r 59022 has been researched along with Muscle Contraction in 6 studies
R 59022: diacylglycerol kinase inhibitor; structure given in first source; platelet activator factor antagonist
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "R 59022 was significantly more active to block the tonic than the phasic component of the contractile response to K+ depolarization." | 1.28 | The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle. ( Holzer, P; Lippe, IT, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (33.33) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Sharma, P | 1 |
| Yadav, SK | 1 |
| Shah, SD | 1 |
| Javed, E | 1 |
| Lim, JM | 1 |
| Pan, S | 1 |
| Nayak, AP | 1 |
| Panettieri, RA | 1 |
| Penn, RB | 1 |
| Kambayashi, T | 1 |
| Deshpande, DA | 1 |
| Nobe, K | 2 |
| Ohata, H | 2 |
| Momose, K | 2 |
| Karibe, H | 1 |
| Oishi, K | 1 |
| Uchida, MK | 1 |
| Evans, RL | 1 |
| McCrohan, CR | 1 |
| Butler, RD | 1 |
| Lippe, IT | 1 |
| Holzer, P | 1 |
6 other studies available for r 59022 and Muscle Contraction
| Article | Year |
|---|---|
Diacylglycerol Kinase Inhibition Reduces Airway Contraction by Negative Feedback Regulation of Gq-Signaling.
Topics: Bronchoconstriction; Cells, Cultured; Diacylglycerol Kinase; Gene Knockdown Techniques; GTP-Binding | 2021 |
Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli.
Topics: Animals; Calcium; Colon; Guinea Pigs; Muscle Contraction; Platelet Activating Factor; Pyrimidinones; | 1993 |
Role of phosphatidic acid in carbachol-induced contraction in guinea pig Taenia coli.
Topics: Animals; Biological Transport, Active; Calcium; Carbachol; Colon; Diacylglycerol Kinase; Diglyceride | 1991 |
Involvement of protein kinase C in Ca(2+)-independent contraction of rat uterine smooth muscle.
Topics: Animals; Blotting, Western; Brain; Calcium; Electrophoresis, Polyacrylamide Gel; Female; In Vitro Te | 1991 |
Tentacle contraction in Heliophrya erhardi (Suctoria): the role of inositol phospholipid metabolites and cyclic nucleotides in stimulus-response coupling.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Chlorides; Ciliophora; Cyclic AMP; Cyclic GMP; Di | 1988 |
The diacylglycerol kinase inhibitor, R 59022, suppresses contractility of intestinal smooth muscle.
Topics: Acetylcholine; Animals; Calcium; Diacylglycerol Kinase; Female; Guinea Pigs; Histamine; In Vitro Tec | 1989 |