
Drugs in Focus: The Use of Racecadotril in Paediatric Gastrointestinal Disease. Journal of pediatric gastroenterology and nutrition, 2020, Volume: 70, Issue:2 Topics: Antidiarrheals; Child; Diarrhea; Gastrointestinal Diseases; Humans; Pharmaceutical Preparations; Thiorphan	2020
Effects of Racecadotril on Weight Loss and Diarrhea Due to Human Rotavirus in Neonatal Gnotobiotic Pigs ( Comparative medicine, 2017, Mar-01, Volume: 67, Issue:2 Topics: Animals; Antidiarrheals; Diarrhea; Drug Evaluation, Preclinical; Rotavirus; Rotavirus Infections; Sus scrofa; Thiorphan; Weight Loss	2017
Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea. The Journal of pharmacology and experimental therapeutics, 2016, Volume: 357, Issue:2 Topics: Animals; Antidiarrheals; Castor Oil; Charcoal; Diarrhea; Dose-Response Relationship, Drug; Endopeptidases; Feces; Gastrointestinal Motility; Male; Protease Inhibitors; Rats; Rats, Wistar; Thiorphan	2016
Racecadotril May Reduce Diarrhoea in Microvillous Inclusion Disease. Journal of pediatric gastroenterology and nutrition, 2017, Volume: 64, Issue:1 Topics: Antidiarrheals; Child, Preschool; Diarrhea; Humans; Malabsorption Syndromes; Male; Microvilli; Mucolipidoses; Thiorphan	2017
[Consensus paper treatment of acute traveler's diarrhea. Practice recommendation for travel advice]. MMW Fortschritte der Medizin, 2017, Volume: 159, Issue:Suppl 4 Topics: Anti-Bacterial Agents; Antidiarrheals; Consensus; Diarrhea; Dysentery; Germany; Humans; Practice Guidelines as Topic; Thiorphan; Travel	2017
Colon in acute intestinal infection. Journal of pediatric gastroenterology and nutrition, 2009, Volume: 48 Suppl 2 Topics: Acute Disease; Antidiarrheals; Caco-2 Cells; Colon; Diarrhea; Drug Evaluation, Preclinical; Gastroenteritis; Humans; Intestinal Absorption; Rotavirus Infections; Thiorphan; Zinc	2009
The potential role of racecadotril in the treatment of diarrhea associated with roflumilast. Archivos de bronconeumologia, 2012, Volume: 48, Issue:11 Topics: Adrenergic beta-2 Receptor Agonists; Adult; Aminopyridines; Antidiarrheals; Benzamides; Child; Cyclic AMP; Cyclopropanes; Diarrhea; Humans; Neprilysin; Phosphodiesterase Inhibitors; Pulmonary Disease, Chronic Obstructive; Thiorphan	2012
[Racecadotril (Tiorfix), oral]. Journal de pharmacie de Belgique, 2012, Issue:4 Topics: Adult; Antidiarrheals; Child; Child, Preschool; Diarrhea; Drug Interactions; Humans; Infant; Infant, Newborn; Thiorphan	2012
Racecadotril (acetorphan) in the treatment of acute watery diarrhoea in children. Journal of the Indian Medical Association, 2002, Volume: 100, Issue:8 Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Fluid Therapy; Humans; Thiorphan	2002
Racecadotril-is there enough evidence to recommend it for treatment of acute diarrhea? Indian pediatrics, 2004, Volume: 41, Issue:12 Topics: Antidiarrheals; Diarrhea; Humans; Thiorphan; Treatment Outcome	2004
Racecadotril in acute diarrhea. Indian pediatrics, 2005, Volume: 42, Issue:5 Topics: Acute Disease; Antidiarrheals; Child; Diarrhea; Drug Evaluation; Female; Humans; Male; Research Design; Thiorphan	2005
Current status of anti-diarrheal and anti-secretory drugs in the management of acute childhood diarrhea. Indian journal of pediatrics, 2006, Volume: 73, Issue:8 Topics: Acute Disease; Antidiarrheals; Antiparasitic Agents; Child; Child, Preschool; Cholera; Diarrhea; Disease Outbreaks; Dysentery, Bacillary; Female; Humans; Infant; Intestinal Diseases, Parasitic; Male; Nitro Compounds; Probiotics; Thiazoles; Thiorphan	2006
A new enkephalinase inhibitor as an alternative to loperamide in the prevention of diarrhea induced by CPT-11. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:8 Topics: Adult; Antineoplastic Agents, Phytogenic; Camptothecin; Clinical Trials as Topic; Diarrhea; Female; Humans; Irinotecan; Loperamide; Male; Middle Aged; Neprilysin; Randomized Controlled Trials as Topic; Thiorphan	1995
Introduction. Enkephalinase inhibition: a rational approach to antisecretory therapy for acute diarrhoea. Alimentary pharmacology & therapeutics, 1999, Volume: 13 Suppl 6 Topics: Acute Disease; Antidiarrheals; Diarrhea; Humans; Neprilysin; Protease Inhibitors; Thiorphan	1999
Naloxone-reversible antidiarrheal effects of enkephalinase inhibitors. European journal of pharmacology, 1987, Dec-01, Volume: 144, Issue:2 Topics: Amino Acids, Sulfur; Animals; Castor Oil; Diarrhea; Drug Interactions; Gastrointestinal Transit; Loperamide; Male; Metalloendopeptidases; Mice; Naloxone; Neprilysin; Rats; Rats, Inbred Strains; Thiorphan; Tiopronin	1987