ra-vii and Leukocytosis

ra-vii has been researched along with Leukocytosis* in 1 studies

Other Studies

1 other study(ies) available for ra-vii and Leukocytosis

Article	Year
Leukocytosis in mice following therapy with a novel antitumor agent, RA-700. Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:3 Nine daily intravenous (iv) injections of RA-700 (an antitumor cyclic hexapeptide) at doses of 2 to 6 mg/kg/day caused increases of WBC counts at 4-6 days after treatment in normal C57BL/6 X DBA/2 (BDF1) mice. The percentages of neutrophils and lymphocytes were modified. There was a decrease of colony-forming units in culture (CFUc) in bone marrow to 40% of the control value on day 1 but CFUc rapidly returned to normal values on day 3. The colony-forming units in spleen (CFUs) in bone marrow decreased during treatment. On the other hand, CFUc and CFUs in spleen were increased from the initiation of treatment to the time prior to the increase of WBC count. Spleen weight increased after treatment, and histologically, increases of immature and also mature granulocytes and megakaryocytes were observed. However, RA-700 did not stimulate the progress of hematoprogenitors in vitro. The results indicated that RA-700 stimulates the progress of hematoprogenitors in the spleen, but this effect is probably indirect. Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Marrow; Colony-Forming Units Assay; Female; Hematopoietic Stem Cells; Leukemia P388; Leukocytosis; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neutrophils; Peptides, Cyclic; Spleen	1989

Article

Year

Leukocytosis in mice following therapy with a novel antitumor agent, RA-700.

Japanese journal of cancer research : Gann, 1989, Volume: 80, Issue:3

Nine daily intravenous (iv) injections of RA-700 (an antitumor cyclic hexapeptide) at doses of 2 to 6 mg/kg/day caused increases of WBC counts at 4-6 days after treatment in normal C57BL/6 X DBA/2 (BDF1) mice. The percentages of neutrophils and lymphocytes were modified. There was a decrease of colony-forming units in culture (CFUc) in bone marrow to 40% of the control value on day 1 but CFUc rapidly returned to normal values on day 3. The colony-forming units in spleen (CFUs) in bone marrow decreased during treatment. On the other hand, CFUc and CFUs in spleen were increased from the initiation of treatment to the time prior to the increase of WBC count. Spleen weight increased after treatment, and histologically, increases of immature and also mature granulocytes and megakaryocytes were observed. However, RA-700 did not stimulate the progress of hematoprogenitors in vitro. The results indicated that RA-700 stimulates the progress of hematoprogenitors in the spleen, but this effect is probably indirect.

Topics: Animals; Antineoplastic Agents, Phytogenic; Bone Marrow; Colony-Forming Units Assay; Female; Hematopoietic Stem Cells; Leukemia P388; Leukocytosis; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neutrophils; Peptides, Cyclic; Spleen

1989