ra-vii and Leukemia

ra-vii has been researched along with Leukemia* in 1 studies

Other Studies

1 other study(ies) available for ra-vii and Leukemia

ArticleYear
Synthesis of [Tyr-5-Ψ(CH2NMe)-Tyr-6]RA-VII, a reduced peptide bond analogue of RA-VII, an antitumor bicyclic hexapeptide.
    Bioorganic & medicinal chemistry letters, 2012, Apr-15, Volume: 22, Issue:8

    A reduced peptide bond analogue of RA-VII, [Tyr-5-Ψ(CH(2)NMe)-Tyr-6]RA-VII (3), was designed and synthesized. The key reduced cycloisodityrosine unit was prepared by reduction of the cycloisodityrosine derived from natural RA-VII, followed by connection with the tetrapeptide segment to afford a hexapeptide. Subsequent macrocyclization of the hexapeptide with FDPP under dilute conditions gave 3. Analogue 3 showed cytotoxic activity against P-388 cells, but its activity was much weaker than that of parent peptide RA-VII.

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Discovery; Humans; Inhibitory Concentration 50; Leukemia; Magnetic Resonance Spectroscopy; Molecular Structure; Oxidation-Reduction; Peptides, Cyclic

2012