rabeprazole has been researched along with Achlorhydria in 6 studies
Rabeprazole: A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, BHCl reversed the impact of hypochlorhydria on dasatinib drug exposure and may be an effective strategy to mitigate potential drug-drug interactions for drugs that exhibit pH-dependent solubility and are administered orally under hypochlorhydric conditions." | 2.79 | The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, N; Dean, B; Ding, X; Dresser, MJ; Frassetto, LA; Frymoyer, A; Jin, JY; Salphati, L; Smelick, GS; Ware, JA; Yago, MR, 2014) |
| "Betaine HCl was well tolerated by all subjects." | 2.78 | Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. ( Benet, LZ; Budha, NR; Dresser, MJ; Frassetto, LA; Frymoyer, AR; Smelick, GS; Ware, JA; Yago, MR, 2013) |
| "Quinine levels were measured fluorometrically from 100 microL samples after simple extraction." | 2.70 | A modification of the quininium resin test for assessing gastric acidity. ( Hurwitz, A; Parsonnet, J; Passaro, DJ; Triadafilopoulos, G, 2002) |
| "We examined 27 patients with hypochlorhydria or achlorhydria based on a predefined basal acid output (BAO) measurement of less than 5." | 1.39 | Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome. ( Metz, DC; Shah, P; Singh, MH; Yang, YX, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, P | 1 |
| Singh, MH | 1 |
| Yang, YX | 1 |
| Metz, DC | 1 |
| Yago, MR | 3 |
| Frymoyer, AR | 1 |
| Smelick, GS | 2 |
| Frassetto, LA | 3 |
| Budha, NR | 1 |
| Dresser, MJ | 2 |
| Ware, JA | 2 |
| Benet, LZ | 3 |
| Frymoyer, A | 1 |
| Ding, X | 1 |
| Dean, B | 1 |
| Salphati, L | 1 |
| Budha, N | 1 |
| Jin, JY | 1 |
| Faber, KP | 1 |
| Wu, HF | 1 |
| Xu, X | 1 |
| Kadiyala, P | 1 |
| Miyazaki, Y | 1 |
| Shinomura, Y | 1 |
| Yasunaga, Y | 1 |
| Higashimoto, Y | 1 |
| Kanayama, S | 1 |
| Aoki, T | 1 |
| Okuda, Y | 1 |
| Narita, T | 1 |
| Miwa, K | 1 |
| Miyazaki, I | 1 |
| Passaro, DJ | 1 |
| Hurwitz, A | 1 |
| Triadafilopoulos, G | 1 |
| Parsonnet, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Gastric pH on the Pharmacokinetics of Dasatinib in Healthy Volunteers[NCT01398046] | Phase 1 | 10 participants (Actual) | Interventional | 2011-08-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for rabeprazole and Achlorhydria
| Article | Year |
|---|---|
Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.
Topics: Achlorhydria; Adult; Anti-Ulcer Agents; Betaine; Female; Healthy Volunteers; Humans; Hydrogen-Ion Co | 2013 |
The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.
Topics: Absorption, Physiological; Achlorhydria; Adult; Antineoplastic Agents; Area Under Curve; Betaine; Cr | 2014 |
Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.
Topics: Absorption, Physiological; Achlorhydria; Administration, Oral; Adult; Atazanavir Sulfate; Betaine; C | 2017 |
A modification of the quininium resin test for assessing gastric acidity.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Adult; Anti-Ulcer Agents; Benzimidazoles; Fem | 2002 |
2 other studies available for rabeprazole and Achlorhydria
| Article | Year |
|---|---|
Hypochlorhydria and achlorhydria are associated with false-positive secretin stimulation testing for Zollinger-Ellison syndrome.
Topics: Achlorhydria; Adolescent; Adult; Aged; Anti-Ulcer Agents; Esomeprazole; False Positive Reactions; Fe | 2013 |
Effect of antrectomy and drug-induced achlorhydria on urinary excretion of N-terminal big gastrin immunoreactivity in rats.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Animals; Benzimidazoles; Female; Gastrectomy; | 1993 |