ra-vii and Leukemia

ra-vii has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for ra-vii and Leukemia

Article	Year
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide. Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8 A reduced peptide bond analogue of RA-VII, [Tyr-5-Ψ(CH(2)NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with FDPP under dilute conditions gave 3. Analogue 3 showed cytotoxic activity against P-388 cells, but its activity was much weaker than that of parent peptide RA-VII. Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Discovery; Humans; Inhibitory Concentration 50; Leukemia; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Peptides, Cyclic	2012

Article

Year

Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.

Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

A reduced peptide bond analogue of RA-VII, [Tyr-5-Ψ(CH(2)NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with FDPP under dilute conditions gave 3. Analogue 3 showed cytotoxic activity against P-388 cells, but its activity was much weaker than that of parent peptide RA-VII.

Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Discovery; Humans; Inhibitory Concentration 50; Leukemia; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Peptides, Cyclic

2012